Gene 6287 (Tetrahymena)
6287
Sequence
Protein domains of 6287.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 6287.AA | PEK-Unclassified | 132-965 | 88 | 0.0 | 2384.12 | In-house | 1-835 (835) | Show / Hide |
Range on Protein: 132-965 Range on HMM: 1-835/835 Sequence Identity: 88% (737 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIEVTEKKKSQKQEEQKRQTLELSSSFAK |.|.|||||||||.||...||.|..||||||||..||||||||||||||.|.|.||.|||||||.|||.||||||..||.|||||||||||||||||||| FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIEVEIKKNSQKQEEQKRQTLELSSSFAK KKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQ |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||| KKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQ QIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQIKIFNNNSNGNS |||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|..||..||||..|.|.||||||||||||||||||||||||| QIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNINHYNINDNNDMENQDPFPNPNVASKQKPSQIKIFNNNSNGNS AEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNN ||||||||||||||||||.||.||.|||||||||||||.|..|||.|..||||||||||||||||||||||||||||||||||||||||||||||||||| AEIPNTKKSSKDIKKLSEYSSVMHANNNEESQENDSQSYNNNQSDYQSNFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNN NNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEI ||||||||||||||||||||||||||||.||||..||||.||.|||||||.||||||||||||||||||||||||||||||||||||||||||||||||. NNQNKNQILETKKQEQNANCAINNKNNKCSHDIGNNNQIIQQCQNNNNNNYNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEF IFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNC |||.|.||||.|.|.||.|||||||||||||||||||||||||.||.||||||||.|||||||||||.|||||||||||||||||||||||||||||||| IFYIQMELCHYTTARYIINRNKKLFSQQQFNQNLSIKNSCANINNNKNIKNQNLCIQSTQSMFNMNETNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNC SDPFDILTFEYKQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDN-MQVKIGDFGLVKKLSKLINPNQKIQYNDHQLYGKKLGNDNSGMKQTSTN |||||||.||||||...|...|||.||||||.|||||||.||||||...| ||.||||||||||..||||.||||||||||||||||.|.|..|.|...| SDPFDILIFEYKQQCREITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKKIEKLINDNQKIQYNDHQLYGKKLNNNNNNMNQNNNN NSFSGASTSPSETNSGYHDKLPFYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELP |.|.||||||||||||||||||||||||||||||||.||.|.||.|||||||||||||.|..||.||||.|||..|.||.|||.||.||||||||||||| NKFVGASTSPSETNSGYHDKLPFYLPKEEITSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCKKGELP KHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL ||||||||||||||||||||||||||||||||||| KHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL |
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Kinase | 6287.AA | PEK | 132-967 | 27 | 5e-243 | 813.65 | In-house | 1-655 (655) | Show / Hide |
Range on Protein: 132-967 Range on HMM: 1-655/655 Sequence Identity: 27% (234 aa) FIQLQKIGQGGF-ASVYRVVHKIDDTEYAVKQIHLKIKDIK----------EDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIEVTEKKKSQKQEEQKR |...|..|.||| .||.| .|.|...||.|.|.|..|..| ....||.|| ||...||. ||||..||...|||. |.|..|.|.|... FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ QTLELSSSFAKKKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQ .. .......|. ||||.|.. |..|.. .| ..|..||.... . LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-C------------------------------------------------------- QQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQI |......|.......|||||.||...|...|....||.|..|| ---------------------------------------------EDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPN------------ KIFNNNSNGNSAEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQG |.|..| .|. ...|...|...... |...|....|....|..|...|.|.........|...|..|.|. .|..|...|.|.........|....|| -IENQFS-INF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQD EKKNINKCNNNNNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQ .... |.|.......|||. ..............||| ..||.|....|......||.|||||...|.....| DEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQ--------------------------- REFQLDKYDEIIFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMH |.....|.|.|.|.... ......|. . . .|||.. . .|||.|..||. |.||. |.|||.|| || ... .. -------YQCHYLYIQMEYCEKKTLRDWIDNNG-C-P-VQFNYW-R-RNSCKNHYNNY-IMNQC-CFQSTWSM-NM-RQW-DE----------------- PTLTYSNSCNCSDPFDILTFEYKQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQ-----VKIGDFGLVKKLSKLINPNQKI--QYNDHQLY ... |..|.|. |...|..||..||. . |.||||||.||||... | ||||||||......|.. .||. | .| |.| ---------------NNCMFWDKDQCWRIFRQILEGLNYIHSQG-MIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQ-SQKNYNQ-QD-QSY GKKLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLP---FYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHP .|. .|||. ...|...||..|..|... .|. ||. .| ||......|...||..|.||||||.. |.|.....|..|.||||||......| WKYVANDNCQWWNTNQQNSPTGQDTHMW-SNN-YHI-QPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQ------HYQKSHYNHKVDMYSLGIIFFEMWYP MNTSM-ELVKTIQNCKK------GELP-KHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTLQE ..|.| | |||...... |..| |.|. |.|..|..|.. ||.|||.|| . | |.. FFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF |
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Kinase | 6287.AA | CAMK | 137-903 | 6 | 1.6e-31 | 98.27 | In-house | 1-323 (425) | Show / Hide |
Range on Protein: 137-903 Range on HMM: 1-323/425 Sequence Identity: 6% (58 aa) KIGQGGFASVYRVVHKIDD------------TEYAVKQIHLK---------------IKDIKEDL------QKHYEKLIREARYLAQ-------VNHPNV ..|.|.|. |....|| . ...|.| | | |...|.. .| ... || . . . ..|||. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IRYFHSWI-------------------------------EVTEKK------------KSQKQEEQKRQTLELSSSFAKKKKSKDNNNVSPSKKDKKEDKQ |. .. . | . .... || . IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQ--------------------------------- LAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFY ---------------------------------------------------------------------------------------------------- FEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQIKIFNNNSNGNSAEIPNTKKSSKDIKKLSEFSSA ---------------------------------------------------------------------------------------------------- MHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNNNNQNKNQILETKKQEQNANCAI ---------------------------------------------------------------------------------------------------- NNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEIIFYLQTELCHQTLAEYITNRNK ---------------------------------------------------------------------------------------------------- KLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNCSDPFDILTFEYKQ---QAIAIL |||. . . .| . ---------------------------------------------------------------------------------FDIV-ERGRFTEREARRYF KEIIKGLYHIHHICKMVHRDLKPHNIFLTDNM-----------------QVKIGDFGLVKKLSK------------------LINPNQKIQYNDHQLYGK . |. .. ..| ||||||| || |.||. ..|| |||. .|. . RQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW----------------- KLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLPFYLPKEEITSTCGTATYAS-PEQLSQKKVRIKAHFQ-----AEFFDHRADIYSLGII . . . . ||| |.. || |..|. . . . . .|. |.|.| ------------------------------------TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQ--NATDEEKPYYGPKCDMWSCGVI |
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Kinase | 6287.AA | TKL | 744-965 | 16 | 3.6e-25 | 87.59 | In-house | 132-364 (364) | Show / Hide |
Range on Protein: 744-965 Range on HMM: 132-364/364 Sequence Identity: 16% (47 aa) QQAIAILKEIIKGLYHIHH-------ICKMVHRDLKPHNIFLTDNMQ--------------VKIGDFGLVKKLSKLINPNQK-------IQYNDHQLYGK .| . . ..| .|... | ....|||||..||.. .|.. .||.|||| . .|. | | . HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESA---------- KLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLPFYLPKEEITS---------TCGTATYASPEQLSQKKVRIKAH-----FQAEFFDHRADIYSLG | . ||| . .|| | .. .. .. . .. ..|.|| | -------------------------------------------E--HQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG IIILQLFH---PMNTSMELVKT---------IQNCKKGELPKHF------------CAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL |.. .. | .. ...|.||. | |.......| . ||.||| ..| ..| IVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 6287.AA | PEK | 132-205 | 36 | 1.8e-23 | 74.18 | In-house | 1-76 (758) | Show / Hide |
Range on Protein: 132-205 Range on HMM: 1-76/758 Sequence Identity: 36% (28 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKI--KDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIE | |..|.||| .|.|. | |. .||.| | ... . || ||.| || .|.| .|||..| | FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLE |
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Kinase | 6287.AA | Pkinase | 744-908 | 18 | 1.1e-21 | 77.8 | Pfam | 108-206 (293) | Show / Hide |
Range on Protein: 744-908 Range on HMM: 108-206/293 Sequence Identity: 18% (32 aa) QQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQV----KIGDFGLVKKLSKLINPNQKIQYNDHQLYGKKLGNDNSGMKQTSTNNSFSGASTS .... ....|..||...| .. .|||||| ||.. .|... ||.|||| |... WECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------------------------------------------- PSETNSGYHDKLPFYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLF | ... |. ||| |..|| . .. ....|..|.|.|. ... --------------Y-NNS-MTTFCGTPWYMAPEVIR----------GGQYYGPKVDMWSCGCILYEML |
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Kinase | 6287.AA | PEK | 865-956 | 35 | 5.7e-19 | 58.87 | In-house | 650-747 (758) | Show / Hide |
Range on Protein: 865-956 Range on HMM: 650-747/758 Sequence Identity: 35% (35 aa) GTATYASPEQLSQKKVRIKAHFQA-----EFFDHRADIYSLGIIILQLFHP-MNTSMELVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRP || .|.||||.. . | . .| ||||||.| |.|| .| || ..|. . ..| .|| | | | .| |.. .| .| || GTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERP |
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Kinase | 6287.AA | HRI | 132-205 | 41 | 2.9e-17 | 56.8 | In-house | 1-69 (613) | Show / Hide |
Range on Protein: 132-205 Range on HMM: 1-69/613 Sequence Identity: 41% (31 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIE |.|. ||.||. ||.| || | ||.| | | | | ... |. || . || .|.|..|| .||| FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIK-KRTKCSCM----KMQREVKVLACLQHHNIVRYHQAWIE |
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Kinase | 6287.AA | NEK | 132-205 | 32 | 5.7e-17 | 56.65 | In-house | 1-75 (286) | Show / Hide |
Range on Protein: 132-205 Range on HMM: 1-75/286 Sequence Identity: 32% (26 aa) FIQLQKIGQGGFASVYRVVHKIDDTE-----YAVKQIHLKIKDIKEDLQKHYEKLI-REARYLAQVNHPNVIRYFHSWIE . ..||||| | .||.| .|.| . |. |.| .... .| .... |.| |.| .|||...|. |.|| YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKI-----NMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE |
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Kinase | 6287.AA | Pkinase | 132-205 | 28 | 1.1e-15 | 56.5 | Pfam | 1-71 (293) | Show / Hide |
Range on Protein: 132-205 Range on HMM: 1-71/293 Sequence Identity: 28% (21 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIE . ..|||.|.|..||. .|| . ..|||.| .. ..|.. ... .| .|..... .||||..|..... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED |
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Kinase | 6287.AA | WEE | 132-205 | 26 | 2.6e-14 | 44.49 | In-house | 1-76 (297) | Show / Hide |
Range on Protein: 132-205 Range on HMM: 1-76/297 Sequence Identity: 26% (22 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHY--EKLIREARYLAQVN-------HPNVIRYFHSWIE | ..||||.| |..|| ....|| ||.|.. .. .... . .||.. .... ||...||. .|.| FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSK-QP------FRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE |
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Kinase | 6287.AA | S_TKc | 132-971 | 6 | 4.8e-14 | 28.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 132-971 Range on HMM: 1-231/231 Sequence Identity: 6% (59 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSWIEVTEKKKSQKQEEQKRQTLELSSSFAK . |.|||.|.|..||...|| .. ..|.|.|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------------------------------------- KKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNIHIQAQTNNQKGKQQQQQQVNQGKQTQ ---------------------------------------------------------------------------------------------------- QIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSPIPNPNVASKQKPSQIKIFNNNSNGNS ---------------------------------------------------------------------------------------------------- AEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNNQNTSKLVQNKKQDQGEKKNINKCNNN ---------------------------------------------------------------------------------------------------- NNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYERRKNKSMDYLTIDQKQREFQLDKYDEI ---------------------------------------------------------------------------------------------------- IFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQQNSINNNLNQNNLMHPTLTYSNSCNC .. .. . || . . --------------------------------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQ SDPFDILTFEYKQQ------------------------AIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKKLSKLINPNQKIQY . . . .|| . | ....|...| ..| . .|||||| ||.|.. ..||.|||| ..| D-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------------ NDHQLYGKKLGNDNSGMKQTSTNNSFSGASTSPSETNSGYHDKLPFYLPKEEITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDH-RADIYSLGIIILQ |. ||| | .|| | ... ..|..|.|.|. -----------------------------------------------------TTFCGTPWYMAPEVL--------------GYGKCKCDWWSCGCILYE LFH---PMNTSMELVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQ---TLQEMEMM .. | .. ....... | . ..|. | ||.||| .. | .. . MLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 6287.AA | WEE | 749-797 | 37 | 5.3e-14 | 43.43 | In-house | 116-184 (297) | Show / Hide |
Range on Protein: 749-797 Range on HMM: 116-184/297 Sequence Identity: 37% (26 aa) ILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNM--------------------QVKIGDFGLVKKLSK || .|..|| ||| | ||| |.|| |||.. .| ||||||.|..... ILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNS |
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Kinase | 6287.AA | PKR | 743-795 | 50 | 1e-12 | 41.73 | In-house | 122-173 (272) | Show / Hide |
Range on Protein: 743-795 Range on HMM: 122-173/272 Sequence Identity: 50% (27 aa) KQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKKL | .. . |.|| | | |..|||||| |||| |. ..|||||||| | KVLILDLYEQIVKGVDYI-HSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTAL |
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Kinase | 6287.AA | NEK | 753-797 | 43 | 1e-12 | 41.49 | In-house | 123-175 (286) | Show / Hide |
Range on Protein: 753-797 Range on HMM: 123-175/286 Sequence Identity: 43% (23 aa) IIKGLYHIHHIC----KMVHRDLKPHNIFLT-DNMQ---VKIGDFGLVKKLSK ....|...| | .|||.|| ||||| .|.. |||||||. | |.. MCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNH |
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Kinase | 6287.AA | TKL | 138-198 | 15 | 1.2e-12 | 41.87 | In-house | 1-89 (364) | Show / Hide |
Range on Protein: 138-198 Range on HMM: 1-89/364 Sequence Identity: 15% (14 aa) IGQGGFASVYRVVHKIDD--------TEYAVKQIHL--------KIKD------------IKEDLQKHYEKLIREARYLAQVNHPNVIR ||.|||. ||. ... . .. |||... .... . ..... .....|.. . . .|||... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQ |
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Kinase | 6287.AA | GCN2 | 859-956 | 28 | 1.5e-12 | 39.86 | In-house | 409-500 (511) | Show / Hide |
Range on Protein: 859-956 Range on HMM: 409-500/511 Sequence Identity: 28% (30 aa) EITSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSL-GIIILQLFHP-MNTSMELVKTIQNCKKGELPKHFCA----KFPRLAEIIKDSLSNDP ..|. ||. | .|||. . ..|.||| |||.. ...| . |.|| |... . .. |.|. | . . . ...|. |. || HHTGKVGTPFYMCPEQQ------------KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDP QKRP |||| QKRP |
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Kinase | 6287.AA | GCN2 | 752-809 | 34 | 2e-11 | 35.88 | In-house | 316-393 (511) | Show / Hide |
Range on Protein: 752-809 Range on HMM: 316-393/511 Sequence Identity: 34% (27 aa) EIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKK---------------------LSKLINPNQKIQYND .|. || .|| |.|||||| ||||. . .||||||||.. .. ... .|. | |. QILEGLNYIHSQ-GMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQ |
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Kinase | 6287.AA | HRI | 749-791 | 53 | 3.7e-11 | 34.77 | In-house | 438-483 (613) | Show / Hide |
Range on Protein: 749-791 Range on HMM: 438-483/613 Sequence Identity: 53% (25 aa) ILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQ----VKIGDFGL | .|. |.. || ||||.|| |||| | | |||||||| IFQQIVEGMFYIHNMF-IVHRDVKPRNIFLHDPDQGHPQVKIGDFGL |
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Kinase | 6287.AA | PEK | 749-793 | 33 | 9.3e-10 | 27.5 | In-house | 447-514 (758) | Show / Hide |
Range on Protein: 749-793 Range on HMM: 447-514/758 Sequence Identity: 33% (23 aa) ILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQ------------------------VKIGDFGLVK . . |. |. || . | |||||| |||.. | .||||||||. WFHQICEGVNYIHS-KGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT |
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Kinase | 6287.AA | HRI | 861-930 | 37 | 1.8e-09 | 28.67 | In-house | 518-576 (613) | Show / Hide |
Range on Protein: 861-930 Range on HMM: 518-576/613 Sequence Identity: 37% (26 aa) TSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELP || || |||||||| .| . | ||.|.| . || | | || . . . | .| TSRVGTCTYASPEQL-----------DGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIP |
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Kinase | 6287.AA | PKR | 132-203 | 29 | 4.3e-08 | 24.95 | In-house | 1-61 (272) | Show / Hide |
Range on Protein: 132-203 Range on HMM: 1-61/272 Sequence Identity: 29% (21 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQVNHPNVIRYFHSW | .. .|| ||| |.. |.|| |..| . || .| . ||...| |...| | FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNN-----------EKAEHEVQALAKLDHVNIVHYHSCW |
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Kinase | 6287.AA | PKR | 861-965 | 32 | 1.4e-07 | 23.04 | In-house | 181-272 (272) | Show / Hide |
Range on Protein: 861-965 Range on HMM: 181-272/272 Sequence Identity: 32% (34 aa) TSTCGTATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELP-KHFCAKFPRLAEIIKDSLSNDPQKRPLLS | || | ||||.. . |. | ||| ||.|. | | | .| .| .. ..|.. | | | .. ||. |. || | TRRKGTLQYMSPEQIFSQ------HYGKEV-----DIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNKEKTL---LQKLLSKKPKDRPNTS KIEQTL | .|| EILRTL |
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Kinase | 6287.AA | GCN2 | 132-389 | 18 | 2e-06 | 17.95 | In-house | 1-265 (511) | Show / Hide |
Range on Protein: 132-389 Range on HMM: 1-265/511 Sequence Identity: 18% (53 aa) FIQLQKIGQGGFASVYR-VVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEK--LIREARYLAQVNHPNVIRYFHSWIE-----VTEKKKSQKQEEQKRQTL | .. .|.||| .|. | . | . ||.| . ...| .|.. | ||. |. .|..| ||. .||| ... . .. . . FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQ-----RKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSD ELSSSFAKKKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQ------QPANSNNPAGQNQQKVVDSNKG----------GISQVASVQNKNSDATNIHI | .|. . .. . .| | . .. ||. . ||. | . ..|| .| . . | | | | .| DESECFSGQYEMPKSVNQS-EEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDW QAQTNN----------QKGKQQQQQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFI-EENSKSIKQDESQQENSHSSGNNL .. || .. .||. | ... ....| .. .|.|... |. ... | ..|.... . .|. DIESNNVRDMESDDNEWEQEQQNNQSFQPKQEDHQ----------------------NQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNK |
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Kinase | 6287.AA | TyrKc | 132-965 | 6 | 8e-06 | -128.74 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 132-965 Range on HMM: 1-280/280 Sequence Identity: 6% (57 aa) FIQLQKIGQGGFASVYRVVHKIDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQV--NHPNVIRYFHSWIE-------------VTE-------- ..|.| | | ||. . | .. ||| .. | ..|||| . .. .|||..| . .. |.| ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK ---KKKSQKQEEQKRQTLELSSSFAKKKKSKDNNNVSPSKKDKKEDKQLAIQSNQANLKQQPANSNNPAGQNQQKVVDSNKGGISQVASVQNKNSDATNI .|. | DYLRKHRPK------------------------------------------------------------------------------------------- HIQAQTNNQKGKQQQQQQVNQGKQTQQIQLNNQDQSDEDNNEDSNTFYFEDEFDNEVVFIEENSKSIKQDESQQENSHSSGNNLNQSNIKSNNDMSDQSP ---------------------------------------------------------------------------------------------------- IPNPNVASKQKPSQIKIFNNNSNGNSAEIPNTKKSSKDIKKLSEFSSAMHGNNNEESQENDSQSFNKGQSDFQLVFESYSEKSKSDLKDECKQIAPDNNN ---------------------------------------------------------------------------------------------------- QNTSKLVQNKKQDQGEKKNINKCNNNNNQNKNQILETKKQEQNANCAINNKNNKNSHDILKNNQISQQTQNNNNNNKNQLQQNQQQNQANSISNTKSYER ---------------------------------------------------------------------------------------------------- RKNKSMDYLTIDQKQREFQLDKYDEIIFYLQTELCHQTLAEYITNRNKKLFSQQQFNQNLSIKNSCANISNNSNIKNQNLCLQSTQSMFNMNESNSFSGQ ---------------------------------------------------------------------------------------------------- QNSINNNLNQNNLMHPTLTYSNSCNCSDPFDILTFEYKQQAIAILKEIIKGLYHIHHICKMVHRDLKPHNIFLTDNMQVKIGDFGLVKKLSKL-INPNQK .. . . | .| ..|. . .|||| |. ...| .|||.|||| ... . -----------------------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--- IQYNDHQLYGKKL-GNDN-----------SGMKQTSTNNS------------FSGASTSPSE--------------TNSGYHDKLPFY-LPKEEITSTCG .. | || .. . . .. . | | |. . ... .|| . | . . . . ---ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS---- TATYASPEQLSQKKVRIKAHFQAEFFDHRADIYSLGIIILQLFHPMNTSMELVKTIQNCKKGELPKHFCAKFPRLAEIIKDSLSNDPQKRPLLSKIEQTL | . . .|.|. || .|| | | . . -------------------------------------------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 6287.AA | Pkinase_Tyr | 765-791 | 51 | 0.000156 | 15.98 | Pfam | 131-157 (270) | Show / Hide |
Range on Protein: 765-791 Range on HMM: 131-157/270 Sequence Identity: 51% (14 aa) KMVHRDLKPHNIFLTDNMQVKIGDFGL ...|||| |. .|.|..|||.|||| NCIHRDLAARNCLVTENNVVKICDFGL |
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Kinase | 6287.AA | Pkinase_Tyr | 132-199 | 26 | 0.00545 | 10.75 | Pfam | 1-69 (270) | Show / Hide |
Range on Protein: 132-199 Range on HMM: 1-69/270 Sequence Identity: 26% (19 aa) FIQLQKIGQGGFASVYRVVHK----IDDTEYAVKQIHLKIKDIKEDLQKHYEKLIREARYLAQV-NHPNVIRY . ..|.|.| | .||. . | .... ||| . . .. |...|||. . | .|||..|. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRL |
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Kinase | 6287.AA | HRI | 634-654 | 38 | 0.012629 | 4.01 | In-house | 395-415 (613) | Show / Hide |
Range on Protein: 634-654 Range on HMM: 395-415/613 Sequence Identity: 38% (8 aa) YLQTELCHQTLAEYITNRNKK . | .|| .| . |. |||. HIQMQLCELSLWDWISERNKR |
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Kinase | 6287.AA | WEE | 895-907 | 69 | 0.288041 | 0.09 | In-house | 217-229 (297) | Show / Hide |
Range on Protein: 895-907 Range on HMM: 217-229/297 Sequence Identity: 69% (9 aa) ADIYSLGIIILQL |||.|||| |. | ADIFSLGITIYEL |