Gene 10356 (Tetrahymena)
10356
Sequence
Protein domains of 10356.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 10356.AA | Ciliate-E2 | 39-238 | 19 | 2.9e-24 | 80.17 | In-house | 1-289 (365) | Show / Hide |
Range on Protein: 39-238 Range on HMM: 1-289/365 Sequence Identity: 19% (57 aa) VCSIEYLDSGSFG-----VVLKYNN--PNKLKKGAV--------KAIIGYLSDEASMKEIKDEIDLQINIC--------------------NPYIAKVKE |. . .|.|| | | .. .|... |. | . . .| . .| |.|. .|.| | .| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE FTK-IVLDKAYIIGFVWMHYYEDGSLKRFLDQLREQNQEI-------DFKTKMRLGIQLFD---------------ALSSMHQKN-IFHRDIKAANILMH . . . .. |.. | |.. |.|. .. . . . ... . | .. |... || ..|.|| |.||||| |||. CFQEKDDNNIYLV----MEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF- QGDCVIADFGISRIQNIEQQ---------ISNSQR---------------------FKGTPMFLDPEIHRG----------HLDKKMDLFAMGIVLLMM . |.|||.|.......| . . . |||... |||..| . |.| |....|..| .| ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM |
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| Kinase | 10356.AA | ULK | 39-235 | 24 | 4.7e-23 | 77.39 | In-house | 1-246 (329) | Show / Hide |
Range on Protein: 39-235 Range on HMM: 1-246/329 Sequence Identity: 24% (60 aa) VCSIEYLDSGSFGVVLKY-NNPNK---LKKGAVKAII-GYLSDEASMKE-------IKDEIDLQINIC--------NPYIAKVKEFTKIVLD-KAYIIGF | .. | .||||.| | |. .| .| |.| | ... . . | .| ||... . .|.| | ..... . ||| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII-- VWMHYYEDGSLKRFLDQLRE------QNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANILMHQGD-------------CVIADFGISRI-QNI- | | ..| |. .. . .. .. . . .|. .. .|..|| ||||| .|||.| |. . ||||| .. .| --MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN -EQQISNSQR----FKGTPMFLDPEIHRGH-----LD-KKMDLFAMGIVL |||. .. ..|||.. |.| |. . .| |.. .|... MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 10356.AA | Ciliate-E1 | 45-229 | 23 | 1.3e-22 | 70.71 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 45-229 Range on HMM: 1-202/202 Sequence Identity: 23% (49 aa) LDSGSFGVVLK---YNNPNKLKKGAVKAIIGYLSDEASMKEIKDEIDLQINICNPYIAKVKEFTKIVLDKAYIIGFVWMHYYEDGSLKRFL--------D . .|||..|.| .|| .. .. . ... ... .||| .. .. . . .. .. . | .|..||. .. . .... .. . . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKK-ECYIIQIIDYIKIDQNYICIII-FECCCCSLKDYLQNHNRLEYWQ QLREQNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANILM-HQGDCVIADFGISRIQNIEQQISNSQRFKGTPMFLDPEI---------HRGHLD |....... .|. ||.. .||.|.|. .||.|| ||||| .||| .|| .|..|||||... ...|....| . | .. || . . QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFL-KNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN KKMDLF .| |.. YKSDIY |
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| Kinase | 10356.AA | ULK | 39-235 | 23 | 1.5e-21 | 73.29 | In-house | 1-242 (324) | Show / Hide |
Range on Protein: 39-235 Range on HMM: 1-242/324 Sequence Identity: 23% (58 aa) VCSIEYLDSGSFG-VVLKY-NNPNK--LKKGAVKAII-GYLSDEASM-------KEIKDEIDLQINIC---NPY--IAKVKEFTKIVLD-KAYIIGFVWM | .. | .|||| .| | |. .. .. |.| | .... .. . .| || .. . .|. | | ..... . ||| | YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII----M HYYEDGSLKRFLDQLRE-----QNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANILMHQGD-------------CVIADFGISRI-QN--IEQQ | ..| |. .. . .. .. . . .|. .. .|..|| ||||| .|||.| |. . ||||| ... .| ||| EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ ISNSQR----FKGTPMFLDPEIHRGH-----LD-KKMDLFAMGIVL . .. ||||.. |.| |. . .| |.. .|... MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF |
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| Kinase | 10356.AA | Ciliate-E2-Unclassified | 132-238 | 25 | 1.3e-20 | 68.28 | In-house | 125-263 (352) | Show / Hide |
Range on Protein: 132-238 Range on HMM: 125-263/352 Sequence Identity: 25% (36 aa) LDQLREQNQEIDFKTKM-----RLGIQLFDALSSMHQKN-IFHRDIKAANILMHQG----DCVIADFGISR-------IQNIEQ-------QISNSQRFK |.. ..|..... . .. |. ..|...|.|| | ||||| |||.... . |.|||||. .. .| . ... | LFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFC GTPMFL----DPEIHRG-HLD----KKMDLFAMGIVLLMM |||... ||. .| . | .| | ...|..| | GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM |
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| Kinase | 10356.AA | C8 | 39-235 | 22 | 2.9e-20 | 67.13 | In-house | 1-226 (226) | Show / Hide |
Range on Protein: 39-235
Range on HMM: 1-226/226
Sequence Identity: 22% (50 aa)
VCSIEYLDSGSFGVVLKYNNPNKLKKGAVKAIIGYLSD-----EASMK---EIKDEIDLQINICNPYIAKVKEFTKIVLDKAY----IIGFVWMHYYED-
. . .|| .|..|.||| .| .. .. . | . . .. . |.. |. . . .. | | .. ... .. ..| .. . ..
FNNFQYLSFGAYGMVLKAKNVKDNREIVLK-FQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM
----GSLKRFLDQLREQNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANIL----MHQG-DCVIADFGISRIQNIEQQISNSQRF--KGTPMFLD
|| . |..|...|... . | . ||. | .. .|.||| ||||| |.| .| ..|||.. ... |. . || ..
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA
PEIHRG------HLDKKMDLFAMGIVL
||| . .. ||| .|.||
PEIEKKQDNQYKQYRIQSDLFSVGLVL
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| Kinase | 10356.AA | Ciliate-C8 | 48-235 | 22 | 1.2e-18 | 63.68 | In-house | 1-238 (238) | Show / Hide |
Range on Protein: 48-235
Range on HMM: 1-238/238
Sequence Identity: 22% (53 aa)
GSFGVVLKYNNPNKLKKGAVKAIIGYLSDEASM--KEIKDEIDLQINICNPYIAKVKEFTKIVLDKAYI-------------------IGFVWMHYYED-
|.||.||| .| .. .| | | . . . ||| .. .. |.. |. . .|... . || . .
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFV--VQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQ
-GSLKRFLDQLREQNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANIL--MHQGD------C---VIADFGISRIQNIEQQISNSQRFKGTPMF-
..|| ..|..|..... . . |. . || | .. .|..|| ||||| |.| |.. | . ||| .. .. . |. ||||
NCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYI
----------LDPEIHRGHLDKKMDLFA-------MGIVL
||. . ... |.| |.||
EMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
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| Kinase | 10356.AA | TKL | 120-235 | 20 | 3.7e-18 | 62.0 | In-house | 117-279 (364) | Show / Hide |
Range on Protein: 120-235 Range on HMM: 117-279/364 Sequence Identity: 20% (35 aa) MHYYEDGS-LKRFLDQLREQNQEIDFKTKMRLGIQLFDALSSMHQ--------KNIFHRDIKAANILMHQ-GD--------------CVIADFGISR-IQ | |.. || | ... . ..|. .. ... .|. ..| |||.| .||| .. . | |.|||.|| .. MEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS NIEQQISN----------------SQRFKGTPMFLDPEIHRGH-----------------LDKKMDLFAMGIVL . ... . . . ||| .. ||. ||. ..|.| ...|||| QSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL |
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| Kinase | 10356.AA | C2 | 125-248 | 27 | 1.8e-17 | 56.36 | In-house | 102-245 (245) | Show / Hide |
Range on Protein: 125-248
Range on HMM: 102-245/245
Sequence Identity: 27% (39 aa)
DGSLKRFLDQLREQNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANILMHQGDCVI-----AD----------FGISRIQNIEQQISNSQRFKGT
.| || .....|.||.. . || . || |. . .|...| ||||| |.|. . | .| | .. .. . . ||.|
QGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKWT
PMF----LDPEIHRGHLDKKMDLFA-MGIVLLMMDNVVQFAYES
||. .. . |..||| .|.||| .|| |. ..
QQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
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| Kinase | 10356.AA | CAMK | 153-238 | 20 | 1.4e-16 | 49.26 | In-house | 187-327 (425) | Show / Hide |
Range on Protein: 153-238 Range on HMM: 187-327/425 Sequence Identity: 20% (30 aa) QLFDALSSMHQKNIFHRDIKAANILM-HQ-----------------GDCVIADFGISRIQNI-------------EQQISN----------SQRFKGTPM |. .|. .|..|| |||.| |||. . .. |.||| ... . | . .| . | ||| QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPE FLD-PEIHRGH---------------LDKKMDLFAMGIVLLMM . ||. .| ..| | ..|..| .| YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM |
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| Kinase | 10356.AA | S_TKc | 39-309 | 19 | 3.4e-15 | 45.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 39-309 Range on HMM: 1-231/231 Sequence Identity: 19% (57 aa) VCSIEYLDSGSFGVVLKYNNPNKLKKGAVKAIIGYLSDEASMKEIKDEIDLQINICNPYIAKVKEFTKIVLDKAYIIGFVWMHYYED--GSLKRFLDQLR .. . .|.||.| | . . .. |.| | . |. ||.. . |.| | ... |. |.. | | . |.|...... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMV----MEYCDGDLGDLFDYIKKRG EQNQE--IDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANILMHQGDCVIADFGISRIQNIEQQISNSQRFKGTPMFLDPEIHRGHLDK-KMDLFAMGI . .. . .. |...|| .|...| |||.| .|||. . |.|||..|. | ||| .. ||. . .| | | . |. RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGC VLL-MMDNVVQFAYESHVAADMIDNYGYYSTSFAKNEIIQELRQKLNTNTIFFKIAEKLITNKVRQRPSAAQCLD---------LL .| |. | . |... | . . .|. . ..||.| ..| . ILYEMLCGYPPFP----QMQMMFKKIG---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 10356.AA | Pkinase | 153-235 | 31 | 5.4e-13 | 47.02 | Pfam | 116-202 (293) | Show / Hide |
Range on Protein: 153-235 Range on HMM: 116-202/293 Sequence Identity: 31% (28 aa) QLFDALSSMHQKNIFHRDIKAANILMH-QGDC----VIADFGISRIQNIEQQISNSQRFKGTPMFLDPEIHR--GHLDKKMDLFAMGIVL |.. .| .|...| |||.| .|||.. .|.. |.|||... . . | . | ||| .. ||..| . ..| | ...|..| QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL |
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| Kinase | 10356.AA | TyrKc | 39-309 | 16 | 4.4e-08 | -91.94 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 39-309
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)
VCSIEYLDSGSFGVVLKYNNPNKLKKGAVKAIIGYLSDEASMKEIKDEIDLQINI--CNPYIAKVKEFTKIVL--------DKAYIIGFVWMHYYEDGSL
. .. | .| ||.| | .. . | ..| .... .|. . .. .| | |. . .. . .|. | | . |.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNI--VRLYGVCTQQGRNFMYIEPLMIV----MEYMPHGDL
KRFLDQLREQNQEIDFKTKMRLGIQLFDALSSMHQKNIFHRDIKAANILMHQGD-CVIADFGISRIQNIE-------QQISNSQRFKGTPMF----LDPE
| .| |.. . |.. .| . . |.||. |||. | |.| . . . |.||| || . . .. ... | |. . ||
KDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE
IH-RGHLDKKMDLFAMGIVL--LMMDNVVQFAY------ESHVAADMIDNYGYYSTSFAKNEIIQELRQKLN--------TNTIFFKIAEKLITNKVRQR
| | | .. |... .. . . . ... .. ..| | . ..| .. . .|
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR-------------MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR
PSAAQCLDLL
|. ... ...
PTFSEIHECF
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| Kinase | 10356.AA | C2 | 48-101 | 33 | 0.000594 | 9.53 | In-house | 1-55 (245) | Show / Hide |
Range on Protein: 48-101 Range on HMM: 1-55/245 Sequence Identity: 33% (19 aa) GSFGVVLKYNNPNKLKKGAVKAIIGYLSDEASMKEIKDEIDLQINICN--PYIAKV |.|| ||| .| .. .. | | .| . |.|. |. . . |. ||| || GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGI-MRQCQNMPYIIKV |
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| Kinase | 10356.AA | TKL | 297-309 | 38 | 0.293638 | 0.3 | In-house | 352-364 (364) | Show / Hide |
Range on Protein: 297-309 Range on HMM: 352-364/364 Sequence Identity: 38% (5 aa) RQRPSAAQCLDLL ..|||. ..|. | EKRPSFQEILKRL |
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