Gene 28433 (Tetrahymena)

28433

Species: Tetrahymena
Alias: 13.m00392, PreTt28433, 28433, TTHERM_00158430, 3829.m01246, 129
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
28433.AA Protein None 1329 None Fasta, JSON
28433.kin_dom Protein Kinase Domain None 256 None Fasta, JSON
28433.NA RNA None 3990 None Fasta, JSON

Protein domain

Protein domains of 28433.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28433.AA NEK 24-279 50 8.10000000001e-160 537.24 In-house 1-286 (286) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-286/286
Sequence Identity: 50% (143 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKT-----YVIKEINMKFMDQKQKQDAV-NEGNLLKHLESPYVVKYYDMFIEQN--DLYIVMEFCE-NGDLLQY---
|. . |.||||.|.||| |.|||||      ||.|.|||. |..|.||.|. || ..||.| .|..||||| |||..   |.||||.|| .||| |    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKKQK--NQFINENKIWLFFLQMLLGLHSIHQQ-----KVLHRDFKTMNIFLTKNSTE---IRIGDLGVAKYLGDTNNLAKT-MVGTPYYLSPEICEEKP
|||||  .... |..|| .| ||.|.|. .|..     |.|||| |..||||||| ..   ..|||.|..| |..|. .|.| .||||||.|||.|..||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKSDIWSLGCILYELCTF--KHPFEAS--NQGALVIKILKN-KVEPLPSM--YSRELQSIISLLLTKDHQKRPDTTTLLSNSII
||.|||||||||.|||.||.  ||||||.  |. .|. || |. . .|.||.  ||..||..||..|.||...||... .|....|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 28433.AA NEK1 24-279 44 5.2e-119 401.67 In-house 1-276 (276) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-276/276
Sequence Identity: 44% (123 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVNEGNLLKHLESPYVVKYYDMFIEQND--LYIVMEFCENGDLLQYIKKQ--KNQF
|. . ..|.||.| ... ..|.||..|||||||   | .| .....||...|. .. | .|||.. |.|     ||||||.|..||| | |..|  |.. 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

INENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLT--KNST--------------EIRIGDLGVAKYLGDTNNLAKTMVGTPYYLSPEICEEKPYNE
. |  |  .| |. |.|  || .|.|||| |. |||||  ||                 ...|| |.|. | .|  .|.| .|||||||||||. |||| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCILYELCTFKHPFEASNQGALVIKILKNKVEPLPSMYSRELQSIISLLLTKDHQKRPDTTTLLSNSII
|||||||||.|||||| |||||| |  .|| ||..  . |.|. ||.|||| .| .. .. . || ....|.  .|
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 28433.AA NEK8 30-279 39 1e-114 328.96 In-house 7-278 (278) Show / Hide 
Range on Protein: 30-279
Range on HMM: 7-278/278
Sequence Identity: 39% (107 aa)

LGQGSYGVVYKGRKKSDG--KTYVIKEINMKFMDQKQKQDAVNEGNLLKHLESPYVVKYYDMFIEQNDLYIVMEFCENGDLLQYIKKQKN-QFINEN---
.|.|. |..   |.|.|.  .  ..|.|||  |. |. |.| || ..|. |. | .. ||| |.| | | |.|| .. | | |.| .|.|  | .|    
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLK

-------------KIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVAKYLGDTNNLA--KTMVGTPYYLSPEICEEKPYNEKSDIW
              |  .| ||....| .||  .|||| || |||.|.  . . ||| | .| ...    .  || ||||||.|||.|| ||||.|||.|
QVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMW

SLGCILYELCTFKHPFEASNQGALVIKILKN-KVEPLPSMYSRELQSIISLLLTKDHQKRPDTTTLLSNSII
.|||.|||.|. |  |||||. ||| ||    . ||... || |. . .. .| .| ..||.   ....  .
ALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 28433.AA NEK4 24-279 41 3.5e-92 312.57 In-house 1-257 (257) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-257/257
Sequence Identity: 41% (107 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVNEGNLLKHLESPYVVKYYDMFIEQND--LYIVMEFCENGDLLQYIKKQKNQFIN
|. .   |.|||| |.  |.. |.| ||.| ...|  .......|  | .||  |  | .|.| . .   |   ||||| ||| ||| .  |.|||||. 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

ENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVAKYLGDTNNLAKTMVGTPYYLSPEICEEKPYNEKSDIWSLGCILYELCTFK
|. .   | |  ..|  .|....|||| || ||||||    |.|||.|... | .  ..||||.|||||.|||.   .||. ||||||||| .||. | |
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNI-IKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

HPFEASNQGALVIKILKNKVEPLPSMYSRELQSIISLLLTKDHQKRPDTTTLLSNSII
| |.| .   |. .|.. .  |.|  || .|| ..  .| |  .|||    ..    |
HAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 28433.AA S_TKc 24-279 31 1.2e-89 305.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVNEGNLLKHLESPYVVKYYDMFIEQNDLYIVMEFCEN--GDLLQYIKKQKNQF--
|. | |.|.|..|.|||.|.|..|. . ||.|.         ... .| ..||.   |..||.||.| . ..||.|||.|..  |||..||||.. .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--INENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVAKYLGDTNNLAKTMVGTPYYLSPEICEEKPYNE-KSDIWSLGCILYE
  ..|  .. .. |....|  .|.....||| |  ||.|..   .| |.| |.|. |       .|..|||.|..||..   .|.  |.|.||.||||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LCTFKHPFEASNQGALVIKILKNKVEPLPSMYSRELQSIISLLLTKDHQKRPDTTTLLS-------NSII
... . ||.   | ....|...          |.|. ..|. .|.|| .|||    .|           .
MLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28433.AA NEK2 24-279 35 4.1e-85 286.55 In-house 1-319 (319) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-319/319
Sequence Identity: 35% (113 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVNEGNLLKHLESPYVVKYYDMFI--EQNDLYIVMEFCENGDLLQYIKKQKN--QF
|. |  .|.||.|...| | |||||  | |||.   |. | .|  |.| |.|. |  |..|.|||  |  ..  ||||||.|| ||| | ||| ..  |.
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

INENKIWLFFLQMLLGLHSIHQ---------------------QKVLHRDFKTMNIFLTKNST-------------------------------------
. |  ||  ..|... |  .|                      . .|||| |  ||||  .                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

-EIRIGDLGVAKYLGDTNNLAKTMVGTPYYLSPEICEEKPYNEKSDIWSLGCILYELCTFKHPFEASNQGALVIKILKNKVEPLPSMYSRELQSIISLLL
  .  || | |. |      |.| |||||| |||  .  .|||||||||.||..||.|. . ||.| || .|  || . . ...|. |||.|. ||.. .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

TKDHQKRPDTTTLLSNSII
  ||..|| .  .| .. |
NVDHYHRPSIEEILQHPQI
Kinase 28433.AA Pkinase 24-279 28 1.4e-76 265.51 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVN--EGNLLKHLESPYVVKYYDMFIEQNDLYIVMEFCENG----DLLQYIKKQKN
|  . |.|.||.|.|||...|..||....|.|. .  . ...| ...  |  ..|.| .|..|..||.| . ...|.|||.||.|    ||  ||. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QFI--NENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTE---IRIGDLGVAKYL-GDTNNLAKTMVGTPYYLSPEICE-EKPYNEKSDIWSL
  .   |. .  ...|.| ||  .|.....||| |  ||.. .| .    ..|.| |.|| .    |  ..| .|||.|..||..   ..|  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYELCTFKHPFEAS------NQGALVIKILK-----NKVEPLPSMYS---------------RELQSIISLLLTKDHQKRPDTTTLLSNSII
||||||... . ||  .      .| ... .|..     .  .. . .|.               .|....|. .|.|| .|||  . .|    .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 28433.AA NEK-Unclassified 24-279 35 7.8e-75 247.13 In-house 1-258 (258) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-258/258
Sequence Identity: 35% (95 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVNEGNLLKHLESPYVVKYYDMFIEQNDLYIVMEFCENGDLLQYIKKQ--KNQFIN
|| .  ||||  | ||  | .   |  ... |  .    |.|.   |   .|  |  | .| | | | |   |.   ..|. |.| . |.|.  ||  ..
YDKITTLGQGGGGAVYLVRHQI-SKRHLVQQISKR----KKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

ENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVAKYLGDTNNLAKTMVGTPYYLSPEICEEKPYNEKSDIWSLGCILYELCTFK
|  |   . ||   .  |||.|..||| |. |||||.  | . .|| |... . .|   |.| |||. ..|||.|...|||..||.||||||.||.||. 
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDT-VSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

HPFEASNQGALVIKILKNKV------EPLPSMYSRELQSIISLLLTKDHQKRPDTTTLLSNSII
  | . | | .  || .         ||  . ||  || .|  .| .. |.||  |....   |
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 28433.AA STE 24-279 23 1e-73 251.24 In-house 1-359 (359) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)

YDNLVKLGQGSYGVVYKGRKKS---------------DGKTYVIKEINMKFMDQ---------------KQKQDAVNEGNLLKHLE--SPYVVKYYDMFI
.... |.|.|..|.|||....                 |. . ||..|..  ..               ...|.  .| ...|..   .|..||||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EQ-------NDLYIVMEFCENGDLLQYIK------KQKN------QFINENKIWLFFLQMLLG-LHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVA
         ..|.|.||....| | . ||      |. |      ....|. |  .  | | | |. .|.... ||| |  ||.|      . . | ||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KYLGD---------------TNN-LAKTMVGTPYYLSPEICEE------KPYNEKSDIWSLGCILYELCTFKHPFEA-SNQGALVIKILK----------
. | |               |.    .|.|||| . .||. .       |.|..|.||||||| . |..| |.|.   ..  |.  .. .          
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----NKVEPLPS-------------------MYSRELQSIISLLLTKDHQKRPDTTTLLS--NSII
    ..  |||.                    .| |..  |.. |.|| .|||... ||.   . |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 28433.AA ULK 24-279 29 7e-69 235.15 In-house 1-324 (324) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

YDNLVKLGQGSYG-VVYKGR-KKSD--GKTYVIKEINMKFMDQKQKQDA--------VNEGNLLKHLE---SPY--VVKYYDMFIEQND--LYIVMEFCE
|    .||.||.| .||||| ||..  .. . .| |..| | .|....          || ...| |    .|.  .||.||.| ..|.  .||.||.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

NGDLLQYIKKQKN-------QFINENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTE-----------IRIGDLGVAKYLGDTN---NLAKT
 ||| |||||.|.       ....|...  || | . |.  .|.... ||| |  || .... .            . |.| | || . . |   .. .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

MV------GTPYYLSPEICE----EKPYN-EKSDIWSLGCILYELCTFKHPFEASNQGALV----------------IKILKNKVEPLP--SMYSRELQS
.|      |||.| .|.| .    .|||.  |.||||||||.||. . | ||...    ..                ||  . .  . |     | |...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

IISLLLTKDHQKRPDTTTLLSNSII
.|. .|..|  .| . . .... ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 28433.AA Ciliate-E2 24-279 23 4.6e-68 232.43 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTY------------------VIKEINMKFMDQKQKQDAVNEGNLLKHLE----------------SPYVVKYYDM
|. . |.|||..|.|||.......| .                   ||...|| | ..|..   .| .... ..                .|...|.|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--EQNDLYIVMEFCENGDLLQYIKKQKNQF---------INENKIWLFFLQMLL---------------GLHSIHQQK-VLHRDFKTMNIFLTKNSTE
|.   .| .|.|||.|. |||..|||..| ..         ..|..|  .. | |                .|...|... ..||| |  ||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

IRIGDLGVAKYLGDTNN-------------------------------LAKTMVGTPYYLSPEICEEKP---------YNEKSDIWSLGCILYELCTFKH
| | |.| .|.. | |.                               ...| .|||.|..||| . |.         |..|.||||||.||||... |.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEASNQGALVIKILKNKVE-PLPSM----------------YSRELQSIISL----LLTKDHQKRPD-TTTLLSNSII
||         ..|...|.. | | .                 | | . .|.     .| || .||..    .| . ..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 28433.AA ULK 24-279 29 1.3e-67 230.94 In-house 1-329 (329) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-329/329
Sequence Identity: 29% (96 aa)

YDNLVKLGQGSYGVVYKGR-KKSD---GKTYVIKEINMKFMDQKQKQDA--------VNEGNLLKHLE----SPY----VVKYYDMFIEQND--LYIVME
|    .||.||.|.||||| ||..   .. ...| |  . |.||....          ||  ..| |     ...    .||.||.| ..|.  .||.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCENGDLLQYIKKQKN--------QFINENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTE-----------IRIGDLGVAKYLGDT---NN
.|. ||| |||||.|.        ....|...  || | | |.  .|.... ||| |  || .... .            . |.| | || . .    ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LAKTMV------GTPYYLSPEICE----EKPYN-EKSDIWSLGCILYELCTFKHPFEASNQGALVIKILKNKVE-PLPSM------------------YS
...|.|      |||.| .|.| .    .|||.  |.||||||||.||. . | ||.|.    ....|... .. |.|.                    |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

RELQSIISLLLTKDHQKRPDTTTLLSNSII
 |....|. .|..|  .| . . |... ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 28433.AA Pkinase_Tyr 24-220 25 4.8e-19 65.12 Pfam 1-210 (270) Show / Hide 
Range on Protein: 24-220
Range on HMM: 1-210/270
Sequence Identity: 25% (55 aa)

YDNLVKLGQGSYGVVYKGRKK----SDGKTYVIKEINMKFMDQKQ--KQDAVNEGNLLKHL-ESPYVVKYYDMFI-EQND--LYIVMEFCENGDLLQYIK
   . |||.|..|.||||. |    ... .  .| .     ...|  ..|  .| ...|.|   | .|..|   . ..    .|||||....|||| | .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KQ--KNQFINENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVAKYL-GDTNN-LAKTMVGTPY-YLSPEICEEKPYNEKSDIW
|.   .| ..   .  . .|   |.   ....  |||  . |. .|.|   ..|.| | |...  | .   ...    |   ..||   .. ...|||.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SLGCILYELCTF
| |  ..|..|.
SFGVLMWEIFTY
Kinase 28433.AA TyrKc 24-283 21 2.3e-16 41.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-283
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YDNLVKLGQGSYGVVYKGRKKSDGKTYVIKEINMKFMDQKQKQDAVNEGNLLKHL--ESPYVVKYYDMFIEQ-------NDLYIVMEFCENGDLLQYIKK
   . ||| | .|.||||. |    .  .| ..        ..|  .| .....|  . | .|. |   ..|         |.||||....|||..|..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QKNQFINENKIWLFFLQMLLGLHSIHQQKVLHRDFKTMNIFLTKNSTEIRIGDLGVAKYLGDT--------NNLAKTMVGTP-----YYLSPEICEEKPY
 ... ..  .   | .|   |   .|.... |||  . |. ...|   ..|.| | .....|            .|.  |.        ..||   .. .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NEKSDIWSLGCILYELCTFKHPFEAS-----NQGALVIKILKNK-VEPLPSM--------YSRELQSIISLLLTKDHQKRPDTTTLLSNSIIVDKL
..|||.|| |  ..|..|.  .            . ||. .|.    | |           . |. .|..     |  .||  ...      ....
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF