Gene 29473 (Tetrahymena)

29473

Species: Tetrahymena
Alias: TTHERM_00265180, PreTt29473, 29473, 794, 23.m00369
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
29473.AA Protein None 818 None Fasta, JSON
29473.kin_dom Protein Kinase Domain None 253 None Fasta, JSON
29473.NA RNA None 2457 None Fasta, JSON

Protein domain

Protein domains of 29473.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
REC 29473.AA REC 3-118 20 3.5e-29 104.2 SMART 1-150 (150) Show / Hide 
Range on Protein: 3-118
Range on HMM: 1-150/150
Sequence Identity: 20% (33 aa)

IHVLVAEDD----NFQRLALI------DILTLCDYQ--------VTAVENGR-------LARDELLKQD-----------SNIDIVLLDLYMP-------
...|...||      .| .|       ..|.  .|.        |... .|.        | . | ...           ...|....|. ||       
MRILIVDDDPAMAPVIREMLRNYTVIQRLLEKEGYENKMWMVEVVDEA-DGETLMNEIWEALELLQEHRDKKEDATTDQSEPPDLIIMDIMMPGDPFEDG

EMDGFELLSLMQEHENLQKIPVIMMSSDKEEEKVATCIAKGAKDYIFKPLRVQNVKAIA
.|||.||.  ..        |.||...  .|| .  ... || ||| || . . . |  
GMDGIELCRRIR--------PIIMLTAHDDEEDRVRALEAGADDYITKPFDPEELLARI
Response_reg 29473.AA Response_reg 5-119 27 1.3e-27 101.43 Pfam 1-115 (115) Show / Hide 
Range on Protein: 5-119
Range on HMM: 1-115/115
Sequence Identity: 27% (33 aa)

VLVAEDDNFQRLALIDILT-LCDY-QVTAVENGRLARDELLKQDSNIDIVLLDLYMPEMDGFELLSLM-QEHENLQKIPVIMMSSDKEEEKVATCIAKGA
||...|.  .| .|  ||.   .|  |.....|. | . . ...  .|....|. ||.|||.||.. . ..|.   ..|.||...  .|. .  ..  ||
VLIVDDHPLMREGLRQILEQKEGYEVVAEADDGEEALEWWQEHH--PDLIIMDINMPGMDGLELCRRIRRQHP-HPQTPIIMCTAHGDEDDAVEALQAGA

KDYIFKPLRVQNVKAIAK
 |||.||   .  .|...
NDYITKPFDPDELHAAIR
Kinase 29473.AA NEK 139-394 41 1.1e-142 480.3 In-house 1-286 (286) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-286/286
Sequence Identity: 41% (119 aa)

YKVLKTLGQGASGSVELVQKN-DGNL-----YALKTISMKYMNDTEKRSAQ-SEVTLLKVLVAPTIIRYYEAFVQND--SIYIVMEYAK-EGALSDK---
|...|..|||. |.| .|..  ||.      |..| |.|. |.. ||. || .|| .|| |  | |..||..|. ..  ...|||||.  .| |..|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQEHKTKGIRIDEETILYFTAQIVIALFFMHQK-----KILHRDIKSQNLFLTKENV----VKLGDFGISKALGTNADFTKT-LVGTPYFMSPEVCAGQS
|...| ||  ..||.|. . .|...|| .||..     ||||||||.||.||||.|     ||.||||||| |....|. .| .|||||.|||||| ...
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YGDKADIWALGCTLYEMVML--RRPFDCE--NINTLFTMIRQQ-DPSPLHDN--CSTDIRMLITLMLNKDPLKRPFIWDLVNIPII
|. |.|||.||| ||||..|  ..||. .  |.. |.. |..  ...|....   |.| ..||..||.||| .|| .... . |.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 29473.AA NEK8 139-394 38 3.7e-97 277.92 In-house 1-278 (278) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

YKVLKTLGQGASGSVEL-VQKNDG--NLYALKTISMKYMNDTEKRSAQSEVTLLKVLVAPTIIRYYEAFVQNDSIYIVMEYAKEGALSDKIQEHKTKGIR
|    ..|.|| |.. |   |.|.   |  .| | |  |   | ..||.|. .|. |  | || ||. |  . .  |.||||  | | ..||.  .... 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQH--QQNKL

IDEET-----------------ILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKE-NVVKLGDFGISKALGTN--ADFTKTLVGTPYFMSPEVCAGQS
  ||.                 || .  |...|. .|||. |||||.| || |.|.  .|||.||||||| ..|   .  |||.||||| |||| | |..
FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKP

YGDKADIWALGCTLYEMVMLRRPFDCENINTLFTMIRQ-QDPSPLHDNCSTDIRMLITLMLNKDPLKRPFIWDLVNIPII
|  | |.||||| ||||  |.| |. .|   | . | | .   |. |  | . |||..  | .|| .||    .   | .
YNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 29473.AA S_TKc 139-394 30 1.5e-84 288.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-231/231
Sequence Identity: 30% (81 aa)

YKVLKTLGQGASGSVELVQKND-GNLYALKTISMKYMNDTEKRSAQSEVTLLKVLVAPTIIRYYEAFVQNDSIYIVMEYAKE--GALSDKIQEHKTKGIR
|..|...|.|| |.| ...... | ..|.| |.         .....|. .||    | |...|..|.  |..|.||||.    | | | |......| |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISKALGTNADFTKTLVGTPYFMSPEVCAGQSYGD-KADIWALGCTLYEM
  ..| .. ....||. || ..|...|.|||.| .|..|..  ..|..|||... |       .|..|||..|.|||.   .||  |.|.|..||.||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

VMLRRPFDCENINTLFTMIRQQDPSPLHDNCSTDIRMLITLMLNKDPLKRPFIWDLVN-------IPII
.  . ||.  .....| .|.           | . . .|  .|.||| ||| . .. .        | .
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29473.AA NEK1 139-394 37 6.2e-84 285.15 In-house 1-276 (276) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-276/276
Sequence Identity: 37% (104 aa)

YKVLKTLGQGASGSVELVQ-KNDGNLYALKTISMKYMNDTEKRSAQSEVTLLKVLVAPTIIRYYEAFVQNDS--IYIVMEYAKEGALSDKIQEHKTKGIR
| ..|..|.|. | . ||. | || .|..| |.   | . |.  .  || .|...  | |..|.|.|. | .   ||||||.  | |  ||.. | ||  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLT--KEN---------------VVKLGDFGISKALGTNADFTKTLVGTPYFMSPEVCAGQSYGD
. | .|. .  ||..|| ..| .|||||||||||.|||  |                 .||||||||.. |    .. .| .||||  ||| |  . |  
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KADIWALGCTLYEMVMLRRPFDCENINTLFTMIRQQDPSPLHDNCSTDIRMLITLMLNKDPLKRPFIWDLVNIPII
| |||.||| ||| . | .||.  |  .|   | |   .|.    |.... |.. |....|  || . ..   |.|
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 29473.AA NEK4 139-394 40 6.9e-79 268.39 In-house 1-257 (257) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

YKVLKTLGQGASGSVELV-QKNDGNLYALKTISMKYMNDTEKRSAQSEVTLLKVLVAPTIIRYYEAFVQNDS--IYIVMEYAKEGALSDKIQEHKTKGIR
|  .|  |.|  | | || .. |.  | .| . .|     |.. |  |. ||  |  | |. | | .   .    |||| .   | |  | ..   |.  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQ--KNQF

IDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISKALGTNADFTKTLVGTPYFMSPEVCAGQSYGDKADIWALGCTLYEMVML
..|. ..    || .|| .||.|.||||| | ||.|||| |..|.||||||. |   .|. ||..||||.||||. . . |  | |||.||| .|||. |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

RRPFDCENINTLFTMIRQQDPSPLHDNCSTDIRMLITLMLNKDPLKRPFIWDLVNIPII
.  ||  ..| |   | |  | |.  | |.|.  |.  ||.| | ||| | |.   | |
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 29473.AA STE 139-394 24 8.2e-70 238.24 In-house 1-359 (359) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-359/359
Sequence Identity: 24% (89 aa)

YKVLKTLGQGASGSVELVQKND----------------GNLYALKTISMKYMN---------------DTEKRSAQSEVTLLKVLV--APTIIRYYEAFV
.. .. .|.||.|.| .  ...                |...| | ....  |               ..|. . . |. ..| .    | |..|| ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QN-------DSIYIVMEYAKEGALSDKIQEHKTKGI----------RIDEETILYFTAQIVIA-LFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISK
..       |...|.|||   | |.| |.. . .|           |..|. | |.. ||. . | . |...| |||||..| .|     ||| |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

ALG----------------TNADFTKTLVGTPYFMSPEVCAG------QSYGDKADIWALGCTLYEMVMLRRPF-DCENINTLFTMIRQ-----------
 |                 |..  ..|.|||| .|.|||  .      . |. |.||| ||||. ||.  . |. |  .   .| ...            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---QDPSPLHD-------------------NCSTDIRMLITLMLNKDPLKRPFIWDLVN--IPII
   ..| || |                   ..| . .  | . |.||| |||   .| .   | |
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 29473.AA Ciliate-E2 139-394 23 2e-68 233.61 In-house 1-365 (365) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-365/365
Sequence Identity: 23% (89 aa)

YKVLKTLGQGASGSVELVQK-NDGNLY------------------ALKTISMKYMNDTEKRSAQSEVTLLKVLV----------------APTIIRYYEA
||..| .|||. ||| .... ......                  . | . ||.|.  ....  .|  ... .                  | ||..||.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--QNDSIYIVMEYAKEGALSDKIQEHKTKG-------IRIDEETILYFTAQIV---------------IALFFMHQKK-ILHRDIKSQNLFLTKENVV
|   ....||.||||.. | | | |...|.|         ...|. |.|...||.                || ..|.|. |.||||| .|...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGISKALGTN-------------------------------ADFTKTLVGTPYFMSPEVCAGQS---------YGDKADIWALGCTLYEMVMLRRP
|. |||.|| . ..                                . ..|..|||..|.||.  |..         |. |.|||.||..||||.. ..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FDCENINTLFTMIRQQDPSPL-----------------HDNCSTDIRMLITL----MLNKDPLKRPF-IWDLVNIPII
|        .  | |.. .                   ....| .   ||      ||.||| ||.  .... | |..
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 29473.AA Ciliate-E2-Unclassified 139-394 24 2.4e-66 226.7 In-house 1-352 (352) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-352/352
Sequence Identity: 24% (85 aa)

YKVLKTLGQGASGSVELVQKNDGN-LYALKTIS------MKYMND----------TEKRSAQSEVT--------LLKVLVAPTIIRYYEAFVQNDSIYIV
||..|..|||. |.| ..|... . .||.|...      .|...            ....  . .         .|. .  | |......| . . ||||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYAKEGALSDKIQ-------------EHKTKGIRIDEETIL-----YFTAQIVIALFFMHQKK-ILHRDIKSQNLFLTKEN---VVKLGDFGISKALGT
|||.. | |.. |.             ... .. ...|. ..     ...|||. .| ..|.|. |.||||| .|.......    .|. |||||| ...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

N---------------ADFTKTLVGTPYFM----SPEVCAGQSYGDK----ADIWALGCTLYEMVMLRRPFDCENINT----------------LFTMIR
|                . ..| .|||..|    .|||  || |...    .|||.||. ||||.. ..||...| .                 |.  | 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

QQDPSPLH-------DNCSTDIRMLIT----LMLNKDPLKRPFIWDLVNIPII
|....  .       .. |     .|.     ||.|.| ||. .... | |..
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 29473.AA Pkinase 139-383 28 3.9e-66 230.81 Pfam 1-282 (293) Show / Hide 
Range on Protein: 139-383
Range on HMM: 1-282/293
Sequence Identity: 28% (82 aa)

YKVLKTLGQGASGSVELVQKNDGNL-YALKTISMKYMNDTEKRSAQS--EVTLLKVLVAPTIIRYYEAFVQNDSIYIVMEYAKEG----ALSDKIQEHKT
|......|.|..|.| . .. . .  .|.|.|. .  .. .....    |. ..| |  | |.|.|..|  .|.||.||||.  |     |.| |.    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--W

KGIRI--DEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVV----KLGDFGISKAL-GTNADFTKTLVGTPYFMSPEVCA-GQSYGDKADIW
.. ..  .|...  .  ||. .| ..|...|.|||.|..|... .....    |..|||..| .   |   ..|..|||..|.|||.  || || |.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCTLYEMVMLRRPFDCE----NINTLFTMIRQQDPSPLHDNCS-----------------------TDIRMLITLMLNKDPLKRP
..||.||||.  | ||. .    | ..   ||..  . ||| ...                        . . .|. .|.||| |||
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase 29473.AA NEK-Unclassified 139-394 34 4.1e-65 214.44 In-house 1-258 (258) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-258/258
Sequence Identity: 34% (91 aa)

YKVLKTLGQGASGSVELVQKNDGNLYALKTISMKYMNDTEKRSAQSEVTLLKVLVAPTIIRYYEAFVQNDSIYIVMEYAKEGALSDKIQEHKTKGIRIDE
|  . |||||  | | ||          . || .      |.  |  . .|  |  | |. | ..|  |  ..   .|   | |  .|| |  |   .||
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKR----KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDE

ETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISKALGTNADFTKTLVGTPYFMSPEVCAGQSYGDKADIWALGCTLYEMVMLRRP
  |     |.. |. . ||.||.||| | || |||.. .| .||||||. .    |  .| |||. .||||||  | | .. |.|.||| .|||      
GRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPF

FDCENINTLFTMIRQQDP------SPLHDNCSTDIRMLITLMLNKDPLKRPFIWDLVNIPII
||  |.  ..  | | |        |     |||   .|. || ... .||   ..|  . |
FDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 29473.AA ULK 139-394 24 2e-63 217.06 In-house 1-324 (324) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-324/324
Sequence Identity: 24% (81 aa)

YKVLKTLGQGASG-SVELV--QKND--GNLYALKTISMKYMNDTEKR--------SAQSEVTLLKVLV------APTIIRYYEAFVQNDS--IYIVMEYA
| . . ||.|. |  |     .|..  . ..| | |..|.||. ...        . ..|. ..| |          |...|. |   ..  |||.||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

KEGALSDKIQEHKT-----KGIRIDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKEN------------VVKLGDFGISKALG---TNADFTK
  | |.. |...|.     .. |. |. .. |  ||. .. ..|...| ||||| ||. ... .            |.|..||| .| .     ... ..
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TLV------GTPYFMSPEVCA----GQSYGDK-ADIWALGCTLYEMVMLRRPFDCENINTLF---------------TMIRQQDPSP---LHDNCSTDIR
|.|      |||..|.|..      .. |.|. .||| ||| .|||.  . || .  .|...               ..  |. . |     ...| ...
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

MLITLMLNKDPLKRPFIWDLVNIPII
 ||  || .|. .|  . .. |.|..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 29473.AA ULK 139-394 25 3.8e-61 209.44 In-house 1-329 (329) Show / Hide 
Range on Protein: 139-394
Range on HMM: 1-329/329
Sequence Identity: 25% (84 aa)

YKVLKTLGQGASGSVELV--QKND---GNLYALKTISMKYMNDTEKR--------SAQSEVTLLKVLVAPT--------IIRYYEAFVQNDS--IYIVME
| . . ||.|. | |     .|..   . ..| | |. ..||  ..         . ..|. ..| |  |         |...|. |   ..  |||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAKEGALSDKIQEHKT------KGIRIDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKEN------------VVKLGDFGISKALGTN---AD
|   | |.. |...|.      .. |. |. .. |  ||. .. ..|...| ||||| ||  ... .            |.|..||| .| .  .   ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FTKTLV------GTPYFMSPEVCA----GQSYGDK-ADIWALGCTLYEMVMLRRPFDCENINTLF-----TMIRQQDPSP-------LHDN-------CS
 ..| |      |||..|.|..      .. |.|. .||| ||| .|||.  . || .  .|...       |....|.|       |  .       .|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

TDIRMLITLMLNKDPLKRPFIWDLVNIPII
 ... ||  || .|. .|  . .| |.|..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 29473.AA Pkinase_Tyr 139-335 25 2.5e-19 66.11 Pfam 1-210 (270) Show / Hide 
Range on Protein: 139-335
Range on HMM: 1-210/270
Sequence Identity: 25% (55 aa)

YKVLKTLGQGASGSVELVQKN-----DGNLYALKTISMKYMNDTE--KRSAQSEVTLLKVL-VAPTIIRYYEAFV-QNDS--IYIVMEYAKEGALSDKIQ
 . .|.||.|| |.| .   .     ..   | |..   .  . .  ...  .|. ..| |   | |.|.| . . | ..  |||||||.. | | |  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EHKTKGIRIDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISKALGTNADFTKTLVGT----PYF-MSPEVCAGQSYGDKADI
.|.. . ... ...| . .||  .. . ..|.. |||.   |  .|..|||| .||| .... .| |   . ...    | . |.||. .   .  | |.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WALGCTLYEMVML
|. | ...|.. .
WSFGVLMWEIFTY
Kinase 29473.AA TyrKc 139-392 21 3.9e-15 22.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 139-392
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

YKVLKTLGQGASGSVELVQKNDGNLYALKTISMKYMNDTEKRSAQSEVTLLKVL--VAPTIIRYYEAFVQN-------DSIYIVMEYAKEGALSDKIQEH
 . .|.|| || | | . . .     | |..         ..   .|  ... |    | |.| | . .|        . ..|||||.. |.| | ...|
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KTKGIRIDEETILYFTAQIVIALFFMHQKKILHRDIKSQNLFLTKENVVKLGDFGISKALGTN-------ADFTKTL--VGT---PYF-MSPEVCAGQSY
. |   .  .. |.|  ||     . |.|.. |||.   |  ......|| .||| |....            .|.    |    |.  |.||.     .
RPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GDKADIWALGCTLYEMVMLRRPFDCE------NINTLFTMIRQQDPSPLHDN--------CSTDIRMLITLMLNKDPLKRPFIWDLVNIP
  | |.|. | ...|.  .  .   .      .   ..  ..| .  |  .|        |.... ....   . || .||  .... . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF