Gene 1429 (Tetrahymena)

1429

Species: Tetrahymena
Alias: PreTt01429, 1429, 180.m00049, TTHERM_00969600, 295, 3749.m00248
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
1429.AA Protein None 861 None Fasta, JSON
1429.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
1429.NA RNA None 2586 None Fasta, JSON

Protein domain

Protein domains of 1429.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1429.AA ULK 179-434 41 4.1e-139 468.44 In-house 1-324 (324) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-324/324
Sequence Identity: 41% (136 aa)

FQLSSVLGQGSFG-KVFKGKNTEN---GQLVAIKMIEKKQIQND------EYLMNGLFSEIQIMKKLK---SEY--VVDLIDVLETS--NNYYIIQEYCD
..|. .||.|||| ||.||.| ..   .|.||.|||.||.....      .|... | .|||||||||   ...  .| |.|..|||  ||.|||.|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDFRSELKKR---------KNLSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIKGNQ-------------HKLADFGFARTVDN--FQRQMLTS
|||... .||.         |.||||| ....|...|||..| |..|||||.||.||||. .|              |.||||||..|||  .. ||...
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTPLYMSPQILM----HEKYT-AKSDLWSLAFIFYEMLYGKTP---YTANSQY----QLVKN-------IQTKPLEFD---PAYNVSDLSKD
.|      ||||||.||||.    ...|. .|.|.|||  |||||||||.|   . .|.||    .|..|       |...|..|.   .....|. .||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FITRCLKIDEKDRMEWTDVYKHPVF
.| |.|..|||||..|.....||.|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 1429.AA ULK 179-434 41 1.7e-136 459.77 In-house 1-329 (329) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-329/329
Sequence Identity: 41% (136 aa)

FQLSSVLGQGSFGKVFKGKNTEN----GQLVAIKMIE---KKQIQND---EYLMNGLFSEIQIMKKLK----SEY----VVDLIDVLETS--NNYYIIQE
..|. .||.||||||.||.| ..    ...||.|||.   ..|..|.   .|... | .||.||||||    ...    .| |.|..|||  ||.|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCDGGDFRSELKKRKN----------LSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIKGNQ-------------HKLADFGFARTVDNF--QRQ
||.|||... .||.|.          ||||| ....|..||||..| |..|||||.||.||||. .|              |.||||||..|||.  . |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MLTSLV------GTPLYMSPQILM----HEKYT-AKSDLWSLAFIFYEMLYGKTP---YTANSQY-----QLVKN-------IQTKPLEFD---PAYNVS
|... |      ||||||.||||.    ...|. .|.|.|||  |||||||||.|   . .|.||     .|..|       |...||.|.   .....|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DLSKDFITRCLKIDEKDRMEWTDVYKHPVF
. .||.| |.|..|||||..|.....||.|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 1429.AA S_TKc 179-434 32 5.9e-84 286.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

FQLSSVLGQGSFGKVFKGKNTENGQLVAIKMIEKKQIQNDEYLMNGLFSEIQIMKKLKSEYVVDLIDVLETSNNYYIIQEYCDG--GDFRSELKKRKN--
...  ..|.|.||||.|..... |..||||.|            . . .||||.|| . ...| |.|| .. ...|.. |||||  || .. .|||.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIKGNQHKLADFGFARTVDNFQRQMLTSLVGTPLYMSPQILMHEKYTA-KSDLWSLAFIFY
    ..| .   .|. ....   . ..|||||||||||||.   . |..|||.|| .        |...||| ||.| .|   .|.  |.| ||.  |.|
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLYGKTPYTANSQYQLVKNIQTKPLEFDPAYNVSDLSKDFITRCLKIDEKDRMEWTDVYK-------HPVF
|||.|..|.    .... |.|             |.  |||| .||. | ..|.   .. .       || |
EMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1429.AA Pkinase 179-434 33 1.4e-79 275.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

FQLSSVLGQGSFGKVFKGKNTENGQLVAIKMIEKKQIQNDEY-----LMNGLFSEIQIMKKLKSEYVVDLIDVLETSNNYYIIQEYCDGG----DFRSEL
... ...|.||||.|.|...  .|..||.| |.|. .  ..      |     |||||||.|.....| |.|. |.....|...|||.||    |  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K--KRKNL--SEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIK-GNQH----KLADFGFARTVDNFQRQMLTSLVGTPLYMSPQILM-HEKYTAKS
.  .....  ||.|  ..|. .| |   . ..||||||||||||||.  ..     |..|||.|. .|.   . .|...||| ||.| ... ...|. |.
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DLWSLAFIFYEMLYGKTPYTAN------SQYQLVKNIQTKPLEFDPA-------------------YNVSDLSKDFITRCLKIDEKDRMEWTDVYKHPVF
| ||.  |.|||| |..|.         .|.|....|  .||.||                     .|.|.  ||||..||. | |.|  .... .|| |
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 1429.AA AGC 179-434 20 6.5e-78 200.19 In-house 1-395 (395) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-395/395
Sequence Identity: 20% (83 aa)

FQLSSVLGQGSFGKVFKGKNT------ENGQLVAIKMIEK--KQIQND----EYLMNG--------LFSEIQIMKKLK----------SEYVVD-LIDVL
|..  |.|.||||||.  .         .|.. |.|...|  | ....    |. |.         ...| .|..|..          . ..|  |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETSNN--YYIIQEY---------CDGG-DFRSELK---KRKNLSEQESLNVMKD-------LLNGFMDLLK-NGIIHRD-LKPENILIKGNQH-KLADFG
.. ..   |.. ||         | || .. . |.   |.. ..|...   .         .. ..  | . .|||||| |||||||.  . | ||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARTVDNF-------------------------------------------------QRQMLTSLVG--TPLYMSPQILMHEKYTAKSDLWS--LAFIFY
..  . |                                                  .|.. ....|  || ||.| ||    |.   | ||  |  ..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGKTPYTANS----------QYQLVKNIQ------TKPLEFDPA--------YNVSDLSKDFITRCLKIDEKDRME----------WTDVYKHPVF
|||.|..|.....          .... ..|.      .....|..          ..|.  ||.|...|. | ..|              .. .|| |
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 1429.AA Ciliate-E2 179-434 23 2.5e-75 256.57 In-house 1-365 (365) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

FQLSSVLGQGSFGKVFKGKNTENGQL------------------VAIKMIEKKQIQND--EYLMN--GLFSEIQ----------IMKKLKSEYVVDLIDV
. .  ..|||.||.|.|.|. .....                  |.||....|.....  |....   .. ||.          |...|.. ... ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LE--TSNNYYIIQEYCDGGDFRSELKKR-----------KNLSEQESLNVMKDLLNGF--------------MDLLKN-G-IIHRDLKPENILIKGNQHK
 .  . ||.|.. |||.||| .. .|..           |...|.| ...|| .|.||              .  |.. . |||||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

LADFGFARTVDNFQR------------------------------QMLTSLVGTPLYMSPQILMHEK---------YTAKSDLWSLAFIFYEMLYGKTPY
..|||... .|...                               .|  ...||| ||.|.||. .|         |. |.|.|||  |.||||.||.|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

TANSQYQLVKNIQTKPLEFDPA---------------Y-NVSDLSKDFITR----CLKIDEKDRME-WTDVYKHPVF
         ..|. ....|...               . ..|.  ||.| .    .|. |.. |.  | .. .|| |
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 1429.AA Ciliate-E2-Unclassified 179-434 26 2.5e-74 253.23 In-house 1-352 (352) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-352/352
Sequence Identity: 26% (92 aa)

FQLSSVLGQGSFGKVFKGKNTENGQLVAIKMIEKKQIQNDEYLMNG---LFSEIQIMKK------------------LKSEYVVDLIDVLETSNNYYIIQ
. .  ..|||.||||.| .. ...|. |.|.. |.||... . ||    .........|                  ......| .... .. .| ||. 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCDGGDFRSELKKRKN-----------------LSEQESL-----NVMKDLLNGFMDLLKNG-IIHRDLKPENILIKGNQ---H-KLADFGFARTVDNF
|||.||| .  .||||.                 ..||...     . .. .|.|.  | ... |||||.||||||.. |.   . |..|||...  ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------QRQMLTSLVGTPLYM----SPQILMHEKYT----AKSDLWSLAFIFYEMLYGKTPYTANSQYQ----------------LVKNIQT
              ..||... .||| ||    .| .|. ..|      |.| |||  |.||||.|. |. .|...|                | .||. 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KPLEFDPAYN------VSDLSKDFIT----RCLKIDEKDRMEWTDVYKHPVF
|...|... .      .|.  ||||.    ..|| . . |. . .. .|| |
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 1429.AA CAMK 184-434 21 3.2e-74 238.37 In-house 1-425 (425) Show / Hide 
Range on Protein: 184-434
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

