Gene 18448 (Tetrahymena)

18448

Species: Tetrahymena
Alias: 920, TTHERM_00721400, 18448, PreTt18448, 115.m00104
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
18448.AA Protein None 492 None Fasta, JSON
18448.kin_dom Protein Kinase Domain None 254 None Fasta, JSON
18448.NA RNA None 1479 None Fasta, JSON

Protein domain

Protein domains of 18448.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18448.AA NEK 9-265 44 4.4e-160 538.1 In-house 1-286 (286) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-286/286
Sequence Identity: 44% (127 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQV-----YALKKVKLRELSYKEKENAL-NEIRILASINSPHIIRYKDAFYDNASGCLCIVMEYAE-NGDLMAK---
. ..|..|.|.|..||||.||.||..     |..||... ..| |||.||. ||.|||.....|.|..|.|.|... ..||||||||.| .|||. |   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LQDYKKRNMFMDEAKIWKYAAQILLGLKSLHDL-----KILHRDLKCANIFLGANNK----VKLGDLNVSKIMKRD--LAYT-QTGTPYYTSPEVWQNQP
.. .|... ...| .||.. .|..|.|| .||      ||||||.|..|||| .||.    ||.||...||.....  .||| |.||||| ||||.||.|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDSKCDVWSMGCVLYELMAHHP--PFEAK--SMEELYKKVCKG-TYQKLPKQ--YSQEMNDFINLCLRKNPKQRPSVNSLLEFQGL
|..|.|.|| ||||||... .|  ||||.  .|..||.|..|| .|...|..  |||.....|...|.|.|.||||.|..||.  .
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 18448.AA NEK1 9-265 40 1.9e-93 316.73 In-house 1-276 (276) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-276/276
Sequence Identity: 40% (111 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALNEIRILASINSPHIIRYKDAFYDNASGCLCIVMEYAENGDLMAKLQDYKKRNMF
. ..|..| |.|  ...|..| |||.|..|  .. . . ||.|...||  |||    | |..||..|  | .| | |||||...|||| | .  | ..  
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

MDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLG--ANN---------------KVKLGDLNVSKIMKRDLAYTQT--GTPYYTSPEVWQNQPYDS
  |  |  .  || |.|.  || ||||||.|  ||||    |                .|||||  .....   ..| .|  ||||| ||| .||.||. 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KCDVWSMGCVLYELMAHHPPFEAKSMEELYKKVCKGTYQKLPKQYSQEMNDFINLCLRKNPKQRPSVNSLLEFQGL
| |.|| |||||||..   ||||...  |  |.|.||| ..|. ||.|    .   ...||. |||||..||   .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 18448.AA S_TKc 9-269 31 2.7e-91 310.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALNEIRILASINSPHIIRYKDAFYDNASGCLCIVMEYAEN--GDLMAKLQDYKKRN
. . ...| |||. |||.. | .|...|.|..|         |....||.|| . . |.|....|.|.|   ..|..||||...  |||.  ....... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

MF--MDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLGANNKVKLGDLNVSKIMKRDLAYTQTGTPYYTSPEVWQNQPYDS-KCDVWSMGCVLYEL
    ..|  ...|..||...|. .|...|.||||| .||.|     .|..|  .....     .|. |||.| .|||    .|.  |||.|| ||.|||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MAHHPPFEAKSMEELYKKVCKGTYQKLPKQYSQEMNDFINLCLRKNPKQRPSVNSLLE-FQGL--LPYV
..  |||.   |....||..           |.|. |||. ||.|.|..||..  .|.  .     |..
LCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18448.AA AGC 9-254 23 1.6e-82 212.35 In-house 1-374 (395) Show / Hide 
Range on Protein: 9-254
Range on HMM: 1-374/395
Sequence Identity: 23% (88 aa)

FNVQKTLGNGAFSWVYKVQRK------QDGQVYALKKVKLRE---LSYK-EKENALNE------------IRILASIN----------SPHIIR-YKDAF
|.. |..| |.|. || |..|      . |..||.|..| ..   .  | . |....|             .||. .|          .| |..  . .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YDNASGCLCIVMEYAE--------NGDLMAKLQDYKK-RNMFMDEAKIWKYAAQ-------ILLGLKSLHD-LKILHRD-LKCANIFLGANNKVKLGDLN
 |.    |..||||..         |...  |. ... ..  .||  .  |||.       |.|.| .||. ..| ||| ||  || | ..  .|| |  
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

VSKIMK----------------------------------------------------RDLAYTQTG--TPYYTSPEVWQNQPYDSKCDVWS--MGCVLY
 .|...                                                    ||...|  |  || | .||.     |.  || ||  .||..|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELMAHHPPFEAKSME----------ELYKKVCKG-----TYQKLP----------KQYSQEMNDFINLCLRKNPKQRP
|... .||| ... .          |...|...|       .|.|          .. |.|  |.|. .| |.|..|.
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRL
Kinase 18448.AA Pkinase 9-265 28 4.5e-79 273.79 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-293/293
Sequence Identity: 28% (86 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALN--EIRILASINSPHIIRYKDAFYDNASGCLCIVMEYAENG----DLMAKLQ-D
. . ...| |.|. ||| ..| .|...|.|..|.|. . ........  ||.|....|.|.|.|..|.|.|  .. ...||||.|.|    ||.. .. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

YKKRNMFMDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLGANNKV----KLGDLNVSK---IMKRDLAYTQTGTPYYTSPEVWQ-NQPYDSKCDV
.... . ..|  . .|. ||| ||. .|. .|.||||| .||..  |. .    |..|  ..|   . .   ..| .|||.| .||| . .|.|..|.|.
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSMGCVLYELMAHHPPFEAK----SMEELYKKVCKGTYQKLPKQYS-----------------------QEMNDFINLCLRKNPKQRPSVNSLLEFQGL
||.||.|||..  .|||  .    .  . ....|.  . .|. ...                       .|. |||. ||.|.||.||.   .|.   .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 18448.AA STE 9-265 24 9.6e-74 251.31 In-house 1-359 (359) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-359/359
Sequence Identity: 24% (89 aa)

FNVQKTLGNGAFSWVYKVQRK------QDGQV---------YALKKVKLRELS---------------YKEKENALNEIRILASIN--SPHIIRYKDAFY
.  .. .|.|||  |||  ..      . |.|         .| |...|.. .                .|... |.||.|.   |  .|.|..| ....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN-----ASGCLCIVMEYAENGDLMAKLQDYKKRNM----------FMDEAKIWKYAAQILLG-LKSLHDLKILHRDLKCANIFLGANNKVKLGDLNVSK
..     . . |.|.||| ..| |   .. ......          ...|  | ... ||| | |. ||...| |||.|.|||.|     ||| |  |..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IMKRD------------------LAYTQTGTPYYTSPEVWQN------QPYDSKCDVWSMGCVLYELMAHHPPFEA-KSMEELYKKVCK-----------
..  .                    .| .||| . .||| |.      ..|| |||.|| ||.. |.   .||.   . |. .. .  .           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---GTYQKLPK-------------------QYSQEMNDFINLCLRKNPKQRPSVNSLLE--FQGL
   |.  .||                    ..|.|..||||.||.|.|..||... ||.     .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 18448.AA NEK4 9-269 35 1.6e-71 243.93 In-house 1-257 (257) Show / Hide 
Range on Protein: 9-269
Range on HMM: 1-257/257
Sequence Identity: 35% (93 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALNEIRILASINSPHIIRYKDAFYDNASGCLCIVMEYAENGDLMAKLQDYKKRNMF
..  |  |.| .  |. |. ..|.  | .||..|.. | .|.  |. |...|     | |. ||. .       |.||| . | |||  ||.  ...| |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLK--QQKNQF

MDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLGANNKVKLGDLNVSKIMK--RDLAYTQTGTPYYTSPEVWQNQPYDSKCDVWSMGCVLYELMAH
..|  .     || ..|  .|. .|||||||  ||||   | .|.||. .|...    |.| |  ||||| |||.. |.||| | |.||.|| .||..  
LEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

HPPFEAKSMEELYKKVCKGTYQKLPKQYSQEMNDFINLCLRKNPKQRPSVNSLLEFQGLLPYV
   |.|| |  |  .. .|    .|..|||.. . .   | | |..|||. ...      ||.
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQ----MPYI
Kinase 18448.AA Ciliate-E2-Unclassified 9-265 27 2.4e-70 240.0 In-house 1-352 (352) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-352/352
Sequence Identity: 27% (98 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVK-LRELSYKEKEN---------ALNEI---------RILAS--INSPHIIRYKDAFYDNASGCLCIVM
....|..|.|.|. |||.|.|...|.||.|  |  .. . | ..|         ..|..         .|.    .|.||....|. ....   ...|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAENGDLMAKLQDYKK--------------RNMFMDEAKIW----KYAAQILLGLKSLHDLK-ILHRDLKCANIFLGANN---KVKLGDLNVSK-----
||.|.|||.  ....||              |..| ... .     .|.||||.||..||  . |.|||.|. ||..  |.   ..|. |.  ||     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------IMKRDLAYTQTGTPYYT----SPEVWQNQPYD----SKCDVWSMGCVLYELMAHHPPFEAKSMEE----------------LYKKVCK
            | |.....|..|||.|     .||| |.| ||     |||.||.|..|||..   .||.... |.                ||.. ..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

GTYQKLP-------KQYSQEMNDFIN----LCLRKNPKQRPSVNSLLEFQGL
. .|. .       |. |.|  ||||     .| |||..|.. . .|. . .
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 18448.AA CAMK 14-261 19 7.8e-70 223.98 In-house 1-421 (425) Show / Hide 
Range on Protein: 14-261
Range on HMM: 1-421/425
Sequence Identity: 19% (82 aa)

TLGNGAFSWVYKVQRKQDG------------QVYALKKVKLRELS--------------------------YKEKENALNEIRILAS-------INSPHI
||| |.|. |.....|...            | .| | .. . |.                           | ..| ..||.|. .       .. |.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYKDAFYD-----------NASG-------CLCIVM---EYAENG----DLMAKLQDYKKRN-----------MFMDEAKIWKYAAQILLGLKSLHDLK
|.  ... |           . |        ....||   ||...|    ||  .... ...              ..|.   .|  ||. ... .|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDLKCANIFLGAN-----------------NKVKLGDLNVSKIMKR-------------------------DLAYTQTGTPYYTS-PEVWQN-----
| |||||. || |  |                 |..|. |   ......                         .. .|. |||.| . ||| .      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QPYDSKCDVWSMGCVLYELMAHHPPFEAK-------------SMEELYKKVCKGTYQKLPKQ-----------------------YSQEMN
         ..|. |||.||.|..|| .   .|||...             ...||..|..|| |.  |..                        |||  
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DFINLCLRKNPKQRPSVNSLLE
|.|. .|...|..|...   |.
DLIRKMLQVDPEKRMTIEQCLN
Kinase 18448.AA Ciliate-E2 9-261 22 6.7e-68 231.89 In-house 1-361 (365) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-361/365
Sequence Identity: 22% (85 aa)

FNVQKTLGNGAFSWVYKVQR-----------------------KQDGQVYALKKVKLRELSYKEKENALN-EIR----------ILASINSPHIIRYKDA
....| .|.|.|. |||...                       |.... ||.| .| ... ....|. .. ||.          || ..|.|.||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYDNASGCLCIVMEYAENGDLMAKLQDY-KKRNMF------MDEAKIWKYAAQILL---------------GLKSLHDLK-ILHRDLKCANIFLGANNKV
|...   .. .||||.. |||.  ...  ||||        ..| .| .. .|||                .|..||  . |.|||.|  ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDLNVSK---------------------------------IMKRDLAYTQTGTPYYTSPEVWQNQP---------YDSKCDVWSMGCVLYELMAHHPP
|. |.  ||                                 |.. ....|. |||.| .||. ....         || |||.||.|..|||..   ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEAKSMEELYKKVCKGTYQKL-----------------PKQYSQEMNDFINL----CLRKNPKQRPS-VNSLLE
|        ... ... ..                   .|. |||. |.|.     .| |.|..|..  . .|.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 18448.AA NEK2 9-265 30 3.7e-67 225.16 In-house 1-319 (319) Show / Hide 
Range on Protein: 9-265
Range on HMM: 1-319/319
Sequence Identity: 30% (97 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALNEIRILASINSPHIIRYKDAFYDNASGCLCIVMEYAENGDLMAKLQDYKKRNMF
  | .|.||| |  ..|| || || . . |  .  ..  ||.    .|. ||     | |.|| |   | ..  | ||||| | |||    . ..|   .
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

MDEAKIWKYAAQILLGLKSLHD---------------------LKILHRDLKCANIFLGANNK-------------------------------------
|.|  ||.  .|... |.  |                        |||||.| ||||| ..                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKLGDLNVSKIMKRDLAYTQT--GTPYYTSPEVWQNQPYDSKCDVWSMGCVLYELMAHHPPFEAKSMEELYKKVCKGTYQKLPKQYSQEMNDFINLCL
  |||||    .. ..|  . .|  ||||| |||. . |.|. | |.||.||..||. | ||||.|..  .|  |. .| .. .| |||.. |. | . .
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

RKNPKQRPSVNSLLEFQGL
  ....|||.. .|.   .
NVDHYHRPSIEEILQHPQI
Kinase 18448.AA ULK 9-253 25 6e-61 208.79 In-house 1-317 (329) Show / Hide 
Range on Protein: 9-253
Range on HMM: 1-317/329
Sequence Identity: 25% (80 aa)

FNVQKTLGNGAFSWVYKVQRKQD----GQVYALKKVKLRELSYKEKENA--------LNEIRILASIN----SPH----IIRYKDAFYDNASGCLCIVME
... . || |.|  |||   |..    ....| |.. . ... |..|.          |||.|.  ..    ...    |....| |..  . .. |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAENGDLMAKLQDYKK------RNMFMDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLGANNK------------VKLGDLNVSKIMKRD-----
| . |||.  .. .||      .. .  | .. ..  ||| |.| ||. .| |||.| .|| .  ..             .|..|   .| .  |     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LAYTQT------GTPYYTSPEVWQ----NQPYD-SKCDVWSMGCVLYELMAHHPPFEAKSMEELYKKVCKGTYQ----------KLPKQ---------YS
...|..      |||.| .|...|    ..||. .|||.||.||..||.    |||.|   ...|.. ..  ..          | | |          |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QEMNDFINLCLRKNPKQR
.|. |.|  .| ...|.|
PECKDLIRRMLQYDEKDR
Kinase 18448.AA Pkinase_Tyr 9-263 25 5.8e-21 71.62 Pfam 1-270 (270) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-270/270
Sequence Identity: 25% (69 aa)

FNVQKTLGNGAFSWVYKVQRK----QDGQVYALKKVKLRELSYKE--KENALNEIRILASI-NSPHIIRYKDAFYDNASG-CLCIVMEYAENGDLMAKLQ
    |.|| |||  |||   |    ....  | |..     . ..  .|  ..|..|. .. . |.|.|.  . .|      ..|||||...|||   |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DYKKRNMFMDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLGANNKVKLGDLNVSKIMKRDLAY-TQTG---TPY-YTSPEVWQNQPYDSKCDVWS
. .  .   .   . ....||  |.  |.. .. |||| . |. .. ||.|| .|   .. .  |  | ...|    |   ..||....  . .| ||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

MGCVLYELMAHH-PP-FEAKSMEELYKKV-CKGTYQKLPKQYSQEMNDFINLCLRKNPKQRPSVNSLLEFQ
 | ...|..     | ..  | ||.|...  .|   . |.  ..|. | . .| ...|..||.   ..|. 
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 18448.AA TyrKc 9-263 24 1.8e-19 71.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-263
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

FNVQKTLGNGAFSWVYKVQRKQDGQVYALKKVKLRELSYKEKENALNEIRILASI--NSPHIIRYKDAFYDN-----ASGCLCIVMEYAENGDLMAKLQD
    |.||.|||  ||| . |   .  | |..|        .|  ..|.||. ..  . |.|.|   .  .       .. |.|||||...|||   |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

YKKRNMFMDEAKIWKYAAQILLGLKSLHDLKILHRDLKCANIFLGANNKVKLGDLNVSKIMKRD-------LAYTQT---GTP-----YYTSPEVWQNQP
....      ..  ... ||  |   ||. .. |||| . |. .|.|. || .|   |.  . |         |...   |.        ..||...   
HRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDSKCDVWSMGCVLYELMAH-HPPFEA-----KSMEELYKKVCKGTYQKLPKQ--------YSQEMNDFINLCLRKNPKQRPSVNSLLEFQ
. .| |||| | ...|..    .| .      .| .|....| .| . . |.          ..|| . .  | . .|..||. . . |. 
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF