Gene 17999 (Tetrahymena)

17999

Species: Tetrahymena
Alias: TTHERM_01027700, 3803.m00213, PreTt17999, 17999, 203.m00054, 257
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
17999.AA Protein None 1880 None Fasta, JSON
17999.kin_dom Protein Kinase Domain None 332 None Fasta, JSON
17999.NA RNA None 5643 None Fasta, JSON

Protein domain

Protein domains of 17999.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_RI 17999.AA LRR_RI 82-106 28 0.040595 8.36 SMART 1-28 (28) Show / Hide 
Range on Protein: 82-106
Range on HMM: 1-28/28
Sequence Identity: 28% (8 aa)

HSNIEVINLASNQLTDEG---LLNMLIG
........|..| |.|||   | ..|  
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17999.AA LRR_RI 110-134 35 0.098595 5.64 SMART 1-28 (28) Show / Hide 
Range on Protein: 110-134
Range on HMM: 1-28/28
Sequence Identity: 35% (10 aa)

HSNLRELYLGNNQFQLGTAI---EGLST
...||||.|.|| .    ..   |||. 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17999.AA LRR_RI 139-166 32 0.395708 1.38 SMART 1-28 (28) Show / Hide 
Range on Protein: 139-166
Range on HMM: 1-28/28
Sequence Identity: 32% (9 aa)

LKNLRILGLGGLNIDDEDLVKLLYGLSE
...|| | |.. .. ||    |  ||..
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17999.AA LRR_RI 197-225 24 0.07327 6.55 SMART 1-28 (28) Show / Hide 
Range on Protein: 197-225
Range on HMM: 1-28/28
Sequence Identity: 24% (7 aa)

GNQIETLYLGQNEQITEDGIVKLFECLSQ
   ...|.|..|  ....|.  | |.|..
NCSLRELWLSNNK-LGDEGCRQLCEGLKH
LRR_RI 17999.AA LRR_RI 254-281 42 0.000275 21.49 SMART 1-28 (28) Show / Hide 
Range on Protein: 254-281
Range on HMM: 1-28/28
Sequence Identity: 42% (12 aa)

NQNLEELNLGNCGIDDEGFKFLHDCLKN
|..|.||.|.|... ||| . |  .|| 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
LRR_RI 17999.AA LRR_RI 282-309 35 0.002672 16.7 SMART 1-28 (28) Show / Hide 
Range on Protein: 282-309
Range on HMM: 1-28/28
Sequence Identity: 35% (10 aa)

NTKLQYLHLWNNYLTYESAQMIEEILEN
|..|. |.|.|| |. | .. . | |. 
NCSLRELWLSNNKLGDEGCRQLCEGLKH
Kinase 17999.AA NEK 727-1058 35 1.3e-150 506.69 In-house 1-286 (286) Show / Hide 
Range on Protein: 727-1058
Range on HMM: 1-286/286
Sequence Identity: 35% (129 aa)

FKILCKLGEGSFSTVFKVLRLVDNKI-----YAMKKVQMSRLNEKEKGNSL-NEIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAG-SGDLLQK---
..|. |.|.|||..|.|| |  |.|.     |..||..|....|||| |.. ||.|||...|...|..|.|||...|...|||||||.   ||| ||   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKEYKLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDEELIWDYFIQCLKGL
.|..|                                                                          .  ...|| |||.||| ...|
IKKQKQ-------------------------------------------------------------------------KGKYFEEEQIWDWFIQMCLAL

KCLHDL-----KIVHRDLKCANIFIGDNNI----IKIGDLNVSKVTRRPEQMAKT-QTGTPYYTAPEVWKGLSYNYKSDVWSLGCIIYELSAQ--KHPFK
|..||      ||.|||.|..|||. .||.    .||||...|||  .  .||.| |.||||| .|||... .||.|||.|||||..||. ..  ||||.
KYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFE

GN--TIEGLFTNIMKG-QYERIPSF--YSEELAFVISQCLLQNPKLRPGCDQLLKLPAF
..   ...|...|||| ||..|||.  ||..|  .|||.|  .|..|| |.|.|..|  
AWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 17999.AA Pkinase 727-1058 23 1.8e-65 228.61 Pfam 1-293 (293) Show / Hide 
Range on Protein: 727-1058
Range on HMM: 1-293/293
Sequence Identity: 23% (87 aa)

FKILCKLGEGSFSTVFKVLRLVDNKIYAMKKVQMSRLNEKEKGNSLN--EIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAGSG----DLLQKLKEY
..|. |.|.|||..|.|  .  ..||.|.|..  .. ..... . ..  ||.|........|....|.| |  .| ...||||.. |    ||   ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

KLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDEELIWDYFIQCLKGLKCLH
                                                                       ...  .  ..|. . .|. | |.||. .|
-----------------------------------------------------------------------WRHGCFY-FSEWECKFYMYQILRGLEYCH

DLKIVHRDLKCANIFIGDNNII----KIGDLNVSKV--TRRPEQMAKTQTGTPYYTAPEVWK-GLSYNYKSDVWSLGCIIYELSAQKHPFKGN------T
. .|.||||| .||.| .|. |    ||.|  ..|.  . . .  ..| .|||.| |||| . |  | .|.|.||.|||.||.   . ||.|       .
SMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHD

IEGLFTNIMKGQYERIPSFYS--------------------EELAFVISQCLLQNPKLRPGCDQLLKLPAF
   .. .||......  .  .                    ||.  .|. || ..|| ||...|.|. | |
QMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 17999.AA Ciliate-E2 727-1058 19 7.7e-59 200.61 In-house 1-365 (365) Show / Hide 
Range on Protein: 727-1058
Range on HMM: 1-365/365
Sequence Identity: 19% (88 aa)

FKILCKLGEGSFSTVFKV-LRLV----------------------DNKIYAMKKVQMSRLNEKEKGNSLN-EIR----------ILASIKCDHIIEYRDS
.|.. |.|.|.|..|.|.  ..|                      ..|||||| .. . ...... .... ||.          || ......||.. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FFDDQSDTLCIVMEYAGSGDLLQKLKEYKLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQD
| . . ... .||||.  |||.. .|. |.   . .|                                                               
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE---------------------------------------------------------------

KQQQMVFMDEELIWDYFIQCLK---------------GLKCLHDLK-IVHRDLKCANIFIGDNNIIKIGDLNVSK------------VTRR---------
 . .   ..|. | ... | |.               .|. ||  . |.|||.|  ||..     ||| |.  ||            . .          
-K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTS

----------PEQMAKTQTGTPYYTAPEVWKGLS---------YNYKSDVWSLGCIIYELSAQKHPFKGNTIEGLFTNIMKGQYE-RIP-----------
           ..|..|. |||.| |||. .| .         |.||.|.||||.|.||.   |.||        . .|...... . |           
RTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQC

---SF--YSEELAFVISQ----CLLQNPKLRPG-CDQLLKLPAF
   |.   |.|    |..    .|  .|. |..  .|.|. | |
KWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 17999.AA Ciliate-E2-Unclassified 727-1058 22 1.1e-58 201.24 In-house 1-352 (352) Show / Hide 
Range on Protein: 727-1058
Range on HMM: 1-352/352
Sequence Identity: 22% (93 aa)

FKILCKLGEGSFSTVFKVLRLVDNKIYAMKKVQMSRLNE-KEKGNS---LNEIRILASIK-----------------CDHIIEYRDSFFDDQSDTLCIVM
.||. ..|.|.|..|.|. .  ....||||    .. .  | . |.   .||. .. ..|                 ..|.. ... . . . ....|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAGSGDLLQKLKEYKL---INEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDE
||.  |||.| .|..|    .                                                               .  .....|.  | ..
EYCEGGDLWQYIKKRKKQKQK--------------------------------------------------------------GNDLFHNMKQRKIFTEQ

ELIW----DYFIQCLKGLKCLHDLK-IVHRDLKCANIFIGDNN---IIKIGDLNVSK---------------VTRRPEQMAKTQTGTPYYT----APEVW
. .     .|| | |.||. ||  . |.|||.|. ||.. .|.    ||| |.  ||                 . ..||..|..|||.|     |||| 
QAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL

KGLSYN----YKSDVWSLGCIIYELSAQKHPFKGNTIEG----------------LFTNIMKGQYERIPSFY-------SEELAFVIS----QCLLQNPK
.|  |.    ||.|.||||.|.||.  ...||..|. |                 |. ||......  ..         |.| .  |.    ..|  ||.
QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPN

LRPGCDQLLKLPAF
 |.. .|.|. | |
KRITFEQILNHPWF
Kinase 17999.AA S_TKc 727-1058 23 6.8e-57 196.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 727-1058
Range on HMM: 1-231/231
Sequence Identity: 23% (80 aa)

FKILCKLGEGSFSTVFKVLRLVDNKIYAMKKVQMSRLNEKEKGNSLNEIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAGS--GDLLQKLKEYKLIN
..|| |.|.|.|..|.|.    ...|.|.|..           . ..||.|| . ....|. . |.| |   | |..||||..   |||.. .|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

EKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDEELIWDYFIQCLKGLKCLHDLKI
 .                                                                         ..|  .. |. | ...|. .|...|
LRFP-----------------------------------------------------------------------FPE-HARFYMYQICCALEYCHSHGI

VHRDLKCANIFIGDNNIIKIGDLNVSKVTRRPEQMAKTQTGTPYYTAPEVWKGLSYNY-KSDVWSLGCIIYELSAQKHPFKGNTIEGLFTNIMKGQYERI
.||||| .||.. .   |||.|  ....        .|. |||.| ||||    .|.. |.|.||.|||.||. . . ||   ... .| .|.       
IHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------

PSFYSEELAFVISQCLLQNPKLRPGCDQLLK-------LPAF
    |.|.   |..||  .|. ||.. ..|.        | |
----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17999.AA CAMK 732-1058 18 1.2e-56 180.67 In-house 1-425 (425) Show / Hide 
Range on Protein: 732-1058
Range on HMM: 1-425/425
Sequence Identity: 18% (90 aa)

KLGEGSFSTVFKVLRLVDN------------KIYAMKKVQMSRLN--------------------------EKEKGNSLNEIRILAS-------IKCDHI
.||.|||..|... .  ..            . .|.| .  ..|                           .| . | ..||.|. .       ..  .|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IEYRDSFFDDQ-----------------SDTLCIVM---EYAGSG----DLLQKLKEYKLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKR
|   . . |..                  . ...||   ||.  |    ||.....| .   |.   | |                              
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF--D-Q------------------------------

IYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDEELIWDYFIQCLKGLKCLHDLKIVHRDLKCANIFIGDN-----------------NIIKIG
                             |   .   ..|.    || | . ... .|...|||||||. || . ||                 | ||| 
----------------------------FDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII

DLNVSKVTRR-----------------------PEQMAKTQTGTPYYTA-PEVWKG--------------LSYNYKSDVWSLGCIIYELSAQKHPFKGN-
|   ... ..                       . |. ||. |||.| | ||| .|                |..|.|.||.|.| | .   . || |  
DFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDC

------------TIEGLFTNIMKGQYERIPSF---------------YSEE--------LAFVISQCLLQNPKLRPGCDQLLKLPAF
            ... || .||||.|. .|..                |.|            |...|  .|. |. ..| |. | .
DNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 17999.AA NEK8 893-1058 34 5.1e-54 152.54 In-house 93-278 (278) Show / Hide 
Range on Protein: 893-1058
Range on HMM: 93-278/278
Sequence Identity: 34% (65 aa)

KQQQMVFMDEE----------------LIWDYFIQCLKGLKCLHDLKIVHRDLKCANIFIGDN-NIIKIGDLNVSKVTRRPEQMA--KTQTGTPYYTAPE
.||   |..|.                .| .||.| . .. ..|.  |.||||| .|||     ...||||   ||.      |.  ||  |||||  ||
HQQNKLFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPE

VWKGLSYNYKSDVWSLGCIIYELSAQKHPFKGNTIEGLFTNIMKG-QYERIPSFYSEELAFVISQCLLQNPKLRPGCDQLLKLPAF
  .| .|| |||.|.|||..||.   |  | .     | . || .  || |.. || |.  ....|| | |  ||  .|... |  
MCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 17999.AA ULK 727-1058 22 3.6e-53 182.96 In-house 1-329 (329) Show / Hide 
Range on Protein: 727-1058
Range on HMM: 1-329/329
Sequence Identity: 22% (88 aa)

FKILCKLGEGSFSTVFKVLRLVD----NKIYAMKKVQMSRLNEKEKGNS--------LNEIRILASIK--------CDHIIEYRDSFFDDQSDTLCIVME
. .  .||.||| .|.|     .    |...| |... . .|.|.. .          |||.|.  .|        . .|... | | ..... . |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAGSGDLLQKLKEYKLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDEELIW
|   ||| | .|..|  .|.  |                                                                     .  |. . 
YCNGGDLEQYIKKNKKLPEDT-E------------------------------------------------------------------EKKRLSEQEAI

DYFIQCLKGLKCLHDLKIVHRDLKCANIFIGDNN------------IIKIGDLNVSKVTRRP---EQMAKTQT------GTPYYTAPEVWKGL----SYN
 .|.| | |.|.||. .|.|||.| .|| | ...            ..||.|   .|.   .   .||..|..      |||.| ||....|.     |.
QFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYY

-YKSDVWSLGCIIYELSAQKHPFKGNTIEGLFTNIMKGQYE-----------RIPSFY--------SEELAFVISQCLLQNPKLRPGCDQLLKLPAF
 ||.|.||||||.||.   | ||... .. .. .|..  ..           . . |.        |.|.   |...|  ..| |   ..|.. | |
DYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 17999.AA NEK4 893-1058 40 1.5e-48 167.61 In-house 92-257 (257) Show / Hide 
Range on Protein: 893-1058
Range on HMM: 92-257/257
Sequence Identity: 40% (67 aa)

KQQQMVFMDEELIWDYFIQCLKGLKCLHDLKIVHRDLKCANIFIGDNNIIKIGDLNVSKVTRRPEQMAKTQTGTPYYTAPEVWKGLSYNYKSDVWSLGCI
|||   |..|. . . |.|   .|  .|. .|.|||||  |||.   |||||||. .|.|     .||||  |||||  ||..    |.||||.||||| 
KQQKNQFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCC

IYELSAQKHPFKGNTIEGLFTNIMKGQYERIPSFYSEELAFVISQCLLQNPKLRPGCDQLLKLPAF
.||.   || |    .  |   |..||   .|  ||..|.  . | | . |. ||   .... |  
VYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 17999.AA NEK1 893-1058 36 1.8e-48 166.28 In-house 92-276 (276) Show / Hide 
Range on Protein: 893-1058
Range on HMM: 92-276/276
Sequence Identity: 36% (67 aa)

KQQ--QMVFMDEELIWDYFIQCLKGLKCLHDLKIVHRDLKCANIFIG--DNN---------------IIKIGDLNVSKVTRRPEQMAKTQTGTPYYTAPE
..|  . .   |  | ..|.|  ..|.  || || |||.|  |||    .|                ..|.||  ....   .   |.|  |||||  ||
NRQKRKGKLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE

VWKGLSYNYKSDVWSLGCIIYELSAQKHPFKGNTIEGLFTNIMKGQYERIPSFYSEELAFVISQCLLQNPKLRPGCDQLLKLPAF
 .  . || |||.|||||. ||| . |||| .|    |   | .| |  ||. ||.|| . .|| .  ||..||   |.|. |  
ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 17999.AA NEK2 888-1058 26 3.1e-40 133.12 In-house 89-319 (319) Show / Hide 
Range on Protein: 888-1058
Range on HMM: 89-319/319
Sequence Identity: 26% (61 aa)

SVVQDKQQQMVFMDEELIWDYFIQCLKGLKCLHD---------------------LKIVHRDLKCANIFI-GDNN-------------------------
....   ..  .|.|| ||  . | .  |.  |                        | |||.| ||||   | |                         
QMIKKCRKERQYMEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVN

-------------IIKIGDLNVSKVTRRPEQMAKTQTGTPYYTAPEVWKGLSYNYKSDVWSLGCIIYELSAQKHPFKGNTIEGLFTNIMKGQYERIPSFY
             ..| ||    .. ..  . |.|  |||||  ||. .|..|| |||.||.||.|||. | . ||..     | . | .| ..|||. |
SGKRGSPMDYSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQY

SEELAFVISQCLLQNPKLRPGCDQLLKLPAF
|..|  .|.  .  ... ||. . .|. |  
SRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase 17999.AA STE 894-1058 26 4e-39 135.8 In-house 143-359 (359) Show / Hide 
Range on Protein: 894-1058
Range on HMM: 143-359/359
Sequence Identity: 26% (59 aa)

QQQMVFMDEELIWDYFIQCLKG-LKCLHDLKIVHRDLKCANIFIGDNNIIKIGDLNVSK-VTR---------------RPEQMAKTQTGTPYYTAPEVWK
|.   ...|..|  .  |.||| |. ||...|.|||.|.|||..     .|. |  |.. .|                   |. .| .||| . |||| .
QH-QHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ

G------LSYNYKSDVWSLGCIIYELSAQKHPF-KGNTIEGLFTNIMK--------------GQYERIPS-------------------FYSEELAFVIS
.        |..|.|.||||| | |.   |.|. ...  . .|  ...              |.  ..|.                    .|.|.   |.
QNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFIN

QCLLQNPKLRPGCDQLLK--LPAF
.||  .|. ||  .||||   | .
KCLQKDPNKRPTASQLLKSEHPFI
Kinase 17999.AA NEK1 727-822 36 5.1e-22 73.27 In-house 1-96 (276) Show / Hide 
Range on Protein: 727-822
Range on HMM: 1-96/276
Sequence Identity: 36% (35 aa)

FKILCKLGEGSFSTVFKVLRLVDNKIYAMKKVQMSRLNEKEKGNSLNEIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAGSGDLLQKLKEYKL
. .. ..|||||  ...| .  |.. |..|  . ..  |||. .|.||  |||  |   |..|..||.   .  | |||||.  ||| || .. |.
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKR
Kinase 17999.AA STE 727-828 18 1.4e-18 62.35 In-house 1-153 (359) Show / Hide 
Range on Protein: 727-828
Range on HMM: 1-153/359
Sequence Identity: 18% (29 aa)

FKILCKLGEGSFSTVFKVLRLV---------------DNKIYAMKKVQMSRLN---------------EKEKGNSLNEIRILASIK--CDHIIEYRDSFF
.... |.|.|.| ||.| ..                  ..|.|.|.. ... |               ..|. . |.||.|.   .  ...|..| ...|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DD-----QSDTLCIVMEYAGSGDLLQKLKEY--------------KLINEKLL
..     . |.|.|.||| . | | . .|..              . ..|...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQI
Kinase 17999.AA NEK4 727-821 31 5.8e-17 57.59 In-house 1-95 (257) Show / Hide 
Range on Protein: 727-821
Range on HMM: 1-95/257
Sequence Identity: 31% (30 aa)

FKILCKLGEGSFSTVFKVLRLVDNKIYAMKKVQMSRLNEKEKGNSLNEIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAGSGDLLQKLKEYK
. ..   | ||.  |. |    | | | |||... .   .|.   . |...|   |   |.|| .|.  .    |.||| .  .||| .|||. |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQK
Kinase 17999.AA TyrKc 727-1056 16 4.7e-16 36.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 727-1056
Range on HMM: 1-280/280
Sequence Identity: 16% (61 aa)

FKILCKLGEGSFSTVFK-VLRLVDNKIYAMKKVQMSRLNEKEKGNSLNEIRILASI--KCDHIIEYRDSFFDD-----QSDTLCIVMEYAGSGDLLQKLK
 . . ||||| | .|.| ...       | |... .      .   ..|.||. ..  . ..|.       ..      .. |.|||||.  |||.. |.
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EYKLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDKQQQMVFMDEELIWDYFIQCLKGLKC
...                                                                                 .   .. .|  .|   
KHRPK----------------------------------------------------------------------------LCMKDLLSFCWQIACGMEY

LHDLKIVHRDLKCANIFIGDNNIIKIGDLNVSKVTRRP------EQMAKTQT--GTP-----YYTAPEVWKGLSYNYKSDVWSLGCIIYELSAQ-KHPFK
||. ...|||| . |. .|.|...||.|   |.           ... ....  |.        .|||...   .. |||||| |  ..|.    . |  
LHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYP

G-----NTIEGLFTNIMKGQYERIPSF--------YSEELAFVISQCLLQNPKLRPGCDQLLKLP
|      . . .. ....| . ..|           ..|.  ...||   .|. ||   .. .. 
GMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 17999.AA NEK2 727-821 37 3.7e-15 47.37 In-house 1-95 (319) Show / Hide 
Range on Protein: 727-821
Range on HMM: 1-95/319
Sequence Identity: 37% (36 aa)

FKILCKLGEGSFSTVFKVLRLVDNKIYAMKKVQMSRLNEKEKGNSLNEIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAGSGDLLQKLKEYK
  .|  .|.||| .. || |  | || . |  .   ..|||.    .|. ||   |   |..| |  .| |. || |||||   ||| |  | ..
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCR
Kinase 17999.AA NEK8 756-819 40 1.2e-14 38.09 In-house 32-93 (278) Show / Hide 
Range on Protein: 756-819
Range on HMM: 32-93/278
Sequence Identity: 40% (26 aa)

KKVQMSRLNEKEKGNSLNEIRILASIKCDHIIEYRDSFFDDQSDTLCIVMEYAGSGDLLQKLKE
| . |.|. |||    .|||..|. .  . ||.| |.| .|.  || |.||||  | | |.. .
KQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDN--TLMIEMEYADGGTLYQMIQH
Kinase 17999.AA Pkinase_Tyr 796-996 18 9.8e-14 47.14 Pfam 75-207 (270) Show / Hide 
Range on Protein: 796-996
Range on HMM: 75-207/270
Sequence Identity: 18% (39 aa)

DQSDT--LCIVMEYAGSGDLLQKLKEYKLINEKLLEDGQNETSESQVEQDSSPKEESDKSSRSQEKNKRIYNKLNQQNESIKSKKSSIQENSSKSVVQDK
||..   ..|||||.  ||||  |.. .                                                                        
DQGEPNQIYIVMEYMPHGDLLDYLRKHR------------------------------------------------------------------------

QQQMVFMDEELIWDYFIQCLKGLKCLHDLKIVHRDLKCANIFIGDNNIIKIGDLNVSKVT-RRPEQ-MAKTQTGTPY-YTAPEVWKGLSYNYKSDVWSLG
 ..  .  ..|. .. .|  ||.  |.. ...|||| . |. ...||..||.|   ..      .   ... .  |   .|||...   .. |||||| |
EDKQPLTMKDLL-QMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

CIIYEL
  ..|.
VLMWEI
Kinase 17999.AA Pkinase_Tyr 727-743 47 0.102798 6.43 Pfam 1-17 (270) Show / Hide 
Range on Protein: 727-743
Range on HMM: 1-17/270
Sequence Identity: 47% (8 aa)

FKILCKLGEGSFSTVFK
 ... |||||.| .|.|
ITFGKKLGEGAFGEVYK