Gene 15734 (Tetrahymena)

15734

Species: Tetrahymena
Alias: 190.m00044, 198, PreTt15734, TTHERM_01000150, 3820.m00269, 15734
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: NEK

Sequence

Name Sequence Type Origin Length Description Download
15734.AA Protein None 807 None Fasta, JSON
15734.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
15734.NA RNA None 2424 None Fasta, JSON

Protein domain

Protein domains of 15734.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15734.AA NEK 4-262 53 9.40000000001e-170 570.24 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-286/286
Sequence Identity: 53% (154 aa)

YTKIKVVGKGSFGYAVLVQSNTENNK---KYYVIKIIDISKMDRKQREEAL-NEVHVLKAMKHPYIITYRESFIEKR--CLCIIMEYAQ-GGDLYTK---
|..||..|.|||| . .|..   ...   | ||.| |....|..|....|. |||..|| .|||.|..|..||||.   ||||.|||.  ||||| |   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IAKQKEKGQLFSEKQIIDWFVQMALAIKHVHDR-----KILHRDLKTQNIFLNAKGD----IKIGDFGIARVLQHTYDCAKT-AIGTPYYLSPEICQEKP
| |||.||..|.|.|| |||.||.||.|..|||     ||||||.|.|||||....     .|||||||..||.||.|.|.|  .|||||.|||.||.||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNQKSDIWSLGCILYEMTTL--NHAFDAN--SMKGLVLKILRG-TYPPIPEQ--YSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
||.|||||||||.|||| ||  .|.|.|.  .|..|..|| .| .|||||..  |||||..||| || |||.||||...|||. |.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 15734.AA NEK1 4-262 55 2.9e-155 522.11 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-276/276
Sequence Identity: 55% (155 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESFIEKRC--LCIIMEYAQGGDLYTKIAKQKEKG
|..||..|.|||| |.||..  ..  . |||| | ..|| .| |||..||| .|. |||| |..|.|||.|  |  | |.|||. ||||. || .|| ||
YHYIKQIGEGSFGKAWLVKHKEDG--QHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKG

QLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLN--AKG---------------DIKIGDFGIARVLQHTYDCAKTAIGTPYYLSPEICQEKPY
.|||| || .||.|. || .|.|||||||||.|.|||||    .|                .|.|||||||.|.|| . |.| ||||||||||||| |||
KLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPY

NQKSDIWSLGCILYEMTTLNHAFDANSMKGLVLKILRGTYPPIPEQYSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
|.|||||||||.||| .|| |.|.||..| |||||..|||||||  ||..|. |.| |. ..|  |||.  |||. |.
NNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase 15734.AA NEK8 4-262 41 1.1e-132 381.14 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-278/278
Sequence Identity: 41% (117 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESFIEKRCLCIIMEYAQGGDLYTKIAKQKEKGQL
|..| |||.|.|| ..|      .  .  ..| |. . |. |.|  |.||. ||.   || || | ..|.|   | | |||| || || .|..|. |  .
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNK-LF

FSEK----------------QIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAK-GDIKIGDFGIARVLQHTYDCA--KTAIGTPYYLSPEICQEKPY
. |.                .|.. |.|| .|. |.|.  ||||||||||||..   . .|||||||. ..   |  .  || .|||||.|||.|. |||
EEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPY

NQKSDIWSLGCILYEMTTLNHAFDANSMKGLVLKILRG-TYPPIPEQYSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
|||||.|.|||.|||| .|  ||.|     ||.|| .. .| ||...|| ..| |... | .|| ||||   |.    .
NQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase 15734.AA NEK4 4-262 50 1e-120 407.31 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-257/257
Sequence Identity: 50% (132 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESF-IEKR-CLCIIMEYAQGGDLYTKIAKQKEKG
|  .|||||||.|   ||..     || ||.| ..  . .|..| .|. |. .|  .||| |..| ||. ||    |.|.| .  |||||.|   .. |.
YCHMKVVGKGSYGEVWLVRHRRD--KKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKL--KQQKN

QLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDIKIGDFGIARVLQHTYDCAKTAIGTPYYLSPEICQEKPYNQKSDIWSLGCILYEMT
|. .|.|...|||| |.|    |...|||||||||||||  |  ||||||||.|||.   | ||| ||||||.|||.   .||. ||||||||| .||| 
QFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMI

TLNHAFDANSMKGLVLKILRGTYPPIPEQYSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
|| |||||  |  |. .|. |  ||.| .||||| .|. .|| | ||.||||. |. . ..
TLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase 15734.AA S_TKc 4-262 30 3.7e-91 310.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESFIEKRCLCIIMEYAQG--GDLYTKIAKQKEKG
|......|||.||   ... .    .... ||||.         | ...|. .||  .||.|... ..| .  .|...|||. |  |||.. | |.. .|
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--QLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDIKIGDFGIARVLQHTYDCAKTAIGTPYYLSPEICQEKPYNQ-KSDIWSLGCILY
  . |.| ..  .. |...|... |...|.||||| .||.|.    |||.|||.||.|       .| .|||.|..||..   .|.  |.|.||.|||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMTTLNHAFDANSMKGLVLKILRGTYPPIPEQYSQDLRDLISEMLIKDPTQRPSIRKILE-------KDFL
|| .    |.      ...|...          |....|.|. .| |||..||.. ..|.         ..
EMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15734.AA NEK-Unclassified 4-262 40 7.9e-86 284.13 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-258/258
Sequence Identity: 40% (107 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESFIEKRCLCIIMEYAQGGDLYTKIAKQKEKGQL
| ||  .|.|  |   ||       |.  | .   |||  ||..    | . .|  ..|| |.|| .|| |   |    .|  ||.|  .| |.  |   
YDKITTLGQGGGGAVYLVRHQI--SKRHLVQQ---ISK--RKKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEP

FSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDIKIGDFGIARVLQHTYDCAKTAIGTPYYLSPEICQEKPYNQKSDIWSLGCILYEMTTL
| |  |  |..||  |.  .| |||.|||||.|||||     . .|||||.|.. || | |.| .||. ..|||.||..||| .||.||||||.||| | 
FDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC

NHAFDANSMKGLVLKILRGTY------PPIPEQYSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
  .||. .|  .  || ..         |.   || || ..|  || ... ||||   |.| |. 
EPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase 15734.AA Pkinase 4-262 25 4.6e-82 283.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-293/293
Sequence Identity: 25% (76 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALN--EVHVLKAMKHPYIITYRESFIEKRCLCIIMEYAQGG----DLYTKIAKQ
|......|.||||   . .   ..    ...|||. .. . ........  |....| ..||.|......| .|. ....|||..||    ||.. |   
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

KEKGQLF--SEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDI----KIGDFGIARVL-QHTYDCAKTAIGTPYYLSPEICQ-EKPYNQKSD
 ...  |  ||....... |.. .... |...|.||||| .||... .|.|    ||.|||.|...    .  ..|  |||.|..||...  ..| .|.|
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSLGCILYEMTTLNHAFDAN------SMKGLVLKILRGTYPPIPEQYS--------------------QDLRDLISEMLIKDPTQRPSIRKILEKDFL
.||.||||||| . .  |.        ... .. .|... ..   .. .                    ....|.|. .| |||..||... ||. ...
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 15734.AA CAMK 9-262 21 1.2e-76 246.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-262
Range on HMM: 1-425/425
Sequence Identity: 21% (90 aa)

VVGKGSFGYAVLVQSN-TENNK---------KYYVIKIIDISKMD--------------------------RKQREEALNEVHVLKA-------MKHPYI
. |.||||   |..   | ...         . . ||||| .|..                           | |.. ..|....|        ..|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITYRESFIE-------------------KRCLCIIM---EYAQGG----DLYTKIAKQKEKG-----------QLFSEKQIIDWFVQMALAIKHVHDRKI
|   | .                     .......|   ||..||    ||. .| ... .|             |.|..   .| |.. |... |...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKTQNIFLNAK-----------------GDIKIGDFGIARVLQH-----------------------TYDCAKTAIGTPYYLS-PEICQ-------
 |||||  || |. .                 ..||| ||| |.....                       . .  ||  |||.| . ||. .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------EKPYNQKSDIWSLGCILYEMTTLNHAFDAN-------------SMKGLVLKILRGTYPPIPEQ-----------------------YSQDLRD
       ...|..|.|.||.|.||| | .    |..              ... |  ||..| |  .|..                        ||. .|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LISEMLIKDPTQRPSIRKILEKDFL
||. || .||..|..|  .|.  ..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 15734.AA NEK11 4-262 40 8.7e-74 251.44 In-house 1-259 (259) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-259/259
Sequence Identity: 40% (105 aa)

YTKIKVVGKGSFGYAVLV-QSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESFIEKRCLCIIMEYAQGGDLYTKIAKQKEKGQ
|   . .| ||||   ||            |.| | .  .       |  |  .|  ..|| |. .  ||.|.   ||| ||  | ||  .|   |. |.
YVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANVEAQLLSRLHHPAIVRFHASFMEQDNFCIITEYCEGRDLDYRIQEYKQAGK

LFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDIKIGDFGIARVLQHTYDCAKTAIGTPYYLSPEICQEKPYNQKSDIWSLGCILYEMTT
.|.| |||.||.|. | .  .|.|.||||||| .||||     .||||||..|.|    | | |  ||| |.|||  . . |  ||||||| ||||||  
IFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNIFLKNN-LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALKHQGYDTKSDIWSLACILYEMCC

LNHAFDANSMKGLVLKILRGTYPPIPEQYSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
..|||   .   .||.|  |  | .|. | ..|  ..  || |.|  |||   ||   ..
MDHAFAGSNFLSIVLNIVEGDTPSLPDRYPRELNTIMERMLNKNPSLRPSAIDILKIPYM
Kinase 15734.AA ULK 4-262 29 5.3e-70 238.88 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-329/329
Sequence Identity: 29% (98 aa)

YTKIKVVGKGSFGYAVLVQSNTENN---KKYYVIKIIDISKMDRKQREEA--------LNEVHVLKAMK--------HPYIITYRESFIEK--RCLCIIM
| .... ||||||  |    | ...   ......|.||..||..|. |           ||. ..| .|        ||.|. . . | ..   .. |||
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

EYAQGGDLYTKIAKQKE------KGQLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAK------------GDIKIGDFGIARVLQHT---Y
|| .|||| . | |.|.      ... .||...|  | | . . |. |...| |||.| ||| .. .            | .||.||| |....      
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

DCAKTAI------GTPYYLSPEICQ----EKPYN-QKSDIWSLGCILYEMTTLNHAFDANSMKGLVLKILRGT---YPPIP----------------EQY
. ..|.       |||.| .|.| |    .|||.  |.||||||||.||| .    | |.    ..|.|..     .||.|                 | 
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SQDLRDLISEMLIKDPTQRPSIRKILEKDFL
|....|||. ||..|...| |.  ...  ..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 15734.AA ULK 4-262 29 2.3e-68 233.46 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-324/324
Sequence Identity: 29% (97 aa)

YTKIKVVGKGSFGYAVLVQSNTENN--KKYYVIKIIDISKMDRKQRE-------EALN-EVHVLKAMK---HPY--IITYRESFIEK--RCLCIIMEYAQ
| .... ||||||  |    | ..|  ..|. .|.||..||  |. |       . |. |. ..| .|   ||.  |. . . | ..    ..||||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLYTKIAKQKE-----KGQLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAK------------GDIKIGDFGIARVLQHTY---DCAKT
|||| . | |.|.     ... .||...|  | | . . |. |...| |||.| ||| .. .            | .||.||| |....      .  .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

AI------GTPYYLSPEICQ----EKPYN-QKSDIWSLGCILYEMTTLNHAFDANSMKGLVL---KILRG---------TYPPIPE------QYSQDLRD
.       |||.| .|.| |    .|||.  |.||||||||.||| .    | ..    ..|   | ..          . |  .       . |....|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LISEMLIKDPTQRPSIRKILEKDFL
||. ||..|...| |.  |..  ..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 15734.AA NEK6 4-253 38 2.6e-68 223.85 In-house 1-252 (252) Show / Hide 
Range on Protein: 4-253
Range on HMM: 1-252/252
Sequence Identity: 38% (98 aa)

YTKIKVVGKGSFGYAVLVQSNTENNKKYYVIKIIDISKMDRKQREEALNEVHVLKAMKHPYIITYRESFIEKRCLCIIMEYAQGGDLYTKIAKQKEKGQL
.   | .||| |   |   . . ..|.  . |.     || | |.. . |. .|| . || .| | .||||   | |..| |. ||.   |   | .. |
FQIEKKIGKGQFS-EVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRL

FSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDIKIGDFGIARVLQHTYDCAKTAIGTPYYLSPEICQEKPYNQKSDIWSLGCILYEMTTL
  |. |  .|||.. |..|.| ....|||.|  |.|. |.| .|.|| |. |        |   .|||||.|||  .|. || |||||||||.||||  |
IPERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAAL

NHAFDANSMK--GLVLKILRGTYPPIP-EQYSQDLRDLISEMLIKDPTQRPSI
   |    |    |  || .  |||.| . ||..||.|.. ..  ||..|| |
QSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase 15734.AA Pkinase_Tyr 43-203 26 2.5e-19 66.06 Pfam 41-210 (270) Show / Hide 
Range on Protein: 43-203
Range on HMM: 41-210/270
Sequence Identity: 26% (45 aa)

DRKQ--REEALNEVHVLKAM-KHPYIITYRESFI-EKRC--LCIIMEYAQGGDLYTKIAKQKEKGQLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQ
. .|  ||. ..|. ..| . .|| |. .    . ...   ..|.|||...|||..   |..| .| .. |..... .| | .  . ..... |||| . 
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAAR

NIFLNAKGDIKIGDFGIARVL-QHTYD-CAKTAIGTPY-YLSPEICQEKPYNQKSDIWSLGCILYEMTTL
|. .. .. .||.||| || .    |   ...    |   ..||  ... .. |||.|| |  ..|. |.
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase 15734.AA TyrKc 4-262 20 1.8e-18 68.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-262
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YTKIKVVGKGSFG---YAVLVQSNTENNKKYYV-IKIIDISKMDRKQREEALNEVHVLKAM--KHPYIITYRESFIEK-------RCLCIIMEYAQGGDL
 |..|. | | ||    ...          . | .| .  ..     ||. ..|  ...    .|| |.      ...         |.|.|||. .|||
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

YTKIAKQKEKGQLFSEKQIIDWFVQMALAIKHVHDRKILHRDLKTQNIFLNAKGDIKIGDFGIARVLQHT--------YDCAKTAIGTP-----YYLSPE
   . | ..|   .. |. ... .| |    . |.... |||| . |. ..... .||.||| .| . .         |  .|.  |.        ..||
KDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

ICQEKPYNQKSDIWSLGCILYEMTTLNHAFDAN------SMKGLVLKILRGTYPPIPEQ--------YSQDLRDLISEMLIKDPTQRPSIRKILEKDFL
  ... .. |||.|| |  ..|. |.      .      | . .. .. .| ..|.|.          .... .....    || .||. . |  ....
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 15734.AA Pkinase_Tyr 4-16 46 7.397453 0.14 Pfam 1-13 (270) Show / Hide 
Range on Protein: 4-16
Range on HMM: 1-13/270
Sequence Identity: 46% (6 aa)

YTKIKVVGKGSFG
 |..|. |.|.||
ITFGKKLGEGAFG
Kinase 15734.AA NEK6 749-765 58 0.000837 8.12 In-house 1-17 (252) Show / Hide 
Range on Protein: 749-765
Range on HMM: 1-17/252
Sequence Identity: 58% (10 aa)

YYLEKEIGVDQFMEVYR
. .|| ||  || ||||
FQIEKKIGKGQFSEVYR