Gene 18358b (Tetrahymena)
18358b
Species: Tetrahymena
Alias: 1051, 186.m00074, 18358b
External Links:
Annotation:
Sequence
Protein domains of 18358b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 18358b.AA | PLK-Unclassified | 1-249 | 67 | 3.2e-195 | 654.84 | In-house | 9-264 (264) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-264/264 Sequence Identity: 67% (172 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRR-------KRLTELEV ||||||||...|.|.|...|||.||||||||.||||||.|||.|||||.|.|||||.|.|||.||||||||.|.|.|..|.|.|| |||||.|| KGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEKKRLTEYEV QCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPF .||..||....||||.||.|||||||||.||.|.||.|..|||||||||.|||.|.||||||||||||||..|..|||||||.||||.|.|||||||||| KCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYTLLIGKPPF ETNDVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF ||.|||.|||||..|.|||||...||..||..|..||...|..||||.......|. ETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY |
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| Kinase | 18358b.AA | PLK | 1-249 | 62 | 3e-189 | 621.3 | In-house | 9-258 (258) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-258/258 Sequence Identity: 62% (156 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRR-KRLTELEVQCYLLQ |||||||||.|... |||.|.||.|||...|...|.|...||.||..|.|.|||||.|||||.|||||.||.|.|........|| ||||| ||..|..| KGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEPEVRYYMYQ ILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETNDVK | ..||||..|.||||||||||||.|.|..|.|||||||.||||||||.|.||||||||||.|.....|||||||.||.|.| ||||||||||||.||| IVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKPPFETKDVK STYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF .|||.|. |.|||||...|| .||..|.|.| ..|..||||.......|| ETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF |
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| Kinase | 18358b.AA | PLK1 | 1-249 | 57 | 2.5e-128 | 424.08 | In-house | 9-253 (253) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-253/253 Sequence Identity: 57% (142 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRRKRLTELEVQCYLLQI |||||.|||... . |.|.|.||.||| | |. .|.|. ||.||..|.||.|||| |||||..||||.||.| . . || .||| .|| | |. || KGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQI LYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETNDVKS . ...|||.|..|||||||||||| |....|.||||||||.|||||||.|.||||||||||.|. ..|||.|||.|| | | |.||.|.|||||. .| VEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLN--KKGHSFEVDIWSIGCIMYILLFGQPPFETKCLKE TYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF ||..|. |||. |. .|| .|...|.|.| .||..||||... ||.|| TYSRIKKNEYRIPS--HISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 18358b.AA | PLK2 | 1-249 | 47 | 6.5e-124 | 401.0 | In-house | 9-257 (257) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-257/257 Sequence Identity: 47% (121 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTN----QTMNELIRRRKRLTELEVQCY |||||.||| | .. | |.|..|.| | . | | || .| | ||.||.| |.|||..|.||||| | . | |. ||| || | KGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHLTEPEVRYY LLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETN ..||. ..|||. ..|||||||||.|. | ||.| |||||| .|| ....||.||||||||||.| . ||| | |.|. | | ||.|.| ||||| MRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQ--GHSCESDIWALGCIMYTMLCGRPPFETA DVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF . | ||. || | | .|. | |. .| ..| || || . .. .||| NLKETYRCIRHNHYHMPT--HLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF |
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| Kinase | 18358b.AA | CAMK | 1-249 | 21 | 2.3e-90 | 291.32 | In-house | 4-425 (425) | Show / Hide |
Range on Protein: 1-249
Range on HMM: 4-425/425
Sequence Identity: 21% (91 aa)
KGGFAKCYEFTNLERK------------QVLAAKVIPKSSLTK-------------------------SRARQKLMSEIRIHKS-------LNHRNIVKF
.|.|.| .. .. . . | |.|.|.|. |.. . |.....||.|.|. |.|.||.|.
RGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKL
QHFFED-------------------QENVYILL---EMCTNQ----TMNELIRRR---------------KRLTELEVQCYLLQILYSIKYLHDNRVIHR
...|| ....|. . |.|.. . . |... .|.|| |.. | ||. ..|.|.. ..||
YEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHR
DLKLGNLFLSDKM-----------------EIKLGDFGLATKLEY-----------------------DGERKRTICGTPNYIA-PEILEAK--------
|||. |. |.|.. ||. |||.|.|.. .|. .| |||| |.| ||.|. |
DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNA
----ETGHSYEVDVWSFGVIAYTLLIGKPPFETN-------------DVKSTYKKIRTNEYSFPE--------------QIQISSA--------AKNMIK
........|.|| ||| |..| |.|||. . . ...||.. .|.||. || .|..|.
TDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIR
KILTTDPSKRPTINELFNDDFF
|.|..||.||.|| . |. ..
KMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 18358b.AA | S_TKc | 1-249 | 32 | 5.2e-88 | 299.6 | SMART | 9-231 (231) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-231/231 Sequence Identity: 32% (86 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTN--QTMNELIRRRKR------LTELE ||.|.|.| .. . ... | |.|. .....||.|.|. .| ||||. .|.| ...|. .|.| . .. ..|..|.| ..| . KGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H VQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSY-EVDVWSFGVIAYTLLIGKP ...|. ||. ..|.|....|||||| |..|.. .||..|||||..| .|.||||.|.|||.| |... ..|.||.|.| | .| |.| ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYP PFETNDVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFN-------DDFF ||. ... ..|||. |. ||..|.|.|. ||.||||. |... . .| PFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 18358b.AA | Pkinase | 1-249 | 29 | 1.7e-85 | 295.16 | Pfam | 9-293 (293) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-293/293 Sequence Identity: 29% (84 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLM-SEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQ----TMNELIR--RRKRL--TEL .|.|...|. .. .. | |.|.|.. .. .... |||.|.|.||| |||.. ..||| ..|. .| | . ..|. |.... .| SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW EVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEI----KLGDFGLATKL-EYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTL |...|..||| ..|.|....||||||. |........| |..||||| .. . .. |.||||.|.|||.. . ......||.||.|.| | . ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDMWSCGCILYEM LIGKPPFETN------DVKSTYKKIRTNEYSFPEQIQIS-------------------SAAKNMIKKILTTDPSKRPTINELFNDDFF | |.||| | . ...|. ...|... .| ...| ||..|. ||.||||. .......| LCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 18358b.AA | CAMKL | 1-249 | 28 | 1.7e-84 | 269.57 | In-house | 9-297 (297) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-297/297 Sequence Identity: 28% (82 aa) KGGFAKCYEFTN-LERKQVLAAKVIPKSSLTKSRARQK------------LMSEIRIHKSLN---HRNIVKFQHFFEDQEN------VYILLEMCTNQT- ||.|.| |. . .. | |.| |. ... .| . ||.|.|.|| | ||.|. . .|..|. .|. .| | . KGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM -MNELIRRR----KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKM--EIKLGDFGLATKLE-Y---DGERKRTICGTPNYIAPEILEA- . . |... .|..| | . | ||. ..|.|.....|||.|. |. |.... ||. |||.... . . .|. .| ||.|.| ||||.. DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGN KETGHSYEVDVWSFGVIAYTLLIGKPPFETN--------DVKSTYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF .. . ..||.|| ||| |... |. ||. .. |.||.. | .| ...| ....|.|.|...|.||||| .. |. .. NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 18358b.AA | ULK | 1-249 | 29 | 9.3e-71 | 241.38 | In-house | 9-329 (329) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-329/329 Sequence Identity: 29% (94 aa) KGGFAKCYEFTNLERK----QVLAAKVIPKSSLTKSR-------ARQKLMSEIRIHKSLN--------HRNIVKFQHFFEDQ--ENVYILLEMCTNQTMN || |.| |. .| ..| .. |.|.|.|... .. . | |..||.| | |. | ||||. ..||.. |.|| .| | . KGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLE ELIRRR----------KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDK------------MEIKLGDFGLATKLEYDG-----ERKRT-- ..| .. |||.| |.. .. ||| |.||....||||.|. | .... . .|..|||.| ....|. . . QYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE --ICGTPNYIAPEILEAK--ETGHS-YEVDVWSFGVIAYTLLIGKPPFETNDVKSTY-----KK----------IRTNEYSFP---EQIQISSAAKNMIK .|||| | ||.||. . . .. |..|.||.|.| | .| |||||... ..| | |... || ...|||. |. |. KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIR KILTTDPSKRPTINELFNDDFF . |. |...| .. |||| .| RMLQYDEKDRISWEELFNHPWF |
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| Kinase | 18358b.AA | Ciliate-E2 | 1-249 | 25 | 6.7e-69 | 235.22 | In-house | 9-365 (365) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-365/365 Sequence Identity: 25% (94 aa) KGGFAKCYEFTN-LERKQV----------------------LAAKVIPKSSLTKSRARQKLMSEIR----------IHKSLNHRNIVKFQHFFE--DQEN .|.|.. |. .. ...||. | |.. |. . ...| ||. | ..||| ||.|. .|. |..| QGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNN VYILLEMCTNQTMNELIRRR-----------KRLTELEVQCYLLQILY---------------SIKYLHDNR-VIHRDLKLGNLFLSDKMEIKLGDFGLA .|. .| | ... ..|. . |..|| |.. . |||. ..||| . .||||.|. |... ||. ||||. IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS TKLEYD-------GERK------------------------RTICGTPNYIAPEILEAKE-------TGHSYEVDVWSFGVIAYTLLIGKPPFETNDVKS .|. | ..| .||||||.| |||||. |. .|..|..|.||.||| | .| ||||| KKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------- TYKKIRTNEYSFPEQ----------------IQISSAAKNMIKK----ILTTDPSKRPT-INELFNDDFF ...| ....||.. ..| .|..||| .| ||.||.| .....| .| -QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 18358b.AA | ULK | 1-249 | 28 | 3.1e-68 | 233.02 | In-house | 9-324 (324) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-324/324 Sequence Identity: 28% (89 aa) KGGFA-KCYEFTNLER---KQVLAAKVIPKSSLTKSRAR-------QKLMSEIRIHKSLN---HRN--IVKFQHFFEDQ--ENVYILLEMCTNQTMNELI || |. | |. .| . .|. |.|.|.|... |. . |.|..||.| | |. | | |||. ..||.. |.|| .| | . ..| KGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYI RRR---------KRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDK------------MEIKLGDFGLATKLEYDG---ERKRTIC------ .. |||.| |.. .. ||. |.||.. .||||.|. |. .... .|..|||.| ...... |.. KKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIK GTPNYIAPEILEAK--ETGHS-YEVDVWSFGVIAYTLLIGKPPFETNDVKSTYKK--------------IRTNEYSFP---EQIQISSAAKNMIKKILTT ||| | ||.||. . . .. |..|.||.|.| | .| ||.||... ..|.. |... || ....||. |. |.. |. GTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQY DPSKRPTINELFNDDFF |...| .. |.|| .| DEKDRISWEEIFNHPWF |
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| Kinase | 18358b.AA | SAK | 1-249 | 40 | 3.8e-68 | 231.12 | In-house | 9-254 (254) | Show / Hide |
Range on Protein: 1-249 Range on HMM: 9-254/254 Sequence Identity: 40% (102 aa) KGGFAKCYEFTNLERKQVLAAKVIPKSSLTKSRARQKLMSEIRIHKSLNHRNIVKFQHFFEDQENVYILLEMCTNQTMNELIRRRKR-LTELEVQCYLLQ ||||| | .. | | |.| | . |. |. |..|| | | |.. .|||. ||. |||| | |. ...| | || | . .. | KGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEEEARHFMHQ ILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYDGERKRTICGTPNYIAPEILEAKETGHSYEVDVWSFGVIAYTLLIGKPPFETNDVK |. . ||| ..|||| | |. |. .|..|. ||||||.|. |. |.|||||||.||| | | | . |||| | . ||||||.|||.|. || IVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEI--ATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVK STYKKIRTNEYSFPEQIQISSAAKNMIKKILTTDPSKRPTINELFNDDFF .| |. || | .| |. .|.|.| .| | |.. | NTLNKVMMAEYIMP--AHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM |
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| Kinase | 18358b.AA | Pkinase_Tyr | 30-181 | 28 | 1.1e-16 | 57.07 | Pfam | 40-202 (270) | Show / Hide |
Range on Protein: 30-181 Range on HMM: 40-202/270 Sequence Identity: 28% (48 aa) TKSRA--RQKLMSEIRIHKSL-NHRNIVKFQHFFE-DQEN--VYILLEMCTNQTMNELIRR----RKRLTELEVQCYLLQILYSIKYLHDNRVIHRDLKL . ... |...|.|..| |.| .| |||.. ..| .|| .| . . . . |. ...|| . .. .|| ||.... ||||| AMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA GNLFLSDKMEIKLGDFGLATKLEYDGE---RKRTICGTP-NYIAPEILEAKETGHSYEVDVWSFGV | ..... .| .||||| . |. . |||. . | ||| . .. . . ||||||| RNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSDVWSFGV |
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| Kinase | 18358b.AA | TyrKc | 13-248 | 20 | 8.4e-16 | 32.77 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-248 Range on HMM: 1-280/280 Sequence Identity: 20% (61 aa) LERKQVL-----------------AAKVIPKSSLTKSRARQKLMSEIRIHKSL--NHRNIVKFQHFFEDQ-------ENVYILLEMCTNQTMNELIRRRK .. ...| | |.. ... |. .|.|.|| ..| .| |||.. .| | ..|..| . . .. .|... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR R-LTELEVQCYLLQILYSIKYLHDNRVIHRDLKLGNLFLSDKMEIKLGDFGLATKLEYD---GERKRTIC-----GTP-----NYIAPEILEAKETGHSY . |. . . .|| |||....||||| | .... .| .||||. ... | ||.| .. |. ||| . .. . PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTT EVDVWSFGVIAY---TLLIGKPPFET-----NDVKSTYKKIRTNEYSFPEQI-------QISSAAKNMIKKILTTDPSKRPTINELFNDDF . ||||||| . |. |..| . . . ...... .. . . ... ...|. ||..||| .|. ..| KSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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| POLO_box | 18358b.AA | POLO_box | 427-495 | 41 | 8.4e-25 | 93.52 | Pfam | 1-74 (74) | Show / Hide |
Range on Protein: 427-495 Range on HMM: 1-74/74 Sequence Identity: 41% (31 aa) YSSKYGLGYLLNNGQAGVF-FNDSTKIILNPKTE-QFDYIE--RNSSSKQDFGAEYTLK-DYPESLQKKLTLLQ |..|||..|.|.|| .|. |||.|||||.|... ..||. .| .... ... .|||.||||||.|. YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK |
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| POLO_box | 18358b.AA | POLO_box | 533-600 | 43 | 1.4e-25 | 96.07 | Pfam | 1-74 (74) | Show / Hide |
Range on Protein: 533-600 Range on HMM: 1-74/74 Sequence Identity: 43% (32 aa) LRTKNAILFRLSNKVVQVI-FQDSSEIILSSELR-AVTYVN--RKKQRETFPLSTAMES--QNKEMSKRLTYTK .||| .| ..|||. ||| | |...|||... . |||| . ...|| |.||||..|. .... |.|||.| YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK |
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