Gene 6348 (Tetrahymena)

6348

Species: Tetrahymena
Alias: 6348, 3722.m00006, TTHERM_00525110, 66.m00147, PreTt06348, 361
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
6348.AA Protein None 2717 None Fasta, JSON
6348.kin_dom Protein Kinase Domain None 251 None Fasta, JSON
6348.NA RNA None 8154 None Fasta, JSON

Protein domain

Protein domains of 6348.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Anoctamin 6348.AA Anoctamin 854-889 36 2.1e-08 31.85 Pfam 1-36 (558) Show / Hide 
Range on Protein: 854-889
Range on HMM: 1-36/558
Sequence Identity: 36% (13 aa)

ICEYFGERIALYFTFQSFYFKAQFSVALLSTPIFIV
|..||||.||.|| . .||... .  |..   ..|.
IRDYFGEKIAFYFAWLGFYTCWLWPPAIFGIICWIY
Anoctamin 6348.AA Anoctamin 911-1310 18 1.1e-17 66.27 Pfam 90-558 (558) Show / Hide 
Range on Protein: 911-1310
Range on HMM: 90-558/558
Sequence Identity: 18% (90 aa)

FIVVIWSNVFYGQWTYREAEFSLKYNQSQSG-EDEEDIRPGFRGEYERSITSNKLNDYSYDRRLTEKSERNYWI------LIFFILIVNIVIIYALIYLQ
....|||..|   |  |.||..... |   . | .|. ||.|.|.|.|||  ....  ....    ...|  ..      ...|.... |.|........
IFMCIWSTLFLEFWKRRQAELAYRWGQHNFEEEEQEEPRPQFKGQYCRSIRNDPITG-IEMEPYYPPWKRFMRQYCISIPIVLFCICLVIGIMIGCFIYR

SYFD-DHNTIDSGKTFMGLNIFIPTIILEFIFWVEEFLFKKFALFTCREANFKTTKEFEQSYSTKLFTFIFFNHLVPPTLISFIID--------------
 . . ...   .  ..  |  ||||||.  .  .  |...|.| . .   | .|  |.| |. .|.|.| |.|  .|  .|.|.                
IWVSEIYHGPFI--YKQYLTSFIPTIINSVCIMILNFIYNKIATWLTDWENHRTQSEYENSLIIKMFLFQFVNYYSPLFYIAFFYGPFFVGYPPYYYRFF

-QNIGCVQDDCSYHLSVYIRSYQYII-VFKSIVEIIYPLLRSSLNNVTQLVKQLVNKDVDQKQQYLFDHVNIEIENQSGLMDSVI--DEIDQPTRDYIEM
  .. | ...|  .|. .  .   .  ... | |...|..   ...      .  .|  ..|    ... .  .|...  ...     | .    ||.||
WRQEECHPGGCMMRLCYQMIYIMITKQIINNIMEVVIPYIKQWWRKW-----KYKKK-EKEK----ENQFLEQWEQEY-ELQPYDVFQERYGTFDDYMEM

FTYYCFNVTYGFGFPLVFAITFGITFIKMIVTRRLFTRRIKRPNPQNASTIGIFRQFMNLGSSLSILTYTGIFCFTR-----------------SQKPDW
.. ... .  .  |||.. . .   .| . .    |..  .|| ||.|..||.  . | . | ||..| ... .||.                 ... .|
CIQFGYVTMFSCAFPLAPFFAWINNWIEIRSDAYKFCYQFQRPWPQRADSIGPWQDIMEFISWLSVITNCFLIYFTSDFIPRLVYYYYSPNGQMNGYINW

---------------------------------------GPFTQLNAFMFISF-FFFVVKFFIDRYYSELDSKTMDILKRQAF
                                          .|  .|.||.  ..|..|.||.   ..     ....||...
SLSYFNVSDFQGAPESQNCRYCDYRYPPWPPYKHTMQYWHVWAQRLWFFFIFEHVVFFLKYFIRWIIPDIPEWVRIKMKRHQY
Kinase 6348.AA NEK 1339-1588 44 2.2e-150 505.88 In-house 8-286 (286) Show / Hide 
Range on Protein: 1339-1588
Range on HMM: 8-286/286
Sequence Identity: 44% (124 aa)

GEGAYSSVYRVKRLEDNQI-----YALKMVKLKELNEVEKQNAL-NEVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYAS-EGDLLQK---IQEHQKK
|.|....||.|.| .|...     |..| .......| |||||. ||||| .. ..||.| |...||..| . |||||.|.  .||| ||   |.....|
GQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQK

GSYMKEEDIWNIFIQMLKGLKSMHDM-----NIMHRDLKSANVFLYEDRI----AKLGDFNVSKLQKKN--LLYT-QTGTPYYASPEVWKDMPYDKKADI
| |. || ||..||||...|| |||.     .|.|||.|..|.||  ...    .|.|||..||.....  ..|| |.|||||.||||... ||. |.||
GKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDI

WSLGCVLYEMAAL--RPPFKAE--DMQQLYKKITSG-KFARIPDF--YSNDLMYIINQLIQVQPYYRPSCNQILKNNIV
||||||||||..|  ..||.|.  .| .||.||. | ....||..  ||.||. .|.|..|. |  ||||||||.. ..
WSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 6348.AA NEK1 1334-1588 38 5.4e-84 285.36 In-house 3-276 (276) Show / Hide 
Range on Protein: 1334-1588
Range on HMM: 3-276/276
Sequence Identity: 38% (105 aa)

FFKVYGEGAYSSVYRVKRLEDNQIYALKMVKLKELNEVEKQNALNEVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYASEGDLLQKIQEHQKKGSYMK
  |. |||..  .. ||. ||.| |..|  .. .  | |.....||| | |  . ||.| ||| |.     .| |||.|.  ||| |||..   ||    
YIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKLFS

EEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLY--EDR---------------IAKLGDFNVSKLQKKNLLYTQT--GTPYYASPEVWKDMPYDKKA
|  | . |.|. ..|. .|| .|.|||.|| |.||   ..                ..||||| ....    ..| .|  ||||| ||| .   ||. | 
EDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKS

DIWSLGCVLYEMAALRPPFKAEDMQQLYKKITSGKFARIPDFYSNDLMYIINQLIQVQPYYRPSCNQILKNNIV
|||||||||||  .|  || |  ...|  ||..| .. ||  ||..|   . |. .. |  ||| ||||.  ..
DIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
S_TKc 6348.AA S_TKc 1332-1588 28 1e-81 278.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 1332-1588
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

NPFFKVYGEGAYSSVYRVKRLEDNQIYALKMVKLKELNEVEKQNALNEVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYASE--GDLLQKIQEHQKKG
  . .. |.||...||...  ....|.|.|..|         .....|..|  . . ||.|.....| |   | |..||.|..   |||.. |......|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SYMKEEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYEDRIAKLGDFNVSKLQKKNLLYTQTGTPYYASPEVWKDMPYDK-KADIWSLGCVLYEM
  ... | ... .. |....|. .|...|.||||| .|..| |    |..|| ....      .|. |||.| .|||    .|.| |.|.||.||.||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

AALRPPFKAEDMQQLYKKITSGKFARIPDFYSNDLMYIINQLIQVQPYYRPSCNQILK-------NNIV
.. .|||   .||...|||            | ..  .|... |. |  ||.. ..|.          .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6348.AA NEK2 1336-1588 32 8e-72 241.11 In-house 5-319 (319) Show / Hide 
Range on Protein: 1336-1588
Range on HMM: 5-319/319
Sequence Identity: 32% (103 aa)

KVYGEGAYSSVYRVKRLEDNQIYALKMVKLKELNEVEKQNALNEVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYASEGDLLQKIQEHQKKGSYMKEE
.. |.| . ... |.| .|  | . |  .  ...|.|.|   .|. |    . ||.| |    ||.|  .| ||| | . ||| | |.   |   || ||
YTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEE

DIWNIFIQMLKGLKSMHD------------------MN---IMHRDLKSANVFLYEDRI---------------------------------------AK
 || |. |..  |.  |                    .   |.|||.| ||.|| .|                                         .|
FIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVK

LGDFNVSKLQKKNLLYTQT--GTPYYASPEVWKDMPYDKKADIWSLGCVLYEMAALRPPFKAEDMQQLYKKITSGKFARIPDFYSNDLMYIINQLIQVQP
||||   .  ..  .. .|  ||||| |||. ....|. | ||||.||..|||.||.|||.|   .||  ||  |.| |||  || .|  ||   | | .
LGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDH

YYRPSCNQILKNNIV
| ||| . ||..  .
YHRPSIEEILQHPQI
Kinase 6348.AA CAMK 1337-1584 18 9.3e-68 217.16 In-house 1-421 (425) Show / Hide 
Range on Protein: 1337-1584
Range on HMM: 1-421/425
Sequence Identity: 18% (76 aa)

VYGEGAYSSVYRVKRLEDN------------QIYALKMVKLKELN--------------------------EVEKQNALNEVRIIAS-------VRSPNV
. |.|... |..... ...            | .| |... | |                           .. ..| ..|..|  .       .. ||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNYKECFIDKQ-----------------LDVLCIVM---DYASEG----DLLQKIQEHQKKG-----------SYMKEEDIWNIFIQMLKGLKSMHDMNI
..  | . |..                  . ...||   .|.| |    ||...|.|| ..|            ...|..   .| |.. ... .|..||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDLKSANVFLYED-----------------RIAKLGDFNVSKLQKKN-------------------------LLYTQTGTPYYAS-PEVWKD------
.|||||  |. | ..                    |. ||  ..  ...                         ...|. |||.|.. ||| .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------MPYDKKADIWSLGCVLYEMAALRPPFKAE-------------DMQQLYKKITSGKFARIPDFYSN-----------------------DLMY
         .|..|.|.||.|..|| |   .||| ..             ....|..||..||.  .|.. |.                       . . 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

IINQLIQVQPYYRPSCNQILK
 |... || |  |... |.|.
LIRKMLQVDPEKRMTIEQCLN
Kinase 6348.AA NEK4 1334-1588 36 1.6e-66 227.34 In-house 3-257 (257) Show / Hide 
Range on Protein: 1334-1588
Range on HMM: 3-257/257
Sequence Identity: 36% (95 aa)

FFKVYGEGAYSSVYRVKRLEDNQIYALKMVKLKELNEVEKQNALNEVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYASEGDLLQKIQEHQKKGSYMK
. || | | |  |. |.   |   | .| ..||.    |.. |. |...    . ||.| ||| .       |.||| .   ||| .| .  |.|.  ..
HMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLK--QQKNQFLE

EEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYEDRIAKLGDFNVSKLQK--KNLLYTQTGTPYYASPEVWKDMPYDKKADIWSLGCVLYEMAALRP
|. . . |.|   .|  ||. .|.|||||  |.||    | |.||| .|.      ..  |  ||||| |||..   ||| | ||||||| .|||. |. 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFKAEDMQQLYKKITSGKFARIPDFYSNDLMYIINQLIQVQPYYRPSCNQILKNNIV
 | | ||  |  .|  |.   .|  || ||  .. |... ||  |||  .|..   .
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 6348.AA Pkinase 1339-1584 26 9.8e-66 229.5 Pfam 8-289 (293) Show / Hide 
Range on Protein: 1339-1584
Range on HMM: 8-289/293
Sequence Identity: 26% (76 aa)

GEGAYSSVYRVKRLEDNQIYALKMVKLKELNEVEKQNALN--EVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYASEG----DLLQKIQEHQKKGSY-
|.|....||. ..  ...|.|.| .|... .. ..|....  |..| .....||.| ....| |   | ...||.|.  |    ||   |.  ...|.. 
GSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFY

MKEEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYEDRIA----KLGDFNVSK---LQKKNLLYTQTGTPYYASPEVWK-DMPYDKKADIWSLGCVL
. |... ... |.|.||. .|.|.|.|||||..|... ..       |..|| ..|   . ..  ..| .|||.|..||| . . .|..|.|.||.||.|
FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

YEMAALRPPFKAE------DMQQLYKKITSGKFARIPDFYS--------------------NDLMYIINQLIQVQPYYRPSCNQILK
|||.  ||||. .      |..|....| .... .  .  .                     ..  .|. .... |. ||.. |||.
YEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase 6348.AA NEK8 1351-1588 33 3.1e-64 182.24 In-house 20-278 (278) Show / Hide 
Range on Protein: 1351-1588
Range on HMM: 20-278/278
Sequence Identity: 33% (89 aa)

RLEDN--QIYALKMVKLKELNEVEKQNALNEVRIIASVRSPNVVNYKECFIDKQLDVLCIVMDYASEGDLLQKIQEHQKKGSYMKEE-------------
| ||.  .   .| . . .. | | | |.||... . .  ||.. | . |.. .  .| |.| ||  | | |.||. | | . . |.             
RKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDN--TLMIEMEYADGGTLYQMIQHQQNK-LFEEERQLKQVNHCFNIYF

---DIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYED-RIAKLGDFNVSK-LQKKNLLYT---QTGTPYYASPEVWKDMPYDKKADIWSLGCVLYEMA
    |   |.||. ..  ||. || ||||| .|.|.  .  . |.|||  || .  | . .|     ||||| |||  .  ||. | |.|.||||||||.
NEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMC

ALRPPFKAEDMQQLYKKITSG-KFARIPDFYSNDLMYIINQLIQVQPYYRPSCNQILKNNIV
 |.  | |.    |  ||... ... |.| |||..   . .. |. |  |||  ||...  .
CLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 6348.AA Ciliate-E2 1332-1588 22 1.7e-61 209.88 In-house 1-365 (365) Show / Hide 
Range on Protein: 1332-1588
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

NPFFKVYGEGAYSSVYRVKRLED-----------------------NQIYALKMVKLKELNEVEK-QNALNEVR----------IIASVRSPNVVNYKEC
  | |. |.|...|||..|. ..                       ..|||.|..| ........ .. ..|..          |  .. .||.....||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FIDKQLDVLCIVMDYASEGDLLQKIQEHQKKG-------SYMKEEDIWNIFIQMLK---------------GLKSMHDMN-IMHRDLKSANVFLYEDRIA
|..|. . . .||.|.. |||.. |....||         |..|. | .|. | |.               .|...|  | |.|||.|  |...      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFNVSKLQKK---------------------------------NLLYTQTGTPYYASPEVWKDMP---------YDKKADIWSLGCVLYEMAALRPP
|. ||  || ...                                 |. .|. |||.| .||. .  .         ||.|.||||||..||||   .||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FKAEDMQQLYKKITSGKFAR-------------IPDFYSNDLMYIINQ----LIQVQPYYRPS-CNQILKNNIV
|    .||  ..  .  ..              ...  |.. . .|..    ..|..|  |..  .|||.. . 
F----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 6348.AA STE 1332-1588 23 2.1e-54 187.06 In-house 1-359 (359) Show / Hide 
Range on Protein: 1332-1588
Range on HMM: 1-359/359
Sequence Identity: 23% (87 aa)

NPFFKVYGEGAYSSVYRVKRL------EDNQI---------YALKMVKLKELN---------------EVEKQNALNEVRIIASVR--SPNVVNYKECFI
  . .. |.||. .||. ..       . ...         .| | ..|.. |               . |.|. |.|..|    .  .||.|.|  |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DKQLDVLCIVMDYASEGDLLQKIQEHQKKG----------SYMKEEDIWNIFIQMLKG-LKSMHDMNIMHRDLKSANVFLYEDRIAKLGDFNVSK
     .|. | |.|.| | . | | . |..  ..|          ....|. |  |  | ||| |.  |...|.|||.|.||..|     .|| || |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LQKKN------------------LLYTQTGTPYYASPEVWKDM------PYDKKADIWSLGCVLYEMAALRPPFKA-EDMQQLYKKITS-----------
   ..                    .| .||| . .||| . .      .|| |.|||||||.. |||  .||.    .|. .. ....           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GKFARIPD-------------------FYSNDLMYIINQLIQVQPYYRPSCNQILK--NNIV
   |.  ..||                    .| ..   ||.  |  |  ||. .| ||     .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 6348.AA ULK 1339-1585 25 7.5e-53 181.9 In-house 8-299 (324) Show / Hide 
Range on Protein: 1339-1585
Range on HMM: 8-299/324
Sequence Identity: 25% (78 aa)

GEGAYS-SVYRVKRLED---NQIYALKMVKLKELNEVEKQ--------NALNEVRIIASVR---SPN--VVNYKECFIDKQLDVLCIVMDYASEGDLLQK
|.|..   ||. .  ..   ||..| ||. .|..|. ...        .  ||..|.       .||  .| ....| ... . ..|.|.|   ||| | 
GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQY

IQEHQK-----KGSYMKEEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYEDR------------IAKLGDFNVSKL-----QKKNLLYTQT-----
|....|     .. .  |. . ..|.| . |.| .|..||.|||.| .|  . ..             ..|..||  .|      . .....|.      
IKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRI

-GTPYYASPEVWKDM----PYD-KKADIWSLGCVLYEMAALRPPFKAEDMQQLY----KKITSGKFARIPDFYSNDLMYIINQLIQVQPY-YRPSCNQIL
 |||.| .|......    ||. .|.|||||||..|||   ..||..   ...|    | |  || .     .   . || || || ... . | . . .
KGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGK-E-----Q---QIYIKNQPIQFPKPPKDPKISPEC

KN
|.
KD
Kinase 6348.AA Ciliate-E2-Unclassified 1334-1588 24 9.2e-51 174.3 In-house 3-352 (352) Show / Hide 
Range on Protein: 1334-1588
Range on HMM: 3-352/352
Sequence Identity: 24% (85 aa)

FFKVYGEGAYSSVYRVKRLEDNQIYALKMVK----------------LKELNEVEKQNALNEVR--------IIASVRSPNVVNYKECFIDKQLDVLCIV
. |. |.|....||.... ...|.||.|. |                . |..|.....  . .|        |  .  .|..|.. .|| |||   ..||
IIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IYIV

MDYASEGDLLQKIQ-------------EHQKKGSYMKEEDIW-----NIFIQMLKGLKSMHDMN-IMHRDLKSANVFLYEDR---IAKLGDFNVSKLQK-
|.|.  |||.| |.             ...|..    |. .      ..| | |.||...|  | | |||.|  |... ..      |. ||  || .. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------KNLLYTQTGTPYYA----SPEVWKDMPYD----KKADIWSLGCVLYEMAALRPPFKAEDMQQ----------------LYKKIT
                .....|..|||.|     .||| .   ||    .|.||||||..||||   ..||....  |                ||..| 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SGKFARIP-------DFYSNDLMYIIN----QLIQVQPYYRPSCNQILKNNIV
 ...   .       .  |.    .||    ......| .|.. .|||.  . 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6348.AA TyrKc 1336-1591 21 1.4e-14 12.95 SMART 5-280 (280) Show / Hide 
Range on Protein: 1336-1591
Range on HMM: 5-280/280
Sequence Identity: 21% (62 aa)

KVYGEGAYSSVYRVKRLEDNQIYALKMVKLKELNEVEKQNALNEVRIIASV--RSPNVVNYKECFIDK-----QLDVLCIVMDYASEGDLLQKIQEHQKK
|. ||||.  ||. .     .  | ||.|        ..  ..| ||  ..  . ||.|.   . ...       . |.||| |.. |||.. ...|..|
KKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

GSYMKEEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYEDRIAKLGDFNVSKLQKKN-------LLYTQT---GTP-----YYASPEVWKDMPYDKK
    . .|  .. .|  .|    |..|. ||||   |. . |....| .||  |.  .           |...   |.         .||....  .  |
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ADIWSLGCVLYEMAAL-RPPFKA-----EDMQQLYKKITSGKFARIPDF--------YSNDLMYIINQLIQVQPYYRPSCNQILKNNIVKKY
 |.|| | ...|.  .  .|         . |...... .|.  ..|.          . ..  |. |  . .|  ||. ..|     ... 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 6348.AA Pkinase_Tyr 1501-1548 23 0.003079 11.59 Pfam 182-232 (270) Show / Hide 
Range on Protein: 1501-1548
Range on HMM: 182-232/270
Sequence Identity: 23% (12 aa)

SPEVWKDMPYDKKADIWSLGCVLYEMAAL-RPP-FKAEDMQQLYKKI-TSG
.||..... .  | |.|| | ...|.  . . | ..  . ...|..|  .|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG
Kinase 6348.AA Pkinase_Tyr 1339-1479 25 0.004922 10.9 Pfam 8-155 (270) Show / Hide 
Range on Protein: 1339-1479
Range on HMM: 8-155/270
Sequence Identity: 25% (38 aa)

GEGAYSSVYRVKRL----EDNQIYALKMVKLKELNEVE--KQNALNEVRIIASV-RSPNVVNYKECFIDKQLD-VLCIVMDYASEGDLLQKIQEH-QKKG
||||. .||. .      ....  | ||.      . .  ..  ..|..|  .  . ||.|..  . .|..    ..||| |.  ||||   ..|   |.
GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

SYMKEEDIWNIFIQMLKGLKSMHDMNIMHRDLKSANVFLYEDRIAKLGDF
.   .. . .. .|  ||.   ...|. ||||   |. . |....| .||
PLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDF
FU 6348.AA FU 2170-2221 20 0.018688 11.6 SMART 1-48 (48) Show / Hide 
Range on Protein: 2170-2221
Range on HMM: 1-48/48
Sequence Identity: 20% (11 aa)

VKKC--CPIGCKN-CTEQTRRNNSKCADCETEQVYDQDKNTCISSSSCSGVIKYG
 ..|  |  .|.  |.  .   . .|  |..  . ... .||.|  .|.    |.
DGVCKPCHPECATGCWGPG---PDQCTSCPHGYYLHHN-GTCVS--QCP-PGYYP
FU 6348.AA FU 2241-2290 25 0.00073 20.08 SMART 1-48 (48) Show / Hide 
Range on Protein: 2241-2290
Range on HMM: 1-48/48
Sequence Identity: 25% (14 aa)

RGELVKLECDPTCQS-CSNQ-PNICKQCSTGNFFIGDSQNCGKCET--SNGYYV
.|.    .|.|.| . |.   |. |. |..|... ..    |.| .  . ||| 
DGVC--KPCHPECATGCWGPGPDQCTSCPHGYYLHHN----GTCVSQCPPGYYP
FU 6348.AA FU 2292-2337 22 0.044416 7.09 SMART 1-48 (48) Show / Hide 
Range on Protein: 2292-2337
Range on HMM: 1-48/48
Sequence Identity: 22% (11 aa)

NDRCKKCDSICKT-CKDS-SQKCDNCIDGKFKDSSTQLCGD-CDLNQQK
...||.|.. |.| |  .   .|  |  |.....    | . |  .  .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-GTCVSQCPPGYYP
VSP 6348.AA VSP 2275-2332 29 3.975364 0.82 Pfam 275-331 (412) Show / Hide 
Range on Protein: 2275-2332
Range on HMM: 275-331/412
Sequence Identity: 29% (18 aa)

DSQNCGKCETSNGYYVE--NDRCKKCDSICKTCK-DSSQKCDNCIDGKFKDSSTQLCGDCD
..  | .|   .||      . | |||| |.||   . . |. |  | .|  ..  |. |.
SNTDCTTC--MDGYVKDGNSQVCTKCDSSCETCTAGQTTTCKTCFTGYYKTGTG--CVKCT
FU 6348.AA FU 2341-2388 30 5.7e-05 23.76 SMART 1-48 (48) Show / Hide 
Range on Protein: 2341-2388
Range on HMM: 1-48/48
Sequence Identity: 30% (16 aa)

GDQCKQCDSTCQT-CEKS-SKNCTKCSIGNYFIGDSQNCGKCET--SNGYYV
...|| |...| | |  .   .||.|. |.|. ..    |.| .  . ||| 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN----GTCVSQCPPGYYP
VSP 6348.AA VSP 2385-2430 43 0.011094 10.23 Pfam 255-299 (412) Show / Hide 
Range on Protein: 2385-2430
Range on HMM: 255-299/412
Sequence Identity: 43% (20 aa)

GYYVDNGRCKKCDSICKTCVDSTQKCDKCIDGKFKDSSTQICGDCD
|| ..||    |   |||| ..|  | .| ||  ||  .| |  ||
GYHLNNGDLVMCSEGCKTCTSNTD-CTTCMDGYVKDGNSQVCTKCD
FU 6348.AA FU 2390-2435 24 0.011345 14.2 SMART 1-48 (48) Show / Hide 
Range on Protein: 2390-2435
Range on HMM: 1-48/48
Sequence Identity: 24% (12 aa)

NGRCKKCDSICKT-CVDS-TQKCDKCIDGKFKDSSTQICGD-CDLNSQK
.|.||.|.. |.| |. .   .| .|  |.....   .| . |  .. .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-GTCVSQCPPGYYP
FU 6348.AA FU 2439-2486 30 0.000164 22.23 SMART 1-48 (48) Show / Hide 
Range on Protein: 2439-2486
Range on HMM: 1-48/48
Sequence Identity: 30% (16 aa)

GDQCKQCDSTCLT-CEKS-SQNCTNCSIGNYFIGETQNCGKCET--SNGYYV
...|| |...|.| |  .   .|| |. |.|. ..    |.| .  . ||| 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN----GTCVSQCPPGYYP
FU 6348.AA FU 2488-2533 22 0.044416 7.09 SMART 1-48 (48) Show / Hide 
Range on Protein: 2488-2533
Range on HMM: 1-48/48
Sequence Identity: 22% (11 aa)

NDRCKKCDSICKT-CKDS-SQKCDNCIDGKFKDSSTQLCGD-CDLNQQK
...||.|.. |.| |  .   .|  |  |.....    | . |  .  .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-GTCVSQCPPGYYP
VSP 6348.AA VSP 2485-2528 33 0.189444 5.69 Pfam 286-331 (412) Show / Hide 
Range on Protein: 2485-2528
Range on HMM: 286-331/412
Sequence Identity: 33% (16 aa)

YVEN---DRCKKCDSICKTCK-DSSQKCDNCIDGKFKDSSTQLCGDCD
||     . | |||| |.||   . . |. |  | .|  ..  |. |.
YVKDGNSQVCTKCDSSCETCTAGQTTTCKTCFTGYYKTGTG--CVKCT
VSP 6348.AA VSP 2440-2483 33 2.127943 1.82 Pfam 293-335 (412) Show / Hide 
Range on Protein: 2440-2483
Range on HMM: 293-335/412
Sequence Identity: 33% (15 aa)

DQCKQCDSTCLTCE-KSSQNCTNCSIGNYFIGETQNCGKCETSNG
. |  |||.| ||   . . |  |. | |  | .  |.||  ...
QVCTKCDSSCETCTAGQTTTCKTCFTGYYKTGTG--CVKCTSCES
FU 6348.AA FU 2537-2584 30 0.002388 18.37 SMART 1-48 (48) Show / Hide 
Range on Protein: 2537-2584
Range on HMM: 1-48/48
Sequence Identity: 30% (16 aa)

GDQCKQCDSTCQT-CEKS-SKNCTKCSIGNYFIGDSQNCGKCDT--ANGYYI
...|| |...| | |  .   .||.|. |.|. ..    |.| .    ||| 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN----GTCVSQCPPGYYP
FU 6348.AA FU 2586-2631 22 0.013825 13.17 SMART 1-48 (48) Show / Hide 
Range on Protein: 2586-2631
Range on HMM: 1-48/48
Sequence Identity: 22% (11 aa)

KDRCKKCDSICKT-CVDS-TQKCDKCIDGKFKDSSTQICGD-CDLNSQK
...||.|.. |.| |. .   .| .|  |.....   .| . |  .. .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-GTCVSQCPPGYYP
VSP 6348.AA VSP 2569-2626 31 0.640917 3.74 Pfam 275-331 (412) Show / Hide 
Range on Protein: 2569-2626
Range on HMM: 275-331/412
Sequence Identity: 31% (19 aa)

DSQNCGKCDTANGYYIE--KDRCKKCDSICKTCV-DSTQKCDKCIDGKFKDSSTQICGDCD
..  | .|  ..||      . | |||| |.||   .|. |. |  | .|  ..  |. |.
SNTDCTTC--MDGYVKDGNSQVCTKCDSSCETCTAGQTTTCKTCFTGYYKTGTG--CVKCT
FU 6348.AA FU 2635-2681 28 0.00144 19.1 SMART 1-48 (48) Show / Hide 
Range on Protein: 2635-2681
Range on HMM: 1-48/48
Sequence Identity: 28% (14 aa)

GDQCKQCDSTCQT-CEKS-FQNCIRCSYGYYFIDNSQICGK-CDTSNGWY
...|| |...| | |  .   .|. |. |||. .|  .| . |  .. ..
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN-GTCVSQCP-PGYYP
VSP 6348.AA VSP 2636-2679 33 0.016244 9.62 Pfam 293-335 (412) Show / Hide 
Range on Protein: 2636-2679
Range on HMM: 293-335/412
Sequence Identity: 33% (15 aa)

DQCKQCDSTCQTCE-KSFQNCIRCSYGYYFIDNSQICGKCDTSNG
. |  |||.|.||   . . |  |. |||       |.||. ...
QVCTKCDSSCETCTAGQTTTCKTCFTGYY--KTGTGCVKCTSCES
FU 6348.AA FU 2684-2715 29 0.121438 1.85 SMART 1-48 (48) Show / Hide 
Range on Protein: 2684-2715
Range on HMM: 1-48/48
Sequence Identity: 29% (14 aa)

SDRCKKCDSMCFS-CEGT-SKNCTKCTHGYYY--------------YS
...||.|.. | . | |    .||.| ||||               | 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
VSP 6348.AA VSP 2684-2712 46 0.151273 6.05 Pfam 292-321 (412) Show / Hide 
Range on Protein: 2684-2712
Range on HMM: 292-321/412
Sequence Identity: 46% (14 aa)

SDRCKKCDSMCFSCE-GTSKNCTKCTHGYY
|. | |||| |  |  |    |  |  |||
SQVCTKCDSSCETCTAGQTTTCKTCFTGYY