Gene 18380 (Tetrahymena)

18380

Species: Tetrahymena
Alias: PreTt18380, 392.m00011, 85, TTHERM_01443850, 18380
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
18380.AA Protein None 722 None Fasta, JSON
18380.kin_dom Protein Kinase Domain None 258 None Fasta, JSON
18380.NA RNA None 2169 None Fasta, JSON

Protein domain

Protein domains of 18380.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18380.AA PLK-Unclassified 90-347 70 6.4e-205 687.06 In-house 1-264 (264) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-264/264
Sequence Identity: 70% (187 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSLHHKNIVQFEHVFEDHDNVYILLELCPYQTLNELIKRR-----
|.||..||.|||||||.|....|  |.|.||||||||.|||.|.| ||||||||||||||||||.|||.||||.|||||||.||..||.|.||||     
YHRGHFLGKGGFAKCYQVKNIET--KKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLF

--KRITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYEGEKKKTVCGTPNYIAPEILEGKD-GHSYEVDMWSLGVII
  ||.||||...|..|||.||||||||.||||||||||.||.|||..||.|||||||.|..||||||.||||||||||||.||. |||||||.||.|.|.
EKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCIL

YTLLIGKPPFETKDVRTTYKRIKMNNYCFPEQIQISDNAKSIITSILNLNPQKRLTLDELLEHPFM
|||||||||||||||..|||.||.|.|.|||...||||||..|..|||.||..|.|.|....|||.
YTLLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 18380.AA PLK 90-347 63 1.9e-195 641.77 In-house 1-258 (258) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-258/258
Sequence Identity: 63% (165 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSLHHKNIVQFEHVFEDHDNVYILLELCPYQTLNELIKRR-KRIT
|.||..||.||||||||.. ..|  |...|.|..|||...|..|| |...||.||..|||.|||.|.|.||||.||||.||.|. ..|....||| ||.|
YERGHFLGKGGFAKCYEMTDIHT--KQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLT

EYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYEGEKKKTVCGTPNYIAPEILEGKD-GHSYEVDMWSLGVIIYTLLIG
|.|.. |..|||..||||||..||||||||||||| ||| .|||||||||..||.||.|||.||||||||||.|.|.  |||||||.||||.|.||||||
EPEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIG

KPPFETKDVRTTYKRIKMNNYCFPEQIQISDNAKSIITSILNLNPQKRLTLDELLEHPFM
||||||||| .||||||.|.|.|||...|||.||..|...|| ||..|.|.|..|.|||.
KPPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase 18380.AA PLK1 90-347 57 1.8e-129 427.87 In-house 1-253 (253) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-253/253
Sequence Identity: 57% (148 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSLHHKNIVQFEHVFEDHDNVYILLELCPYQTLNELIKRRKRITE
| .|. || ||||.|||..  ||  | .||.|..||| | |. || |.  ||.||..|||..||.| | |||..||||.||||  . | || |||| |||
YEKGRFLGKGGFAHCYEIRDKDT--KEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITE

YETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYEGEKKKTVCGTPNYIAPEILEGKDGHSYEVDMWSLGVIIYTLLIGKP
.|.  |..|||.. .|||.||||||||||||||| |.. .||||||||||.||.||.||| ||||||||||.|. | |||.|||.||.| |.|.||.|.|
PECRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN-KKGHSFEVDIWSIGCIMYILLFGQP

PFETKDVRTTYKRIKMNNYCFPEQIQISDNAKSIITSILNLNPQKRLTLDELLEHPFM
||||| .. ||.||| |.|  |.  .||  |...| ..|. .|..| | ...|.  |.
PFETKCLKETYSRIKKNEYRIPS--HISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase 18380.AA PLK2 90-347 49 7.2e-127 410.68 In-house 1-257 (257) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-257/257
Sequence Identity: 49% (129 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSLHHKNIVQFEHVFEDHDNVYILLELCPY----QTLNELIKRRK
| |||||| ||||.|||   .||   ...|.||.|.|   | .|| |   || .|  |.|..|||| | ||| ||.|||||.|      . .    | |.
YCRGKLLGKGGFARCYEMTDMDT--HYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRH

RITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYEGEKKKTVCGTPNYIAPEILEGKDGHSYEVDMWSLGVIIYTLL
  || |   |  |||  |.|||| .||||||||||.|. ||| .|||||||| ..| |.. ..| ||||||||||.| .. ||| | | |.|| | ||.|
HLTEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVL-NRQGHSCESDIWALGCIMYTML

