Gene 22589 (Tetrahymena)
22589
Sequence
Protein domains of 22589.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 22589.AA | NAK | 108-382 | 35 | 6.9e-126 | 422.25 | In-house | 1-299 (299) | Show / Hide |
Range on Protein: 108-382 Range on HMM: 1-299/299 Sequence Identity: 35% (114 aa) IQEDKLLSEGNFTNFVGGYGYVWKAHN--------VNNKQEVFAVKRMICQVDLFEQLHEAFNLVYFQKQGKQKEDLAKRELEILYKLPQHDNLVRFIDG ... |.| | ||..||..... .|...|..|.|||||.. ..|... .|||.|...||..|.|.|..||. YTVEKYLAE-------GGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHS------------------DEQDLNACKREIEMMKKLQHHNNIVQYIDS DILQED--QSTSQAVFVMEYCPDGTLFNLMESRQK-SGG-FTEKEIIHIILQICKGLQVLHSIN----ITHRDLKIENVLLK----DGMFKLCDFGSAST .| ..| . |......||||..|.|..||..|.. .|. |||.||..|....|.|.|..|... |.|||.||||.||. ||..|||||||..| HINERDDSNGTWEVFLLMEYCCHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTT DVVDLRK--QQSE---QEELYERYTTLQSRPPEMCDVFSEEIIDSKVDIWMLGCIVYCLCFYIHPFYE------ASKLAIISASYK-------------- .... .. .... .......|||.. |.|||||..|. .||.|||||.|||. |..|||.|||.. |||||....|| AIIQPENRWEAQYRSMVQDWINKYTTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMH ----HLLTPSPKYRPKIEEVINIL ..||| |..||.|..|.|.| DLIRYMLTPDPEQRPNIYQVLNQL |
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Kinase | 22589.AA | NAK-Unclassified | 177-362 | 24 | 4.3e-45 | 155.32 | In-house | 57-367 (405) | Show / Hide |
Range on Protein: 177-362 Range on HMM: 57-367/405 Sequence Identity: 24% (75 aa) AKRELEILYKLPQHDNLVRFIDGDILQEDQST-SQAVFV-MEYCPDGTLFNLME------SRQ-KSGGFTEKEIIHIILQICKGLQVLH----------- .||| .. .. | | | || | .|. .. | ||. ||||..|.| .| | .. |.|.|. | ...| |.|..| MKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYCSRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATS -----------------------------------SINITHRDLKIENVLLK------------------------------------------------ || . |||.||||||. RVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDIKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN -----------DGMFKLCDFGSAS--TDVVDLRKQQSEQEELYERYTTLQSRPPEMCDVFSEEIIDSKVDIWMLGCIVYCLCFYIHPFYEASKLA----- .| .|||||||.. . |.. .. .. ...||.| |.||| | .. .||.|.||| ||| | .|||. || |. NNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQYLQDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVT --IIS--ASYK |.. . |. YKILHGLGKYE |
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Kinase | 22589.AA | BIKE | 175-362 | 36 | 1.3e-44 | 154.58 | In-house | 40-232 (267) | Show / Hide |
Range on Protein: 175-362 Range on HMM: 40-232/267 Sequence Identity: 36% (72 aa) DLAKRELEILYKLPQHDNLVRFIDGDILQEDQSTSQAVFVMEYCPDGTLFNLMESRQKSG-GFTEKEIIHIILQICKGLQVLHSIN--ITHRDLKIENVL . ..|| .|. .. | |.| ..| | . . |||| . |.| | . | |||.|. .| .| || | |||||.||.| NVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGVWECMILMEYCRH-QVVNMMNQRLQQGQYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENIL LKDGM---FKLCDFGSASTDVVDLRKQQSEQ-EELYERYTTLQSRPPEMCDVFSEEIIDSKVDIWMLGCIVYCLCFYIHPFYEASKLAIISASYK |.| . ||||||| . . . .|. . .. |.|||. | ||| | .|. .| | ||| |||. | |||. || | |.||| . ... LHDHGPPHYVLCDFGSATNKFLNPQKHGVNYVKDEIEKYTTMCYRAPEMIDLYSGKEITTKADIWALGCMLYKLCFFCLPFGE-SQLAICDGNFT |
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Kinase | 22589.AA | Pkinase | 124-384 | 23 | 1.9e-39 | 140.57 | Pfam | 10-272 (293) | Show / Hide |
Range on Protein: 124-384 Range on HMM: 10-272/293 Sequence Identity: 23% (69 aa) GGYGYVWKAHNVNNKQEVFAVKRMICQVDLFEQLHEAFNLVYFQKQGKQKEDLAKRELEILYKLPQHDNLVRFIDGDILQEDQSTSQAVFVMEYCPDG-- |..| |.|.|.... . ..|||.. . . ... ....| .|..|. .| .|.| ||..| . .|||||. | GSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL---------------SEIQIMKRL-NHPNIVRLYDWFED-----KDHIYMVMEYCEGGLY --TLFNLMESRQKSGGF--TEKEIIHIILQICKGLQVLHSINITHRDLKIENVLLK-DGMF----KLCDFGSAST-DVVDLRKQQSEQEELYERYTTLQS || ... ...|.| .|.|......||..||. .|| .| ||||| ||.|.. .| |.||||.| | .. .. . |. VMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWY RPPEMCDVFSEEIIDSKVDIWMLGCIVYCLCFYIHPFYEA----SKLAIISASYKHLLTPSPKYRPKI---------------------EEVINILEN ..|| . . . ...|||.| .|||.|.... ||... . . . .. . .| . .|. || . .... MAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW |
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Kinase | 22589.AA | GAK | 180-362 | 35 | 2.2e-39 | 128.46 | In-house | 46-239 (277) | Show / Hide |
Range on Protein: 180-362 Range on HMM: 46-239/277 Sequence Identity: 35% (69 aa) ELEILYKLPQHDNLVRFIDGDILQE---DQSTSQAVFVMEYCPDGTLFNLMESRQKSGGFTEKEIIHIILQICKGLQVLHSIN--ITHRDLKIENVLL-K | .. || | | | |.| .|| . |||| . | .. . | .. |. | | .| .|| | |||.|||| |. EICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRMECYKPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGN DGMFKLCDFGSASTDVVDLRK-----QQSEQEELYERYTTLQSRPPEMCDVFSEEIIDSKVDIWMLGCIVYCLCFYIHPFYEASKLAIISASYK .. ||||||||.| . . | |. |.|| |.|||||..| | |.||| .||. | .|. ||| .||.|| . |. QKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPIGHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYM |
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Kinase | 22589.AA | S_TKc | 108-446 | 19 | 7.9e-35 | 122.95 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 108-446 Range on HMM: 1-231/231 Sequence Identity: 19% (66 aa) IQEDKLLSEGNFTNFVGGYGYVWKAHNVNNKQEVFAVKRMICQVDLFEQLHEAFNLVYFQKQGKQKEDLAKRELEILYKLPQHDNLVRFIDGDILQEDQS . ... . |..| |.|..... ....|.|.. . ..||..|| | .|.|.|...| YEILRKIGK-------GAFGKVYKCRHKK-TGRIVAIKIIK--------------------------EHIRREIQILKK--HHPNIVKLYDVFQD----- TSQAVFVMEYCPD--GTLFNLMESRQKSGG---FTEKEIIHIILQICKGLQVLHSINITHRDLKIENVLLKDGMFKLCDFGSASTDVVDLRKQQSEQEEL . .|||||. |.|| ....|.. |. |.| .. ... |||..|. .|| .| ||||| ||.|| . |.||||.| -DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------------- YERYTTLQSRPPEMCDVFSEEIIDS-KVDIWMLGCIVYCLCFYIHPFYEASKLAIISASYKHLLTPSPKYRPKIEEVINILENWDNLQEIPLNEQAKQTK . |. ..||.. . |.|.| .|||.| .. ||. . . .|... TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------ QQEQQFEQDMKVRDEKVKQMIEKNRQQRIEEEQRKK--LQAEADNAF . ..| .... .|. ..|. . . . . .. | --------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 22589.AA | Ciliate-E2 | 171-430 | 17 | 9.3e-31 | 102.79 | In-house | 56-353 (365) | Show / Hide |
Range on Protein: 171-430 Range on HMM: 56-353/365 Sequence Identity: 17% (62 aa) KQKEDLAKRELEILY--------KLPQ---------HDNLVRFIDGDILQEDQSTSQAVFVMEYCPDGTLFNLMESRQKS--------GGFTEKEIIHII |... .. . .. |. . |.|...... ...... .||||| |.|| ......|. . ||||||..|. KKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE---CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIM LQICK---------------GLQVLHSIN-ITHRDLKIENVLLKDGMFKLCDFGSASTDVVDLRKQQ--SEQEELYERY-------------------TT ||.. .|. ||| | | |||.| ||.|. |..||| . | ... ...... . | KQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNT LQSRPPEMCD-VFS---------EEIIDSKVDIWMLGCIVYCLCFYIHPFYEASKLAIISASYKHLLTPSPKYRPKIEEVINILENWDNLQEIPLNEQAK . |..|. ... .. | |.||| ||.| |...| .|| ICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------------------------------------- QTKQQEQQFEQDMKVRDEK-------------------------VKQ----MIEKNRQQRI |.|. ... . . .. |. |..|. ..|| ----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI |
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Kinase | 22589.AA | ULK | 108-285 | 24 | 1e-29 | 100.94 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 108-285 Range on HMM: 1-189/329 Sequence Identity: 24% (52 aa) IQEDKLLSEGNFTNFVGGYGYVWKAHNVNNK---QEVFAVKRMICQ-VDLFEQLHEAFNLVYFQKQGKQKEDLAKRELEILYKLP---QHDN----LVRF .. .. | .| | .| |. |...| .|..|.| . | . .... | |.. .| |.| .|. || .| | |.. YCLNHCLGKGSFG-------KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQE----------GQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKL IDGDILQEDQSTSQAVFVMEYCPDGTLFNLMESRQKS-------GGFTEKEIIHIILQICKGLQVLHSINITHRDLKIENVLLKDG-------------M .| ....... ..||||..|.|..... ..|. . ..|.|.|... ||. |.. ||. || |||.| .|.|...| YD--WFETSNH-NNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGV FKLCDFGSA .|..||| | LKIADFGFA |
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Kinase | 22589.AA | Ciliate-E2-Unclassified | 124-380 | 20 | 2.4e-29 | 98.93 | In-house | 10-348 (352) | Show / Hide |
Range on Protein: 124-380 Range on HMM: 10-348/352 Sequence Identity: 20% (71 aa) GGYGYVWKAHNVNNKQEVFAVKRMI----CQVDLFEQLHEAFNLVYFQKQGKQKEDLAK---RELE-ILYKLPQHDNLVRFIDGDILQEDQSTSQAVFVM ||.| |.|. . ..| ...| | |. . . . .. . ... . . |.| . . ... ||. .| | ..|.... ..|.. .|| GGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHP-HPFIVKMFY-----CFQDKQNIYIVM EYCPDGTLFNLMESR--------------QKSGGFTEKEII-----HIILQICKGLQVLHSIN-ITHRDLKIENVLLKDGM----FKLCDFGSAS----- |||..|.|.. ...| ... |||.... ... ||..||. ||. | | |||.| ||.|..... |..|||... EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN -------TDVVDLRKQQSEQEELYERYTTLQSR----PPEMCDVFSEEIID----SKVDIWMLGCIVYCLCFYIHPFY---------------------- ..|. |.... . |.. .||. . .. | |.||| ||.| |...| .||| NNCDTNQQ----QKMQIWKQQMMWTFCGTPNYMPQYTAPEV---LQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ EASKL----------------AIISASYKHLLT--------PSPKYRPKIEEVIN .. ..| ..|.... |..|. .|...| LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN |
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Kinase | 22589.AA | ULK | 124-285 | 25 | 3.9e-29 | 100.56 | In-house | 10-185 (324) | Show / Hide |
Range on Protein: 124-285 Range on HMM: 10-185/324 Sequence Identity: 25% (49 aa) GGYG-YVWKAHNVNNK--QEVFAVKRMI-CQVDLFEQLHEAFNLVYFQKQGKQKEDLAKRELEILYKLP--QHDN--LVRFIDGDILQEDQSTSQAVFVM | .| .| |. |.... ....|.| . .. .... | |.. .| |.| .|. || .| | |...| ....... ..| GSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE----------GQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYD--WFETSNH-NNIYIIM EYCPDGTLFNLMESRQKS------GGFTEKEIIHIILQICKGLQVLHSINITHRDLKIENVLLKDG-------------MFKLCDFGSA |||..|.|..... ..|. . ..|.|.|... ||| |.. ||. || |||.| .| |...| .|..||| | EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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Kinase | 22589.AA | CMGC | 168-315 | 19 | 1.6e-27 | 86.78 | In-house | 47-295 (513) | Show / Hide |
Range on Protein: 168-315 Range on HMM: 47-295/513 Sequence Identity: 19% (49 aa) KQGKQKEDLAK-------------RELEILYKL----------------PQHDNLVRFIDGDILQEDQST--------------SQAVFVMEYCPDGTLF |. . .|. || ||..|| .| ..| |.|. . ||.. ..|. . .|.||.. .|. KNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLY--DIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH-DLY NLMESRQ--KSG----GFTEKE------------IIHII------LQICKGLQ--VLHSIN--ITHRDLKIENVLLKD---------------------G ..... | . | ...| . | ... ||..|| .|| . | ||||| ||.|. . | QYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNG MFKLCDFGSASTDVVDLRK---------------QQSEQEELYERYTTLQSRPPE |.||||.| . .. .... .... |. |.|| RLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPE |
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Kinase | 22589.AA | TKL-ciliate1 | 179-348 | 27 | 4.2e-27 | 89.82 | In-house | 47-219 (279) | Show / Hide |
Range on Protein: 179-348 Range on HMM: 47-219/279 Sequence Identity: 27% (51 aa) RELEILYKLPQHDNLVRFIDGDILQEDQSTSQA----VFVMEYCPDGTLFNLMESRQKS--GGFTEKEIIHIILQICKGLQVLHSIN--ITHRDLKIENV ||.. . |. || ||. .. .|. ...||.|. ||.| .. .| .| . .. .. | .|.| ||. . . |||||..| REIQQHIKIKQHINLQQLQG---------ISFYDNNFYIIMEHCHKGTMFDIC-HRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNI LL-KDGMFKLCDFGSASTDVVDLRKQQSEQEEL---YERYTTLQSRPPEMCD--VFSEEIIDSKVDIWMLGCIVYCLCFYIHPF |. .. .| |.|.. . . . . | | .. .| || . || | .|. | |.||. .| . | ||| || LYDEPYQYKICNFPHVKIADFHRIRNCSFQ-DMQNEMQRNTTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPF |
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Kinase | 22589.AA | Pkinase_Tyr | 171-283 | 33 | 4.6e-12 | 41.48 | Pfam | 43-156 (270) | Show / Hide |
Range on Protein: 171-283 Range on HMM: 43-156/270 Sequence Identity: 33% (40 aa) KQ--KEDLAKRELEILYKLPQHDNLVRFIDGDIL-QEDQSTSQAVFVMEYCPDGTLFNLMESR-QKSGGFTEKEIIHIILQICKGLQVLHSINITHRDLK .| .||. . |..|. .|..|.|.||.. | .. |.... | ||||.| | | . .. . .| |..... .||.||.. |.|.|. |||| EQNCREDFMR-EAKIMKQLGHHPNIVRLY-GVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLA IENVLLK-DGMFKLCDFG |.|.. .. | |||| ARNCLVTENNVVKICDFG |
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Kinase | 22589.AA | TyrKc | 108-382 | 20 | 6.2e-11 | -45.9 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 108-382 Range on HMM: 1-280/280 Sequence Identity: 20% (67 aa) IQEDKLLSEGNFTNFVGGYGYVWKAHNVNNKQEVFAVKRMICQVDLFEQLHEAFNLVYFQKQGKQKEDLAKRELEILYKL-PQHDNLVRFIDGDILQED- |. .| | ||.| | |.|.. . ||| . .||. ||..|. || ..|.|.||.. | ..|. ITLGKKLGEGAF-------GEVYKGTWK----IQVAVKMLKEDA---------------------REDF-MREARIMCKLGGHHPNIVRLY-GVCTQQGR --QSTSQAVFVMEYCPDGTLFNLMESRQKSGGFTEKEIIHIILQICKGLQVLHSINITHRDLKIENVLLKDGM-FKLCDFGSASTDVVDLRKQQSEQEEL . . ||||.| | | . .... .. |. ... .||..| . ||| |. |||| |.|.... | .||| . .. NFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS--------------RDI YER--------YTTL----QSR--------PPEMCDVFSEEIIDSKVDIWMLGCIVYCLCFYIHPFYEA------SKLAIISASYKHLLTPSPKY----- |. | . ... .|| . . .| |.|. | . .. | . |. | .| . | |.. YDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS ----------------------RPKIEEVINIL || .|.. .. FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 22589.AA | TKL-ciliate1 | 369-382 | 50 | 0.015034 | 4.54 | In-house | 266-279 (279) | Show / Hide |
Range on Protein: 369-382 Range on HMM: 266-279/279 Sequence Identity: 50% (7 aa) PKYRPKIEEVINIL |. ||. .|.| || PNKRPNFNEIIQIL |
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Kinase | 22589.AA | GAK | 124-148 | 40 | 0.035422 | 2.94 | In-house | 10-33 (277) | Show / Hide |
Range on Protein: 124-148 Range on HMM: 10-33/277 Sequence Identity: 40% (10 aa) GGYGYVWKAHNVNNKQEVFAVKRMI ||.. |. | .| .|. |.|||. GGFAFVYVAQDVQTGREY-ALKRML |
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Kinase | 22589.AA | ULK | 326-350 | 52 | 0.088287 | 2.1 | In-house | 234-258 (329) | Show / Hide |
Range on Protein: 326-350 Range on HMM: 234-258/329 Sequence Identity: 52% (13 aa) DSKVDIWMLGCIVYCLCFYIHPFYE |.|.||| |||| | . . |||. DYKCDIWSLGCIFYEMLYGKPPFYA |
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Kinase | 22589.AA | ULK | 326-339 | 71 | 0.11493 | 1.76 | In-house | 230-243 (324) | Show / Hide |
Range on Protein: 326-339 Range on HMM: 230-243/324 Sequence Identity: 71% (10 aa) DSKVDIWMLGCIVY |.|.||| |||| | DYKCDIWSLGCIFY |