Gene 1647 (Tetrahymena)

1647

Species: Tetrahymena
Alias: 337.m00012, 1647, PreTt01647, 3805.m00066, TTHERM_01345780, 255
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
1647.AA Protein None 1237 None Fasta, JSON
1647.kin_dom Protein Kinase Domain None 233 None Fasta, JSON
1647.NA RNA None 3714 None Fasta, JSON

Protein domain

Protein domains of 1647.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1647.AA Fused 39-236 59 1.9e-123 416.38 In-house 54-251 (251) Show / Hide 
Range on Protein: 39-236
Range on HMM: 54-251/251
Sequence Identity: 59% (118 aa)

RLKHENIILLLDAFETPHEFCVVTEFAQGELFEILEDDRSLPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISANGVVKLCDFGFARALSSNTQV
|..| .|| ..| |||  |  |||..| .||. .||.|  .||  ||.|| .|. || ||||.|| ||||||||||   |...|||||||||..| || |
RMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVRRIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHV

LTSIKGTPLYMAPELVKEQPYNHTVDLWSLGVILYELFVGQPPFYTNSIYKLIDLIIKDPVKYPDNMSQEFKDFLMGLLNKNPSERADWPNLLNHPFI
|||||||||||||||| |||| |. |.|||| |||||.||||||..|||..|. .|..|.||.|  .. ... || ||| | |  |  ||.|| |||.
LTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCANSIFHLVSMIKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase 1647.AA AGC 4-236 22 3.2e-107 277.72 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

YHILHQIGEGSFGKVFKGRRK------NTGQILALKFISKRR---------LKH----------------ENIIL--------------------LLDAF
...|  ||.||||||.  |.|       ||.. |.| ..|..         ..|                 ||                      |  .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPHE--FCVVTEFAQ----------G-ELFEILE---DDRSLPESEVRKIAQQ-------LILALDYLHS-NRIIHRD-MKPQNILISANGVVKLCDFG
...     . | |...          | ||| .|    . ....|...| .| .       ..|||.|||| . ||||| .|| |||. ..| .||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARALSS--------------------------------------------------NTQVLTSIKG--TPLYMAPELVKEQPYNHTVDLWS--LGVILY
..  . .                                                  ...  ... |  || ||||| .    |....| ||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELFVGQPPFYTNS----------IYKLIDLII------KDPVKYP----------DNMSQEFKDFLMGLLNKNPSERAD----------WPNLLNHPFI
|. .|.|||| ..           ... ..|.      ...||.|          ...|.| ||.. .||.|.|..|               . |||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 1647.AA ULK 4-236 29 1.2e-102 347.3 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-329/329
Sequence Identity: 29% (96 aa)

YHILHQIGEGSFGKVFKGRRKNT----GQILALKFIS-------K-------------------RRLK--------HENIILLLDAFETPHE--FCVVTE
|.. |..|.||||||.||| |.|    ... | | |.       .                   ..||        |.||. |.| |||...  .  ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FAQG-ELFEILEDDRS----------LPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISAN------------GVVKLCDFGFARALSSN---TQ
. .|  |..... ..           |.|.|.... .|.. .. .||...|||||.|||||||. .            ||.|..|||||. ....    |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VLTSIK------GTPLYMAPELVK----EQPYN-HTVDLWSLGVILYELFVGQPPFYTNSIYKLI-----DL----------IIKDPVKYP-----DNMS
.... .      ||||||||....    ..||. ...|.||||.|.||. .|.||||.. .....     .|          | | | ..|     .. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QEFKDFLMGLLNKNPSERADWPNLLNHPFI
.|.||.. ..| .....| .|. |.|||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 1647.AA ULK 4-236 28 2.3e-102 346.35 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

YHILHQIGEGSFG-KVFKGRRKNT---GQILALKFIS--------KR------------------RLK---HEN--IILLLDAFETPHE--FCVVTEFAQ
| . |..|.|||| ||.||| |.|   .|. | | |.        ..                   ||   |.|  |. |.| |||...  .. ..|. .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

G-ELFEILEDDRS---------LPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISAN------------GVVKLCDFGFARALSSNT---QVLTS
|  |..... ..          |.|.|.... .|.. .. .||.. |||||.|||||||. .            ||.|..|||||. . .|.   |....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IK------GTPLYMAPELVK----EQPYN-HTVDLWSLGVILYELFVGQPPFYTNSIYKLI----DL----------IIKDPVKYPD-----NMSQEFKD
..      ||||||||....    ..||. . .|.||||.|.||.  |..||... .....    .|          | . |...|.     . |.|.||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLMGLLNKNPSERADWPNLLNHPFI
.....| .....| .|. ..|||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 1647.AA S_TKc 4-236 35 7.5e-98 332.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-231/231
Sequence Identity: 35% (92 aa)

YHILHQIGEGSFGKVFKGRRKNTGQILALKFISKRRL---------KHENIILLLDAFETPHEFCVVTEFAQG---ELFEILEDDRS------LPESEVR
|.|| .||.|.||||.|.| |.||.| |.| |. ...         .|.||. |.|.|.. .....|.|.. |   .||..... ..      .|| ..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

KIAQQLILALDYLHSNRIIHRDMKPQNILISANGVVKLCDFGFARALSSNTQVLTSIKGTPLYMAPELVKEQPYNH-TVDLWSLGVILYELFVGQPPFYT
....|...||.|.||..||||| ||.|||..   ..|.||||.|| |       |.. ||| |||||..   .|..  .| ||.|.||||...|.|||. 
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-

NSIYKLIDLIIKDPVKYPDNMSQEFKDFLMGLLNKNPSERADWPNLLN-------HPFI
  .......|           |.|.|||....|.|.|..|     .|.       ||..
-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1647.AA CAMK 9-236 22 4.2e-87 280.62 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-236
Range on HMM: 1-425/425
Sequence Identity: 22% (96 aa)

QIGEGSFGKVFKGRRKNTG------------QILALKFISKRRLK---------------------------------------------------HENI
..|.||||||.....|||.            |  | |.|.|..||                                                   |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ILLLDAFETPH-------------------EFCVVT---EFAQG-ELFE--------------------ILEDDRSLPESEVRKIAQQLILALDYLHSNR
| |....|.||                   ... |.   |...| |||.                    |. ... ..|.|.|.. .|.. |..|.||. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDMKPQNILISAN-----------------GVVKLCDFGFARALSSN-----------------------TQVLTSIKGTPLYMA-PELVK------
|.||| || |||.. |                 . .|..|||||. . ..                       .| ..   ||| ||| ||...      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------EQPYNHTVDLWSLGVILYELFVGQPPFYTN-------------SIYKLIDLIIKDPVKYPDN------------------------MSQEFK
        ...|.  .| ||.||||| . .| ||||               ..|.|   |.|    .|.                          ||| |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFLMGLLNKNPSERADWPNLLNHPFI
|.. ..|...|..|.     ||||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 1647.AA Ciliate-E2-Unclassified 4-236 25 1.7e-81 277.09 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YHILHQIGEGSFGKVFKGRRKNTG-----------QILALKFISK------------------------------RRLKHENIILLLDAFETPHEFCVVT
|.|..|||.|.||||.| ..|...           || . | | .                              . ..|..|. ....|..   .. |.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFA------------------QGELFEILEDDRSLPESEVR-----KIAQQLILALDYLHSN-RIIHRDMKPQNILISANG---VVKLCDFGFARALSSN
|..                  ...||. .. .. ..| ...     ... |....|.|||..  ||||| ||.|||.. ||    .|..|||... . .|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------TQVLTSIKGTPLYM----APELVKEQPYNHT----VDLWSLGVILYELFVGQPPFYTNSIYK----------------LIDLIIK
                | .... ||| ||    |||. ..| |.|.    .| |||||||||.  |..||| |. ..                |.. |..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

DPVKYP--------DNMSQEFKDFLM----GLLNKNPSERADWPNLLNHPFI
 ....|        .. |.| |||.      .|.|||..| ... .||||..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 1647.AA Pkinase 38-236 33 5.6e-81 280.12 Pfam 55-293 (293) Show / Hide 
Range on Protein: 38-236
Range on HMM: 55-293/293
Sequence Identity: 33% (81 aa)

RRLKHENIILLLDAFETPHEFCVVTEFAQG-----ELFEILE--DDRSL--PESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISANGVV----KLC
.||.|.||. |.|.||.. . ..|.|...|     .||....  .....  .| |..... |.. .|.|.||..|||||.||.||||. ||..    |.|
KRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC

DFGFARAL-SSNTQVLTSIKGTPLYMAPELVK-EQPYNHTVDLWSLGVILYELFVGQPPFYTN------SIYKLIDLIIKDPVKYPD-------------
|||.|. .   | . .|.. ||| |||||...  |.| . || ||.|.||||.. |.|||.        . ...|..| . |....              
DFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH

--------NMSQEFKDFLMGLLNKNPSERADWPNLLNHPFI
        |.|.|.|||. ..|.|.|..|  .. .|.||..
WHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 1647.AA CAMKL 4-236 29 6.2e-78 248.27 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-297/297
Sequence Identity: 29% (88 aa)

YHILHQIGEGSFGKVFKGRR-KNTGQILALKFISKRRLK----------------------------------HENIILLLDAFETPHE------FCVVT
| |. ..|.||||||  ..  ..||.  | |.| |....                                  |.||| |.. .|||        .. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFAQGE---LFEILEDD----RSLPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISANG--VVKLCDFGFARALSSN----TQVLTSIKGTPLYM
| ..|    ||. ..      ...||.| |.. .|.. |..|.||..|.||| || |||.. ||  ..|..||||.     .     | |.   |.| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APELVKE--QPYN-HTVDLWSLGVILYELFVGQPPFYTNSI-------YKLIDLIIKDPVKYPD---NMSQEFKDFLMGLLNKNPSERADWPNLLNHPFI
|||...   .||.   || ||.||||| . .|. ||   ..       . .  ..|.   .||.    .| . .|.. ..|..||..|.   ...|||. 
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 1647.AA Ciliate-E2 4-236 23 2.7e-75 256.47 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

YHILHQIGEGSFGKVFKGRRKNTGQ-------------------------------------ILALKFISK---------------RRLKHENIILLLDA
| .. .||.|.||.|.|........                                     |.  . | .               ..|.| ||| . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--TPHEFCVVTEFAQG-ELFEILE------------DDRSLPESEVRKIAQQLIL---------------ALDYLHSNR-IIHRDMKPQNILISANGV
|.  . . .  |.|..|| .||....            |  .. | |...| .|..                || ||||.  ||||| ||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLCDFGFARALSSNTQ-------------------------------VLTSIKGTPLYMAPELVKEQP---------YNHTVDLWSLGVILYELFVGQP
.|..|||... .. . |                               .  .| ||| ||||| .. ..         |.. .|.|||||||||.  |.|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFYTNSIYKLIDLIIKDPVKYP------------------DNMSQEFKDFLMG----LLNKNPSERAD-WPNLLNHPFI
||        .. |.. ....|                  .. ||| ||..      .|.|.|..| . |  .||||..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 1647.AA STE 4-236 23 5.2e-75 255.5 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YHILHQIGEGSFGKVFKGRRKN---------------TGQILALKFIS---------------------------------KRRLK--HENIILLLDAFE
. .. .||.|.||.|.|.....               ||.| | | ..                                  ....  |.||.  .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TP-------HEFCVVTEFAQ-GELFEILE----DDRSLP----------ESEVRKIAQQLILA-LDYLHSNRIIHRDMKPQNILISANGVVKLCDFGFAR
         .| ... |.   | | .|..      ..|.          ||....|..|.. . |.||||..||||| ||.|||.     |||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ALSS---------------NTQ-VLTSIKGTPLYMAPELVKE------QPYNHTVDLWSLGVILYELFVGQPPFYT-NSIYKLIDLIIK-----------
 |..               ..|   ... ||| .|||| ..       ..|.  .| ||||  . |.  |.||. . .  . .   ...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----DPVKYPD-------------------NMSQEFKDFLMGLLNKNPSERADWPNLLN--HPFI
    .| . ||                   ..|.|||||.   |.|.|..|..   ||.  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1647.AA RSK 7-236 30 3.1e-72 246.3 In-house 1-278 (278) Show / Hide 
Range on Protein: 7-236
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

LHQIGEGSFGKVFKGRRK---NTGQILALKFISK--------------------RRLK-HENIILLLDAFETPHEFCVVTEFAQG-ELFEILEDDRS---
| . |.|..||||  |..   .|||| | | ..|                     | . | .|. | .||.|. ..  ..|.  | |||. |.  ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISA---NGVVKLCDFGFARALSSN-TQVLTSIKGTPLYMAPELVK---EQP-YNHTVDLWSLGV
. |.|.. .. ...||...||.  ||||| || |||      .| .||.||||.. .. . .| . .  .|  |||||..|    |  ... .|.|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

ILYELFVGQPPFYT---NSIYKLIDLIIKDP--VKYP--DNMSQEFKDFLMGLLNKNPSERAD-----WPNLLNHPFI
..||...|.|||.    |.  .... | |    .. |  ...|||.||.. ..| ..|. |          ...||..
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 1647.AA Pkinase_Tyr 38-196 26 4.3e-17 58.52 Pfam 58-231 (270) Show / Hide 
Range on Protein: 38-196
Range on HMM: 58-231/270
Sequence Identity: 26% (47 aa)

RRL-KHENIILLLDAFE--TPH-EFCVVTEFAQG-ELFEILED----DRSLPESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISANGVVKLCDFGF
. | .|.||. |. .      . . ..|.|....  | . | .    ...|. ..  ....|   ...||.|...||||    |.|.. |.||| |||| 
KQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGL

ARAL-SSNTQVLTSIKGTPL---YMAPELVKEQPYNHTVDLWSLGVILYELFV-GQPP-FYTNSIYKLIDLI-IK
||.. .  .  ... .|..|    ||||  ..  ...  | || || ..|.|  |. | ..  | . ....|  .
ARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase 1647.AA Fused 4-38 51 3.1e-16 52.06 In-house 1-35 (251) Show / Hide 
Range on Protein: 4-38
Range on HMM: 1-35/251
Sequence Identity: 51% (18 aa)

YHILHQIGEGSFGKVFKGRRKNTGQILALKFISKR
||..  .|.|||| |.|.|||   .. |.|||.||
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKR
Kinase 1647.AA TyrKc 4-236 23 9.3e-16 32.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-236
Range on HMM: 1-280/280
Sequence Identity: 23% (66 aa)

YHILHQIGEGSFGKVFKGRRKNTGQILALKFISK-------------RRL--KHENIILLLDAFETP-------HEFCVVTEFAQ-GELFEILEDDRS-L
 . ....||| ||.|.||. |   .  | | . .             ..|  .|.||. |. .  ..       .  ..|.|..  | | . | . |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

PESEVRKIAQQLILALDYLHSNRIIHRDMKPQNILISANGVVKLCDFGFARALSSN------TQVLTS--IKGTP--L---YMAPELVKEQPYNHTVDLW
. ..  ... |     .||||...||||    |.|...|..|| .||| .|.. .       ... ..   ||.   |    ||||  ..  ...  | |
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

SLGVILYELF-VGQPPFYT-----NSIYKLIDLIIKD-PVKYPDN--------MSQEFKDFLMGLLNKNPSERADWPNLLNHPFI
| || ..|.|  ||.| .       | . .| .. .    . |.|        ...|  .      . .|..|    ..  | ..
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 1647.AA Pkinase 4-37 55 5.4e-11 39.95 Pfam 1-34 (293) Show / Hide 
Range on Protein: 4-37
Range on HMM: 1-34/293
Sequence Identity: 55% (19 aa)

YHILHQIGEGSFGKVFKGRRKNTGQILALKFISK
|||. .||.||||.|.|...|.||.| |.| |.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK
Kinase 1647.AA Pkinase_Tyr 4-33 38 7.8e-05 17.0 Pfam 1-34 (270) Show / Hide 
Range on Protein: 4-33
Range on HMM: 1-34/270
Sequence Identity: 38% (13 aa)

YHILHQIGEGSFGKVFKGRRK----NTGQILALK
 ......|||.||.|.||. |    ||..  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
HEAT 1647.AA HEAT 1011-1041 29 0.009689 13.35 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1011-1041
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

IYQELKKLIVHKEGSVRAKVCNFIGNICRHS
| . | |.. ... .||. .|. .|..|.|.
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 1647.AA HEAT 1053-1083 25 0.009126 13.44 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1053-1083
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LISACIECCKDSDKATRKFACFAVGNAGFHN
.......|..|.|   |. || ..|.   | 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT 1647.AA HEAT 1093-1123 29 6.7e-07 27.75 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1093-1123
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

VVPLLVDLLKDPEEKTRANAAGALGNFVRNS
..|.|. .|.||... |..|. .||......
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
Arm 1647.AA Arm 1093-1121 44 2e-06 25.5 Pfam 13-41 (41) Show / Hide 
Range on Protein: 1093-1121
Range on HMM: 13-41/41
Sequence Identity: 44% (13 aa)

VVPLLVDLLKDPEEKTRANAAGALGNFVR
.||.||.||..|.|... ||..||.| ..
CVPPLVQLLHHPDEEVQENACWALWNLCA