Gene 29340 (Tetrahymena)

29340

Species: Tetrahymena
Alias: 800, TTHERM_00260770, PreTt29340, 23.m00236, 29340
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
29340.AA Protein None 857 None Fasta, JSON
29340.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
29340.NA RNA None 2574 None Fasta, JSON

Protein domain

Protein domains of 29340.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29340.AA NEK 82-340 43 1.8e-135 456.38 In-house 1-286 (286) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-286/286
Sequence Identity: 43% (123 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSK-----WAIKNIYVSGG-EDVKKKRQ-SEYKILKKLDNPHIIKFKEAINYRNQQLIQIIMEYTD-GGDLEKL---
|..|||||.|..|.|..|....||..     ...|.| ...  |  |.. | .| .|||.|..|.|.|.....  .. . . |.||| . ||||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IEKQKQSAKPFEEEKILDFFIQICLGLDCIHKN-----KIIHRDIKPANIFLTAFGQ----LKIGDFGVSKELQYTKQCLKT-IVGTPYYIAPEIVSGYA
|.||||. |.||||.|.|.|||.||.|...|..     ||.||||||.|||||. .     .||||||.||.|..|.....|  ||||||..||....  
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNSSVDIWSLGVILYQLCCLQP--PFQDW--NEANLYCKIKKK-PYPPIAQLY-YSGKLKTLISKLLRKCPKERYTLKQIFDESLI
||. .||||||..||..|.|.|  ||. |  |  .|| ||.|   |||| . . || .|. |||..|.| |..|.. .||.  ..|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 29340.AA S_TKc 82-340 31 3.2e-83 283.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIKNIYVSGGEDVKKKRQSEYKILKKLDNPHIIKFKEAINYRNQQLIQIIMEYTDG--GDLEKLIEKQKQ--S
|. ..|||.||.|.|.... ...| . ||| |         .. ..| .|||| . |.|.|.....     . . ..||| ||  ||| ..|.|..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

AKPFEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAFGQLKIGDFGVSKELQYTKQCLKTIVGTPYYIAPEIVSGYAYNS-SVDIWSLGVILYQ
 .|| |  .  .. |||..|. .|...|||||.||.||.|.   ..||.|||....|       .|..|||.|.|||..    |.  ..|.||.|.||| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCCLQPPFQDWNEANLYCKIKKKPYPPIAQLYYSGKLKTLISKLLRKCPKERYTLKQIFD-------ESLI
..| .|||.  ... .. ||.            |  .| .|.|.|.| |..|.|  ...           .
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29340.AA NEK1 82-340 40 1.3e-80 274.07 In-house 1-276 (276) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-276/276
Sequence Identity: 40% (113 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIKNIYVSG-GEDVKKKRQSEYKILKKLDNPHIIKFKEAINYRNQQLIQIIMEYTDGGDLEKLIEKQKQSAKP
|  ||.||||..| . ||..  ||.  .|| | |.  .|  . .   | .||.|.. | |.|.||.   . . .  |.||| ||||| . |..|| . |.
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLT--AFG---------------QLKIGDFGVSKELQYTKQCLKTIVGTPYYIAPEIVSGYAYNS
| |  |...|.||||.|  ||. ||.|||||. |||||    |                .|.||||... |. |    .| .|||||. |||     || 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

SVDIWSLGVILYQLCCLQPPFQDWNEANLYCKIKKKPYPPIAQLYYSGKLKTLISKLLRKCPKERYTLKQIFDESLI
  ||||||..|| || |  ||.  |. ||  || . .|||| .  || .|. |.|..... |. |    ||     |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPH-YSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 29340.AA CAMK 87-340 21 1.4e-70 226.47 In-house 1-425 (425) Show / Hide 
Range on Protein: 87-340
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

KIGEGAYGQVHLVQSIRDG------------SKWAIKNIYVSGGED---------------------------VKKKRQSEYKILKK-------LDNPHI
..|.|..|.|.|.. ....             |.||| |  .   |                            .|. ..|..|.||       || |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKFKEAINYRN-----------------QQLIQIIM---EYTDGG----D-LEKLIEK-----------QKQSAKPFEEEKILDFFIQICLGLDCIHKNK
||. |..  ..                 .. . ..|   || .||    | .....|.              . . |.|.    .| ||| ... .|...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDIKPANIFLTAF-----------------GQLKIGDFGVSKELQYTK-----------------------QCLKTIVGTPYYIA-PEIVSG-----
|.|||.|| || |.                   ...|| ||| .....  .                       | .|| .|||.|.| ||...|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------YAYNSSVDIWSLGVILYQLCCLQPPFQDW-------------NEANLYCKIKKKPY--PPIA---------------------QLYYSGKL
           |. ..|.||.||||| . |  |||..              |. .|. ||.|  |  ||                       . . |   
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQEC

KTLISKLLRKCPKERYTLKQIFDESLI
| ||.|.|.. |..|.|..|. .   .
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 29340.AA Ciliate-E2 82-340 25 1.7e-70 240.52 In-house 1-365 (365) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIK----------------------NIYVSGGEDVKKKRQSEYK-------------ILKKLDNPHIIKFKEA
|  |||||.|..|.| ... .... . |||                      .|.   .   .|. .....             ||..|..|.|||..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

INYRNQQLIQIIMEYTDGGDLEKLIEKQKQSA-------KPFEEEKILDFFIQICL---------------GLDCIHKNK-IIHRDIKPANIFLTAFGQL
    ... | ..||| .||||...|...|..        |.| |..|.... ||.                .|  .|... |||||||| ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGVSK----------------ELQYTK----------------QCLKTIVGTPYYIAPEIVS---------GYAYNSSVDIWSLGVILYQLCCLQP
|| ||| ||                .... |                .  .||.|||.| ||||..         .  |. ..||||||||||.... .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFQDWNEANLYCKIKK-KPYPPIAQ---------------LYYSGKLKTLISK----LLRKCPKERYT-LKQIFDESLI
||        . .||. |   | ..               .. | . | ||.|    .| | |..|.|  .||..   .
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 29340.AA Pkinase 82-340 28 3.2e-70 244.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIKNIYVSGGEDVKKKRQ----SEYKILKKLDNPHIIKFKEAINYRNQQLIQIIMEYTDGG----DLEKLIEK
|. ..|||.|..|.| . . . .| ..|.| | .. .|. .|...    || .|.|.|. |.|......  . .. .  ..||| .||    ||  .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIY-MVMEYCEGGLYVMDLFDYIST

QKQSAKPF--EEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAFGQL----KIGDFGVSKEL-QYTKQCLKTIVGTPYYIAPEIVS-GYAYNSSV
  .. ..|  .|. . ... ||. ||. .|...|||||.||.||..   |..    ||.|||..| .    .. ..|..|||.|.|||..  |  | ..|
--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSLGVILYQLCCLQPPFQDW------NEANLYCKIKKKPYPPIAQLYYS-------------------GKLKTLISKLLRKCPKERYTLKQIFDESLI
|.||.|.|||...| .|||..       ..  ..|.|...|..   .  .|                     .| .|...|.|.||.|.| .||.    .
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 29340.AA ULK 82-340 29 3.5e-70 239.49 In-house 1-324 (324) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

YRWIKKIGEGAYG-QVHLVQSIRD---GSKWAIKNIYVSGGEDVKK---------KRQSEYKILKKLD---NPH--IIKFKEAINYRNQQLIQIIMEYTD
|  ....|.|..| .|.    ...   . ..|.| |  ..  . |.         . ..| .|.|||.   .|.  |.|...  .  |   | ||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLEKLIEKQKQ-----SAKPFEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAF------------GQLKIGDFGVSKELQYT---KQCLKT
|||||..|.|.|        | ..|.... ||.||| |. ..||..||||||||.|| ..              |.|||.||| .| ...    .| ..|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

IV------GTPYYIAPEIVS----GYAYNSS-VDIWSLGVILYQLCCLQPPFQDWNEANLYCK--------------IKKKPYPPI---AQLYYSGKLKT
.|      |||.| ||.|..    .  |... .||||||.|.|..   ..||. |   ..| .              ||..| ..    ..   | ..| 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LISKLLRKCPKERYTLKQIFDESLI
||...| . .|.| .  .||.  ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 29340.AA ULK 82-340 28 8e-68 231.64 In-house 1-329 (329) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

YRWIKKIGEGAYGQVHLVQSIRD----GSKWAIKNIYVSGGEDVKKKR---------QSEYKILKKLD--------NPHIIKFKEAINYRNQQLIQIIME
|  ....|.|..|.|.    ...    . |.|.| |  .     .. .         ..| ||.|||.        .|.|.|...  .  |   | ||||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YTDGGDLEKLIEKQKQ------SAKPFEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAF------------GQLKIGDFGVSKELQYT---KQ
| .|||||..|.|.|         | ..|.... ||.||. |. ..||..||||||||.|| ..              |.|||.||| .| ...    .|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

CLKTIV------GTPYYIAPEIVS----GYAYNSS-VDIWSLGVILYQLCCLQPPFQDWNEANLYCKIKKKP-------------YPPIAQLY-----YS
 ..| |      |||.| ||.|..    .  |... .||||||.|.|..   .|||. |    .| .|..|               |.  . .      |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

GKLKTLISKLLRKCPKERYTLKQIFDESLI
 ..| ||...| . .|.| .  ..|.  ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 29340.AA CAMKL 82-340 34 1.6e-67 214.53 In-house 1-297 (297) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-297/297
Sequence Identity: 34% (103 aa)

YRWIKKIGEGAYGQVHLVQSIRD-GSKWAIKNIY--VSGGEDVKKKR------------QSEYKILKKLD---NPHIIKFKEAI---NY--RNQQLIQII
|| .| .|.|..|.| | . ||  | | ||| |       ....||.            . |..|.|.|.    |.|||. | |   ..   . . |...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

MEYTDGGD--LEKLIEKQKQSAKPFEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAFG--QLKIGDFGVSKELQ-Y---TKQCLKTIVGTPYY
||| .||.  |   |.|..   ....|.    .| ||. ... .|...|.|||||| || |.  |  ..|| ||| | . . .   . | |||  |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

IAPEIVSG--YAYN-SSVDIWSLGVILYQLCCLQPPFQDW--------NEANLYCKIKKKPYPPIAQLYYSGKLKTLISKLLRKCPKERYTLKQIFDESL
 ||||..|    |.   |||||.||||| . | . || |         |  .|| ||..  | |   .. |  .. ||.|.| ..|..|.|..||     
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

I
 
M
Kinase 29340.AA Ciliate-E2-Unclassified 82-340 29 2.3e-65 223.48 In-house 1-352 (352) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-352/352
Sequence Identity: 29% (103 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIKNIYVSGGEDVKKKRQ----------SEYK--------------ILKKLDNPHIIKFKEAINYRNQQLIQI
|. ||.||.|..|.|...| . .. . |.| . ..   ..|....           . |              ||. ...|.|.|. ..   ...| | |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIYI

IMEYTDGGDLEKLIEKQKQSA-------------KPFEEEKIL-----DFFIQICLGL-DCIHKNKIIHRDIKPANIFLTAFG---QLKIGDFGVSKELQ
.||| .||||.. |.|.|...             | |.|....     ..| ||..||  ..|||.|||||||| ||...  |   ..|| ||| ||..|
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

YTKQC---------------LKTIVGTPYYI----APEIVSGYAYNSS----VDIWSLGVILYQLCCLQPPFQDWNEAN----------------LYCKI
.  .|               ..|..|||.|.    |||.  |  |. |    .||||||||||...  ..||.| |.                  || .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

KKKPYPPIAQLY------YSGKLKTLIS----KLLRKCPKERYTLKQIFDESLI
|.|..    .         | . | .|.    |.| |.|..|.|..||.   ..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 29340.AA NEK4 82-340 34 1e-60 208.03 In-house 1-257 (257) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-257/257
Sequence Identity: 34% (89 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIKNIYVS-GGEDVKKKRQSEYKILKKLDNPHIIKFKEAINYRNQQLIQIIMEYTDGGDLEKLIEKQKQSAKP
|  .| .| | || | ||.. ||. .. .| .         .|    | ..| .|  | |...||     | |.  |.| . .|||| .   .||  .  
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQF--

FEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAFGQLKIGDFGVSKELQYTKQCLKTIVGTPYYIAPEIVSGYAYNSSVDIWSLGVILYQLCCL
 ||. ... |.|| ..|  .|. .|.||| |  |||||    .||||||.|. |.   .  ||..|||||. ||. .  .|.   ||||||  .| .  |
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

QPPFQDWNEANLYCKIKKKPYPPIAQLYYSGKLKTLISKLLRKCPKERYTLKQIFDESLI
   |.  .   |  .| .   ||...  ||  |. |. ..| | |..|  . .||    |
KHAFDAKDMNSLIYQIIQGQPPPMPP-NYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 29340.AA STE 82-340 24 1.5e-53 184.25 In-house 1-359 (359) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-359/359
Sequence Identity: 24% (91 aa)

YRWIKKIGEGAYGQVHLVQSI------RDGSK---------WAIKNIYVSGGE----------------DVKKKRQSEYKILKKLD--NPHIIKFKEAIN
.. |.|||.||.|.|..   .      . | .          ||| . ..  .                . ... . | ||.||..   |.|.|.  .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

YR-----NQQLIQIIMEYTDGGDLEKLIE-K----------QKQSAKPFEEEKILDFFIQICLG-LDCIHKNKIIHRDIKPANIFLTAFGQLKIGDFGVS
.      | . . |.||| ||| |...|. |          ...  ..|.|. |  .  ||. | |. .|...|||||||||||.|      |. ||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

KELQY---------------TKQ-CLKTIVGTPYYIAPEIVSG------YAYNSSVDIWSLGVILYQLCCLQPPFQD-WNEANLYCKIKK----------
. |.                | |   .|.|||| . |||....        |. ..||||||  .  ... .||. |  .  ... ....          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KPYPPIAQ------------------LYYSGKLKTLISKLLRKCPKERYTLKQIFD--ESLI
    .| ||. .                    .| ..|  |.| |.| |..| | .|      . |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 29340.AA Pkinase_Tyr 127-275 26 2.3e-17 59.44 Pfam 52-205 (270) Show / Hide 
Range on Protein: 127-275
Range on HMM: 52-205/270
Sequence Identity: 26% (41 aa)

SEYKILKKL-DNPHIIKFKEAINYRNQQ-LIQIIMEYTDGGDLEKLIEKQKQSAKPFEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAFGQLK
.| ||.|.| ..|.|...  ..  . ..  | |.|||  .||| .   |.. . .|.  . .|.. .||. |..  . ...||||.   |. .|  .. |
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

IGDFGVSKEL---QYT-KQCLKTIVGTPYYIAPEIVSGYAYNSSVDIWSLGVILY
|.||| .. .    |  ..  .. .  . . |||  . . ...  |.|| || ..
ICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSDVWSFGVLMW
Kinase 29340.AA TyrKc 82-340 20 3.3e-15 23.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 82-340
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YRWIKKIGEGAYGQVHLVQSIRDGSKWAIKNIYVSGGEDVKKKRQSEYKILKKL--DNPHIIKFKEAINYRNQ-------QLIQIIMEYTDGGDLEKLIE
 . .||.||||.|.|.. . .    . |.| .  .     ..   .| .|..||  ..|.|...  ..  . |       . . |.||| ..||| . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVC--TQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KQKQSAKPFEEEKILDFFIQICLGLDCIHKNKIIHRDIKPANIFLTAFGQLKIGDFGVSKEL----------QYTKQ----CLK--TIVGTPYYIAPEIV
| .     .  .. |.| .||. | . .|....||||.   |. ... .. ||.||| |...          .| ..    . |    .      |||  
KHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RWMAPECI

SGYAYNSSVDIWSLGVILYQLCCL-QPPFQD-----WNEANLYCKIKKKPYPPIAQLYY-------SGKLKTLISKLLRKCPKERYTLKQIFDESLI
  . ...  |.|| || .. .. . |.|  .      . . .. ..|.  ..|. . .|       . .. .....  .  |..| | ..|   ...
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 29340.AA Pkinase_Tyr 82-98 47 0.054997 7.35 Pfam 1-17 (270) Show / Hide 
Range on Protein: 82-98
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

YRWIKKIGEGAYGQVHL
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ITFGKKLGEGAFGEVYK