IGKPPFETKDVRTTYKRIKMNNYCFPEQIQISDNAKSIITSILNLNPQKRLTLDELLEHPFM
.| ||||| . . ||..|. | | .|.    .  |...| ..|  .|. |  ||....| | 
CGRPPFETANLKETYRCIRHNHYHMPTHLSPP--ARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase 18380.AA AGC 90-347 22 4.6e-104 269.36 In-house 1-395 (395) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-395/395
Sequence Identity: 22% (88 aa)

YSRGKLLGSGGFAKCYEVIALDT----DPKAIFAAKIIPKST---LTKSRQRVKLISE------------IKIHKSLH----------HKNIVQ-FEHVF
.   |..| |.| |.| |   |.    | . ..| |.. |..   ..| ..  . ..|             .| . ..          | .||.   . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDHDN--VYILLELCP----------Y-QTLNELIK--RRKRITEYETQIYVMQ-------IVNALKYLHQ-NKIIHRD-LKLGNLFLGDNMTLKIGDFG
.| |.  .|...|..|             ..  | .  ...| .| ....|  .       || || |||. ..||||| ||. |. | ..  .|. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LATKIEYEG--------------------------------------------------EKKKTVCG--TPNYIAPEILEGKDGHSYEVDMWS--LGVII
|....  .|                                                  .. .| ||  ||.|.|||||     .....| ||  ||...
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLM

YTLLIGKPPFETKDVR----------TTYKRIK------MNNYCFP--------EQIQISDNAKSIITSILNLNPQKRLT----------LDELLEHPFM
| .|.|.|||  ...            ....|.      ...  ||        |. ..|..||..|.  |. .| |||.           .|. .||. 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 18380.AA S_TKc 90-347 33 2.5e-99 337.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSLHHKNIVQFEHVFEDHDNVYILLELCPY--QTLNELIKRRKR-
|  ....|.|.|.|.| ..  .   . |.| |||.           ....||.|.|. ||.|||..  ||.| |..|. .|.|.    .| ..||.|.| 
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----ITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYEGEKKKTVCGTPNYIAPEILEGKDGHSY-EVDMWSLGVI
     ..| ... |. ||..||.|.|...|||||||  |..| .  ..||.|||||...       .|.||||.|.|||.|    |... ..|.||.|.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

IYTLLIGKPPFETKDVRTTYKRIKMNNYCFPEQIQISDNAKSIITSILNLNPQKRLTLDELLE-------HPFM
.| .| |.|||.  .. ...|.|.            |. ||..|  .|. .|.||.|  |.|.       ||..
LYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18380.AA CAMK 95-347 24 7.9e-99 319.09 In-house 1-425 (425) Show / Hide 
Range on Protein: 95-347
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

LLGSGGFAKCYEVIAL-DT----------DPKAIFAAKIIPKSTLTK-------------------------SRQRVKLISEIKIHKS-------LHHKN
 ||.|.|.| ...|   .|          . .  .|.|||.|. |..                          . | .. .||.|.|.       |.|.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVQFEHVFEDHDN-------------------VYILL---ELCPYQ----TLNELIKRR---------------KRITEYETQIYVMQIVNALKYLHQNK
|... .|.||...                   .|. .   |.|.       | . |...               .|.|| |.. |. ||. |..|.|...
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKLGNLFLGDNM-----------------TLKIGDFGLATKIEY-----------------------EGEKKKTVCGTPNYIA-PEILEG-----
|.|||||. |. | ||.                 ..|| |||.|.|..                        ||.| ||.|||| |.| ||.|.|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------KDGHSYEVDMWSLGVIIYTLLIGKPPFETK-------------DVRTTYKRIKMNNYCFPE--------------QIQISDN--------AK
        |.......||||.||| |..| |.|||. .             . . ....|.  .| ||.                 |||.        .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SIITSILNLNPQKRLTLDELLEHPFM
. | ..|. .|.||.|... |.||.|
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 18380.AA Pkinase 90-347 32 1.1e-94 325.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLIS--EIKIHKSLHHKNIVQFEHVFEDHDNVYILLELCPYQ----TLNELIK-
| .|. .|||.|...|. .  .|    |.| |||.|.  .|| ... ..   ||.|.|.|.|.|||.. ..|||.|..|. .|.|.       | ..|. 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-RRKRI--TEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTL----KIGDFGLATKI-EYEGEKKKTVCGTPNYIAPEILEGKDGHSYEVDM
 |....  .| | . |. ||. .|.|.|...|||||||. |... .|...    ||.||||| .. .  ..  .|.||||.|.|||.. |  .....|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGVIIYTLLIGKPPFETK------DVRTTYKRIKMNNYCFPEQIQIS-------------------DNAKSIITSILNLNPQKRLTLDELLEHPFM
||.|.|.| .| |.|||  .      | .  ..||..  . |...  .|                   ...|..|...|...|.||.| ...|.||..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18380.AA CAMKL 90-347 30 1.1e-90 289.66 In-house 1-297 (297) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YSRGKLLGSGGFAKCYEVIA-LDTDPKAIFAAKIIPKSTLTK-------------SRQRVKLISEIKIHKSLH---HKNIVQFEHVFEDHDN------VY
|  || || |.|.|    .  . |  .   | ||| |. ...             ..   ..  ||.|.|.|.   |.||... .|.|. ..      .|
YRIGKTLGKGSFGKVKLATHIRTT--GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

ILLELCPYQT--LNELIKRR----KRITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNM--TLKIGDFGLATKIE-Y---EGEKKKTVCGTP
. .|.|.     | . |...    .|..| |.. |  ||| |..|.|...|.|||.|. |. | .|.  ..|| |||...... .   .|.| || ||.|
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

NYIAPEILEG--KDGHSYEVDMWSLGVIIYTLLIGKPPFETK--------DVRTTYKRIKMNNYCFPEQIQISDNAKSIITSILNLNPQKRLTLDELLEH
.| ||||..|  |. . ..||.||.||| |... |. ||.          .. . |..|.   |..|  ...|  ....| ..|. || || |......|
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PFM
|.|
PWM
Kinase 18380.AA ULK 90-347 28 7.4e-83 281.57 In-house 1-324 (324) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-324/324
Sequence Identity: 28% (94 aa)

YSRGKLLGSGGFA-KCYEVIALDTDP-KAIFAAKIIPKSTLTKSRQRV-------KLISEIKIHKSLH---HKN--IVQFEHVFEDH--DNVYILLELCP
|.  . ||.| |. | |. .  .|.  . ..|.|.|.|. . |. ..        .|..||.| | |.   |.|  ||.. ..||.   .|.|| .|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

YQTLNELIKRR---------KRITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDN------------MTLKIGDFGLATKIEYEG---EKKKT
  .| ..||..         ||..| |.... .||.|..|.||...|||||.|. |. . ..             .|||.|||.| ......    . .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VC------GTPNYIAPEILE----GKDGHSYEVDMWSLGVIIYTLLIGKPPFETKDVRTTYKR--------------IKMNNYCFP---EQIQISDNAKS
 .      ||| | ||.||.    .|. ..|..|.||||.|.| .| ||.||..   ...|..              || ..  ||   ....||.. |.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

IITSILNLNPQKRLTLDELLEHPFM
.|   |  .. .| . .|...||..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 18380.AA ULK 90-347 29 1.2e-82 280.87 In-house 1-329 (329) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-329/329
Sequence Identity: 29% (97 aa)

YSRGKLLGSGGFAKCYEVIALDTD--PKAIFAAKIIPKSTLTKSRQRVK-------LISEIKIHKSLH----HKN----IVQFEHVFEDH--DNVYILLE
|.  . ||.| |.| |. .  .|.   . ..|.|.|.|... .. .          |..|||| | |.    |||    ||.. ..||.   .|.|| .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCPYQTLNELIKRR----------KRITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDN------------MTLKIGDFGLATKIEYEG----
.|.  .| ..||..          ||..| |.... .||.|..|.||...|||||.|. |  . ..            ..|||.|||.| ......    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-EKKKT----VCGTPNYIAPEILE----GKDGHSYEVDMWSLGVIIYTLLIGKPPFETKDVRTTYKRIKMNNYC---------------FP---EQIQIS
 ..  .    .|||| | ||.||.    .|. ..|..|.||||.|.| .| |||||..   ...|..|.....                ||   ...|||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

DNAKSIITSILNLNPQKRLTLDELLEHPFM
.. |..|   |  .. .| . .||..||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 18380.AA Ciliate-E2 90-347 26 2.3e-77 263.31 In-house 1-365 (365) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-365/365
Sequence Identity: 26% (99 aa)

YSRGKLLGSGGFA-----KCYEV--------IALDT---------DPKAIFAAKIIPKSTLTKSRQRVKLISEIK----------IHKSLHHKNIVQFEH
|   |..|.|.|.     | ..|        |  .          . . |.| ||. |. .    |  ... ||.          | ..| |.||...  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VFE--DHDNVYILLELCPYQTLNELIKRR-----------KRITEYETQIYVMQIVN---------------ALKYLHQNK-IIHRDLKLGNLFLGDNMT
.|.  | .|.|. .|.| ...| ..|| .           |..||.| . .  ||..               ||.|||... |||||.|. |...     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKIGDFGLATKIEYEGEKK-------------------------------KTVCGTPNYIAPEILEGKD--------GHSYEVDMWSLGVIIYTLLIGKP
.|| ||||..|.  . ...                               .|.||||.| |||||.||.        |..|..|.||||||.| .| |||
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFETKDVRTTYKRIKMNNYCFPEQ----------------IQISDNAKSIITS----ILNLNPQKRLT-LDELLEHPFM
||        .. || ... ||..                 ..|...| .|      .|. .|.||.|  ...|.||..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 18380.AA Pkinase_Tyr 90-245 29 2.7e-19 65.99 Pfam 1-165 (270) Show / Hide 
Range on Protein: 90-245
Range on HMM: 1-165/270
Sequence Identity: 29% (50 aa)

YSRGKLLGSGGFAKCYEVIAL--DTDPKAIFAAKIIPKSTLTKSRQ--RVKLISEIKIHKSL-HHKNIVQFEHVFE-DHDN--VYILLELCPYQTLNELI
 . || ||.| | . |. ..   . ..|   | |.. |   . ..|  | ....|.|| |.| ||.|||..  |   . .   .|| .|..|.  | .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KR----RKRITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYEGE
..    ....|  .   . .|| ... ||.....|||||   |  ...|.. ||.|||||  | |. .
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDD
Kinase 18380.AA TyrKc 90-347 23 3e-17 56.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 90-347
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YSRGKLLGSGGFAKCYEVIALDTDPKAIFAAKIIPKSTLTKSRQRVKLISEIKIHKSL--HHKNIVQFEHVFEDH-------DNVYILLELCPYQTLNEL
 . || ||.| | . |. ..         | | . ...      |  ...|..| ..|  ||.|||..  |  ..       . ..|..|..|.  |.. 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKRRKR-ITEYETQIYVMQIVNALKYLHQNKIIHRDLKLGNLFLGDNMTLKIGDFGLATKIEYE---GEKKKTVC-----GTP-----NYIAPEILEGKD
...... ..  .   .  || .   |||....|||||   |  .|.| | ||.||||. .|. .   || |..       |.         ||| .  ..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY

G-HSYEVDMWSLGVI---IYTLLIGKPPFET-----KDVRTTYKRIKMNNYCFPEQI-------QISDNAKSIITSILNLNPQKRLTLDELLEHPFM
|  . . | || ||    |.|.  |..| .      .. .  ....|  ..  . .          .|   .|...  . .| .| |  |.  | ..
GKFTTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
POLO_box 18380.AA POLO_box 480-548 33 2e-26 98.91 Pfam 1-74 (74) Show / Hide 
Range on Protein: 480-548
Range on HMM: 1-74/74
Sequence Identity: 33% (25 aa)

YSNKYGLGYALNNGTIGVF-FNDFTKIVIDPEGQ-YIEYYE--KQPEEKYQKSITFTPDNY-PQELKKKVTLLE
|..|||..| |.|||..|. ||| |||...|... ...|..  .. .... . .| . ... |..|.||.|.| 
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box 18380.AA POLO_box 594-661 39 7.9e-23 86.96 Pfam 1-74 (74) Show / Hide 
Range on Protein: 594-661
Range on HMM: 1-74/74
Sequence Identity: 39% (29 aa)

VKTKNAILFRLQNKIVQVS-FSDKTEIILNSIMK-IVTFNN--KQGIRQNYPLTPDLKM--YSPEMEKRLKYTK
 .|| .| ..| |..|||  | |.|.|||.. ||  ||. .  ... ||.|||.  |..  |.... |.|.|.|
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK