Gene 5505 (Tetrahymena)
5505
Group:
Other
Family:
Ciliate-E8
Sequence
Protein domains of 5505.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 5505.AA | Ciliate-E8 | 294-398 | 69 | 2e-87 | 273.04 | In-house | 29-138 (138) | Show / Hide |
Range on Protein: 294-398 Range on HMM: 29-138/138 Sequence Identity: 69% (76 aa) KFKQLNEACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLINKKID-----QEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDT || |||.|||||.||.|||||..|....||.||||||||||||.|.|..|||| |.|.||||||||.||||||..||||.||||.|......||| KFDILNEICIQMLVCHRNIQNIYDVYQNENNKIVIVQKMQGENLRKYLKFKKIDGSYICQNKRMGYIQQIMDAFCYLHNNNIIHCDFKLNNILVQRNDDT KIKIIDFGFS |||||||||| KIKIIDFGFS |
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Kinase | 5505.AA | CAMK | 298-411 | 18 | 1.4e-18 | 55.87 | In-house | 79-281 (425) | Show / Hide |
Range on Protein: 298-411 Range on HMM: 79-281/425 Sequence Identity: 18% (38 aa) LNEACIQML-------LCHPNIQNIEEVFA------------VTNN-------EIVIV----QKMQGE----NLNKLLINK----------------KID ..| .| .. | |||| .. ||. .. ....| ..| | .. . ... RREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFT QEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDD---------------TKIKIIDFGFSQIKIFNK-------------------------FF . | |..|| | |.||.||.| | |.||. . ..| .||||||||..... .. . EREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMK TPLG |. | TFCG |
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Kinase | 5505.AA | Ciliate-E2 | 283-433 | 21 | 3.1e-18 | 59.18 | In-house | 58-283 (365) | Show / Hide |
Range on Protein: 283-433 Range on HMM: 58-283/365 Sequence Identity: 21% (51 aa) NELFQQTTELQKFKQLNEAC--------IQMLLCHPNIQNIEEVFA--VTNNEIVIVQKMQGENLNKLLINK------------KIDQEKAMGYIQQIMK |...|. |.. ....|. |. .| |||| .. |.| .|| . || .| ....|. ... ... ...|| . NQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQ ---------------AFCYLHSLN-IIHSDFKLENVVTVLDDDTKIKIIDFGFSQIKIFN----------KFFTPLG----------------------- |. |||| | ||| | |.||.. |||||||.|.. . | .. . GFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTIC YTKGYEPI----EEK---------YTFESDIFSIG .| || . .| |....||.|.| GTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG |
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Kinase | 5505.AA | CAMKL | 292-398 | 26 | 2.7e-15 | 45.13 | In-house | 33-176 (297) | Show / Hide |
Range on Protein: 292-398 Range on HMM: 33-176/297 Sequence Identity: 26% (39 aa) LQKFKQLN---------------------EACIQMLLC---HPNIQNIEEVF------AVTNNEIVIVQKMQGEN---LNKLLINK-----KIDQEKAMG . |.| | |..|...| |||| . ||. | ..|..| . | .... ... . | IDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARR YIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFS | .||. | |.||..|.| | |.||. ... .||||||||| YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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Kinase | 5505.AA | HUNK | 300-398 | 33 | 1.1e-14 | 43.17 | In-house | 50-162 (433) | Show / Hide |
Range on Protein: 300-398 Range on HMM: 50-162/433 Sequence Identity: 33% (38 aa) EACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLINKK---IDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLEN------VVTVLDDDTKI || |. .. |||| || || . | .| ... || . | || |. | .| . ..|.| | || . |||| .| EAQIMQMMRHPNIVRLYEVMETDNNYYLVMEYCPGGDLMHKVCEKKGGRLEEGVARRYIRQLVSAVHHMHHHGVVHRDLKIENLETYLSLSLLLDDDHNI K-----IIDFGFS | ||||| | KNYVAFIIDFGLS |
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Kinase | 5505.AA | AMPK | 343-400 | 36 | 2.9e-14 | 38.83 | In-house | 94-149 (254) | Show / Hide |
Range on Protein: 343-400 Range on HMM: 94-149/254 Sequence Identity: 36% (21 aa) NKKIDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFSQI ..... . | ..||| . |.| ..| | | |.||. ||.. .||| ||| | . HGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENL--LLDHNKNIKIVDFGLSNM |
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Kinase | 5505.AA | Ciliate-E2a | 333-433 | 26 | 6.2e-14 | 37.42 | In-house | 82-203 (275) | Show / Hide |
Range on Protein: 333-433 Range on HMM: 82-203/275 Sequence Identity: 26% (32 aa) QGENLNKLLINKK-IDQE--KAMGYIQQIM-KAFCYLHSLNIIHSDFKLENVVTV-LDDD----TKIKIIDFGFSQIK---IFNKFFTPLGYTKGYEP-- .| | . ....| ...| ... ..||. ... |.|..||.| | |.||. .. . ..|||||||... . .. |. | | || . EGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCG-TPGYVAPE ----IEE----KYTFESDIFSIG |. .|. |..|.| VLNNKEVLKHKQYDTKCDMWSCG |
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Kinase | 5505.AA | Ciliate-E2-Unclassified | 309-433 | 23 | 6.4e-14 | 44.68 | In-house | 80-257 (352) | Show / Hide |
Range on Protein: 309-433 Range on HMM: 80-257/352 Sequence Identity: 23% (43 aa) HPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLIN------------------KKIDQEKAM-----GYIQQIMKAFCYLHSLN-IIHSDFKLENVVTVL ||.| . ...| ..| . . ....| .| . . . |... ..| |. || ....|||. | ||| | |.||. .. HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENI--LF DDDT---KIKIIDFGFSQ-----------------IKIFNKFFTPLGYTKGYEP-------IEE-KYT----FESDIFSIG |.. .|||||||.| | ..... | | | .| | ... .| ...||.| | DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCG-TPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG |
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Kinase | 5505.AA | NuaK | 307-398 | 34 | 7.4e-14 | 32.28 | In-house | 56-146 (252) | Show / Hide |
Range on Protein: 307-398 Range on HMM: 56-146/252 Sequence Identity: 34% (32 aa) LCHPNIQNIEEVFAVTNNEIVIVQKMQGENLNKLLIN-KKIDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFS | ||.| .| ||| . ... | .| . . |.. . | || | | | .|.| | ||||. ||.. .|| ||| | LNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENI--LLDQNCNAKIADFGLS |
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Kinase | 5505.AA | Aur | 339-398 | 45 | 1.7e-13 | 31.48 | In-house | 91-149 (257) | Show / Hide |
Range on Protein: 339-398 Range on HMM: 91-149/257 Sequence Identity: 45% (28 aa) KLLINKKIDQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDD-DTKIKIIDFGFS . ..||..| ..| |..|| |. |.|| |||| | | ||. ||. . .||| ||| | QKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENI--LLDQCNGNIKICDFGWS |
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Kinase | 5505.AA | Pkinase | 298-433 | 25 | 1.9e-12 | 45.07 | Pfam | 46-199 (293) | Show / Hide |
Range on Protein: 298-433 Range on HMM: 46-199/293 Sequence Identity: 25% (40 aa) LN--EACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQGE----NLNKLLI---NKKI--DQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDD .. |..| |.|||| . ..| .. .. ..| | .. .... . . . |. || .. |.|| .||| | |.||. .|. RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI--LIDN DTKI----KIIDFGFSQI--KIFNKFFTPLGYTKGY---EPIE--EKYTFESDIFSIG . | ||.|||.. | .| . | .| | | ..|. ..|..|.| NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG |
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S_TKc | 5505.AA | S_TKc | 278-534 | 16 | 9.6e-11 | -19.37 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 278-534 Range on HMM: 1-231/231 Sequence Identity: 16% (49 aa) YHLFGN---------ELFQQTT--------ELQKFKQLNEACIQMLLCHPNIQNIEEVFAVTNNEIVIVQKMQG--ENLNKLLINKK-------IDQEKA |.. . . . .. . ..| | . |||| .. .|| .. .. . | .| ... ... .. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HA MGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFSQIKIFNKFFTPLGYTKGY---EPIEEKYTF-ESDIFSIGKSINKIYANNKFYK |..|| .| |.||..||| | | ||. |||.|||.. . | . | | | . .|.. ..|. |.| . .. . RFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYEMLCGYPPFP SITFSVQQEPENKKTQFIEFQNKYKQFNIIAITQQILLLLDENITPQNQSFVECLADNDIKLFVLKLLSY--EKRISQNQNIE-----IQIQLL . .. |..| . . | |. |.| . |||.. . . . . . ---------------------QMQMMFKKIG-------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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TyrKc | 5505.AA | TyrKc | 279-474 | 16 | 0.000488 | -157.34 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 279-474 Range on HMM: 1-280/280 Sequence Identity: 16% (46 aa) HLFGNEL---------------------FQQTTELQKFKQLNEACIQMLL--CHPNIQNIEEVFAVT-------NNEIVIVQKMQGENLNKLLINKK--I .| .| . . .. | ..|| | . | |||| .. | ... | . .|.. | ... . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDF--MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL DQEKAMGYIQQIMKAFCYLHSLNIIHSDFKLENVVTVLDDDTKIKIIDFGFSQIKIFNK--------FFTPLG--YTKGYEPI---------EEKYTFES .. . || . |||| |.|| | |. .... .|| ||| | .| .. .. . .|. || . |.|..| CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNC--LVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS D----------IFSIGKSINKI-----YANNKFYKSITFSVQQEPENK--------KTQFI----------------EFQNKYKQF | ||. |.. | .. . .. .. . |.. ...| DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |