Gene 5034 (Tetrahymena)

5034

Species: Tetrahymena
Alias: TTHERM_01046870, PreTt05034, 5034, 821, 210.m00041
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: SAK

Sequence

Name Sequence Type Origin Length Description Download
5034.AA Protein None 1569 None Fasta, JSON
5034.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
5034.NA RNA None 4710 None Fasta, JSON

Protein domain

Protein domains of 5034.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5034.AA PLK-Unclassified 38-292 50 5.1e-179 601.02 In-house 1-264 (264) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-264/264
Sequence Identity: 50% (133 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSAYKRLKNEIEIHLDLKHKNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKHH-------
|...|..|.|.......||.|.|||.||.|...|.|.....|...|..||.||..|.||||||....|||.||.|...|||..|.|..|.|..       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDHQVKICDFGLAVRLNGNEQEKNTICGTPNYISPEILNKQP--YGMKIDCWSFGCILYA
|.|.|.|.|..||.....|||||...||||||||||..|.....|||||||||..|......|.|||||||||.||||....  .....||||||||||.
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LIVGHPPFQGQDIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILMHPFY
|..|.|||...|..||.||.......|. |..||||.|||...|.|||.|.|.|||||.|||||
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 5034.AA PLK 38-292 47 3.1e-161 528.69 In-house 1-258 (258) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-258/258
Sequence Identity: 47% (124 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSAYKRLKNEIEIHLDLKHKNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKHH-KKLSET
| . |..|.|. . . ....|.||..||||||.|............|.||||| .|.|.||||....|||.|| |.|.|||....|.||.|.. |.|.|.
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDHQVKICDFGLAVRLNGNEQEKNTICGTPNYISPEIL--NKQPYGMKIDCWSFGCILYALIVGHP
|.....|....||||||.. ||||||||||..|.....|||.|||||.||......|.|.|||||||.||.|  |||......||||.|||.|.|..|.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFQGQDIVQTLKKVTSQEQFFELPNN--ISDNLKDLLVNIINWNQDSRFTIDQILMHPFY
||. .|. .|.|...  ......|..  |||..|||.....|||.|.|.||||||.|||.
PFETKDVKETYKRIK--HNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 5034.AA S_TKc 38-292 35 8.4e-105 355.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSAYKRLKNEIEIHLDLKHKNIVKMIKSFEDSENLYLVMEYCEG--GDLFHYLKHHKK---
| |  .||.|| . | |.. .||....|||...          .....||.|.   .|.||||.. .|.| ..||.|||||.|  ||||.|.|....   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDHQVKICDFGLAVRLNGNEQEKNTICGTPNYISPEILNKQPYGM-KIDCWSFGCILYA
   ..| .|....| ....|.|.|.. |||||||  |.||..  ..|||||||| .|       .|.||||.|..||.|   .||  |.| ||.||||| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LIVGHPPFQGQDIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILM-------HPFY
...| |||.  .. ...||.             |. .||.. .. ... . | |. ..|        ||. 
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5034.AA CAMK 43-292 23 1.3e-98 318.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 43-292
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

PIGSGAGSLVVKVKSIKTK------------KEYAIKVVDKQ-------------SQYYKS------------AYKRLKNEIEIHLD-------LKHKNI
 .|.|. . | ... ..|.            ...|||..||.             ..  ||              |....||||.         |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKMIKSFEDSEN-------------------LYLVM---EYCEGG----DLFHYLKHH---------------KKLSETEAKRITYKLAEGLKYLHDKSI
.|..  .||...                   .|.||   |||.||    ||| |.. |               ....| ||.|.   ......|.|.. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNVLLSSDH-----------------QVKICDFGLAVRLNGNE-----------------------QEKNTICGTPNYIS-PEILNK------
.|||||. |.||....                 ..||.|||.| .....|                       |  .| |||| |.. ||.||.      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QPYGMKIDCWSFGCILYALIVGHPPFQGQ-------------DIVQTLKKVTSQE-QFFELP-------------NNISDN--------LKD
        ..|| |.|.|| |.|||.. .|.|||.|              .. ....|... . .| . .             ..|||.         ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLVNIINWNQDSRFTIDQILMHPFY
|. .. . . . |.||.|.| ||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5034.AA Pkinase 38-292 35 1.8e-93 321.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-293/293
Sequence Identity: 35% (104 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSAYKRLK-NEIEIHLDLKHKNIVKMIKSFEDSENLYLVMEYCEGG----DLFHYLK--HH
| |  .||||. . | | . ..| |..|.|...|...  .  . ... .||.|.. |.|.|||... .|||. ..|.||||||||    |||.|..   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKL--SETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDHQV----KICDFGLAVRL-NGNEQEKNTICGTPNYISPEILN-KQPYGMKIDCWSF
...  || |.|.. | ...||.|.|...|||||||. |.|.... ..    ||||||||  . . | .  .|.||||.|..||...  |.|| |.| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYALIVGHPPFQGQ------DIVQTLKKVTSQEQFFELPNNIS-------------------DNLKDLLVNIINWNQDSRFTIDQILMHPFY
||||| .. |.|||.|.      |  | .... . .  |. |. .|                   ...||.. ......  .| |..||| ||. 
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5034.AA CAMKL 38-292 30 2.2e-86 275.7 In-house 1-297 (297) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YIISHPIGSGAGSLVVKVKSIKT-KKEYAIKVVDKQSQYYKSAYKR------------LKNEIEIHLDLK---HKNIVKMIKSFEDSEN------LYLVM
|.|   .| |. . |   . |.| ....|||..||.    .   |.            .. ||.|.  |.   |.||.|.   .|..|.      .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCEGGD--LFHYLKHH----KKLSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDH--QVKICDFGLAVR---L-NGNEQEKNTICGTPNYI
|||.||.  ||.|.. |    ....| ||.|.   . ....|.|.. |.|||.|. |.||....  ..||.|||..       .|..|  .| ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

SPEILNK--QPYG-MKIDCWSFGCILYALIVGHPPFQGQ--------DIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILMHPFY
.|||...  .||   |.|.|| | ||||...|. || ..        .|   ..|. ..  ..  .. .|  ..||.  . . | . |.||.||..||..
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 5034.AA ULK 38-292 31 3.4e-81 276.07 In-house 1-329 (329) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-329/329
Sequence Identity: 31% (103 aa)

YIISHPIGSGAGSLVVKVKSIKTK----KEYAIKVVDKQSQYYKS-------AYKRLKNEIEIHLDLK----HKN----IVKMIKSFEDS--ENLYLVME
|...| .|.|.   | | . .|||    . .|.|..|||..  |.       . . |||||.|   ||    |||    |||... ||.|   |.|..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGGDLFHYLKHHKK----------LSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDH------------QVKICDFGLAVRLNGN---EQ
||.||||..|.| .||          ||| ||. . . ...|.|.||.. |||||.|. |.|.. .             ..||.|||.|  .. .   .|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

EKNTIC------GTPNYISPEILN----KQPYG-MKIDCWSFGCILYALIVGHPPFQGQDIVQTL-----KKVT----------SQEQFFELP---NNIS
   |        ||| | .|.||.    ..||.  | | ||.|||.| ...| |||... . ..      | .           .|   |. .   ..||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DNLKDLLVNIINWNQDSRFTIDQILMHPFY
...|||.   .  ... |....... ||. 
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 5034.AA Ciliate-E2-Unclassified 38-292 27 7.2e-80 271.65 In-house 1-352 (352) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-352/352
Sequence Identity: 27% (99 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEY--------AIKVVDKQSQYYKSAYKRLKNEIEIH----------------LDLKHKNIVKMIKSFEDSENLYL
|.| . ||.|. . | |.. .|.| .|        .... .|| .. .  ... ..|....                |...| .||||.  |.| .|.|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYCEGGDLFHYLKHHKK-----------------LSETEAK-----RITYKLAEGLKYLHDKS-IIHRDLKLGNVLLSSDH---QVKICDFGLAVRLN
||||||||||. |.|. ||                 ..| .||     .... . .||.||| |  |||||.|. |.|.....   ..||.|||.. ...
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

GN---------------EQEKNTICGTPNYI----SPEILNKQPYG----MKIDCWSFGCILYALIVGHPPFQGQDIVQ----------------TLKKV
 |               .|. .|.||||||.    .||.| .| |.     |.|.||.|.|||... | .||....  |                 ... 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

-TSQEQFFELPN-----NISDNLKDLLV----NIINWNQDSRFTIDQILMHPFY
   . ||.. |.     ..|.. ||..      ....|...| |..||| ||. 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5034.AA ULK 38-292 30 1e-79 271.14 In-house 1-324 (324) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-324/324
Sequence Identity: 30% (101 aa)

YIISHPIGSGAGSLVVKVKS--IKT---KKEYAIKVVDKQSQYYKSAY-------KRLKNEIEIHLDLK---HKN--IVKMIKSFEDS--ENLYLVMEYC
|...| .|.|.   |.  |   .||   .. .|.|..||...  |.         . |||||.|   ||   |.|  |||... ||.|   |.|..||||
YCLNHCLGKGSFG-VKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

EGGDLFHYLKHHKK---------LSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDH------------QVKICDFGLAVRLNGNE---QEKN
.||||..|.| .||         ||| ||. . . ...|.|.||.. |||||.|. | |.. .             ..||.|||.|  .. |.   |   
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TIC------GTPNYISPEILN----KQPYG-MKIDCWSFGCILYALIVGHPPFQGQDIVQTLKK--------------VTSQEQFFELPN---NISDNLK
|..      ||| | .|.||.    ..||.  | | ||.|||.| .. | .||... . .. ..              .  |   | .|.   .||...|
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DLLVNIINWNQDSRFTIDQILMHPFY
||.   .  ... |.....|. ||. 
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 5034.AA SAK 38-292 39 1e-79 271.13 In-house 1-254 (254) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-254/254
Sequence Identity: 39% (102 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSAYKRLKNEIEIHLDLKHKNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKHH-KKLSET
| . | .| |.   | . |.|.| .| |||..||.  .     .| .||.|||  |||  |... . |||.   |||.| |. |..  |.||. .  .|.
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDHQVKICDFGLAVRLNGNEQEKNTICGTPNYISPEILNKQPYGMKIDCWSFGCILYALIVGHPPF
||...  ..  |. |||   |.|||| | |.||. | ..|| |||||  |.  .    |.|||||||||||  . . |.. | || ||.|| |..| |||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

QGQDIVQTLKKVTSQEQFFELPNNISDNLKDLLVNIINWNQDSRFTIDQILMHPFY
. . . .|| ||   |  ...|  .|   .||.  ..  |   | |.. .| ||| 
DTDAVKNTLNKVMMAE--YIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase 5034.AA Ciliate-E2 38-292 27 4.5e-79 269.01 In-house 1-365 (365) Show / Hide 
Range on Protein: 38-292
Range on HMM: 1-365/365
Sequence Identity: 27% (105 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKV-------------VDKQSQYYKSA----YKRLKNEIEIH----------------LDLKHKNIVKMIKS
|..   ||.|. . | |.| .|..|..|||.             |...  . |.      . .|.|| |                   |.|.||.||. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DSENLYLVMEYCEGGDLFHYLKHH-----------KKLSETEAKRITYKLAE---------------GLKYLHDKS-IIHRDLKLGNVLLSSDHQV
|.  | .|.|||||||.|||||.|.|..           |...| |.|.|......               .|.||| |  |||||.|. |.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KICDFGLAVRLNGNEQEK-------------------------------NTICGTPNYISPEILNKQP---------YGMKIDCWSFGCILYALIVGHPP
||.||||. ... ..|..                               |||||||.| .|||||...         |. |.| ||.|.||| .. | ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGQDIVQTLKKVTSQEQFFELP----------------NNISDNLKDLLVN----IINWNQDSRFT-IDQILMHPFY
|        ...   ..  |  |                ...|.. |||. .    ... ... |.| ..||| ||. 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5034.AA RSK 40-292 28 5.2e-77 262.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 40-292
Range on HMM: 1-278/278
Sequence Identity: 28% (78 aa)

ISHP--IGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSA-YKRLKNEIEIHLDLK-HKNIVKMIKSFEDSENLYLVMEYCEGGDLFHYLKHHKK---
..    .| |. .|. |.   .|...|| ||..|     .    .. . |..| .. . |..||.   .|.. . |||.||||.||.||  |...|    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSS---DHQVKICDFGLAVR-LNGNEQEKNTICGTPNYISPEILN---KQP-YGMKIDCWSFGC
.||.||. . ....  ...||.. |||||||. |.|. .   .  .|..|||..    . ..|  .| |.| .|. ||.|.   .|  ..   | ||.|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

ILYALIVGHPPFQG---QDIVQTLKKVTSQEQFFELP--NNISDNLKDLLVNIINWNQDSRFT-----IDQILMHPFY
..| . .|.|||||   ..  ...|.. . .  ...|  ...|.. |||.      .   | .     ...|. ||. 
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 5034.AA Pkinase_Tyr 65-183 33 2.7e-24 82.9 Pfam 32-158 (270) Show / Hide 
Range on Protein: 65-183
Range on HMM: 32-158/270
Sequence Identity: 33% (44 aa)

AIKVVDKQSQYYKSAY---KRLKNEIEIHLDL-KHKNIVKMIKSFE-DSEN--LYLVMEYCEGGDLFHYLKHH----KKLSETEAKRITYKLAEGLKYLH
|.|.. |.  .. .     . . .|..|   | .|.|||...     ..|   .|.||||...||| .||. |    ..|.  .   . .  |.|. ||.
AVKML-KE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE

DKSIIHRDLKLGNVLLSSDHQVKICDFGLA
.| .|||||   |.|......|||||||||
SKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 5034.AA TyrKc 38-295 24 7.1e-18 66.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-295
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

YIISHPIGSGAGSLVVKVKSIKTKKEYAIKVVDKQSQYYKSAYKRLKNEIEIHLDL--KHKNIVKMIKSFEDS-------ENLYLVMEYCEGGDLFHYLK
    . .|.||   |.| . .    . |.|.. . .       . . .|..|   |  .|.|||...    ..       | |..||||...||| .||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

HHKK-LSETEAKRITYKLAEGLKYLHDKSIIHRDLKLGNVLLSSDHQVKICDFGLAVRLNGN----EQEKNTIC----GTP-----NYISPEILNKQPYG
 |.. |.  .   . .  |.|  |||.| .|||||   |.|....|.|||.||||.  .       | ..        |.         .|| .|.  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

MKIDCWSFGCILY-ALIVGHPPFQGQ----DIVQTLKKVTSQEQFFELPNN--------ISDNLKDLLVNIINWNQDSRFTIDQILMHPFYEEM
 | | ||||  ..  .  | .|  |.       | . .   |    . | |         .| . ..     . . ..| |  .|     .|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF