Gene 10969 (Tetrahymena)
10969
Group:
Other
Family:
Ciliate-Unique
Sequence
Protein domains of 10969.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10969.AA | Ciliate-B3 | 171-240 | 30 | 4.1e-08 | 25.87 | In-house | 1-69 (69) | Show / Hide |
Range on Protein: 171-240 Range on HMM: 1-69/69 Sequence Identity: 30% (21 aa) LAKVIFAKIFLCVYHLHQNGLIHCDISLDNFLVNINQDKETLQIFINDFNHTKNNQNAIIDNTLISGKHF .| | .. . ||. . |||| .|| ||| .|||| ... | || | ..... . . . . . FALKHFHQVVEKIKILHEKNICHCDIKVDNILVN-QQDKENYKVIIIDFGHCQRKCQNCKSEMICGTLTY |
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| Kinase | 10969.AA | S_TKc | 45-331 | 14 | 4.9e-08 | -59.07 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 45-331
Range on HMM: 1-231/231
Sequence Identity: 14% (45 aa)
LNMKHSLGKGSAGKVLKVYDFEVEKLQAIKLYENEDYFNTEQNIINNLPGGLPVIPFLNEKQHKFFCFLLKDQQSVVPQGYRFRNDLFIEDKQRLALIMD
. .|||. ||| |... . .. ||| . ...| | . . .| . |.. ..| ..|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------EHIRREIQ----ILKK-HHPNIVKLYDVFQD-------DHLYMVME
VYDV---NLVQYLQDTADNND---FTNEEKIYLAKVIFAKIFLCVYHLHQNGLIHCDISLDNFLVNINQDKETLQIFINDFNHTKNNQNAIIDNTLISGK
| .| .|... . |. |. ... |.. . ..|..| ||.|. .| |.. .| | || . .|..
YCDGDLGDLFDYIKKRGRHGLRFPFP----E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------TTFCGTP
HF-PPEIQITSPITCEIHTPDHTINAKRLDFYSLFCCYYQIFSILKIPIQNLDQDSYSVMNYFYRPHQNYDIICQEIIKIIFDLDVD-----EDFM----
.. .||. . .. | .|. |. | .. . | . .| . .. . . ..|. ... | . | .
WYMAPEVL--------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTAEALQDEWD
----RYL
..
IKCHPWF
|
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| Kinase | 10969.AA | Other-Unique | 131-233 | 11 | 2e-06 | 18.48 | In-house | 1-169 (249) | Show / Hide |
Range on Protein: 131-233 Range on HMM: 1-169/249 Sequence Identity: 11% (20 aa) LFIEDKQRLALIMDVYDVNLVQYLQDTADNNDFTNEEK-------------------------------------------------------IYLAKVI .. .| . ........ .|... ..... .... . . . IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEHWMN FAKIFLCVYHLHQNGLIHCDISLDNFLVNINQDKE--------------TLQIFINDFNHTKNNQNAIIDNT . .. .. .|||.|..|||||...|...|.| .. ...| |.||| | . ..... CCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF |
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| Kinase | 10969.AA | DYRK1 | 45-82 | 36 | 9e-06 | 15.7 | In-house | 1-38 (321) | Show / Hide |
Range on Protein: 45-82 Range on HMM: 1-38/321 Sequence Identity: 36% (14 aa) LNMKHSLGKGSAGKVLKVYDFEVEKLQAIKLYENEDYF ... ..|||| |.| | || . ... |||. | | YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPF |
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| Kinase | 10969.AA | NIM1 | 172-196 | 44 | 9e-06 | 12.9 | In-house | 102-126 (258) | Show / Hide |
Range on Protein: 172-196 Range on HMM: 102-126/258 Sequence Identity: 44% (11 aa) AKVIFAKIFLCVYHLHQNGLIHCDI .| ||| | . |.| | .. .| || CKPIFAQIVSAVKHMHSRNIVHRDI |
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| Kinase | 10969.AA | CK1 | 185-219 | 30 | 8.4e-05 | 12.78 | In-house | 147-192 (339) | Show / Hide |
Range on Protein: 185-219 Range on HMM: 147-192/339 Sequence Identity: 30% (14 aa) HLHQNGLIHCDISLDNFLVNINQ-----------DKETLQIFINDF ..| .| || || |||.. .|. ..| |... || YMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDF |
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| Kinase | 10969.AA | MAST | 171-202 | 40 | 0.000132 | 9.28 | In-house | 103-134 (337) | Show / Hide |
Range on Protein: 171-202 Range on HMM: 103-134/337 Sequence Identity: 40% (13 aa) LAKVIFAKIFLCVYHLHQNGLIHCDISLDNFL .|| ..| . ||. || | .|.|. || | MAKMYIAETVLCLEYLHSYGIVHRDLKPDNML |
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| Kinase | 10969.AA | Ciliate-E2 | 130-219 | 25 | 0.00021 | 11.01 | In-house | 99-200 (365) | Show / Hide |
Range on Protein: 130-219
Range on HMM: 99-200/365
Sequence Identity: 25% (29 aa)
DLFIE-DKQRLALIMDVYDV-NLVQYLQ--DTA-------DNNDFTNEEKIYLAKVIF-----------AKIFLCVYHLHQNG-LIHCDISLDNFLVNIN
. |.| |.. . |.|. .. .| .|.. .. | . || .| .|. | |. | | |.. .||... || || ..| |.
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
QDKETLQIFINDF
|.| ||
-------IKIIDF
|
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| Kinase | 10969.AA | NuaK | 46-75 | 33 | 0.000322 | 6.4 | In-house | 2-31 (252) | Show / Hide |
Range on Protein: 46-75 Range on HMM: 2-31/252 Sequence Identity: 33% (10 aa) NMKHSLGKGSAGKVLKVYDFEVEKLQAIKL ... |||| ||| . .. . .. |||. EFQKTLGKGTYGKVKLATEHSTGREVAIKS |
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| Kinase | 10969.AA | Ciliate-E9 | 171-206 | 27 | 0.000452 | 8.47 | In-house | 112-148 (298) | Show / Hide |
Range on Protein: 171-206 Range on HMM: 112-148/298 Sequence Identity: 27% (10 aa) LAKVIFAKIFLCVYHLHQNG-LIHCDISLDNFLVNIN .||..| . . . ..|| . | |. ..| |.. | VAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLIDKN |
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| Kinase | 10969.AA | DYRK2 | 46-82 | 37 | 0.000476 | 8.69 | In-house | 2-38 (318) | Show / Hide |
Range on Protein: 46-82 Range on HMM: 2-38/318 Sequence Identity: 37% (14 aa) NMKHSLGKGSAGKVLKVYDFEVEKLQAIKLYENEDYF .. .|||| | |.|.|| ... |||. |. | EILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRF |
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| Kinase | 10969.AA | Ciliate-E2 | 45-74 | 33 | 0.011914 | 4.9 | In-house | 1-30 (365) | Show / Hide |
Range on Protein: 45-74 Range on HMM: 1-30/365 Sequence Identity: 33% (10 aa) LNMKHSLGKGSAGKVLKVYDFEVEKLQAIK . .|.|. |.| |. . .| |..||| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIK |
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| Kinase | 10969.AA | DYRK2 | 177-195 | 47 | 0.147805 | 0.45 | In-house | 109-127 (318) | Show / Hide |
Range on Protein: 177-195 Range on HMM: 109-127/318 Sequence Identity: 47% (9 aa) AKIFLCVYHLHQNGLIHCD ..| | ||.| .|||| HSILQCLRFLHKNNIIHCD |
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