Gene 11042 (Tetrahymena)

11042

Species: Tetrahymena
Alias: 750, TTHERM_01284760, 11042, 307.m00027, PreTt11042
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
11042.AA Protein None 593 None Fasta, JSON
11042.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
11042.NA RNA None 1782 None Fasta, JSON

Protein domain

Protein domains of 11042.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11042.AA ULK 46-305 41 2.1e-147 496.03 In-house 1-324 (324) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-324/324
Sequence Identity: 41% (136 aa)

FSEDRLLGEGAFG-VVYKGEDKNT---KQKVAIKQISQSKFQNDPIV------LKNLKREIEIMQDLK---HEN--IVQLFNFTYTA--SNVYIILEYCD
.. .. ||.|.|| .||||..|.|   .|.||.|.|...|.....        ...||.||.||. ||   |.|  ||.|. ...|.   |.|||.|||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDILSLMKKN-------EGKRFSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLHKGI-------------AKISDFGFARMLDQTNLNSQQKLT
|||  ...|||       |.||.||..||. |.|| ..||.||...||||||||.|||.|.|.             .||.|||||...|  |.. |.  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

AL------GSPLYMSPQILS----QEQFS-SKCDIWSLGVMFYEMIYGRTP---WTAQSQI----ELLNK-------INSQPLQFP---SDVISSYNTKD
..      |.||||.||||.    |.... .||||||||..||||.||..|   | ...|.    .|.|.       |. ||.|||   .|.. | ..||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

IIVRMLKVQENERISWEEIFAHPLL
.| |||...|..||||||||.||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 11042.AA ULK 46-305 41 4.2e-144 485.04 In-house 1-329 (329) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-329/329
Sequence Identity: 41% (137 aa)

FSEDRLLGEGAFGVVYKGEDKNTK----QKVAIKQISQSKFQNDPIV------LKNLKREIEIMQDLK--------HENIVQLFNFTYTA--SNVYIILE
.. .. ||.|.||.||||..|.||    .|||.|.|...|.....        .. ||.||.||. ||        |.|||.|. ...|.   |.|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCDGGDILSLMKKN--------EGKRFSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLHKGI-------------AKISDFGFARMLDQTNLNSQ
||.|||  ...|||        |.||.||..||. |.|| ..||.||...||||||||.|||.|.|.             .||.|||||...|  |.. |
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

QKLTAL------GSPLYMSPQILS----QEQFS-SKCDIWSLGVMFYEMIYGRTP---WTAQSQI-----ELLNK-------INSQPLQFP---SDVISS
. .|..      |.||||.||||.    |.... .||||||||..||||.||..|   | ...|.     .|.|.       |..||||||   .|.. |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

YNTKDIIVRMLKVQENERISWEEIFAHPLL
 ..||.| |||...|..||||||.|.||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 11042.AA S_TKc 46-305 33 7.1e-94 319.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

FSEDRLLGEGAFGVVYKGEDKNTKQKVAIKQISQSKFQNDPIVLKNLKREIEIMQDLKHENIVQLFNFTYTASNVYIILEYCDG--GDILSLMKKNEGKR
.   |..|.||||.|||. .|.|...||||.|.           ....|||.|..  .|.|||.|. . .. ...|...|||||  || ....||. ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLHKGIAKISDFGFARMLDQTNLNSQQKLTALGSPLYMSPQILSQEQFSS-KCDIWSLGVM
    |.|  | . ..|| .| . .||.||||||.||.|||| .   ||.|||.|| |           |  |.| ||.| .|   ...  |||.||.|..
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

FYEMIYGRTPWTAQSQIELLNKINSQPLQFPSDVISSYNTKDIIVRMLKVQENERISWEEIFA-------HPLL
.|||..|..|.    . ....||             |   ||.| ..|..  ..|..  |...       || .
LYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11042.AA CAMK 51-305 25 1.1e-89 289.07 In-house 1-425 (425) Show / Hide 
Range on Protein: 51-305
Range on HMM: 1-425/425
Sequence Identity: 25% (107 aa)

LLGEGAFGVVYKGEDKNTK------------QKVAIKQISQSKFQND------------------------PIVLKNLKREIEIMQD-------LKHENI
 ||.|.||.|.....|||.            |||||| |. .| ...                        |  .||..||||||.        |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLFNFTY------------TASN--------VYIIL---EYCDGG----DILSLMKKNEG-------------KRFSEEIAIKHFRQITEAFKMLHSKG
..|. .              | |.        .|...   |||.||    |...  .....             .||.|. | . |||| .| . .||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPANILL-HK-----------------GIAKISDFGFARMLDQTNLNS--------------------QQKLTALGSPLYMS-PQILSQ-----
|.|||.|| |||| ..                 .  ||.|||||...|. . |                     |   |  |.| ||. | .|..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EQFSSKCDIWSLGVMFYEMIYGRTPWTAQ-------------SQIELLNKINSQPLQFPSDV---------------ISSY-------NTK
         .  . |||.||.||. | |  |. |. .              .. ||. || .   .||..                ||           |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DIIVRMLKVQENERISWEEIFAHPLL
| | .||.|  ..|.. |.. .|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 11042.AA Pkinase 46-305 30 8.7e-89 306.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FSEDRLLGEGAFGVVYKGEDKNTKQKVAIKQISQSKFQNDPIVLKNLKR--EIEIMQDLKHENIVQLFNFTYTASNVYIILEYCDGG----DILSLMKKN
.   | .|.|.||.|||. .|.| ..||.|.|. .   ... ..... |  ||.||. |.|.|||.|. . .. ...|...|||.||    |  ....  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

EGKRF--SEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLH-KGIA----KISDFGFARMLDQTNLNSQQKLTALGSPLYMSPQILS-QEQFSSKCD
....|  ||. ... ..|| .. . .||.||||||.||.|||.. .|      ||.|||.|. .|  . |..   |  |.| ||.| ..  ..  ..|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGVMFYEMIYGRTPWTAQ------SQIELLNKINSQPLQFPSDVISS-------------------YNTKDIIVRMLKVQENERISWEEIFAHPLL
.||.|...|||. ||.|.  .      .|......| . || |...  .|                    . ||.| ..|..  ..|...|.|. || .
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 11042.AA CAMKL 46-305 33 7.8e-86 273.89 In-house 1-297 (297) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-297/297
Sequence Identity: 33% (101 aa)

FSEDRLLGEGAFGVVYKGED-KNTKQKVAIKQISQSKFQNDPIVLKN-----------LKREIEIMQDLK---HENIVQLFNFTYTASN------VYIIL
.   . ||.|.||.|  ... ..|..||||| |  .| .|||...||           ..|||.||. |.   |.||..|.   .| ..      .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCDGGD--ILSLMKKNEGKR--FSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLH-KG--IAKISDFGFARMLDQT-NLNSQQKLTALGSPLYM
|||.||.   .   .|....|  ..|. | . |||| .| . .||.||.|||||| ||||  .|   .||.||||. | .   . . |   |  ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPQILSQ--EQFS-SKCDIWSLGVMFYEMIYGRTPWTAQ--------SQIELLNKINSQPLQFPSDVISSYNTKDIIVRMLKVQENERISWEEIFAHPLL
.| |..   ...   | ||||.||. | |..|. |. ..         . .|..||...  ..|  .  |   .|.| .||.|  ..|.. ..|  || .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 11042.AA Ciliate-E2 46-305 26 3.2e-84 286.12 In-house 1-365 (365) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-365/365
Sequence Identity: 26% (99 aa)

FSEDRLLGEGAFGVVYKGEDKNTKQKVAIKQISQSK-----------------FQNDPIVLKNLKREIEIMQ----------------DLKHENIVQLFN
.   ...|.|.||.|||..........|||.|   |                  .. .  ....|.|| ||.                 |.| ||.... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

FTY--TASNVYIILEYCDGGDILSLMKKN----------EGKRFSEEIAIKHFRQITE---------------AFKMLHSKG-IIHRDIKPANILLHKGI
. .  . .|.|...|||.||| ....|.|          . |.|.|. ... ..||..               |.. ||||. |||||||| |||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

AKISDFGFARMLDQTNLNSQQKLTA-----------------------------LGSPLYMSPQILS---------QEQFSSKCDIWSLGVMFYEMIYGR
 ||.|||... .|. | | .. .                               .|.| ||.|.||.         |.. . |||||||||..|||..|.
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

TPWTAQSQIELLNKINSQPLQFP----------------SDVISSYNTKDIIVR----MLKVQENERIS-WEEIFAHPLL
.|.        ...|  ....||                |    | ..||.| .    ||......||. ||.|. || .
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 11042.AA Ciliate-E2c 46-305 30 9.6e-84 284.52 In-house 1-310 (310) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-310/310
Sequence Identity: 30% (97 aa)

FSEDRLLGEGAFGVVYKG---EDKNTKQKV-------AIKQISQSKF----QNDPIVLKNLKREIEIMQDLKHENIVQLFNFTYTASNVYIILEYCDGGD
....  || | .| |||.   ||... ...       ||| .  . .     |. .... ..|||..| ...| .|..  ..  | ...|.|.||| ||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

ILSLMKKNEGK-RFSEEIAIKHFRQITEAFKMLHSK-GIIHRDIKPANILLHKGIAKISDFGFARMLDQTNLNSQQ-KLTALGSPLYMSPQILSQ-EQFS
 ... ..   | . .|.  .  | ||  ||| ||.. .|.||||||.|||.|.|. || ||||..  .  | .  |   |  |.|.||.||||.   .  
LEQYIYH---KPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYT

SKCDIWSLGVMFYEMIYGRTPWT------------------AQSQIELLNKIN---------------SQPLQFPSD--VISSYNTKDIIVRMLKVQENE
.| |||||||. |.|.. . ||                   . .. .|   |                 |...|| .  .  |  .|..| .|| | |. 
EKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEK

RISWEEIFAHPLL
||.|.||| |...
RIDWDEIFNHECI
Kinase 11042.AA AGC 46-305 21 2.7e-82 211.8 In-house 1-395 (395) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

FSEDRLLGEGAFGVVYKGEDK------NTKQKVAIKQISQSK-FQNDPI-VLKNLKRE------------IEIMQDLK----------HENIVQ-LFNFT
|   ...|.|.|| ||  ..|       |..  |.| .. ..  . .    ... ..|             .|.. ..          | .||. |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YTASN--VYIILEY---------CDGG-DILSLMKKN-EGKRFSEEIAIKHFRQ-------ITEAFKMLHS-KGIIHRD-IKPANILLHK-GIAKISDFG
 . ..  .|...||         | || . .. ...    .||.|| |   . .       |. |.  ||| .|||||| .|| |||| . |  |..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FARM---------------------------------LDQTNLNSQQ--------------KLTALG--SPLYMSPQILSQEQFSSKCDIWS--LGVMFY
.. .                                 ....|.....                |  |  .| ||.| ||     .  ||.||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIYGRTPWTAQS----------QIELLNKIN------SQPLQFPSD--------VISSYNTKDIIVRMLKVQENERIS----------WEEIFAHPLL
||..|..| ....          . |. .||       .....||..        .  | . ||.| ..|..  ..|.            ||| .||  
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 11042.AA Ciliate-E2-Unclassified 46-305 27 1.5e-77 263.96 In-house 1-352 (352) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

FSEDRLLGEGAFGVVYKGEDKNTKQKVAIKQISQSKFQNDPIV------------LKNLK--------REIE-IMQDLKHENIVQLFNFTYTASNVYIIL
.   . .|.|.||.||| ..|..||. |.|...... ... ..            ..|.|        ..   |.....|..|| .|    .  |.||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCDGGDILSLMKKNEG---------------KRFSEEIAI-----KHFRQITEAFKMLHSKG-IIHRDIKPANILLHKG----IAKISDFGFARMLD--
|||.||| .  .||...               |.|.|. |.     . |.|| .... ||.|. |||||||| |||....      ||.|||... ..  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------QTNLNSQQKLTAL-GSPLYM----SPQILSQEQFS----SKCDIWSLGVMFYEMIYGRTPWTAQSQIE----------------LLNKINS
         ... ..||...   |.| ||    .| .| ... .     ||||||||| .|||..|. |  ......                |...|. 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

QPLQFPS------DVISSYNTKDIIV----RMLKVQENERISWEEIFAHPLL
...|||.      . ..| . ||.|     .|||.. |.||..|.|. ||..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 11042.AA STE 46-305 25 1.9e-69 237.03 In-house 1-359 (359) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-359/359
Sequence Identity: 25% (91 aa)

FSEDRLLGEGAFGVVYKGEDK------NTKQK---------VAIKQISQSKFQN-------------DPIVLKNLKREIEIMQDLK--HENIVQLFNFTY
.   . .|.||||.|||. ..       |...         .||||.. .. .|             ..  ......||.||....  |.|||. .   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TA-------SNVYIILEYCDGGDILSLMKKNEGK------------RFSEEIAIKHFRQITEA-FKMLHSKGIIHRDIKPANILLHKGIAKISDFGFARM
         ....|..||.||| . ...|.. |.            ||.|.. ..  ||| ..  . |||..|||||||||||||    .|..|||..  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LDQTNL------------NSQQKL-TALGSPLYMSPQILSQ------EQFSSKCDIWSLGVMFYEMIYGRTPWTAQSQIELLNKIN--------------
|....             ..|||  |  |.| .|.| ...|       . . |||||||| .  ||. |. ||   .  . .  |.              
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--SQPLQFPSDVI-----------------SSYNTKDIIVRMLKVQENERISWEEIFA--HPLL
   .| ..|...                   | . || | . |.   |.| . ..     || .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 11042.AA MARK 46-305 38 1e-68 223.81 In-house 1-262 (262) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-262/262
Sequence Identity: 38% (103 aa)

FSEDRLLGEGAFGVVYKGEDKNTKQKVAIKQISQSKFQNDPIVLKNLKREIEIMQDLKHENIVQLFNFTY--TASN-VYIILEYCDGGDILSLMKKNEGK
.   . .|.|....|... .|.|..||||| | . .  |||  .||..||||||. |.|.||..||      | .. .|.|.||. ||. .. .|. .. 
YKMLKTIGHGSYAKVKLACHKHTGRKVAIK-IYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

RFSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILL-HKG--IAKISDFGFARMLDQTNLNSQQKLTAL-GSPLYMSPQILSQEQFS-SKCDIWSLGV
| .|| | . |||| .| . .|||.|.|||||| |||. ..|   .||.||||..       .. |||.   |.| ||.|.|....     | |||||||
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI-----PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV

MFYEMIYGRTPWTAQS--QIELLNKINSQPLQFPSDVISSYNTKDIIVRMLKVQENERISWEEIFAHPLL
  | |. |. |. ...  . ||  ||..   ..|.    |   ...| |.|.|  .||.. |||  || .
VLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 11042.AA Pkinase_Tyr 46-261 29 1e-37 128.36 Pfam 1-228 (270) Show / Hide 
Range on Protein: 46-261
Range on HMM: 1-228/270
Sequence Identity: 29% (69 aa)

FSEDRLLGEGAFGVVYKGEDK----NTKQKVAIKQISQSKFQNDPIV--LKNLKREIEIMQDL-KHENIVQLFNFTY-TASN--VYIILEYCDGGDILSL
 . .. |||||||.||||. |    |||..||.| . .   . ..    .. . ||..||  | .|.|||.|    .       .||..||. .|| |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

MKKN--EGKRFSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLH-KGIAKISDFGFARML-DQTNLNSQQKLTALGSPLYMSPQILSQEQFSSKCD
 .|.  ...... .  ..  .|| ..   |.||..||||.   |.|.. ....||.||| || . .  .  ....  .      |.|  ..   |..| |
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSD

IWSLGVMFYEMIY-GRTP-WTAQSQIELLNKI
.|| ||  .|..  |..| .   |  |....|
VWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase 11042.AA TyrKc 46-305 25 5.2e-28 100.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-280/280
Sequence Identity: 25% (74 aa)

FSEDRLLGEGAFGVVYKGEDKNTKQKVAIKQISQSKFQNDPIVLKNLKREIEIMQDL--KHENIVQLFNFTYTA-------SNVYIILEYCDGGDILSLM
 . .. |||||||.||||. |   ..||.| .  ..       .. . ||..||  |  .|.|||.|.    .          ..|..||...|| ..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKNEGKRFSEEIAIKHFRQITEAFKMLHSKGIIHRDIKPANILLHKG-IAKISDFGFARMLDQT-------NLNSQQKLTALG--SPL-YMSPQILSQEQ
.|...| .. .  ..   || .    ||||..||||.   |.|.... ..|||||| .| ..            ....        |.  |.|  .    
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FSSKCDIWSLGVMFYEMI-YGRTPWTA-----QSQIELLNKINSQ-PLQFPSD------VISSYNTKDIIVRMLKVQENERISWEEIFAHPLL
|..| |.|| ||. .|.  || .|.        | .|..... .   .  | .      |. .    .|. .  . . ..| . .||  | ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF