Gene 2548 (Tetrahymena)
2548
Group:
Other
Family:
Ciliate-F2
Sequence
Protein domains of 2548.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 2548.AA | Ciliate-F2 | 40-239 | 81 | 1.1e-166 | 560.04 | In-house | 1-200 (200) | Show / Hide |
Range on Protein: 40-239 Range on HMM: 1-200/200 Sequence Identity: 81% (163 aa) YQYVGILGNGLFGQQIQAYSENYQSVAIKIIYSKNSGLETALKQSTKYKQIKNTQHLAQIHEIVYNPSLNTYYIVQELADCSLKEILESCKLTDKQIYET |||||||||||||||||||||||||||||||||||||||...|||||||||.|.||..|||.|||||..|.|..|||..||..|..|.||||||.|.||. YQYVGILGNGLFGQQIQAYSENYQSVAIKIIYSKNSGLEPEIKQSTKYKQIDNKQHVYQIHVIVYNPFFNKYHFVQETEDCCIKQQLQSCKLTDNQQYEE TLQLLEGLAELENLGLIHGDIKTENILYNRPKNKFMFTDFGLAQVLMKSNKPASSNSKQLQRTQIYGAPELEKEQDTSRFQNKMDTYALGMVLSEIIIGK ..|...||||||||||||||||.||..|||||..|||.||.|.|.||||||||||||||||||||||||||||||||||||||||||||||||||||||| IQQFINGLAELENLGLIHGDIKIENMIYNRPKQRFMFDDFQLIQILMKSNKPASSNSKQLQRTQIYGAPELEKEQDTSRFQNKMDTYALGMVLSEIIIGK |
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| Kinase | 2548.AA | Ciliate-E1 | 46-226 | 24 | 2.1e-30 | 96.29 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 46-226 Range on HMM: 1-202/202 Sequence Identity: 24% (50 aa) LGNGLFGQQIQAYSENYQ--SVAIKIIYSK---NSGLETALKQSTK-YKQIKNTQHLAQIHEIVYNPSLNTYYIVQELADCSLKEILE------------ .||| |.. ..|...|.. .||.||| . |. .. ... . ....|. . . || .. . ......|..|. .||||. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ --SCKLTDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNKFMFTDFGLAQVLMKSNKPASSNSKQLQRTQIYGAPELEK-----EQDTSRFQ ...|..|. . . ||..||.||.....||.||| .|||.|. ... ..|||....|..... ..... . |. | || . .... QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQN---QQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN NKMDTY | | | YKSDIY |
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| Kinase | 2548.AA | Ciliate-A8 | 40-175 | 37 | 3.6e-23 | 77.2 | In-house | 1-151 (151) | Show / Hide |
Range on Protein: 40-175 Range on HMM: 1-151/151 Sequence Identity: 37% (56 aa) YQYVGILGNGLFGQQIQAYSENYQS-VAIKIIYSKNSGLETALK----QSTKYKQIKNTQHLAQIHEIVYNPSLNTYYIVQELADC--------SLKEIL | |. .|..| | .||||.| | ||||||. | . | . ||| . || | ... .. || |. || .| .|| YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL E--SCKLTDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNKFM | . |.| .||. | |||..| ... | ||.||| .||||.. ||.| ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
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| Kinase | 2548.AA | CMGC | 40-182 | 18 | 2.5e-22 | 69.34 | In-house | 1-251 (513) | Show / Hide |
Range on Protein: 40-182 Range on HMM: 1-251/513 Sequence Identity: 18% (46 aa) YQYVGILGNGLFGQQIQAYS---------------ENYQSVAIKIIYSKNSGLETAL-------KQSTKYKQIKNTQHLA---------------QIHE- |. .. .| | .|. ... |. . ||||.| .. |.|. . .. . || .|| . |. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IV------YNPS---------------LNTYYIVQELADCSLKEILESCK----------LTDKQ------------IYETT------LQLLEGLA--EL || | . .| |.| |. |..|........ |.. . | . |.|.||. . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC ENLG--LIHGDIKTENILYNRPKNKF-------------------MFTDFGLA . || |.| |||| | . . ||||| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA |
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| Kinase | 2548.AA | S_TKc | 40-310 | 16 | 3.9e-14 | 30.3 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 40-310 Range on HMM: 1-231/231 Sequence Identity: 16% (50 aa) YQYVGILGNGLFGQQIQAYSEN-YQSVAIKIIYSKNSGLETALKQSTKYKQIKNTQHLAQIHEIVYNPSLNTYYIVQELADC---SLKEILESCK----- |. . ..| | ||. ... . . |||||| .. | .. .. . .. ..... .. . .|.| |..| .|........ YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK-------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --LTDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNKFMFTDFGLAQVLMKSNKPASSNSKQLQRTQIYGAPELEKEQDTSRFQN-KMDTYA .. .. . |....|. . ..| || |.| |||| .. . .||||| .| . . | | |||. . | | .. FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----------TTFCGTPWYMAPEVL------GYGKCKCDWWS LGMVLSEIIIGKG-FELEESIDIKNNNDIQDYIPFDSHHKFYIEKIILNMVKVSKKERQETSELINTLKKNFEFNEQ-----DLMA--------IYI .| .| | . |. |. . . . |.|. ..|... ..| .... . .... .. CGCILYEMLCGYPPFP----------------------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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| Kinase | 2548.AA | C8 | 112-232 | 24 | 1.7e-13 | 43.3 | In-house | 94-226 (226) | Show / Hide |
Range on Protein: 112-232 Range on HMM: 94-226/226 Sequence Identity: 24% (32 aa) YIVQE--LADCSLKEILESCKLTDKQ-----IYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNKF---MFTDFGLAQVLMKSNKPASSNSKQLQR . |.| |.. ||.. . .. ...| . ..|...|. .. .| ||| .|.| .|. |||.| . |. . | . CFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCG TQIYGAPELEKE--QDTSRFQNKMDTYALGMVL |. | ||| ||. .. .. . | . .|.|| TWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 2548.AA | Ciliate-C8 | 112-232 | 24 | 3.9e-13 | 43.7 | In-house | 88-238 (238) | Show / Hide |
Range on Protein: 112-232 Range on HMM: 88-238/238 Sequence Identity: 24% (37 aa) YIVQELADCS----LKEILESCKLTDKQ-----IYETTLQLLEGLAELENLGLIHGDIKTENIL-----YNRPKNKFMF----TDFGLAQVLMKSNK-PA ..| |. |. ||. .. |. .... . . | ..... | .| ||| .|.| . | | |||.| | |. FFVMEMEKCQQNCNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYH SSNSKQLQRT--------QIYGAPELEKE---QDTSRFQNKMDTYALGMVL |.. |. . . | |||.||. . |. | | | .| || SKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL |
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| Kinase | 2548.AA | Ciliate-C5 | 88-306 | 28 | 4.9e-13 | 39.0 | In-house | 45-260 (260) | Show / Hide |
Range on Protein: 88-306
Range on HMM: 45-260/260
Sequence Identity: 28% (63 aa)
KQIKNTQHLAQIHEIVYNPSLNTYYIVQELADCSLKEILESC-----KLTDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNKFMFTDFGLA
| .|.| . . | . | || . |.||.|..| | || .|. .... ||| |.| |||||. |. .|.| .
KLLKDTPYVFKSIEEFLNEKKSKYYQISKRYSCNLKDIMQSFFDQKKTLPLNQIIGFAIQMSTVFEKIQQNNLIHSDVKPENILYDSQEKCFNLCDYGES
QVLMKSNKPASSNSKQLQRTQIYGAPELEKEQDTSRFQNKMDTYALGMVLSEIIIGKGFELEESIDIKNNNDIQDYIPFDSHHKFYIEKIILNMVKVSKK
|| | .| |. | |||. . . |. | | | ||..| |. .|| | |. |.| . . .|| .. .. |..||. |. . .
----KSFKDGSKTYDLKGFTRKYAAPEITDD--NGFFNIKYDIYGLGIILLELTLGKFLEDEDCTFIRNGK-LPNYISKNALYQ-DINQIIIKMLEKMPQ
ERQETSELINTLKKNFEFNEQDLM
.| . || | . |....
NRIDSFELTKQLNELRLKLESQFI
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| Kinase | 2548.AA | Ciliate-E3 | 40-236 | 27 | 7.8e-13 | 36.64 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 40-236 Range on HMM: 1-202/202 Sequence Identity: 27% (57 aa) YQYVGILGNGLFGQQIQAYS-ENYQSVAIKIIYSKNSGL-------ETALKQSTKYKQIKNTQHLAQIHEIVYNPSLNTYYIVQELADC-SLKEILESCK | |||.| || .|.. | | |||| | .| .. .|| | |.. ..|...| . . ||||. .|.. . . YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQNKMIFIVQEYCSNGDLYHYIKQQN LTDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKN--KFMFTDFGLAQVLMKSN--KPASSNSKQLQRTQIYGAPELEKEQDTSRFQNKMDTY .| ||. |...|. .. .||.||| .||| .| . |||.. | | . . . . | .| |||. ..| | . | | KTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQG----WTPFYAAPEQNDQQQIS---KESDYY ALGMVLSEII .| |. ... SVGAVFCQLC |
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| Kinase | 2548.AA | TKL | 154-239 | 21 | 1.7e-12 | 41.35 | In-house | 160-286 (364) | Show / Hide |
Range on Protein: 154-239 Range on HMM: 160-286/364 Sequence Identity: 21% (27 aa) GLIHGDIKTENILYNRPKN-------------KFMFTDFGLAQVLMKS-NKPASSNS-------------KQLQR-TQIYGAPEL--------------E ..|| |.|..||| .. . . .||||.... .| |. ..... . |. | . |||. | PIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE KEQDTSRFQNKMDTYALGMVLSEIIIGK .. . . |.| |. |.|| ||. .. -FCKGFEYSEKCDVYSFGIVLWEILTRC |
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| Kinase | 2548.AA | Ciliate-E2 | 40-297 | 17 | 3.5e-12 | 38.11 | In-house | 1-348 (365) | Show / Hide |
Range on Protein: 40-297 Range on HMM: 1-348/365 Sequence Identity: 17% (65 aa) YQYVGILGNGLFG--QQIQAYSENYQS-----------------VAIKIIYSKNS---GLETALKQSTKYKQIK---------------NTQHLAQIHEI | . ..|.| || . . .....|. |.|||.. |. ..| .. ...|. | .. ...| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC VYNPSLNTYYIVQELADC-SLKEILESC------------KLTDKQIYETTLQLLE---------------GLAELENLG-LIHGDIKTENILYNRPKNK .. . |..|.| |... .|....... ..|.|.| . . |.|. .| .| . . || ||| ||||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ FMFTDFGLAQVLMKSNK-----PASSNSKQLQR-----------------------TQIYGAPELEKEQD------TSRFQNKMDTYALGMVLSEIIIGK .||||.. . ..|. . . . .. . | | ||| . .. . | | ..||..| | . || IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK G-FELEESIDIKNNNDIQ-DYIPFDSHHKFYIEKIILNMVKVSKKERQETSELIN-----TLKKN | .... ...|. . .... . .. . ... | || ||. ||. |.|. PPF-----QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKW-KSWKKWSQECKDLIKKFGKRMLQKD |
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| Kinase | 2548.AA | Pkinase | 109-194 | 23 | 2.5e-09 | 34.07 | Pfam | 73-170 (293) | Show / Hide |
Range on Protein: 109-194 Range on HMM: 73-170/293 Sequence Identity: 23% (23 aa) NTYYIVQELADC-----SLKEILE---SCKL--TDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNK---FMFTDFGLAQVL-MKSNKPASS . .|.|.|.... .|..... .... ..... .|.|.||. . . | || |.| ||||... . . .||||| .. .| ... DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTT |
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| Kinase | 2548.AA | TyrKc | 40-294 | 15 | 5e-06 | -125.79 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 40-294 Range on HMM: 1-280/280 Sequence Identity: 15% (45 aa) YQYVGILGNGLFGQQIQAYSENYQSVAIKIIYSKNSGLETALKQSTKYKQI-KNTQHLAQIHEIVYNP-----SLNTYYIVQELADC-SLKEILESCK-- . .||.| ||. .. . ||.| . . .| .. ... .. ... ... .. . . ..|| |... .||. | ... ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK LTDKQIYETTLQLLEGLAELENLGLIHGDIKTENILYNRPKNKFMFTDFGLAQVLMKS--------NKPASS--NSKQ------LQRTQIYGAPELEKEQ |. |. . .| .| . |. ..|| |. . |.|..... .||||. . . ... ..| . ||| LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-------APECI--- DTSRFQNKMDTYALGMVLSEII-IGKGFELE------ESIDIKNNNDIQDYIPFDSH---------HKFYIEKIILNMVKVSKKERQETSELINTL ....| | | .. | .. || |. . . ... .. . .. | . .. . |.. . ..| ||.. . NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | 2548.AA | Pkinase | 40-70 | 31 | 0.172371 | 6.35 | Pfam | 1-32 (293) | Show / Hide |
Range on Protein: 40-70 Range on HMM: 1-32/293 Sequence Identity: 31% (10 aa) YQYVGILGNGLFGQQIQAYSENYQS-VAIKII |. ....| | ||. ... ... ||.||| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKII |
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