Gene 28502 (Tetrahymena)

28502

Species: Tetrahymena
Alias: TTHERM_00161100, 28502, 3829.m01323, PreTt28502, 13.m00461, 125
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
28502.AA Protein None 1158 None Fasta, JSON
28502.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
28502.NA RNA None 3477 None Fasta, JSON

Protein domain

Protein domains of 28502.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28502.AA NEK 17-271 48 5.3e-160 537.85 In-house 1-286 (286) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-286/286
Sequence Identity: 48% (139 aa)

YKQIKLLGEGSFGKAYLVECQSDGSL-----CVIKKMDTKSMTEAEKQETV-REAHILEALNHPCIVKFREVYKTKK--ALCIVMDFCD-GGDLAKK---
|. || .|.|||||.|.|...|||.      .|.||.....|.| |||...  |..||. |.|| |||... .  ..   |||||..|. ||||..|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQDYK--GKFIPENQILDWFTQICLALKHIHDR-----KIVHRDLKTQNIFLMKDNA----LKVGDFGIAKVLRHTRENCKT-MVGTPYYISPEILEAKP
|. .|  ||...|.||.|||.|.|||||..|||     ||.|||.|.||||| |.|     .|.|||||.||| ||..  .| .||||||.|||... ||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YSFRSDIWSLGVILYEMCAQ--KPPFDGI--GLSNLALKIVKG-VYAPISSY--YSKDMTQLISLLLNVDPSKRPQVNQILKLPII
|...|||||||..|||||..  |.||..    . .|..||.||  |.||.|.  ||.|. .|||..|..||..|| .||||..|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 28502.AA NEK1 17-271 48 6e-128 431.36 In-house 1-276 (276) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-276/276
Sequence Identity: 48% (135 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVREAHILEALNHPCIVKFREVYKTKKA--LCIVMDFCDGGDLAKKIQDY--KGKF
|  || .||||||||.||   .||...|||      | | |..| ..|. ||. . || |||..|         | |||..||||||..||.    ||| 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IPENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLM--KDN---------------ALKVGDFGIAKVLRHTRENCKTMVGTPYYISPEILEAKPYSF
..| ||..||.||||||.||||||| |||.|.|||||   |.                 .|.||||||..| || |  .| .|||||.|||| . |||  
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

RSDIWSLGVILYEMCAQKPPFDGIGLSNLALKIVKGVYAPISSYYSKDMTQLISLLLNVDPSKRPQVNQILKLPII
 |||||||..||| |. | ||..  . || |||..| |.||.. ||..   |.| .....|. || |||||. |.|
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 28502.AA NEK8 17-271 37 8.49999999999e-111 317.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-278/278
Sequence Identity: 37% (104 aa)

YKQIKLLGEGSFGKAYLVECQSDG--SLCVIKKMDTKSMTEAEKQETVREAHILEALNHPCIVKFREVYKTKKALCIVMDFCDGGDLAKKIQDYKG-KFI
|  |  .| |.|| . |    .|.  .| ..|  ..  |.| | |    |  .|  |.|| |.   .     ..| |.|  .||| |. .||. .. .| 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

PEN----------------QILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKD-NALKVGDFGIAKVLRHTRENC--KTMVGTPYYISPEILEAKPYS
.|                 .||. |.|.|.|. |.|.  |.||||||||||. .. . .|.|||||.|..         || ||||||.|||. | ||| 
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

FRSDIWSLGVILYEMCAQKPPFDGIGLSNLALKIVKG-VYAPISSYYSKDMTQLISLLLNVDPSKRPQVNQILKLPII
. ||.|.|| .|||||  |  |..  |..| .||. .  |.|||. ||..| .|.. .| .|| .|| . ||.. | .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 28502.AA NEK4 17-271 42 1.1e-103 350.8 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-257/257
Sequence Identity: 42% (110 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVREAHILEALNHPCIVKFREVYKTKKA--LCIVMDFCDGGDLAKKIQDYKGKFIP
|  .|  | ||.|  .||  . |.   |.|||. |     |.... .|| .|  | || ||.. | ..      |.||| ||.|||| .| .  |..|..
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

ENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNALKVGDFGIAKVLRHTRENCKTMVGTPYYISPEILEAKPYSFRSDIWSLGVILYEMCAQKP
|.|...|| || .||  .|...|.||||||||||| | | .|.|||||..||    .  |||.|||||.|||.   .|| ..|||||||  .|||   | 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFDGIGLSNLALKIVKGVYAPISSYYSKDMTQLISLLLNVDPSKRPQVNQILKLPII
 ||   .  |  .|..|   |..  ||.|. .|.  .|.  | ||| . .|.. | |
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 28502.AA S_TKc 17-271 31 2.1e-95 324.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVREAHILEALNHPCIVKFREVYKTKKALCIVMDFCDG--GDLAKKIQDYKGKF--
|. ....|.|.||| |..   ..| .. ||...         . . ||  ||.  .|| |||. .|. . . |..||..|||  ||| . |......   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IPENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNALKVGDFGIAKVLRHTRENCKTMVGTPYYISPEILEAKPYSF-RSDIWSLGVILYEM
  .|| ..  .. |||.||...|...|.||||| .||.| .   .|..|||.|..|       .|..|||.|..||.|   .|.. ..|.||.|.|||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CAQKPPFDGIGLSNLALKIVKGVYAPISSYYSKDMTQLISLLLNVDPSKRPQVNQILK-------LPII
.. .|||.     .. .|...          |... ..|. .|..||.||| . ..|.        | .
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28502.AA Pkinase 17-271 28 4.4e-89 307.05 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-293/293
Sequence Identity: 28% (83 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVR--EAHILEALNHPCIVKFREVYKTKKALCIVMDFCDGG----DLAKKIQ-DYK
|. .. .|.||||. |.   ...| . ..|... ..  . ..|. .|  |..|.  ||||.||...... .|. ...||..|.||    ||.  |. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKF-IPENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNAL----KVGDFGIAKVL-RHTRENCKTMVGTPYYISPEILE-AKPYSFRSDIWSL
|.|  .|... ....||. .|...|...|.||||| .||.. ... .    |..|||.||..     . ..| .|||.|..||..  ...|. ..|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYEMCAQKPPFDGI----GLSNLALKIVKGVYAPISSYYS-----------------------KDMTQLISLLLNVDPSKRPQVNQILKLPII
|.|||||.  .|||.|     .  .   .|..  ..|... ..                       ... ..|. .|..||.|||   |||. | .
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 28502.AA NEK2 17-271 31 5.8e-81 272.37 In-house 1-319 (319) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-319/319
Sequence Identity: 31% (102 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVREAHILEALNHPCIVKF--REVYKTKKALCIVMDFCDGGDLAKKIQDYKG--KF
|   . .|.||||. . |   ||| . | | ..  .|.|.|.|  | |  ||  | || ||..  . . .... | ||| .| ||||.  |. ..   ..
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPENQILDWFTQICLALKHIHD---------------------RKIVHRDLKTQNIFLMKDNA-------------------------------------
..|  |.  ..|.|.||. .|                      . | |||.|  ||||  |                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--LKVGDFGIAKVLRHTRENCKTMVGTPYYISPEILEAKPYSFRSDIWSLGVILYEMCAQKPPFDGIGLSNLALKIVKGVYAPISSYYSKDMTQLISLLL
   | |||| |..|.|     .| |||||| ||| ..  .|. .|||||.| ..||||| .||| .     |. || .| . .| ..||..   .|.. .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

NVDPSKRPQVNQILKLPII
|||...|| .. ||. | |
NVDHYHRPSIEEILQHPQI
Kinase 28502.AA CAMK 22-271 22 3.6e-80 257.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 22-271
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

LLGEGSFGKAYLVECQSDG------------SLCVIKKMDTKSMT--------------------------EAEKQETVREAHILEA-------LNHPCI
 ||.||||| .|..  ...              . || .|.| ..                          .  ...  || .|.         |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKFREVYK------------TKKA--------LCIVM---DFCDGG----DLAKKIQDYKG-------------KFIPENQILDWFTQICLALKHIHDRK
.|. |||             | .         ...||   ..|.||    ||  .|.. ..             . ..| .   .| ||| |....|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKTQNIFLMKD-----------------NALKVGDFGIAKVLRH-----------------------TRENCKTMVGTPYYIS-PEILEA-----
|||||||  || | ..                 | .|. ||| |.....                       . . .||..|||.|.. ||.|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KPYSFRSDIWSLGVILYEMCAQKPPFDGI-------------GLSNLALKIVKGVYAPISSYYSK-----------------------DMT
         ..|.. .|.||.||||| |   .|||.|               ...|  || || |  ...| |.                       .  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QLISLLLNVDPSKRPQVNQILKLPII
.||. .|.|||.||. . |.|. | .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 28502.AA Ciliate-E2-Unclassified 17-271 24 6.4e-75 255.21 In-house 1-352 (352) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-352/352
Sequence Identity: 24% (86 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLC------VIKKMDTKSMTEAEKQETVREAHILEALN-------------------HPCIVKFREVYKTKKALCI
|| || .|.|.||| |.... ... .         .... .   . .. | ..|..... ..                   ||.|||. .. ..|. ..|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMDFCDGGDLAKKIQDYKG---------------KFIPENQIL-----DWFTQICLALKHIHDRK-IVHRDLKTQNIFLMKDN---ALKVGDFGIAK---
||..|.|||| . |...|.               | ..|.|..     ..| ||...|...|  . |.|||.| .||.. ...    .|. ||||.|   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

------------VLRHTRENCKTMVGTPYYI----SPEILEAKPYS----FRSDIWSLGVILYEMCAQKPPFDGIGLSN----------------LALKI
              .  .....|..|||.|.    .||.|. . |.    . .||||||||||||. ...||..                     |  .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

VKGVYA----------PISSYYSKDMTQ-LISLLLNVDPSKRPQVNQILKLPII
 .. .            ..|   ||. . |.. .|...|.||.. .|||. |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 28502.AA NEK-Unclassified 17-271 36 1.3e-74 246.36 In-house 1-258 (258) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-258/258
Sequence Identity: 36% (97 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVREAHILEALNHPCIVKFREVYKTKKALCIVMDFCDGGDLAKKIQDYKGK--FIP
| .|  || |  |  |||  |      | .    |      |.       ||  | || || . . .     |    |.||||.| ..||   .|   . 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKRK-----KKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

ENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNALKVGDFGIAKVLRHTRENCKTMVGTPYYISPEILEAKPYSFRSDIWSLGVILYEMCAQKP
|  |  |. |.  |.  || |||.|||||.||||| .|  .  |||||.... |||.  .| |||. ..|||... .||  |||.|||| |.||||.  |
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

PFDGIGLSNLALKIVKGVY------APISSYYSKDMTQLISLLLNVDPSKRPQVNQILKLPII
 ||   .  .  ||...         |.|. || |. |.|  .|  .. .||    |. .. |
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 28502.AA Ciliate-E2 17-271 25 1.2e-70 241.0 In-house 1-365 (365) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

YKQIKLLGEGSFG-----KAYLVECQS-----DGSL---------CVIKKMDTKSMTEAEKQETVREAHIL----------------EALNHPCIVKFRE
|| ||..|.|.||     | ..| .|.     |  .         . ||.   |.| . ..... .| ||.                | |||| |.|. |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VYK--TKKALCIVMDFCDGGDLAKKIQDYKGKF---------IPENQILDWFTQICL---------------ALKHIHDRK-IVHRDLKTQNIFLMKDNA
...  ... . .||..|.|||| . |.. | |.         . |..|.. ..||.                ||...| .. |.|||.| .||..     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKVGDFGIAK------------VLRHTRENCK--------------------TMVGTPYYISPEILEAKP---------YSFRSDIWSLGVILYEMCAQK
.|. |||..|            ...    . |                    | .|||.| .||||. |.         |.. .||||||||||||.  |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

PPFDGIGLSNLALKIVKG--VYAP----------------ISSYYSKDMTQLISL----LLNVDPSKRPQ-VNQILKLPII
|||         ... |   .  |                .  . |... .||.     .|..||.||..  .|||. |..
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 28502.AA ULK 17-271 28 6.3e-70 238.62 In-house 1-324 (324) Show / Hide 
Range on Protein: 17-271
Range on HMM: 1-324/324
Sequence Identity: 28% (92 aa)

YKQIKLLGEGSFG-KAYLVECQSD---GSLCVIKKMDTKSMTEAEKQ--------ETVREAHILEALN---HPC--IVKFREVYKTK--KALCIVMDFCD
|  .. ||.|||| | |  ... .   . .  .|..| |.| . ...           .|  |.  |.   ||   |||. ....|.  . ..|.|..|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLAKKIQDYKG-------KFIPENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNA------------LKVGDFGIAKVLRHT---RENCKT
|||| . |. .|.       |...|....  | ||| ..|..|...|.|||.| ||| . ....            ||..||| ||..         |.|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MV------GTPYYISPEILE----AKPYS-FRSDIWSLGVILYEMCAQKPPFDGIGLSNLAL---KIVKG-------VY-APISSY-------YSKDMTQ
.|      |||.| .|.||.     |||. . .||||||.|.|||   |.|| .   ... |   | ..        ..  ||  .        |... .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LISLLLNVDPSKRPQVNQILKLPII
||. .| .|...|    .|.. |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 28502.AA Pkinase_Tyr 17-210 23 7.1e-30 101.81 Pfam 1-208 (270) Show / Hide 
Range on Protein: 17-210
Range on HMM: 1-208/270
Sequence Identity: 23% (50 aa)

YKQIKLLGEGSFGKAYLVECQ----SDGSLCVIKKMDTKSMTEAE--KQETVREAHILEAL-NHPCIVKFREVYK-TKKA--LCIVMDFCDGGDLAKKIQ
 . .| ||||.||. |. ..     ...  . .|..   . .. .  ...  ||| |.  | .|| ||..  |    ..   ..||| .. .||| .  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DY--KGKFIPENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNALKVGDFGIAKVL------RHTRENCKTMVGTPYYISPEILEAKPYSFRSD
.    .. ..  ..|.. .||. .. . ......|||| . |. . ..|  |..||| |. .       ..|...|  .  . . .|| .  . ..  ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWM-APECINYGKFTTKSD

IWSLGVILYEMC
.|| || ..|..
VWSFGVLMWEIF
Kinase 28502.AA TyrKc 17-269 21 9.9e-27 96.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-269
Range on HMM: 1-280/280
Sequence Identity: 21% (61 aa)

YKQIKLLGEGSFGKAYLVECQSDGSLCVIKKMDTKSMTEAEKQETVREAHILEAL--NHPCIVKFREVYKTK-------KALCIVMDFCDGGDLAKKIQD
 . .| |||| ||. |. .       . .|..   .     ...  ||| |.  |  .||.||..  |  ..       . |.||| ....||| . ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YKGKFIPENQILDWFTQICLALKHIHDRKIVHRDLKTQNIFLMKDNALKVGDFGIAKVLRHT-----RENCKTM---VGTP-----YYISPEILEAKPYS
...| ..  . |.. .||.    ..|.....|||| . |. . ...  |..||| .. . .      ..  ...    |.         .|| .  . ..
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FRSDIWSLGVILYEMCAQ-KPPFDG-----IGLSNLALKIVKGVYAPISSY--------YSKDMTQLISLLLNVDPSKRPQVNQILKLP
. ||.|| || ..|..   ..|  |     .  . .  .. .| . |.  .         ...| |...   . ||..||  ..| .. 
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF