Gene 22242 (Tetrahymena)

22242

Species: Tetrahymena
Alias: 3701.m01481, 503, 18.m00268, PreTt22242, TTHERM_00216170, 22242
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
22242.AA Protein None 287 None Fasta, JSON
22242.NA RNA None 867 None Fasta, JSON
22242.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of 22242.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22242.AA NEK 12-266 47 8.99999999999e-155 520.48 In-house 1-286 (286) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-286/286
Sequence Identity: 47% (135 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNV-----YVMKQINISKMNSRMKQDAI-NEVHILSKLNNPYVVKYYDSFVDKN--LLCIVMEYCD-SGDLSSF---
.. . |.||||||.||||.|  ||..     ||.|.||...|... ||.|. |||.||..|..|..|||||||....   ||||||||.  |||. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IKSQL--GRPLQEMKIWKYFIMSCMGLDYIHRK-----KILHRDIKAMNIFLNKDDS----LRIGDLGVAKVLSDQGNFAST-MVGTPFYLSPEMCEEKP
|| |   | ...|..||..||  |..|.|.| .     |||||||| .||||.|...    ..|||.|..|||..   .|.| .|||| |.|||.|..||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNEKSDIWSLGCVLYELCTY--RHPFEAQ--NQGALVLRIIRG-KYNPIPTS--YSKDLVSMVDMCLCKDYKKRPNARDILQTQRS
||.|||||||||||||.||   .|||||.  |. .|...|..| .|.|||    ||.|| ... ..|.|| ..||....||..   
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 22242.AA NEK1 12-267 44 5.9e-112 378.24 In-house 1-276 (276) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-276/276
Sequence Identity: 44% (122 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNL--LCIVMEYCDSGDLSSFIKSQ--LGRP
.. . ..|.|||| ...||.  || .||.| ||..|| .  .... ||| ||.|.  | .|||..||.      | ||||||| |||   |. |   | .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LQEMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLN--KDD---------------SLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNE
 .|  |  .|.  |..| .|| .||||||||. ||||   |..                ...|| |.|..|..   .|.| .||| |||||.|. |||| 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCVLYELCTYRHPFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQTQRSV
||||||||||||||||  |||||.|  .|||.|..| | |||  ||..| | |   . .. . || . .|| .. ..
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQIL-ERPFI
Kinase 22242.AA NEK8 18-261 38 6.8e-110 314.95 In-house 7-273 (278) Show / Hide 
Range on Protein: 18-261
Range on HMM: 7-273/278
Sequence Identity: 38% (103 aa)

LGQGSFGVVYKVKRVVDG--NVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSGDLSSFIKSQLGRPLQEMK---
.|.|.||..    |  |.     . |||| . | ..  |.| ||. .||.|. | .. |||.| . | | |.|||.| | |  .| .| .  . |..   
VGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLK

--------------IWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKD-DSLRIGDLGVAKVLSDQGNFA-S-TMVGTPFYLSPEMCEEKPYNEKSDIW
              |  ||.  | .. ..| . |||||.|  |||....   . ||| | .|....    . . | |||| |.|||||| ||||.|||.|
QVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMW

SLGCVLYELCTYRHPFEAQNQGALVLRIIRG-KYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDIL
.|||||||.|. .  ||| |. |||. |... .|.||.  ||... ..|  || .|  .|| |  |.
ALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIM
Kinase 22242.AA NEK4 12-266 39 2.1e-93 316.64 In-house 1-257 (257) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-257/257
Sequence Identity: 39% (102 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSF-VDKN-LLCIVMEYCDSGDLSSFIKSQLGRPLQ
.. .   |.||.| |. |.   |.  |||| ..  .  .| ...|  |. .||.|  | .|.| .|.  . . .|.||| .|..|||    | | .  |.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRH
|  .   |.   |.| |.|.|.||||| |  |||| |   ..|||.|...|| . ...|.||.|||.|.|||.   .||. ||||||||| .||. | .|
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

PFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQTQRS
 |.| .   |. .|| |.  |.|  ||.||  .|   | |  .|||  .||.|    
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 22242.AA S_TKc 12-266 31 1.9e-89 304.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDS--GDLSSFIKSQLGRP--
.. | |.|.|.||.|||.. . .| .. .|.|.         .....|. ||.| . |..||.||.|.| . |..||||||   ||| ..||.. ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LQEMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNE-KSDIWSLGCVLYEL
  . |  ...|.   | .|.|.|...|.|||.|  ||.|..   . |.| |.|..|       .|..|||.|..||..   .|.  |.|.||.||.|||.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

CTYRHPFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQ-------TQRS
.. . ||.   | ......|.          |... .... ||.|| .||| | ..||        .  
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22242.AA NEK2 12-266 32 6.3e-78 261.97 In-house 1-319 (319) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-319/319
Sequence Identity: 32% (105 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKN--LLCIVMEYCDSGDLSSFI---KSQLGR
 . |. .|.||||...||.|  || . | | |.  .|..  .|  ..|. ||..|  |..|.|||  .|.    | ||||||  ||||. |   ...  .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

PLQEMKIWKYFIMSCMGLDYIHR------------------KK---ILHRDIKAMNIFLNKDDS------------------------------------
 . |  ||. .   |  |  .|.                  .    |||||||  ||||  |..                                    
-MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYS

---LRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRHPFEAQNQGALVLRIIRGKYNPIPTSYSKDLVSMVDMC
      || | |..|     || | ||||.| |||  .  .|||||||||.||..||.|. . ||.| || .|   |  |....||  ||..|   .   
QVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFM

LCKDYKKRPNARDILQTQRS
.  | ..||.   |||  . 
INVDHYHRPSIEEILQHPQI
Kinase 22242.AA Pkinase 12-263 30 3.2e-76 264.32 Pfam 1-290 (293) Show / Hide 
Range on Protein: 12-263
Range on HMM: 1-290/293
Sequence Identity: 30% (90 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAIN--EVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSG----DLSSFIKSQLG
. ...|.|.||||.||| ... .| ....|.|. .. .| ..| ...  |..|. .|| |..|..||.| ||. ...|||||. |    ||...|. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPL--QEMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSL----RIGDLGVAKVL-SDQGNFASTMVGTPFYLSPEMCE-EKPYNEKSDIWSL
...  .|  . .|.   . ||.|.|...|.|||.|  ||...... .    .|.| |.||..    .  ..| .|||.|..|| .   ..|  |.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYELCTYRHPFEAQ------NQGALVLRIIRGKYNPI-PTSYS-------------------KDLVSMVDMCLCKDYKKRPNARDILQT
||.|||... | ||  .      .| ... || ....    |...|                   ... . .. ||||| ||||.|..||| 
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH
Kinase 22242.AA STE 12-262 24 4.8e-73 248.98 In-house 1-353 (359) Show / Hide 
Range on Protein: 12-262
Range on HMM: 1-353/359
Sequence Identity: 24% (89 aa)

FDTLGKLGQGSFGVVYKVKRVV---------------DGNVYVMKQINISKMNS---------------RMKQDAINEVHILSKLN--NPYVVKYYDSFV
.. ..|.|.|.||.||| ...                 |... .||.|... |.                 .|. ..|. |..|.|   |..||||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DK-------NLLCIVMEYCDSGDLSSFIKS--QLGRPLQ----------EMKIWKYFIMSCMG-LDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAK
..       . |.|.|||.| | |...||.    |.||.          |  | ..    . | |.|.|...| |||||. ||.|       . | ||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VLSD----------------QGNFASTMVGTPFYLSPEMCEE------KPYNEKSDIWSLGCVLYELCTYRHPFEAQNQGALVLRIIRG-----------
 |.|                ..    |.|||| . .||. .       |.|..|.|||||||.. |..| ..|.   .     ..|...           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KYNPIPT-------------------SYSKDLVSMVDMCLCKDYKKRPNARDILQ
    .  |.|.                   ..|...   .. || ||..|||.| . |.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase 22242.AA NEK-Unclassified 12-267 35 3e-72 238.45 In-house 1-258 (258) Show / Hide 
Range on Protein: 12-267
Range on HMM: 1-258/258
Sequence Identity: 35% (93 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSGDLSSFIKSQLGR--PLQ
.| .  ||||  | || |.  .     | .   |||   . |    | . |||.|  | .| | ||| .   |    .||| |.|   |. . ..  |. 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKRKKKKKRQ--NKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYRH
|  | . .|   | . ||| .||.||| |  |||| .|| . .|| |..... .    | | |||. ..||| |...|||..||.|||||..||.||.  
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

PFEAQNQGALVLRIIRGKY------NPIPTSYSKDLVSMVDMCLCKDYKKRPNARDILQTQRSV
 | ..| | .   | ..         |.   || ||  ..   | ... .|| | .|.  |  .
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVE-QDYI
Kinase 22242.AA NEK6 12-257 39 2.7e-68 223.81 In-house 1-252 (252) Show / Hide 
Range on Protein: 12-257
Range on HMM: 1-252/252
Sequence Identity: 39% (100 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKM-NSRMKQDAINEVHILSKLNNPYVVKYYDSFVDKNLLCIVMEYCDSGDLSSFIK--SQLGRPL
|    |.|.| |  ||. . ..|. .  .|.. |  |   . .|| | |. .| .|| | |.|||.||.. | | ||.|  | ||.|  ||   . .| .
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

QEMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQGNFASTMVGTPFYLSPEMCEEKPYNEKSDIWSLGCVLYELCTYR
 |  |||||.  |  |. .| |...|||||  |.|.  .   ..||||. .  | .   |  .||||.|.|||  .|. || |||||||||.|||.    
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQ

HPF--EAQNQGALVLRIIRGKYNPIPTS-YSKDLVSMVDMCLCKDYKKRPNA
 ||  .  |  .|  .| .  | |.|.  ||..|  .| ||.. | ..||. 
SPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 22242.AA Ciliate-E2 12-266 22 1.2e-63 217.35 In-house 1-365 (365) Show / Hide 
Range on Protein: 12-266
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVY------------------VMKQINISKMNSRMKQDAINEVHIL----------------SKLNNPYVVKYYDS
.. . |.|||.||.|||.|.  ... .                   .|....  |. ....   .| ||.                ..||.|...|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--DKNLLCIVMEYCDSGDLSSFIKSQ----------LGRPLQEMKIWKYFIMSC---------------MGLDYIHRKK-ILHRDIKAMNIFLNKDDS
|   |.| . .|||||. ||| ..||..             .. | .| ...   .                .| |.| |. |.|||||  ||..     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LRIGDLGVAKVLSDQ----------G---------------------NFASTMVGTPFYLSPEMCEEKP---------YNEKSDIWSLGCVLYELCTYRH
. | |.| .| ..|.          .                     | . | .||| |..||. . |.         |..|.||||||..|||... ..
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFEAQNQGALVLRIIRG-KYN-P----------------IPTSYSKDLVSMVDM----CLCKDYKKRPN-ARDILQTQRS
||         ...|   |.. |                .. . |..   .       .|.|| .||.. . .||. .  
PF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 22242.AA Ciliate-E2-Unclassified 12-262 24 7.7e-62 211.76 In-house 1-348 (352) Show / Hide 
Range on Protein: 12-262
Range on HMM: 1-348/352
Sequence Identity: 24% (84 aa)

FDTLGKLGQGSFGVVYKVKRVVDGNVYVMKQINISKMNS--RMKQ--------DAINEVH-------------ILSKLNNPYVVKYYDSFVDKNLLCIVM
.  . ..|||.||.|||...  .. .|.||... .....   ...        ...|.               ||. ...|..||... | ||. ..|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCDSGDLSSFIKSQLG---------------RPLQEMKIW-----KYFIMSCMGLDYIHRKK-ILHRDIKAMNIFLNKDD---SLRIGDLGVAKVLSDQ
|||. |||. .||.. .               . ..| ..      .||   . ||.|.|.|. |.|||||  ||.....     ..| |.| .| . ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

GNF---------------ASTMVGTPFYL----SPEMCEEKPYN----EKSDIWSLGCVLYELCTYRHPFEAQNQGA---------------LVLRIIRG
 |.               ..|..||| |.    .||. ... |.    .|.||||||..|||... ..||...|.                  ....|  
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

K------YNP--IPTSYSKDLVSMVD----MCLCKDYKKRPNARDILQ
|      ...  ||   |.    ..      .| |. .||... .||.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 22242.AA Pkinase_Tyr 12-207 25 2.5e-25 86.4 Pfam 1-210 (270) Show / Hide 
Range on Protein: 12-207
Range on HMM: 1-210/270
Sequence Identity: 25% (53 aa)

FDTLGKLGQGSFGVVYKVKRV-----VDGNVYVMKQINISKMNSR-MKQDAINEVHILSKL-NNPYVVKYYDSFV-DKNL--LCIVMEYCDSGDLSSFIK
   . |||.|.||.||| .        .  |   | .. . | .  ...| ..|. |...| ..| .|..|   . ..    ..|||||.  ||| .. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SQ--LGRPLQEMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVL--SDQG-NFASTMVGTPFYLSPEMCEEKPYNEKSDIWS
..   ..||    . .. .  ..|..| ..|.. |||. | |. ....   .|.| | |. .   |.    ..      . ..||   .. ...|||.||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

LGCVLYELCTY
 | ...|..||
FGVLMWEIFTY
Kinase 22242.AA TyrKc 12-264 21 1.7e-22 82.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-264
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FDTLGKLGQGSFGVVYK--------VKRVVDGNVYVMKQINISKMNSRMKQDAINEVHILSKL--NNPYVVKYYDSFVDK-------NLLCIVMEYCDSG
   . ||| | ||.|||        || . ..                 ..| ..|  |..||  ..| .|. |   ...         |.|||||.. |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLSSFIKSQLGRPLQEMKIWKYFIMSCMGLDYIHRKKILHRDIKAMNIFLNKDDSLRIGDLGVAKVLSDQ---GNFASTMV-----GTP-----FYLSPE
|| .....  .. |.  .  .. .  . | .|.|.|.. |||. | |. ....   .|.| | .. . |    |   .. .     |.        ..||
DLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

MCEEKPYNEKSDIWSLGCVLYELCTY-RHPFEA-----QNQGALVLRIIRGKYNPIPTS--------YSKDLVSMVDMCLCKDYKKRPNARDILQTQ
   .. ...|||.|| | ...|..||   | .       .   .. .. .|.. |.| .         .... ..  .|   | ..||. ..| .  
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF