Gene 1924 (Tetrahymena)
1924
Sequence
Protein domains of 1924.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 1924.AA | NEK | 4-254 | 41 | 2.3e-117 | 396.21 | In-house | 1-286 (286) | Show / Hide |
Range on Protein: 4-254 Range on HMM: 1-286/286 Sequence Identity: 41% (120 aa) YDKVKLVCKIEMGDVFLVEEK-TSKH---------RIFIDER-EQQTYHPE-NEAKLLEQLDHPNIIKMQEHFYHKK--YFCLIMEFAE-KGDLNKL--- |...| . . | |..|. | ..|| .| ... |... ||...|.||.||||.| ..|.... ..| .||..| .||| .. YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS ILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDR-----KYIHRDIKIHNIFLSNENI----VKLGDFGISIQLDKSEIYAKT-QLGTPYYLSPEVVQGKN | . ||| .|. |.|..| |.|.|||.||.||| | .||||| ||||...|. ||.|||||| .|... .|.| | |||||.||||.|.| IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP YDQKVDIWMIGCFLYEICEL--SRPFQGA--TWSEVDYKIQNI-EPEPIDES--YSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI |..|.|||..|| |||.| | .||.. . . .||.. ...|| . ||| ||||. ..|||||.||||.|.|.||| | YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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Kinase | 1924.AA | NEK1 | 44-254 | 41 | 1.5e-78 | 267.26 | In-house | 47-276 (276) | Show / Hide |
Range on Protein: 44-254 Range on HMM: 47-276/276 Sequence Identity: 41% (96 aa) NEAKLLEQLDHPNIIKMQEHFYHKKY--FCLIMEFAEKGDLNKLILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLS--NEN--- ||...|. ..||||.| .| | . .||... |||.. | . | | | | .. |||.|||... |||| .||||| ||||. . NEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGS ------------IVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQGATWSEVDYKIQNIEPEPIDESYS .||||||||. | . ||.| .||||||||| | | |..| ||| || ||| | |..||... | || || || GSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYS QFLQNLVKKLLQKDPQQRPSINDIIEMPEI . ||.||.......|. |||.|.| | | | YELQSLVSQMFKRNPRHRPSVNQILERPFI |
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Kinase | 1924.AA | NEK8 | 44-254 | 39 | 5.1e-71 | 201.95 | In-house | 49-278 (278) | Show / Hide |
Range on Protein: 44-254 Range on HMM: 49-278/278 Sequence Identity: 39% (91 aa) NEAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKGDLNKLILNLKQ---KEE------------YLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIH || .| |.||||| .|| . || |. | | .|. . || | ||...|. | | |.|| ..|. |||.| NEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQ NIFLSNE-NIVKLGDFGISIQL-DKSEIY-AKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQGATWSEVDYKIQNI-EPEPIDESYS |||. ..||.|||||| . .|. . .|| .|||||.||| ..|| |.|| |.| .|| ||| | | | | .. ... || . |||.. || NIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYS QFLQNLVKKLLQKDPQQRPSINDIIEMPEI . || .||.||.|||| | || . NEMRMLVHNCLQQDPEQRPSASQIMAMPLC |
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Kinase | 1924.AA | NEK4 | 4-254 | 40 | 4.3e-69 | 235.87 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 4-254 Range on HMM: 1-257/257 Sequence Identity: 40% (107 aa) YDKVKLVCKIEMGDVFLVEEKTSKHR-----IFID--EREQQTYHPENEAKLLEQLDHPNIIKMQEHFYHKKY--FCLIMEFAEKGDL-NKLILNLKQKE |. .| | | |.|.|| .. | . .| .|. .. | ||.|| || ||||.. | . . .| | | ||| .|| .|| YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRR-ERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL---KQQKN EYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEIC . | |.||.. | | .| |.|... .||| | |||| ||.|.|||||| |. . .||| .|||||.|||. . || | ||| .|| .||. QFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI ELSRPFQGATWSEVDYKIQNIEPEPIDESYSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI | |. |.| . | |. ||| |||||...|.| |..|||| ||. || | TLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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Kinase | 1924.AA | S_TKc | 4-254 | 26 | 1.4e-64 | 221.73 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-254 Range on HMM: 1-231/231 Sequence Identity: 26% (70 aa) YDKVKLVCKIEMGDVFLVEEKTSKHRI---FIDEREQQTYHPENEAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEK--GDLNKLILNLKQ--KEEYL |...... | .| |... .| .... |. | ..| ..|.. .||||.|. ..|.. ......||... ||| ..| . . . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF NEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQ-KVDIWMIGCFLYEICEL .| .. ...|.|.|..|.|... ||||.| ||.|.. .|..|||.. || .|. |||.|..|||. |. |.|.| .|| ||| . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG SRPFQGATWSEVDYKIQNIEPEPIDESYSQFLQNLVKKLLQKDPQQRPSINDIIE-------MPEI ||. ... ...| ..... ...|.|||||..||.. .. . .| . YPPFP-----QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 1924.AA | Ciliate-E2 | 4-254 | 24 | 2.1e-60 | 206.05 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 4-254 Range on HMM: 1-365/365 Sequence Identity: 24% (93 aa) YDKVKLVCKIEMGDVFLVEE--------------------------------KTSKHR-IFIDEREQQTY----HPE----NEAKLLEQLDHPNIIKMQE |...|. .. |.|.... |. |.. |.. ..|.. . . . || ..||||.||||||| | YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE HFY--HKKYFCLIMEFAEKGDLNKLILNLKQKE-------EYLNEKQVLDLFCQLCL---------------AVKYLHDRK-YIHRDIKIHNIFLSNENI .|. .... |.||... ||| ..| | |.|. .|..||...... |.. |..||| .. |||||| ||.. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- VKLGDFGISIQLDKSEI-------------------------------YAKTQLGTPYYLSPEVVQGKN---------YDQKVDIWMIGCFLYEICELSR .|. |||.| ..|.... ..|..|||.|..||...||. || |.||| .|. ||| . . IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFQGATWSEVDYKIQNIE------PEP--------------IDESYSQFLQNLVKK----LLQKDPQQRPS-INDIIEMPEI || .|.|. |.| . .. || ..| || .|||||..|.. ...|.. | . PF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 1924.AA | Pkinase | 33-254 | 25 | 5.9e-58 | 203.64 | Pfam | 36-293 (293) | Show / Hide |
Range on Protein: 33-254 Range on HMM: 36-293/293 Sequence Identity: 25% (67 aa) DEREQQTYHPEN--EAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKG----DLNKLILNLKQKEEYL--NEKQVLDLFCQLCLAVKYLHDRKYIHRD .|.... .. . |.... |.||||... . |. |.. ...||..|.| || .| ... . |... . . |.. ...|.|... |||| HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRD IKIHNIFLSNENIV----KLGDFGISIQ--LDKSEIYAKTQLGTPYYLSPEVVQ-GKNYDQKVDIWMIGCFLYEICELSRPFQGA----TWSEVDYKIQN .| ||...|.. . |..|||.. | . ... ..| |||.|..|||.. |. |..|||.| .|| ||| . ||.|. . . ...|.. LKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICR IEPEPIDESYS-----------------------QFLQNLVKKLLQKDPQQRPSINDIIEMPEI | . |...... . .. ..|..|.|||..||.. .| . | . IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 1924.AA | ULK | 43-254 | 26 | 3.5e-55 | 189.65 | In-house | 58-324 (324) | Show / Hide |
Range on Protein: 43-254 Range on HMM: 58-324/324 Sequence Identity: 26% (71 aa) ENEAKLLEQLD---HPN--IIKMQEHFYHK--KYFCLIMEFAEKGDLNKLILNLKQ-----KEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNI .|| ... .|. ||| |.|. . |. . .....|||. . ||| ..| . | .. .|.|.... | |.| . |.||....|||||| || KNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNI FLSNEN------------IVKLGDFGISIQLD---KSEIYAKTQL------GTPYYLSPEVVQ----GKNYD-QKVDIWMIGCFLYEICELSRPFQGATW ..| . ..|..||| . ..| ... .|.. |||.| .|...| .|.|. |.||| .|| .||. . ||.. LIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-F SEVD----------------YKIQNIEPEP--IDESYSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI .. . | |.|.. . | |. ...| ...||.|. .| |. .|...| . NDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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Kinase | 1924.AA | NEK-Unclassified | 4-254 | 33 | 7.7e-55 | 179.86 | In-house | 1-258 (258) | Show / Hide |
Range on Protein: 4-254 Range on HMM: 1-258/258 Sequence Identity: 33% (86 aa) YDKVKLVCKIEMGDVFLVEEKTSKHRIF--IDEREQQTYHPENEAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKGDLNKLILNLKQKEEYLNEKQV |||. . . | |.|| . || . | | .. | .| || || |. . |. .. . |.| ..| | | ..| . YDKITTLGQGGGGAVYLVRHQISKRHLVQQISKRKKKKKR-QNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRI LDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQG . |. || | | || |||| | |||| . .| .|||||| .| |.| ||. ..||||.| . |. . |.| || .||.| | MQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDT ATWSEVDYKIQNIEP------EPIDESYSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI || .|| . ||. || ||.... .|....||||| .|.|.. | HNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI |
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Kinase | 1924.AA | CAMK | 43-250 | 21 | 1.3e-54 | 174.01 | In-house | 79-421 (425) | Show / Hide |
Range on Protein: 43-250 Range on HMM: 79-421/425 Sequence Identity: 21% (74 aa) ENEAKLLEQ-------LDHPNIIKMQEHFYH-------------------KKYFCLIM---EFAEKG----DLNKLILNLKQKE-----------EYLNE ..| ... . ||||||||. |.. .|.....| |... | || | ... ...| RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTE KQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNE-----------------NIVKLGDFGISIQLDKSE-----------------------IYAKT ... .| |.| ||.|.|... .|||.| || |.. | .|. ||| ....|..| || REARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKT QLGTPYYLS-PEVVQGKN--------------YDQKVDIWMIGCFLYEICELSR--PFQGATWSEVDY-------------KIQNIEPEPIDES------ . |||.| . |||..|| |..|.|.| .|. || |. ||.| . .| ||.. . . ... FCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM--LCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISC -----------------YSQFLQNLVKKLLQKDPQQRPSINDIIE || ..|..|.||.||..|..| .. . NYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN |
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Kinase | 1924.AA | ULK | 43-254 | 26 | 1.5e-54 | 187.58 | In-house | 58-329 (329) | Show / Hide |
Range on Protein: 43-254 Range on HMM: 58-329/329 Sequence Identity: 26% (71 aa) ENEAKLLEQLD--------HPNIIKMQEHFYHK--KYFCLIMEFAEKGDLNKLILNLKQ------KEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIK .|| |.. .|. ||||.|. . |. . ... .|||. . ||| ..| . | .. .|.|.... |.|.. . |.||....|||||| KNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIK IHNIFLSNEN------------IVKLGDFGISIQLDKS--EIY-AKTQL------GTPYYLSPEVVQ----GKNYD-QKVDIWMIGCFLYEICELSRPFQ || ..| . ..|..||| . ..|.. |. ..|.. |||.| .|...| .|.|. |.||| .|| .||. ||. PQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY GATWSEVD-----YKIQN-------IEPEPIDES-------YSQFLQNLVKKLLQKDPQQRPSINDIIEMPEI . .. . |.| |. .|.. |. ...| ...||.|. .| |. .....| . AW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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Kinase | 1924.AA | NEK11 | 45-254 | 38 | 2.3e-50 | 173.63 | In-house | 51-259 (259) | Show / Hide |
Range on Protein: 45-254 Range on HMM: 51-259/259 Sequence Identity: 38% (81 aa) EAKLLEQLDHPNIIKMQEHFYHKKYFCLIMEFAEKGDLNKLILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFG ||.|| .|.|| |.. | . ||.| |. | || | || | |... | || | | |.|.|. .|||.| |||| | |..|.|||| EAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKN-NLLKIGDFG ISIQLDKSEIYAKTQLGTPYYLSPEVVQGKNYDQKVDIWMIGCFLYEICELSRPFQGATWSEVDYKIQNIEPEPIDESYSQFLQNLVKKLLQKDPQQRPS .| | | | | ||| |.||| .. . || | ||| . | |||.| . | |. . . .| . . . | . | .. ..| |.| ||| VSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPS INDIIEMPEI ||. .| . AIDILKIPYM |
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Kinase | 1924.AA | Pkinase_Tyr | 44-207 | 26 | 1.2e-22 | 77.28 | Pfam | 52-224 (270) | Show / Hide |
Range on Protein: 44-207 Range on HMM: 52-224/270 Sequence Identity: 26% (45 aa) NEAKLLEQL-DHPNIIKMQEHFY-HKKY--FCLIMEFAEKGDLNKLILNLKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVK .|||.. || .||||... . ... ...||....||| . . . .. |. |. |. | . . ||.....||||. |. ....|.|| REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK LGDFGISIQLDKSEIY--AKTQLGTPY-YLSPEVVQGKNYDQKVDIWMIGCFLYEICELS-RP-FQGATWSEV .||| . . . . | ... | ..||. . . . | |.|. | ..||. . | ..| . .|| ICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEV |
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Kinase | 1924.AA | TyrKc | 7-252 | 20 | 1.2e-16 | 46.25 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 7-252 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) VKLVCKIEMG---DVFLVEE------KTSKHRIFIDEREQQTYHPENEAKLLEQL--DHPNIIKMQEHFYHK-------KYFCLIMEFAEKGDLNKLILN ..| |. | |.. . |. |. .. . .||... .| .||||... .. . ...||....|||.. . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFM--REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK LKQKEEYLNEKQVLDLFCQLCLAVKYLHDRKYIHRDIKIHNIFLSNENIVKLGDFGISIQLDKS-------EIYAKTQ--LGTP----YYLSPEVVQGKN . | |. |. |. | . |||....||||. |. ......|| .||| | .. . | |.. | ..||. . . HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YDQKVDIWMIGCFLYEICEL-SRPFQG-----ATWSEVDYKIQNIEPEPIDES--------YSQFLQNLVKKLLQKDPQQRPSINDIIEMP . | |.|. | ..||. . | | ...|| .... . |. .. .. . .. |. . || .||. ..|.| FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |