Gene 17542 (Tetrahymena)

17542

Species: Tetrahymena
Alias: 108.m00194, 199, 17542, TTHERM_00697500, PreTt17542, 3818.m00727
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
17542.AA Protein None 1701 None Fasta, JSON
17542.kin_dom Protein Kinase Domain None 227 None Fasta, JSON
17542.NA RNA None 5106 None Fasta, JSON

Protein domain

Protein domains of 17542.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 17542.AA NEK 785-1005 42 3.4e-122 412.27 In-house 24-272 (286) Show / Hide 
Range on Protein: 785-1005
Range on HMM: 24-272/286
Sequence Identity: 42% (105 aa)

KQI---KQYAMKRLNLDEDNQKQQVIF--NEVKVLENLVHPNIIKYYETFQYEQ--KLCIVMEYAE-GGDLKKQ---VTEKQHKKEFFDESQIWNMFSQI
...   |.|..|. |... ..|..     |||..|. | ||||.|||. |. ||  .|||||||.| |||| ..     ....|...|.|.|||..| |.
GKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQM

CLAVKYLHDN-----KILHRDLKILNVFICNNGL----IKLGDFGVSKQLENKDILTST-HVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTL--D
|||.||.||.     ||||||.|  |.|. .|.     .|.||||.||.|...  . .| .||| ||.|||.|.. .||.|.|||.|||.|||.|||   
CLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLYEMCTLKPK

KPFKSD--NLLGLIKQITQN-DPAPISDH--YSSTMVQLVQVMMQKEPD
.||...  |...|...|... ...||..|  ||. . .|.. | ||.|.
HPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPE
Kinase 17542.AA NEK8 805-1005 42 3e-84 240.42 In-house 45-264 (278) Show / Hide 
Range on Protein: 805-1005
Range on HMM: 45-264/278
Sequence Identity: 42% (93 aa)

QVIFNEVKVLENLVHPNIIKYYETFQYEQKLCIVMEYAEGGDLKKQVTEKQHKKEFFDES----------------QIWNMFSQICLAVKYLHDNKILHR
| . ||. ||  | ||||| ||. |  .. | |.||||.|| |     . | |. |..|                 .|  .| |.|.|| ..|.. ||||
QMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKL-FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHR

DLKILNVFICNN-GLIKLGDFGVSKQLENK-DILTS-THVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTLDKPFKSDNLLGLIKQITQN-DPAPI
||| .|.|     ...|.|||| || .  |    |. | ||| ||.||| |   .|| | |.| ||| |||.|.| . |  .||. |.  |.|    .||
DLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPI

SDHYSSTMVQLVQVMMQKEPD
|||||. | .||    |..|.
SDHYSNEMRMLVHNCLQQDPE
Kinase 17542.AA NEK1 788-1004 41 2.3e-81 276.65 In-house 25-261 (276) Show / Hide 
Range on Protein: 788-1004
Range on HMM: 25-261/276
Sequence Identity: 41% (98 aa)

KQYAMKRLNLDE-DNQKQQVIFNEVKVLENLVHPNIIKYYETFQYEQK--LCIVMEYAEGGDLKKQVTEKQHKKEFFDESQIWNMFSQICLAVKYLHDNK
..|..|  |. .   .  .   |||..|... ||||.||.| |. . .  | |||||..|||| .   ..  |   | | || . |.|||||... || |
QHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIHDRK

ILHRDLKILNVFIC--NNG---------------LIKLGDFGVSKQLENKDILTSTHVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTLDKPFKSD
|||||.|  |.|    .||               |.||||||... | . . . .| .|| |||||| |.   ||.| ||| ||| |||||||  || . 
ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEAN

NLLGLIKQITQNDPAPISDHYSSTMVQLVQVMMQKEP
|.  |.  |.|   .||. |||     || .| .. |
NWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNP
Kinase 17542.AA NEK4 788-1005 40 9.3e-67 228.09 In-house 25-243 (257) Show / Hide 
Range on Protein: 788-1005
Range on HMM: 25-243/257
Sequence Identity: 40% (90 aa)

KQYAMKRLNLD-EDNQKQQVIFNEVKVLENLVHPNIIKYYETFQYEQK--LCIVMEYAEGGDLKKQVTEKQHKKEFFDESQIWNMFSQICLAVKYLHDNK
||| ||...|   . ....    |...|  | ||||..| | .. |    |.||| . ||||| ..   || | .| .|.|. . | || .|  |.|. .
KQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKNQFLEEYQVVEWFVQIAMALQYMHEKH

ILHRDLKILNVFICNNGLIKLGDFGVSKQLENKDILTSTHVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTLDKPFKSDNLLGLIKQITQNDPAPI
|||||||  |.|.    .||.||||.|. |.|.  . .| .|| ||.|||      |..| ||| ||| .||. ||   |   ..  || || |  | |.
ILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPM

SDHYSSTMVQLVQVMMQKEPD
.  ||  . .||  |..| |.
PPNYSQDLQNLVYQMLEKQPT
Kinase 17542.AA Pkinase 788-1004 25 9.6e-56 196.31 Pfam 25-278 (293) Show / Hide 
Range on Protein: 788-1004
Range on HMM: 25-278/293
Sequence Identity: 25% (67 aa)

KQYAMKRLNLDEDNQKQQVI-FN--EVKVLENLVHPNIIKYYETFQYEQKLCIVMEYAEGG----DLK----KQVTEKQHKKEFF--DESQIWNMFSQIC
|..|.|........ ..... ..  |.... .| ||||...|..|........||||.|||    ||.           ...  |  .| .. ... ||.
KIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------WRHGCFYFSEWECKFYMYQIL

LAVKYLHDNKILHRDLKILNVFICNNGLI----KLGDFGVSKQL-ENKDILTSTHVGTAYYLSPEQCN-QHSYNHKVDIWMLGCLLYELCTLDKPFKSD-
 ...|.|...|.|||||  |..| ||| |    |..|||..||. . ..  ..| .|| .|..|| .. .  | .|||.| .||.|||...   ||... 
RGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC

-----NLLGLIKQITQ-NDPAPISDHYS-------------------STMVQLVQVMMQKEP
     . . .|..| .   . ...  .|                   ... ...  . .| |
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP
Kinase 17542.AA NEK6 810-1010 41 1.3e-55 181.43 In-house 49-252 (252) Show / Hide 
Range on Protein: 810-1010
Range on HMM: 49-252/252
Sequence Identity: 41% (84 aa)

EVKVLENLVHPNIIKYYETFQYEQKLCIVMEYAEGGDLKKQVTEKQHKKEFFDESQIWNMFSQICLAVKYLHDNKILHRDLKILNVFICNNGLIKLGDFG
|. .| .| |||.||||. |  . .| ||.| |. ||. . .   . .|    |  ||  | |.| |.. .|  ...|||.|  ||||  || .|||| |
EIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLIPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLG

VSKQLENKDILTSTHVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTLDKPFKSD--NLLGLIKQITQNDPAPI-SDHYSSTMVQLVQVMMQKEPDI
. .    |       ||| ||.|||      || | ||| |||||||.  |  ||  |  ||  | |.| | |  |. .||||  . ||| .... .|. 
LGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEW

IIRL
   .
RPDI
S_TKc 17542.AA S_TKc 776-1015 25 4.5e-55 190.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 776-1015
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

WKIIK----------FLYFKQI--KQYAMKRLNLDEDNQKQQVIFNEVKVLENLVHPNIIKYYETFQYEQKLCIVMEYAEG--GDLKKQVTEKQHKKEF-
..|..          ..  .    ...|.|...        . | .|...|..  ||||.|.|..||  ..|..||||..|  |||..   ......   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FDESQIWNMFSQICLAVKYLHDNKILHRDLKILNVFICNNGLIKLGDFGVSKQLENKDILTSTHVGTAYYLSPEQCNQHSYNH-KVDIWMLGCLLYELC
 |.| ... .. |||.|..|.|...|.|||||  |.....   ||..|||...||       .| .|| .|..|| .   .|.. |.|.| .||.|||..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TLDKPFKSDNLLGLIKQITQNDPAPISDHYSSTMVQLVQVMMQKEPD----IIIRLN-------NQFK
.   ||   ..  ..|.|            |. . .... ..||.|.    .   |.        .. 
CGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 17542.AA STE 785-1005 24 3.2e-54 186.44 In-house 37-343 (359) Show / Hide 
Range on Protein: 785-1005
Range on HMM: 37-343/359
Sequence Identity: 24% (77 aa)

KQIKQYAMKRLNLDEDN----------------QKQQVIFNEVKVLENLV--HPNIIKYYETFQYE-------QKLCIVMEYAEGGDLKKQVTEKQHKKE
.. . .|.|..||...|                ...| | .|.|.. ..   ||||.||| .. .|       ..|.|.||| .|| | . . .|  ...
ETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGK

----------FFDESQIWNMFSQICLA-VKYLHDNKILHRDLKILNVFICNNGLIKLGDFGVSKQLENK----------------DILTSTHVGTAYYLS
          .|.||||  .  ||. .  .|||...| |||.|  |...     .|| ||||..||...                .  . | |||  . .
PLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMA

PEQCNQ------HSYNHKVDIWMLGCLLYELCTLDKPFKSDNLLGLIKQITQN---------------DPAPISD-------------------HYSSTM
||  .|      . |. |.||| |||.. |..|   |.   . .  . .|..|               .| |. |                   ..|. .
PEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEF

VQLVQVMMQKEPD
 . ..   ||.|.
KDFINKCLQKDPN
Kinase 17542.AA NEK-Unclassified 809-1005 33 1.3e-51 168.99 In-house 42-244 (258) Show / Hide 
Range on Protein: 809-1005
Range on HMM: 42-244/258
Sequence Identity: 33% (69 aa)

NEVKVLENLVHPNIIKYYETFQYEQKLCIVMEYAEGGDLKKQVTEKQHKKEFFDESQIWNMFSQICLAVKYLHDNKILHRDLKILNVFICNNGLIKLGDF
| . .|  | || |. | . |    ||    .| .||.| . .  .  | | |||  |   . |.  || | |  ||.|||||  |.|     .. .|||
NKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDF

GVSKQLENKDILTSTHVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTLDKPFKSDNLLGLIKQITQNDPA-------PISDHYSSTMVQLVQVMMQ
|.|. ..       | |||  ..||| | .  || . |.| |||..||.|| .  |   |.. .   | | |..       |.|  ||  . |..  |..
GISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQ-DDNRLEEALEPVSKTYSTDLQQVIRFMLR

KEPD
....
RNFQ
Kinase 17542.AA Ciliate-E2 786-1005 27 1.2e-50 172.12 In-house 46-350 (365) Show / Hide 
Range on Protein: 786-1005
Range on HMM: 46-350/365
Sequence Identity: 27% (86 aa)

QIKQYAMKRLNLDEDNQKQQVIF------------NEVKVLENLVHPNIIKYYETFQ--YEQKLCIVMEYAEGGDLKK--QVTEKQHKKE-----FFDES
.||.||||... .. .|. |.|             || ..||.| ||||||.||.||   .... .||||..||||..  .   |....|      |.| 
KIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEK

QIWNMFSQICL---------------AVKYLHDNK-ILHRDLKILNVFICNNGLIKLGDFGVSKQLENKDI-----------------------------
.| ... ||.                |..||| .. |.|||.|  |...     ||. ||| ||.. .. .                             
EIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQ

--LTSTHVGTAYYLSPEQCN---------QHSYNHKVDIWMLGCLLYELCTLDKPFKSDNLLGLIKQITQNDPA-P----------------ISDHYSST
  .. | .||..|..||  |         |. |..|.||| ||..|||...   ||        ..|| |..   |                . .. |  
QNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQE

MVQLVQV----MMQKEPD
. .| .     |.||.|.
CKDLIKKFGKRMLQKDPE
Kinase 17542.AA Ciliate-E2-Unclassified 788-1005 25 2.4e-46 158.74 In-house 25-338 (352) Show / Hide 
Range on Protein: 788-1005
Range on HMM: 25-338/352
Sequence Identity: 25% (81 aa)

KQYAMKRLNLDEDNQKQQV-----------IFNEVK-------------VLENLVHPNIIKYYETFQYEQKLCIVMEYAEGGDLKKQVT-----------
..|||| ..   .. ..|.           . |. |              | |. ||.|.|....|| .|...|||||.|||||..  .           
QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGND

--EKQHKKEFFDESQIW-----NMFSQICLAVKYLHDNK-ILHRDLKILNVFICNNG---LIKLGDFGVSKQLEN---------------KDILTSTHVG
  ....... |.| |.      ..| ||... .||| .. |.|||.|  |... |||    ||. ||| ||....               |. ...| .|
LFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCG

TAYYL----SPEQCNQHSYN----HKVDIWMLGCLLYELCTLDKPFKSDN-------------------LLGLI-KQITQNDPAP---ISDHYSSTMVQL
| .|.    .||   .. |.    .|.||| ||..|||...   ||.. |                   |.  | ....|....|   |..| | .   .
TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDF

VQ----VMMQKEPD
..     |..| |.
INDLLQKMLKKNPN
Kinase 17542.AA NEK11 810-1004 38 1.8e-44 154.05 In-house 51-244 (259) Show / Hide 
Range on Protein: 810-1004
Range on HMM: 51-244/259
Sequence Identity: 38% (76 aa)

EVKVLENLVHPNIIKYYETFQYEQKLCIVMEYAEGGDLKKQVTEKQHKKEFFDESQIWNMFSQICLAVKYLHDNKILHRDLKILNVFICNNGLIKLGDFG
| ..|  | || |...   |   .  ||. || || ||  .. | ..    | | ||   | |. | | |.|. .|||||||  |.|. || |.|.||||
EAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGKIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNN-LLKIGDFG

VSKQLENKDILTSTHVGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTLDKPFKSDNLLGLIKQITQNDPAPISDHYSSTMVQLVQVMMQKEP
||. |     |  |  ||  |.|||      |  | ||| | |.|||.| .|  |   | | .. .|   |   . | |   .  ..  |. |.|
VSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCCMDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNP
Kinase 17542.AA Pkinase_Tyr 791-960 26 8.3e-20 67.71 Pfam 32-210 (270) Show / Hide 
Range on Protein: 791-960
Range on HMM: 32-210/270
Sequence Identity: 26% (48 aa)

AMKRLNLDEDNQKQ---QVIFNEVKVLENL-VHPNIIKYYETFQ-YEQK--LCIVMEYAEGGDLKKQVTEKQHKKEFFDESQIWNMFSQICLAVKYLHDN
| | |  .   ..|   .  ..|.|.. .|  ||||...|      ..   ..|||||...|||..   .. . |. .. ... .|  ||. .  ||...
AVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

KILHRDLKILNVFICNNGLIKLGDFGVSKQLENKDIL-TSTH---VGTAYYLSPEQCNQHSYNHKVDIWMLGCLLYELCTL
.. ||||   |. . .|. .| .||| .. ..|.|   ....   .    . .||  |   ...| |.|. | |..|..|.
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSDVWSFGVLMWEIFTY
TyrKc 17542.AA TyrKc 779-1021 20 6.4e-15 18.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 779-1021
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

IKFL------YFKQIKQY------AMKRLNLDEDNQKQQVIFNEVKVLENL--VHPNIIKYYETFQYE-------QKLCIVMEYAEGGDLKKQVTEKQHK
|...       | .. .       | | |. |     .. . .| ... .|   ||||.. |     .       . |.|||||...||||.   ....|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KEFFDESQIWNMFSQICLAVKYLHDNKILHRDLKILNVFICNNGLIKLGDFGVSKQLENK-------DILT-----STH-VGTAYYLSPEQCNQHSYNHK
   .  ..  ..  ||.    |||.... ||||   |. . .|. .| .||| |. ....       |  .     ... .     ..||  | . ...|
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDIWMLGCLLYELCTL-DKPFKS-----DNLLGLIKQITQNDPAPISDH-----YSSTMVQLVQVMMQK--EPDIIIRLNNQFKKLKEQY
 |.|. | ...|..|. ..|         .   .|... | .  |. ..     .  .. . .  .|..  . |   | .  |. ..|. 
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPT--FSEIHECF