Gene 24991 (Tetrahymena)

24991

Species: Tetrahymena
Alias: 24991, 188.m00067, PreTt24991, TTHERM_00997660, 846
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
24991.AA Protein None 528 None Fasta, JSON
24991.kin_dom Protein Kinase Domain None 238 None Fasta, JSON
24991.NA RNA None 1587 None Fasta, JSON

Protein domain

Protein domains of 24991.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24991.AA NEK 6-243 40 3.9e-137 461.89 In-house 1-286 (286) Show / Hide 
Range on Protein: 6-243
Range on HMM: 1-286/286
Sequence Identity: 40% (117 aa)

FDVIRKLGEGAYSSVFKVRKISNGQD-----YAMKNIKMGSLSAKEQENAI-NEVRFLASLSSQEIIGYKEAFYDEKTGLLHIIMEYCA-GGDLLNK---
...|.|.|.|....|.|||..|.|.      |..|.|.||..| ||..||. |||| |..| .. |..|...|..|. . |.|.||||  |||| .|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IRNLKKKNQYLDEKVVW---------------L----------DFKCANIMLTRDHK---NLKLGDLNVSKVAKKG--MLYT-QTGTPYYASPEVWRDKP
| . |.|..|..|...|                          | |..||.||....   |.|.||...||| ...  |.|| |.|||||.||||...||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNSKSDVWSLGCVIYELVSL--NPPFKAQ--DMEGLFKKVQKG-QYDPIPSW--YSQDLTDFLSLCLQVNPKMRLTTSELLETPYI
||.|||.||||||.||...|  ..||.|.  .|..|..|..|| ||.||||.  ||||| ...|..||..|..| .....||.|.|
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 24991.AA S_TKc 6-243 27 6.2e-65 222.95 SMART 1-231 (231) Show / Hide 
Range on Protein: 6-243
Range on HMM: 1-231/231
Sequence Identity: 27% (73 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIKMGSLSAKEQENAINEVRFLASLSSQEIIGYKEAFYDEKTGLLHIIMEYCAG--GDLLNKIRNLKK--
....||.|.||...|.|.|... |. .|.| ||         |....|.. | .     |. ....|.|   . |...|||| |  |||.  |.. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

KNQYLDEKVVWL--------------------DFKCANIMLTRDHKNLKLGDLNVSKVAKKGMLYTQTGTPYYASPEVWRDKPYNS-KSDVWSLGCVIYE
......| ...                     | | .||.|..   ..|..|  ....      .|. |||.| .|||    .|.  |.|.||.||..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LVSLNPPFKAQDMEGLFKKVQKGQYDPIPSWYSQDLTDFLSLCLQVNPKMRLTTSELLE-------TPYI
...  |||   .|. .|||.            |... ||.. |||..|. |.|  |.|.        |..
MLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24991.AA Ciliate-E2 6-243 21 3e-54 184.6 In-house 1-365 (365) Show / Hide 
Range on Protein: 6-243
Range on HMM: 1-365/365
Sequence Identity: 21% (81 aa)

FDVIRKLGEGAYSSVFKVRKISNG-----------------------QDYAMKNIKMGSLSAKEQENAIN-EVR----------FLASLSSQEIIGYKEA
...|.|.|.|...||.|.......                       . ||||..|   . ...||. |. |..           | .|..  || ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYDEKTGLLHIIMEYCAGGDLLNKIRNLKKKN-----------------------------------------QYLDE-K-VVWLDFKCANIMLTRDHKN
|.....  . ..|||| ||||.  |.| |||                                          .|| . . ..  | |  ||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

LKLGDLNVSKVAKKG---------------------------------MLYTQTGTPYYASPEVWRDKP---------YNSKSDVWSLGCVIYELVSLNP
.|. |.  || ...                                  | .|. |||.| .||. . |.         |. |.|.||||...||... .|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFKAQDMEGLFKKVQKGQYD-PIP--------------SW--YSQDLTDFLSL----CLQVNPKMRLT-TSELLETPYI
||        ... .....| | |              ||   ||.  |...     .||..|. |.|  ...|. |..
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24991.AA Ciliate-E2-Unclassified 6-243 20 1.2e-51 177.44 In-house 1-352 (352) Show / Hide 
Range on Protein: 6-243
Range on HMM: 1-352/352
Sequence Identity: 20% (71 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIK-MGSLSAKEQEN---------AINEVR--------FLAS---LSSQEIIGYKEAFYDEKTGLLHIIM
. .|...|.|....|.|.......| |||| .| . . . | ..|         ..|.          ...    |... .. .|. ......  . |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCAGGDLLNKIRNLKK-----------------------K---------------NQYLDEK-VVWLDFKCANIMLTRDHK--NLKLGDLNVSK-----
||| ||||.. |.. ||                       |               ...  .. ..  | |. ||... ..|  ..|. |.  ||     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------VAKKGMLYTQTGTPYYA----SPEVWRDKPYN----SKSDVWSLGCVIYELVSLNPPFKAQDMEG----------------LFKKVQK
            . |. |..|..|||.|     .||| . . |.     |.|.||||...||..  ..||.... |                 |... ..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

GQYDPIPSWY-------SQDLTDFLS----LCLQVNPKMRLTTSELLETPYI
....  ...        |.   ||..     .|..||. |.| ...|. |..
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 24991.AA NEK2 150-243 41 4.1e-41 136.13 In-house 226-319 (319) Show / Hide 
Range on Protein: 150-243
Range on HMM: 226-319/319
Sequence Identity: 41% (39 aa)

GTPYYASPEVWRDKPYNSKSDVWSLGCVIYELVSLNPPFKAQDMEGLFKKVQKGQYDPIPSWYSQDLTDFLSLCLQVNPKMRLTTSELLETPYI
||||| |||.  . .|| |||.||.||.|||. .| |||.|     |  |...| ...||. ||..| .  .. . |... |  . |.|. | |
GTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase 24991.AA ULK 6-243 22 4e-40 139.64 In-house 1-324 (324) Show / Hide 
Range on Protein: 6-243
Range on HMM: 1-324/324
Sequence Identity: 22% (72 aa)

FDVIRKLGEGAYS-SVFKVR-KISN--GQDYAMKNIKMGSLSAKEQE--------NAINEVRFLASLS---SQE--IIGYKEAFYDE--KTGLLHIIMEY
. ....||.|..   |.| | |..|  .|..| | | . ... |..|        . .||.. .  |    ..   |. ... |..   .   . |||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNN--IYIIMEY

CAGGDLLNKIRNLKK-----KNQYLD--------------------EKVVWLDFKCANIMLTR-DHKN----------LKLGDLNVSKVAKKG-----ML
| |||| . | . ||     ....|                     ....  | | .||...  ..|.          ||..|   .|.  ..     |.
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

YTQT------GTPYYASPEVWR----DKPYN-SKSDVWSLGCVIYELVSLNPPFKAQDMEGLF----KKVQK----------GQYDPIP----SWYSQDL
.|.       |||.| .|...      |||. .|.|.|||||..||..   .||...  . ..    | ...           . .. .       |...
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

TDFLSLCLQVNPKMRLTTSELLETPYI
 |... .||...| | .  |... | .
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 24991.AA NEK1 114-243 39 1.1e-39 135.41 In-house 129-276 (276) Show / Hide 
Range on Protein: 114-243
Range on HMM: 129-276/276
Sequence Identity: 39% (59 aa)

DFKCANIMLT--RDHK--------------NLKLGDLNVSKVAKKGMLYTQT--GTPYYASPEVWRDKPYNSKSDVWSLGCVIYELVSLNPPFKAQDMEG
| |  || ||  ..                 .||||  ....    |.| .|  ||||| ||| .  |||| |||.|||||| |||. |  || |. .  
DIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKN

LFKKVQKGQYDPIPSWYSQDLTDFLSLCLQVNPKMRLTTSELLETPYI
|  |. .| | |||. ||..|   .|  ...||. |  .  .|| | |
LVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 24991.AA CAMK 116-243 20 1.4e-39 124.73 In-house 206-425 (425) Show / Hide 
Range on Protein: 116-243
Range on HMM: 206-425/425
Sequence Identity: 20% (45 aa)

KCANIMLTRDH----------------KNLKLGDLNVSKVAKKG-------------------------MLYTQTGTPYYAS-PEVWRD-----------
|. ||.|. ..                 |.|. |   ... ..|                         ...|. |||.|.. ||| .            
KPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATD

---KPYNSKSDVWSLGCVIYELVSLNPPFKAQ-------------DMEGLFKKVQKGQYDPIPSW-----------------------YSQDLTDFLSLC
   ..|. |.|.||.|.. | ...  ||| .              ... ||.|..||.|| .|..                        ||.  |... .
EEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKM

LQVNPKMRLTTSELLETPYI
|||.|. |.| .. |. | .
LQVDPEKRMTIEQCLNHPWM
Kinase 24991.AA STE 114-243 26 2.4e-37 129.45 In-house 177-359 (359) Show / Hide 
Range on Protein: 114-243
Range on HMM: 177-359/359
Sequence Identity: 26% (50 aa)

DFKCANIMLTRDHKNLKLGDLNVSK-VAK-----------------KGMLYTQTGTPYYASPEVWR------DKPYNSKSDVWSLGCVIYELVSLNPPFK
| |.|||.|       || |  |.. ...                 ... .| .||| . .||| .      ||.|. |.|.|||||.| |..  .||. 
DIKPANILL------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWH

A-QDMEGLFKKVQK--------------GQYDPIPS-------------------WYSQDLTDFLSLCLQVNPKMRLTTSELLE--TPYI
  ..|. .| . ..              |.  |.|.                    .|... ||...||| .|. | |.|.||.   | |
DMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 24991.AA NEK4 114-243 42 1.1e-33 118.17 In-house 127-257 (257) Show / Hide 
Range on Protein: 114-243
Range on HMM: 127-257/257
Sequence Identity: 42% (56 aa)

DFKCANIMLTRDHKN-LKLGDLNVSKVAK--KGMLYTQTGTPYYASPEVWRDKPYNSKSDVWSLGCVIYELVSLNPPFKAQDMEGLFKKVQKGQYDPIPS
| |  || ||.  || .|.||. .|.|      |  |  ||||| |||..  .||. |||.||||| .||.. |   | | ||  |  .. .||  |.| 
DLKTQNIFLTK--KNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPP

WYSQDLTDFLSLCLQVNPKMRLTTSELLETPYI
 ||||| . .   |.  |. |    ...  |||
NYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 24991.AA Pkinase 107-243 24 1.2e-32 116.52 Pfam 126-293 (293) Show / Hide 
Range on Protein: 107-243
Range on HMM: 126-293/293
Sequence Identity: 24% (42 aa)

DEKVVWLDFKCANIMLTRDHKN---LKLGDLNVSK---VAKKGMLYTQTGTPYYASPEVWR-DKPYNSKSDVWSLGCVIYELVSLNPPFKAQ------DM
.....  | | .||.. ..  .   .|..|  ..|     ... ..| .|||.|..||| | ...| .|.|.||.||..||... .|||. .      |.
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQ

EGLFKKVQKGQYDPI-PSWYS-------------------QDLTDFLSLCLQVNPKMRLTTSELLETPYI
  ..... .....   | |.|                   ... ||.. ||...|| |.|  ..|. |..
MQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 24991.AA NEK1 6-108 37 1.3e-24 82.37 In-house 1-103 (276) Show / Hide 
Range on Protein: 6-108
Range on HMM: 1-103/276
Sequence Identity: 37% (39 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIKMGSLSAKEQENAINEVRFLASLSSQEIIGYKEAFYDEKTGLLHIIMEYCAGGDLLNKIRNLKKKNQY
...|...|||..  ...|.. . || |..| |.    . || |.. |||  || .    |..|||.|  .  |.| |.|||| ||||  || . | |.. 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LDE
  |
FSE
Kinase 24991.AA STE20 147-243 34 1.5e-22 79.39 In-house 181-288 (288) Show / Hide 
Range on Protein: 147-243
Range on HMM: 181-288/288
Sequence Identity: 34% (37 aa)

TQTGTPYYASPEVWRD-----KPYNSKSDVWSLGCVIYELVSLNPPFKA-QDMEGLFKKV--QKGQY-DPI--PSWYSQDLTDFLSLCLQVNPKMRLTTS
|  ||||. .||| .      |.|..|.|.||||  . |..  .||.   . |  .|..   |..   .    |. .|... ||...|||..|. | |.|
TFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTAS

ELLETPYI
.||. |.|
QLLKHPFI
Kinase 24991.AA NEK2 6-112 32 5.8e-22 70.64 In-house 1-107 (319) Show / Hide 
Range on Protein: 6-112
Range on HMM: 1-107/319
Sequence Identity: 32% (35 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIKMGSLSAKEQENAINEVRFLASLSSQEIIGYKEAFYDEKTGLLHIIMEYCAGGDLLNKIRNLKKKNQY
 .|   .|.| . .. ||| .| |   . | |. |..  ||    ..|.  |  |  . |. |     |...  | |.||||.||||   |   .|  ||
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LDEKVVW
..|...|
MEEEFIW
Kinase 24991.AA Pkinase 6-97 25 6.4e-20 71.52 Pfam 1-96 (293) Show / Hide 
Range on Protein: 6-97
Range on HMM: 1-96/293
Sequence Identity: 25% (25 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIKMGSLSAKEQENAIN--EVRFLASLSSQEIIGYKEAFYDEKTGLLHIIMEYCAGG----DLLNKIR
. ..||.|.|....|.| .....|. .|.| ||  . . ........  |.. ...|..  |. ....|.|   . ....|||| ||    ||   |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIS
Kinase 24991.AA NEK4 6-111 33 1.3e-18 63.57 In-house 1-104 (257) Show / Hide 
Range on Protein: 6-111
Range on HMM: 1-104/257
Sequence Identity: 33% (35 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIKMGSLSAKEQENAINEVRFLASLSSQEIIGYKEAFYDEKTGLLHIIMEYCAGGDLLNKIRNLKKKNQY
.. ..  | | |  |. ||.   .  | || ...   | .|.  |  |.. |  |    |. ||| .  |   .| |.| .| |||| .| .  ..||| 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLK--QQKNQF

LDEKVV
|.|. |
LEEYQV
Kinase 24991.AA STE20 6-90 24 1e-17 61.59 In-house 1-93 (288) Show / Hide 
Range on Protein: 6-90
Range on HMM: 1-93/288
Sequence Identity: 24% (23 aa)

FDVIRKLGEGAYSSVFKVRKISNGQD----YAMKNIKMGSLSA--KEQENAINEVRFLASLSSQEIIGYKEAFYDEKT--GLLHIIMEYCAGG
.. ..|.|.|.| .|.|......|.     .| | ... . .   .|.|. ..|..... . .. |. | .... ..|    | |.||||.||
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGG
Kinase 24991.AA STE 6-111 16 1.4e-17 58.78 In-house 1-153 (359) Show / Hide 
Range on Protein: 6-111
Range on HMM: 1-153/359
Sequence Identity: 16% (25 aa)

FDVIRKLGEGAYSSVFKVRKI------SNGQD---------YAMKNIKMGSLSA---------------KEQENAINEVRFLASLS--SQEIIGYKEAFY
.. |.|.|.||. .|.| ...      ..|.          .|.| ... . ..               .|... ..|....  ..  .. |. |  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DEK-----TGLLHIIMEYCAGGDLLNKIRNLKKKNQ----------YLDEKVV
.|       . |.|.|||..|| |   |.. .....          ...|...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQI
Kinase 24991.AA CAMK 11-111 15 7.4e-16 46.89 In-house 1-181 (425) Show / Hide 
Range on Protein: 11-111
Range on HMM: 1-181/425
Sequence Identity: 15% (28 aa)

KLGEGAYSSVFKVRKI-SNG-----------QDYAMKNIKMGSLS--------------------------AKEQENAINEVRFLASLS-------SQEI
.||.|... |.... . ..|           | .|.| |.   |.                          .| ..|  .|.. . .|.          |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGYKEAFYDEK-----------------TGLLHIIM---EYCAGG----DLLNKIRNLKKKN-----------QYLDEKVV
|   |.. |..                 .  ....|   ||| ||    ||...|.  ...             ...|. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA
Kinase 24991.AA TyrKc 6-247 18 1e-13 -0.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 6-247
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FDVIRKLGEGAYSSVFKVRKISNGQDYAMKNIKMGSLSAKEQENAINEVRFLASL--SSQEIIGYKEAFYDEKT-----GLLHIIMEYCAGGDLLNKIRN
   ..||||||.  |.| . .   .. | | .| ..     .|  ..| | . .|  . . |.    .  ...      . | |.|||...|||.. .|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LKKKNQYLDEKVVWL------------------DFKCANIMLTRDHKNLKLGDLNVSKVAKKG-------MLYTQT---GTP-----YYASPEVWRDKPY
 ..|   ..... .                   |  . |......|   | .|   |.  . .         |...   |.         .||..... .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NSKSDVWSLGCVIYELVSL-NPPFKA-----QDMEGLFKKVQKGQYDPIPSW--------YSQDLTDFLSLCLQVNPKMRLTTSELLETPYIQRRL
..|||||| | ...|. ..  .|         . . ....|..| . |.|           .... .  . | . .|..| | ||.       ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase 24991.AA Pkinase_Tyr 156-239 26 1.2e-08 29.97 Pfam 182-268 (270) Show / Hide 
Range on Protein: 156-239
Range on HMM: 182-268/270
Sequence Identity: 26% (23 aa)

SPEVWRDKPYNSKSDVWSLGCVIYELVSLN-PP-FKAQDMEGLFKKV-QKGQYDPIPSWYSQDLTDFLSLCLQVNPKMRLTTSELLE
.||..... ...|||||| | ...|....   | ..  . | ..... ..|.  |.|   .... | . .| . .|..| | ||..|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHE
Kinase 24991.AA Pkinase_Tyr 82-98 52 0.009518 9.93 Pfam 84-100 (270) Show / Hide 
Range on Protein: 82-98
Range on HMM: 84-100/270
Sequence Identity: 52% (9 aa)

IIMEYCAGGDLLNKIRN
|.|||...||||.  |.
IVMEYMPHGDLLDYLRK
Kinase 24991.AA Pkinase_Tyr 6-22 47 0.763854 3.48 Pfam 1-17 (270) Show / Hide 
Range on Protein: 6-22
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FDVIRKLGEGAYSSVFK
   ..||||||. .|.|
ITFGKKLGEGAFGEVYK