Gene 22407 (Tetrahymena)

22407

Species: Tetrahymena
Alias: 3701.m00190, PreTt22407, TTHERM_00220790, 18.m00433, 507, 22407
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E8

Sequence

Name Sequence Type Origin Length Description Download
22407.AA Protein None 1000 None Fasta, JSON
22407.kin_dom Protein Kinase Domain None 157 None Fasta, JSON
22407.NA RNA None 3003 None Fasta, JSON

Protein domain

Protein domains of 22407.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22407.AA Ciliate-E8 446-582 81 3.7e-122 383.18 In-house 1-138 (138) Show / Hide 
Range on Protein: 446-582
Range on HMM: 1-138/138
Sequence Identity: 81% (113 aa)

SEIYSAKKDGVDFILKTINLESESSKMSKFDILNEIAIQMLVSHRNILKVYDLYQNEKGKIVLVQKRLGENLREYLK-KKIDGSYICQNKRYGYILQIIN
||||||||||||||||||||||||||||||||||||.|||||.||||...||.||||..|||.|||..|||||.||| |||||||||||||.|||.||..
SEIYSAKKDGVDFILKTINLESESSKMSKFDILNEICIQMLVCHRNIQNIYDVYQNENNKIVIVQKMQGENLRKYLKFKKIDGSYICQNKRMGYIQQIMD

VFQYLHNLNIIHCDLKLDNILVQPNDDSKIKLIDFGFS
.|.||||.||||||.||.|||||.|||.|||.||||||
AFCYLHNNNIIHCDFKLNNILVQRNDDTKIKIIDFGFS
Kinase 22407.AA CAMK 453-602 17 5.6e-24 73.54 In-house 30-289 (425) Show / Hide 
Range on Protein: 453-602
Range on HMM: 30-289/425
Sequence Identity: 17% (48 aa)

KDGVDFILKTINLESESSKM-------------------------SKFDILNEIAIQML-------VSHRNILKVYDLYQ------------NEKG----
. |. .  | |. .  ..|.                         ..  ...||.| ..       ..|.||.| |. |.            . .     
N-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFT

---KIVLVQKRLGENLREYLKKK---ID-GSYICQN---------------KRY------GYILQIINVFQYLHNLNIIHCDLKLDNILVQPNDD-----
   ....| .       ||       .|  .||...               .|.       |. ||.   .|.|..||.|.|||..|||.. |.|     
KDKHMYMVME-----IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPV

----------SKIKLIDFGFSQIKLFNK-------------------------YFKPIGTTFYLA-P
           .||.|||||....  ..                         .  . ||  | | |
EHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP
Kinase 22407.AA CAMK-Unique 465-602 19 5e-19 59.26 In-house 51-244 (363) Show / Hide 
Range on Protein: 465-602
Range on HMM: 51-244/363
Sequence Identity: 19% (39 aa)

LESESSKMSKFDILNEIAIQMLVSHRNILKVYDL----YQNEKG--------------KIVLVQKRLGEN-LREYLKK------------------KIDG
. ... |       .|..|  .|.| ||.|.||     .. .|               ....|. .. .. | ... |                  .. |
RYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQG

SYIC-QNKRYGYILQIINVFQYLHNLNIIHCDLKLDNILVQPN--D------------DSKIKLIDFGFSQIKLFNKYFKP------IGTTFYLAP
..    .    .....  .  |.|...|.| ||||.||.|. .  |            ...|||.||| .  ...|   ..      .||  |.||
HFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLC--CHYNHNKMCHMMQTMCGTPCYMAP
Kinase 22407.AA Pkinase 445-602 25 7.2e-19 67.81 Pfam 12-180 (293) Show / Hide 
Range on Protein: 445-602
Range on HMM: 12-180/293
Sequence Identity: 25% (45 aa)

MSEIYSAKKDGVD--FILKTINLESESSKMSKFDIL-NEIAIQMLVSHRNILKVYDLYQNEKGKIVLVQKRLGE-----NLREYLK---KKID--GSYIC
... | ... |    . .|.|....|.|.. . ... .||.|   ..| ||.. || ... |..| .|.  ..       | .|..   ..        |
FGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWEC

QNKRYGYILQIINVFQYLHNLNIIHCDLKLDNILVQ--PNDDSKIKLIDFGFSQI--KLFNKYFKPI-GTTFYLAP
..    |..||.   .|.|. .|||.|||..|||.   .. |...|..|||..       |  .. . || .|.||
KF----YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP
Kinase 22407.AA Ciliate-E2 460-619 20 9.2e-19 61.02 In-house 52-280 (365) Show / Hide 
Range on Protein: 460-619
Range on HMM: 52-280/365
Sequence Identity: 20% (49 aa)

LKTINLESESSKMSKFDILNEIA----------IQMLVSHRNILKVYDLYQN-EKGKIVLVQKRLGE-NLREYLKKK---------IDGSYICQNKRYGY
.|...     ..... .|..||           |. ...| ||.| |. .|.  . .| ||   .   .|..|.|..         .|  |.  ...  .
MKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYI

ILQIINVF---------------QYLHNLN-IIHCDLKLDNILVQPNDDSKIKLIDFGFSQIKLFN-----------KYFKPI-----------------
. ||...|               .|||. | ||| |.|..|||.       ||.||||.|..   .           .|                     
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQN

------GTTFYLAPSELKKNN-------QLCTFESEIY
      ||  |.||  |.. .       .  .... |.
MFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIW
Kinase 22407.AA Ciliate-E2-Unclassified 434-602 20 5.1e-18 59.11 In-house 1-235 (352) Show / Hide 
Range on Protein: 434-602
Range on HMM: 1-235/352
Sequence Identity: 20% (49 aa)

FTDVKKINGTKMSEIYSAKKDGVDFI------LKTINLESESSKMSKFDILNE-IAIQ----------------MLVSHRNILKVYDLYQNE-KGKIVLV
.. .|.|.    ...| ....  ...       | ..  . . . .. .|.|| ....                 |..| ....|...|. . | .| .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

QKRL-GENLREYLKKKID----GSYICQNKRY---------------GYILQIINVFQYLHNLN-IIHCDLKLDNILVQPND-DSKIKLIDFGFSQIKL-
   . | .|..|.||.      |  . .|...                |. ||.. ..|||  | ||| |.|..|||.. |    .||.||||.|     
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------FNKYFKPIGTTFYL----AP
                ....   .||  |.    ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAP
S_TKc 22407.AA S_TKc 434-677 22 1.1e-17 66.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 434-677
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

FTDVKKINGTKMSEIYSAKK--DGVDFILKTINLESESSKMSKFDILNEIAIQMLVSHRNILKVYDLYQNEKGKIVLVQKRLGE---NLREYLKKKIDG-
.. ..||    ... | ...  .|  . .| |.           .|..||.| .   | || | || .|.  ... .|   ..    .|..|.||.  . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SYICQNKRYGYILQIINVFQYLHNLNIIHCDLKLDNILVQPNDDSKIKLIDFGFSQIKLFNKYFKPIGTTFYLAPSELKKNNQ--------------L
  ...       |. ||..  .|.|...|||.||| .|||.       ||..|||.. .         .|| .|.||  | . .               .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEM

CT----FESEIYMIAKTMIEILELNETNLENPKFLISQQLKQLIRNMTEKKIEERCVMSDVLQ----IFKLDFF
..    |. ...|. | .                  |...|..||.. .|  |.|    ..||    | .  .|
LCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22407.AA AGC 538-602 19 6.3e-17 38.85 In-house 151-276 (395) Show / Hide 
Range on Protein: 538-602
Range on HMM: 151-276/395
Sequence Identity: 19% (25 aa)

YILQ-------IINVFQYLHN-LNIIHCD-LKLDNILVQPNDDSKIKLIDFGFSQIKLF-----------------------------------------
|. .       |.  ..|||. ..||| | ||..|||   .    ||| |||.. .                                            
YAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNM

-----------NKYFKPIG--TTFYLAP
           ..     |  |  |.||
SQEDDTTRKKRDRTWTFCGPCTPEYMAP
Kinase 22407.AA Ciliate-E2a 541-583 40 2.1e-15 41.81 In-house 109-157 (275) Show / Hide 
Range on Protein: 541-583
Range on HMM: 109-157/275
Sequence Identity: 40% (20 aa)

QII-NVFQYLHNLNIIHCDLKLDNILVQ---PNDD--SKIKLIDFGFSQ
|..   ..|.|..||.| |||..|||     .|..  |.||.||||...
QLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLAT
Kinase 22407.AA CAMKL 480-582 31 7.1e-15 43.76 In-house 62-176 (297) Show / Hide 
Range on Protein: 480-582
Range on HMM: 62-176/297
Sequence Identity: 31% (36 aa)

EIAIQMLVS---HRNILKVYDLYQNEK-----GKIVLVQKRLGEN---LREYLKKKIDGS-YICQNKRYGYILQIINVFQYLHNLNIIHCDLKLDNILVQ
||.|.....   | || | |. .....     .||.||    .     | .|..|. ..   .  .    |  ||.   .|.|...|.| |.|..|||. 
EIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLD

PNDDSKIKLIDFGFS
 |....||.||||||
ENGNNNIKIIDFGFS
Kinase 22407.AA CMGC 477-582 17 1.8e-14 43.08 In-house 68-251 (513) Show / Hide 
Range on Protein: 477-582
Range on HMM: 68-251/513
Sequence Identity: 17% (33 aa)

ILNEIAIQMLVS-----------------HRNILKVYDLYQNEK----------------GKIVLVQKRLGENLREYLKKKID------GSYICQNK---
.| || | . ..                 | ||.| || .. ..                 .. ||   .. .| .|.|.. .      . .  . .   
ALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENK

---------RYGYI------LQIINVFQ--YLHNLN--IIHCDLKLDNILVQPNDDS------------------KIKLIDFGFS
            ..       ||..     |.|  .  |||.|||  |||. .| ..                  ..|..|||..
HPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLA
Kinase 22407.AA MARK 547-582 52 1e-13 41.4 In-house 118-153 (262) Show / Hide 
Range on Protein: 547-582
Range on HMM: 118-153/262
Sequence Identity: 52% (19 aa)

QYLHNLNIIHCDLKLDNILVQPNDDSKIKLIDFGFS
.|.|. ||.|.|.|..|||.  |   .||.||||||
NYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS
Kinase 22407.AA TyrKc 434-672 17 1.6e-08 -84.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 434-672
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

FTDVKKINGTKMSEIYSAKKDGVDFILKTINLESESSKMSKFDILNEIAIQMLV--SHRNILKVYDLYQNE-------KGKIVLVQKRLGENLREYLKKK
 |  ||.      |.| .. . ..   |... ..      . |...|. | . .  .| ||.. |     .       .   ...    . .|..||.|.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

IDGSYICQNKRYGYILQIINVFQYLHNLNIIHCDLKLDNILVQPNDDSKIKLIDFGFSQIKLFN-------KYFK------PI--GTTFYLAPSELKKNN
 .   .|  .   . .|| .  .|||  |.|| ||   |.||  |    .|  ||| |             .| .               .||  .  | 
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY

QLCTFES----------------EIYMIA-----KTMIEILELNETNLENPKFLI---------SQQLKQLIRNMTEKKIEERCVMSDVLQIF
  .|..|                .          .. .|..|. ..    |.            .. . |...   . . |.|. .|.. ..|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 22407.AA Ciliate-E2a 452-503 32 0.001553 6.3 In-house 21-72 (275) Show / Hide 
Range on Protein: 452-503
Range on HMM: 21-72/275
Sequence Identity: 32% (17 aa)

KKDGVDFILKTINLESESSKMSKFDILNEIAIQMLVSHRNILKVYDLYQNEK
|..| .|  | ..   . .|. |. . |||.|   ..| ||.| |. |..|.
KQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDEN
Kinase 22407.AA Ciliate-E2 643-677 30 0.050679 2.71 In-house 329-365 (365) Show / Hide 
Range on Protein: 643-677
Range on HMM: 329-365/365
Sequence Identity: 30% (12 aa)

ISQQLKQLIRN----MTEKKIEERCVMSDVLQIFKLDFF
.||. |.||..    | .|. |.|    .  ||..  .|
WSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 22407.AA Ciliate-E2-Unclassified 635-677 24 0.085591 2.03 In-house 302-352 (352) Show / Hide 
Range on Protein: 635-677
Range on HMM: 302-352/352
Sequence Identity: 24% (13 aa)

NLENPKFL-------ISQQLKQLIR----NMTEKKIEERCVMSDVLQIFKLDFF
|...|||        .|.. | .|.     | .|....|    .  ||..  .|
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI---TFEQILNHPWF