VLGQGSFGKVFKGKNTENG------------QLVAIKMIEKKQIQND------------------------EYLMNGLFSEIQIMKK-------LKSEYV
.||.||||||.........            | ||||.|.||.....                        .. .  ...||.||||       |. . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VDLIDVLE------------TSNN--------YYIIQ---EYCDGG----DFRSELKKRKN---------------LSEQESLNVMKDLLNGFMDLLKNG
. |..| |            | ..        .|..    |||.||    |  . ......               ..|.|   ... .. .   . ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPENILIKGN------------------QHKLADFGFA--RTVDNFQR--------------------QMLTSLVGTPLYMS-PQILMH-----
|.||||||||||.  |                  . |..|||||   . .. ..                    |...  .||| ||. | .|       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKYTAKSDLWSLAFIFYEMLYGKTPYTAN-------------SQYQLVKNIQTKPLEFDPAY----------------------NVSDLSK
         . |. |.| ||.  | | || |. |. .              ..|.| ..|..   .|.| |                      .||.  |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFITRCLKIDEKDRMEWTDVYKHPVF
|.| ..|. | ..||  ... .|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 1429.AA Ciliate-E2c 179-434 28 7.7e-67 228.36 In-house 1-310 (310) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-310/310
Sequence Identity: 28% (89 aa)

FQLSSVLGQGSFGKVFKGKNTE---NGQLV-------AIKMIEKKQI----QNDEYLMNGLFSEIQIMKKLKSEYVVDLIDVLETSNNYYIIQEYCDGGD
.   . ||.||.|||.|... |   | ...       ||||.  | .     |.    . .  ||..||.... ...  .|   |... |.| ||| ||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

FRSELKKRKNLSEQESLNVMKDLLNGFMDLLKN-GIIHRDLKPENILIKGNQHKLADFGFARTVDNFQRQMLT---SLVGTPLYMSPQILMH-EKYTAKS
  . .... ...|.. |   . ....|  | |. .|.|||.|||||||.  . |.|||||.. ....  |  .     .|||.||.||||    .|| ||
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DLWSLAFIFYEMLYGKTPYT------------------ANSQYQLVKNIQ---------------TKPLEFDPA--YNVSDLSKDFITRCLKIDEKDRME
|.|||    |.||. | |                    .|.. .|...|                |... | ..   |.|   |..| . |  ||..| .
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

WTDVYKHPVF
| ..  |. .
WDEIFNHECI
Kinase 1429.AA CAMKL 179-434 28 1.6e-63 201.53 In-house 1-297 (297) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-297/297
Sequence Identity: 28% (86 aa)

FQLSSVLGQGSFGKVFKGKNTEN-GQLVAIKMIEKKQIQNDEYLMNG-----------LFSEIQIMKKLK---SEYVVDLIDVLETSNN------YYIIQ
...  .||.||||||  .... . |. ||||.|.|| |.||.. ..            .. ||||||.|.    . .. | .|.||...      .|.. 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCDGGD--FRSELKKRKN----LSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIKGNQH---KLADFGFARTVDN--FQ-RQMLTSLVGTPLYM
|||.||.      ..|...    ..| |     . .. .   . ..||.|||.||||||.  |.    |..||||.   ..  |.  |.|.   |.| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPQILMH--EKYT-AKSDLWSLAFIFYEMLYGKTPYTAN--------SQYQLVKNIQTKPLEFDPAYNVSDLSKDFITRCLKIDEKDRMEWTDVYKHPVF
.| |.    ..|   | | ||.  | | |..|. |  .          .  | . | .   .... | ||   .|.| . |. . ..|.   .. .|| .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 1429.AA STE 179-434 22 5.7e-61 208.87 In-house 1-359 (359) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

FQLSSVLGQGSFGKVFKGKNT------ENGQL---------VAIKMIEKKQIQN-------------DEYLMNGLFSEIQIMKKLK--SEYVVDLIDVLE
... ...|.|.||.|.|..|       ..|..         .||| ..... .|             ..  |. .  ||.||||..  ....|  ..  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS-------NNYYIIQEYCDGGDFRSELK---KR-KNLS----------EQESLNVMKDLLNGFMDLLK-NGIIHRDLKPENILIKGNQHKLADFGFART
         .. .|. ||.||| ... .|   .. |.|.          |..   . ...| |....|  ..|||||.|| |||.     ||.|||..  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VDN---------------FQRQMLTSLVGTPLYMSPQILMH------EKYTAKSDLWSLAFIFYEMLYGKTPYTANSQY-----------------QLVK
...                . |. ...|||| .|.| ...        .|..|.| |||     ||. || |.   .                   || .
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-C

NIQTKPLEFDPA-----------------YNVSDLSKDFITRCLKIDEKDRMEWTDVYK--HPVF
 .. .|  . .                   ..|.  |||| .||..| ..|   ..  |  || .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1429.AA RSK 182-434 30 2e-55 190.45 In-house 1-278 (278) Show / Hide 
Range on Protein: 182-434
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

SSVLGQGSFGKVFKGKNT---ENGQLVAIKMIEKKQIQNDEYLMNGLFSEIQIMKKLK-SEYVVDLIDVLETSNNYYIIQEYCDGGDFRSELKKRKN---
 .|||||..||||  . .    .||. | | ..|. | . .      . |..|..  . .  .|.| .. .|    |.| ||| ||..   |.|.|    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIKG---NQH-KLADFGFARTVDNFQRQMLTSLVGTPLYMSPQILM---HEK-YTAKSDLWSLAF
.|| |   .|  .      | . |||||||||||||      . | || ||||..  .. . |.. . ..|  || | .|.   ... ...  |.|||  
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IFYEMLYGKTPYTA---NSQYQLVKNIQTKP--LEFDPAYNVSDLSKDFITRCLKIDEKDRME-----WTDVYKHPVF
. |||| |..|...   |.. .. |.||..   |...   ..|.  ||.|...|. |...|         .. .|| |
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 1429.AA Pkinase_Tyr 179-329 29 1.7e-19 66.69 Pfam 1-163 (270) Show / Hide 
Range on Protein: 179-329
Range on HMM: 1-163/270
Sequence Identity: 29% (48 aa)

FQLSSVLGQGSFGKVFKGKNT----ENGQLVAIKMIEKKQIQNDEYLMNGLFSEIQIMKKL-KSEYVVDLIDVLE-TSNN--YYIIQEYCDGGDFRSELK
 ..  .||.|.||.|.||. .    .... ||.||. | .   .. ..  ...|..|||.| . . .| |. |    .    .||. ||. .|| .. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----RKNLSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIK-GNQHKLADFGFARTVDN
|    ...|. .. |.   .  .|   |  ...|||||   |.|.. .|. | .||| ||.. |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN
Kinase 1429.AA TyrKc 179-434 23 1e-17 63.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 179-434
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FQLSSVLGQGSFGKVFKGKNTENGQLVAIKMIEKKQIQNDEYLMNGLFSEIQIMKKL--KSEYVVDLIDVLETS-------NNYYIIQEYCDGGDFRSEL
 .|  .|| | ||.|.||. .   . ||.||. .         .  . .|..||.||  . . .| |. |  ..         ..|. ||...|| .. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKRKN-LSEQESLNVMKDLLNGFMDLLKNGIIHRDLKPENILIKGNQ-HKLADFGFARTVDNF-------QRQMLTSLVGTP--L---YMSPQILMHEKY
.|... |. .. |. . .  .|   | ....|||||   |.|.. |.  | .||| .| ...        .  . ..  |.   |    |.|  ... |.
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TAKSDLWSLAFIFYEML-YGKTPYTA-----NSQYQLVKNIQTKPLEFDPAYN-------VSDLSKDFITRCLKIDEKDRMEWTDVYKHPVF
| ||| ||     .|.. ||..||        | .........      |...        .|   . ...| . | .||   ...  |  |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Efhand 1429.AA efhand 469-497 31 0.000524 19.08 Pfam 1-29 (29) Show / Hide 
Range on Protein: 469-497
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

DLEDLFKKYDFSHDSKLEMKEFSKLMKSI
.|...||..|  .| ... .|| ..||..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 1429.AA EFh 469-497 27 0.001983 18.29 SMART 1-29 (29) Show / Hide 
Range on Protein: 469-497
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

DLEDLFKKYDFSHDSKLEMKEFSKLMKSI
.....|...|  .| ... .|| ..|||.
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 1429.AA efhand 505-533 37 8.2e-07 29.35 Pfam 1-29 (29) Show / Hide 
Range on Protein: 505-533
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

EIEYIFNKFDDDKDNTISFEEFTKWLSNN
|.. .|..|| |.| .|.|||| ..... 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 1429.AA EFh 505-533 37 0.000222 21.8 SMART 1-29 (29) Show / Hide 
Range on Protein: 505-533
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

EIEYIFNKFDDDKDNTISFEEFTKWLSNN
|.. .|..|| |.| .|.|||| . ... 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 1429.AA efhand 701-729 34 0.005872 15.24 Pfam 1-29 (29) Show / Hide 
Range on Protein: 701-729
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

NLGDLFSKYDKSDDKQLDISEFSKLLKKV
 | ..|...||  | ..|. || ...||.
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 1429.AA EFh 701-729 27 0.007568 13.6 SMART 1-29 (29) Show / Hide 
Range on Protein: 701-729
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

NLGDLFSKYDKSDDKQLDISEFSKLLKKV
 . ..|...||  | ..|  || ...|..
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 1429.AA efhand 737-765 44 4.3e-05 23.06 Pfam 1-29 (29) Show / Hide 
Range on Protein: 737-765
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

ELNCTFTIFDKNGDQSITFNEFFETLQEI
||.  | .|||.||  |.|.|| | ....
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 1429.AA EFh 737-765 37 4.4e-05 24.13 SMART 1-29 (29) Show / Hide 
Range on Protein: 737-765
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

ELNCTFTIFDKNGDQSITFNEFFETLQEI
|..  | .|||.||  |.|.|| . ....
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL