Gene 27893 (Tetrahymena)
27893
Group:
Other
Family:
Ciliate-E7
Sequence
Protein domains of 27893.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 27893.AA | Ciliate-E7 | 59-343 | 60 | 1.1e-198 | 666.38 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 59-343 Range on HMM: 1-290/290 Sequence Identity: 60% (177 aa) YDLKKQTNDYNASYKCKAYDNKSHQDVFIYYYITFAQYDIYYLKQILKAIEIQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQTNLSFITQSQQQLT | .|. |.||||.....|.. . ||| . | .|||.|.|||||||||||||.||||||...||.|||.||||||||||||..||||.|||| YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQ---CYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLT DEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEFTSCVGNQNQKIRS-YIHKNYYMSPEYIVEKIITE-KSDIWSAGCIFAELINRVK ||||..||||||||||||||.||....|.|||||||..|.||||.|..|.||....|.. ||.|||||||.||||...|. |.|||..||||.|||.|.| DEHIKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYK LFSG---HDDFTAITQILQFCGEQNEE--DLKFYKQINREKLSTLMPKEEQIS-LQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL .||. ||....|||...|||.|||| |||.|||.||......|||..... .||.|||||||..|||.|||.||..||||..|||||.|. FFSDFCCHDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF |
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| Kinase | 27893.AA | p38 | 132-343 | 37 | 5.4e-47 | 158.52 | In-house | 79-289 (289) | Show / Hide |
Range on Protein: 132-343 Range on HMM: 79-289/289 Sequence Identity: 37% (80 aa) EINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEFTSCVGNQNQKIRSYIHKNYYMSPEYIV ... |.|. ||.. |. | .|. |.|.|||| |||||.| ||||| |. | | | .| || ..| | . ... |. | .|| . DFQDVYMVTHFMGADLNNIMKCQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-HCDDEMTGYVATRWYRAPEIML EKII-TEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLM---PKEEQISLQVRFPNANPLALDLLGKMLTFN .. |.. |||| ||| |||| . || | | ...|.. || || | . |. |. . . |. .. .. |..|||.|.||| ||| NWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEE---FWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELD LEKRFNALECLQHEYL .|| | | .||.|. PDKRITAEEAMQHPYF |
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| Kinase | 27893.AA | nmo | 102-343 | 29 | 1.1e-41 | 125.52 | In-house | 43-292 (292) | Show / Hide |
Range on Protein: 102-343 Range on HMM: 43-292/292 Sequence Identity: 29% (75 aa) KQILKAIEIQKFLNHENIEKIYNFDIISYPEI---NKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCS | . . . . | .|.| . ||. |.. . .||| . || | | | |.|. .|.. |.||||| | |.|||.|. . | . .||.| KRVFRELKMLCFFKHDN--VLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCV IKISEFTSCVGNQNQKIRSYIHK---NYYMSPEYIV-EKIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLS .|| .| . .. . . || || .. . |. |||| |||||||. | || . . | . | ||.|. . . . LKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHML TLMPKEEQISLQVRFPN---ANPLALDLLGKMLTFNLEKRFNALECLQHEYL .|. ... . |. | .|| .|| |. .|| . . |.| || RMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL |
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| Kinase | 27893.AA | ERK7 | 110-343 | 29 | 1.5e-37 | 125.83 | In-house | 52-292 (292) | Show / Hide |
Range on Protein: 110-343 Range on HMM: 52-292/292 Sequence Identity: 29% (71 aa) IQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEF----- .| | .|.|| ...| .| .|.| .|| | | . . . | | | |. |||.|||. |.||.... | | | ..|.| .|. | LQEFHCHPNIIRLIN--VIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARS -TSCV--GNQNQKIRSYIHKNYYMSPEYIVE-KIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLMPKE .. ..||. . |. | .|| . . | | || ||| .|.. .| | . | .||. .. .||.. . . .. |... IAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQ EQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL .. .|. .|.. . |.||| ..| || .|| | ..||| | KRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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| Kinase | 27893.AA | ERK1 | 100-343 | 35 | 3e-37 | 130.06 | In-house | 40-289 (289) | Show / Hide |
Range on Protein: 100-343 Range on HMM: 40-289/289 Sequence Identity: 35% (89 aa) YLKQILKAIEIQKFLNHENIEKIYNFDIISYPEINKM---YVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSD | . |. |.| . .|||| .| ||| . |..| |.| . | | | . .. |.| .|| .|.||||| | ||||| .. | | . .| YCQRTLREIKILTRFKHENIINIQ--DIIRADTIEQMRDVYIVQCLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT CSIKISEFTSCVGNQNQK-----IRSYIHKNYYMSPEYIVE-KIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLK-FYKQIN | .|| .| .. . |. .| || .. | | |||| ||| ||.. .| | . || | ..||. . CDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKA REKLSTLMPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL |. | | | ...... ||.| . |||||.|||||| .|| . | | | || RNYLQSL-PHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL |
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| Kinase | 27893.AA | MAPK | 236-343 | 37 | 1.9e-34 | 116.43 | In-house | 212-328 (328) | Show / Hide |
Range on Protein: 236-343 Range on HMM: 212-328/328 Sequence Identity: 37% (44 aa) TEKSDIWSAGCIFAELIN-RVKLFSGHDDFTAITQILQFCGEQNEEDLKFYK--QINREKLSTL--MPKEEQISLQVRFPN----ANPLALDLLGKMLTF |.. |.||.||||||... | || |.| ...|....| ||.... . . |. .. | .|| ..... ||| |||.|.||| |||.| TKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVF NLEKRFNALECLQHEYL . .|| .. |.|||.|. DPDKRITVEEALQHPYF |
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| Kinase | 27893.AA | ERK5 | 102-343 | 29 | 1.4e-33 | 117.91 | In-house | 43-295 (295) | Show / Hide |
Range on Protein: 102-343
Range on HMM: 43-295/295
Sequence Identity: 29% (75 aa)
KQILKAIEIQKFLNHENIEKIYNF--DIISYPEINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSI
| .. . | . |.|| | . | |. .||| | | | | |.| .| ||| .|.||||| | |.|||... | | . .| | .
KRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCEL
KISEF-------TSCVGNQNQKIRSYIHKNYYMSPEYIV-EKIITEKSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINRE
|| .| | .. . .|. .| || .. . | |.|| |||| |.| | ..| | . |.. | ..
KIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVY
KLSTL-MPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALECLQHEYL
.| . .. .| | . |||||..|| | .| . . ||| .|
NYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
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| Kinase | 27893.AA | CMGC | 223-343 | 17 | 4.8e-31 | 98.52 | In-house | 290-513 (513) | Show / Hide |
Range on Protein: 223-343 Range on HMM: 290-513/513 Sequence Identity: 17% (40 aa) YYMSPEYIVE----------KIITEKSDIWSAGCIFAELINR--------VKLFSGHDD-----------FTAITQILQFCGEQN--------------- .| .|| .. . |.. |.||.||||||.... || ||.. . .| . .| . WYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKH EEDLKFYKQINREKL--------------STL----------MPKEEQISLQVRFPN-----------------------------------ANPLALDL ||. ... . .. | |. .... ||. ..|.|.|| EEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL LGKMLTFNLEKRFNALECLQHEYL | |||... .|| | ..|||.|. LKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | 27893.AA | ERK | 240-343 | 43 | 4.7e-29 | 102.84 | In-house | 199-307 (307) | Show / Hide |
Range on Protein: 240-343 Range on HMM: 199-307/307 Sequence Identity: 43% (47 aa) DIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQ-NEEDLKFYKQINREKLSTLMPK--EEQISLQVRFPNAN--PLALDLLGKMLTFNLEKRFNA ||||.||||||...| ||.| | |..|.| | ||||. . .| |. . .|. . .... .||||| |.|.||| |||.|. .|| .. DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV LECLQHEYL |||.|.|. EECLEHPYF |
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| Kinase | 27893.AA | ERK | 100-204 | 41 | 8.4e-25 | 88.72 | In-house | 46-152 (307) | Show / Hide |
Range on Protein: 100-204 Range on HMM: 46-152/307 Sequence Identity: 41% (44 aa) YLKQILKAIEIQKFLN-HENIEKIYNFDIISYP-EINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDC |.|..| | ...... |||| .... .. ..| ..| |.|...|.| | | .|||.|.|.|.|.||||||..| |||||... | |. | .||.| YCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNC SIKISEF ||. | DLKICDF |
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| Kinase | 27893.AA | MAPK | 108-182 | 41 | 4.5e-23 | 76.46 | In-house | 55-139 (328) | Show / Hide |
Range on Protein: 108-182 Range on HMM: 55-139/328 Sequence Identity: 41% (35 aa) IEIQKFL-NHENIEKIYNFDIIS-----YP--EINKMYVVSDFMQTNLSFITQSQQQLTDEHIQFFMYQILRA--LHYIHSAKIV | ..... .|||| |... . .. | | |.|...|.|.| | .|||.|.|.|||.|||||||. | ||||| .. IKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVI |
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| Kinase | 27893.AA | Pkinase | 223-343 | 24 | 9.5e-21 | 74.45 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 223-343 Range on HMM: 176-293/293 Sequence Identity: 24% (31 aa) YYMSPEYIV-EKIITEKSDIWSAGCIFAELINRVKLFSGH------DDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLMPKEEQISLQVRFPNANPL .||.|| | . .. |.|.||.|||..|.... .|.|| |. | .|. | ....| | ... . . . . .... .|... WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIM---GPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEE ALDLLGKMLTFNLEKRFNALECLQHEYL ..|.. ..|... .|| .| ..|||... CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 27893.AA | MAPK-Unclassified | 236-343 | 25 | 4.4e-18 | 61.55 | In-house | 427-575 (575) | Show / Hide |
Range on Protein: 236-343 Range on HMM: 427-575/575 Sequence Identity: 25% (38 aa) TEKSDIWSAGCIFAELINR-----------VKLFSGHD------------D-----FTAITQ---ILQFCGEQNEEDLKFYKQIN-REKLSTLMPKEEQI . ..||||.||||||.... || | | | . . | |. | .|||. | .. . |. .... .| DTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVH SLQVRFPNAN---------PLALDLLGKMLTFNLEKRFNALECLQHEYL . |..| ....|.. ||| || ||..| . |.|.| FTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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| Kinase | 27893.AA | MAPK-Unclassified | 102-205 | 41 | 1.7e-16 | 55.68 | In-house | 44-154 (575) | Show / Hide |
Range on Protein: 102-205 Range on HMM: 44-154/575 Sequence Identity: 41% (47 aa) KQILKAIEIQKFLNHENIEKIYNFDIISYPEINK-----MYVVSDFMQT---NLSFITQSQQ-QLTDEHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQ | .| | |. |||.|| .| ||. | |.| |.||| .| | .| | . ..||| |.||||| | |.||| |. | | . KRVLREIRILRYLNHPNIIQIQ--DIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLL INSDCSIKISEFT || |||..| |. INQDCSVRICDFG |
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| Kinase | 27893.AA | CMGC | 108-182 | 22 | 3.3e-16 | 48.88 | In-house | 72-206 (513) | Show / Hide |
Range on Protein: 108-182
Range on HMM: 72-206/513
Sequence Identity: 22% (31 aa)
IEIQKFLN-----------------HENIEKIYNFDIISYPE-------------INKMYVVSDFMQTNLSFITQSQQ---------QLTDEH-------
|.| | || |.|| |.|.. . .. |..| | ..|...| . ...| |.. |
IKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHR
-----IQFFM------YQILRALH--YIHSAK--IV
|..|| |||||.|. |.||.. |.
RPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNII
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| Kinase | 27893.AA | S_TKc | 59-343 | 18 | 9.1e-16 | 54.29 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 59-343 Range on HMM: 1-231/231 Sequence Identity: 18% (59 aa) YDLKKQTNDYNASYKCKAYDNKSHQDV---FIYYYITFAQYDIYYLKQILKAIEIQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQT---NLSFITQ |.. .. . .|....|... | | ..|.. |.| | .|.|| |.| . ...|.| ... . .| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIK SQQQ------LTDEHIQFFMYQILRALHYIHSAKIV----------FGFLLPRFIQINSDCSIKISEFTSCVGNQNQKIRSYIHKNYYMSPEYIVEKIIT ... .. |..|.||||..|| |.|| .|. . |||. | .. .... .||.|| . . KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYG E-KSDIWSAGCIFAELINRVKLFSGHDDFTAITQILQFCGEQNEEDLKFYKQINREKLSTLMPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNAL |.|.|| |||..|.. . .|. . .. ... | |.|.. |.|... ||| | KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------------SPEAKDFIRKCLQKDPEKRPTA- ECLQ-------HEYL |.|| |... EALQDEWDIKCHPWF |
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| Kinase | 27893.AA | Pkinase | 108-182 | 29 | 3e-08 | 30.26 | Pfam | 51-130 (293) | Show / Hide |
Range on Protein: 108-182 Range on HMM: 51-130/293 Sequence Identity: 29% (25 aa) IEIQKFLNHENIEKIYNFDIISYPEINKMYVVSDFMQT-----NLS-FIT-QSQQQL--TDEHIQFFMYQILRALHYIHSAKIV |.| | |||.|| ..| . ...|.| .... |. .|. ... . ......|.||||||.| |.|| .|. IQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | 27893.AA | TyrKc | 72-343 | 14 | 4.9e-05 | -141.15 | SMART | 16-280 (280) | Show / Hide |
Range on Protein: 72-343 Range on HMM: 16-280/280 Sequence Identity: 14% (45 aa) YKCKAYDNKSHQDVFI-----YYYITFAQYDIYYLKQILKAIEIQKFL--NHENIEKIYNFDIIS---YPEINKMYVVSDFMQTN--LSFITQSQQQLTD ||.... ..| . . .. ... ..| . | .|.|| ..| . . . .| ...| .| .... .. .|. YKGTWK-----IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM EHIQFFMYQILRALHYIHSAKIVFGFLLPRFIQINSDCSIKISEFT-SCVGNQN-------QKIRS--YIHKN-----YYMSPEYIVEKIITEKSDIWSA .. |..|| . |.|| ... | | . .... .||| | | . . .|. ... |.|| | ... |.|||.|| KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF GCIFAELINRVKLFSGH---DDFTAITQILQFCGEQNEEDLKFY----KQINREKLSTLMPKEEQISLQVRFPNANPLALDLLGKMLTFNLEKRFNALEC | |. . . . ...... . . . . |. . . .. . .. |.| . |. GVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI LQHEYL ||.. --HECF |
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