Gene 17883 (Tetrahymena)
17883
Sequence
Protein domains of 17883.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 17883.AA | Ciliate-E7 | 51-333 | 59 | 4.4e-217 | 727.46 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 51-333 Range on HMM: 1-290/290 Sequence Identity: 59% (172 aa) YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENIN-SNLHIMMESKNLYIVKELMDINLKDVTFSRQELTDEH |||.|.||.||.|.||.|.|||||.||.||..|..|.|.|||||.||...|..||..||.|. .|.|..||..|.|.|...|..|||..|.|||.||||| YQIKREIWYDTYIYFCKAYIDREYQQKQFIYYIFYEQCYLKYIIKAIEIQKFLNHENHEKIYNFNFHSYMEINNMYVVSDFMQTNLKYITQSRQQLTDEH IKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIH--SNFPHEVN--YYNKKGYYPPQRILELPENLSKTDIWHVGVIILQLLYGYPFFE ||||.||||.||...|||..|||.||.|.|....|||.||..||. .|||||.| |.||..|..|..|.|..|..|||||||||.|.|.|...|.||. IKWFMYQILRALHYIHSQKIYHTQLTPRFIQINQNCDIKISDFIWCIGNFPHEINKKYINKNYYMSPYYIVEQMETFSKTDIWHVGCIFLELIQRYKFFS KRNRGGRNGVLQAYFYSIGSPSEE--DLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF .......|||...|||..||..|| ||..||.|..||.|||...||||.|||.|||||||||||||||||||||||||..|||..|||| DFCCHDYNGVITQYFYFCGSQNEEDLDLKYYKQYNRQYNQLKMPKQYCKQSWQVQFPNANPLLCDLLDKMLVFNEDKRFNVKECLQHPYF |
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| Kinase | 17883.AA | ERK | 68-333 | 36 | 1e-71 | 244.6 | In-house | 17-307 (307) | Show / Hide |
Range on Protein: 68-333 Range on HMM: 17-307/307 Sequence Identity: 36% (108 aa) AAIDRE-----YGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQ-HENINSNLHIMMES-----KNLYIVKELMDINLKDVTFSRQELTDEHIKWFVYQ .||| | |||| ||.|. . ..| ....| ||...|| |||| ....|||.. ...|.| |||.. | . .|.|||.|.|.. |.|| SAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELSDDHCQYFMYQ ILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIHSNFPH-EVNYYNKKG-------------YYPPQRILELPENLSKTDIWHVGVIILQLLYGYP || .| ..||.||.|. | . ||. .|||||| |. ..... ... . . | .|. .| .... ...|||..|.|. .| . | ILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE-CNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKP FFEKRNRGGRNGV--LQAYFYSIGSP-SEEDLSQYKDYTEQYEQLKSLNQ--YCKKSWQDQFPNAN--PLLCDLLDKMLVFNEDKRFSLKECFLHPYF .|. |.. | ... | ||.| ||||| ||... . .. .|.|. . .|.|.. ||||| |. .|||.|||||..||| . .|| |||| LFP-----GKDYVHQINRIFQIIGTPHSEEDL-QYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF |
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| Kinase | 17883.AA | MAPK | 68-189 | 38 | 1.2e-28 | 96.03 | In-house | 17-158 (328) | Show / Hide |
Range on Protein: 68-189 Range on HMM: 17-158/328 Sequence Identity: 38% (54 aa) AAIDRE------YGQKVFIKVIKLEECILKYIIQAIRSIKIENHF-QHENINSNLHIMMES-----------KNLYIVKELMDINLKDVTFSRQELTDEH .|||.. .|.|| || | . . ..| ||. .|| .|||| . |.|.. . . .||| |||. .| . |.|.|.|.| SAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIKSQQPLSDDH IKWFVYQILKA--LNFLHSQNVYHTELTARDILLKENCDLKI |. |.||||.. | ..|| || | | ||. ||||||| IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKI |
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| Kinase | 17883.AA | MAPK | 215-333 | 33 | 1e-24 | 82.25 | In-house | 203-328 (328) | Show / Hide |
Range on Protein: 215-333 Range on HMM: 203-328/328 Sequence Identity: 33% (44 aa) ILE--LPENLSKTDIWHVGVIILQLLY-GYPFFEKRNRGGRNGV--LQAYFYSIGSPSEEDLSQYK--DYTEQYEQLKSL---NQYCKKSWQDQFPN--- .| . .. . |.|.|| | .| . |.| |.. . .. . .|.||||.... . . .| ..|| .| ||.|.. ||| MLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP-----GKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNY--IQSLGNLPKYPKKPWEKMFPNANF -ANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF |||. .|||.|||||. ||| . .|. |||| NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF |
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| Kinase | 17883.AA | ERK5 | 51-192 | 36 | 3.8e-22 | 77.84 | In-house | 1-147 (295) | Show / Hide |
Range on Protein: 51-192 Range on HMM: 1-147/295 Sequence Identity: 36% (54 aa) YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENINSNLHIMM------ESKNLYIVKELMDINLKDVTFSRQE |.|. | | .|. | ||.| || | . .| .|| ||.|.|| |.| | |. |.| .||. | . | | YKIIEKIGNGAYGVVC-SARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQP LTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF .| |||..|.||||. | ..|| .| | .| .| |||.||| | FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDF |
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| Kinase | 17883.AA | nmo | 98-192 | 37 | 2e-21 | 62.08 | In-house | 47-146 (292) | Show / Hide |
Range on Protein: 98-192 Range on HMM: 47-146/292 Sequence Identity: 37% (37 aa) RSIKIENHFQHENINSNLHIMMESKN-----LYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF | .|. |.|.|. | | |. . .|.| ||| | . | |.|. .|.| |.||||. | .||| |. | .. ..|. || ||| | RELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDF |
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| Kinase | 17883.AA | CMGC | 226-333 | 17 | 2.8e-20 | 62.49 | In-house | 317-513 (513) | Show / Hide |
Range on Protein: 226-333 Range on HMM: 317-513/513 Sequence Identity: 17% (35 aa) DIWHVGVIILQLLYG--------YPFFE---------KRNRGGRNGVLQAYFYSIGSPS---------------EEDLSQYKD----------------- |.| || |. .. | .|.| | | |. | .|.|. ||. .... DMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDK-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMT ---YTEQYEQLKS---LNQYCKKSWQDQFPN-----------------------------------ANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF . .. ...| . .. .|.|...||. ..|.. |||.|||... ||| . ... |||| NHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | 17883.AA | ERK1 | 51-192 | 35 | 9.8e-17 | 59.25 | In-house | 1-144 (289) | Show / Hide |
Range on Protein: 51-192 Range on HMM: 1-144/289 Sequence Identity: 35% (52 aa) YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENINSNLHIMMES-----KNLYIVKELMDINLKDVTFSRQEL | |. | . ... .|.|. .|.| || | | | .| ||| . |.|||| |. . . .|||..||. | . |.| YTNLQYI-GEGAYGMVCSAYDTVHKQRVAIKKISPFEHQT-YCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKL-LKTQHL TDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF .|| .|.||||. | ..|| || | .| .|| ||||| | SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF |
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| Kinase | 17883.AA | CMGC | 69-192 | 20 | 1e-16 | 50.55 | In-house | 18-248 (513) | Show / Hide |
Range on Protein: 69-192
Range on HMM: 18-248/513
Sequence Identity: 20% (47 aa)
AID--------------REYGQKVFIKVIKLEECILKYII----------QAIRSIKIENHFQ-----------------HENINSNLHIMMESK-----
..| .|....| || ||... |.| ||| |.. |.|| . . | . ..
CRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNE
------------NLYIVKELMDINLKDVTFSRQ---------ELTDEH------------IKWFV------YQILKALN--FLHSQN--VYHTELTARDI
.||.| |.|| .|... . | .|.. | || |. ||||..|. ..||.. . |. | |
YEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENI
LLKENCDL--------------------KITGF
|. .||.| || |
LINHNCELITRMMWKSEDWNPCQKNGRLKICDF
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| Kinase | 17883.AA | S_TKc | 51-333 | 22 | 4.5e-16 | 58.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 51-333 Range on HMM: 1-231/231 Sequence Identity: 22% (69 aa) YQILRLIWRDTNISFCLAAIDREYGQKVFIKVIKLEECILKYIIQAIRSIKIENHFQHENINSNLHIMMESKNLYIVKELMDI---NLKDVTFSRQE--- |.|||.| . . ..... |..| ||.|| ....| |.| . .|.|| . .. . ..||.| |..| .|.|. .|. YEILRKI-GKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIHSNFPHEVNYYNKKG---YYPPQRILELPENLS-KTDIWHVGVIILQL .. |.. ..|||..||...||... | | ||| | .||. | . . . | | .| . | |.| .|.|. . RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM LYGYPFFEKRNRGGRNGVLQAYFYSIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFL-------H |.||| |. .|. | || | ..|...|.|... .|| . |.. | LCGYPPFP---------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH PYF |.| PWF |
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| Kinase | 17883.AA | p38 | 284-333 | 40 | 2.5e-14 | 45.08 | In-house | 240-289 (289) | Show / Hide |
Range on Protein: 284-333 Range on HMM: 240-289/289 Sequence Identity: 40% (20 aa) LKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF ..|. |. .. .. |..|||. |||.|||. .||| . .| |||| IQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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| Kinase | 17883.AA | p38 | 118-189 | 34 | 2.7e-13 | 41.49 | In-house | 77-147 (289) | Show / Hide |
Range on Protein: 118-189 Range on HMM: 77-147/289 Sequence Identity: 34% (25 aa) MMESKNLYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKI |.. .. |.| ..|. |. . | |.|.||. |||||..| . || .. | | | . |.|.|.| MNDFQDVYMVTHFMGADLNNI-MKCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRI |
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| Kinase | 17883.AA | ERK1 | 226-333 | 37 | 2.8e-13 | 46.12 | In-house | 186-289 (289) | Show / Hide |
Range on Protein: 226-333 Range on HMM: 186-289/289 Sequence Identity: 37% (41 aa) DIWHVGVIILQLLYGYPFFE-KRNRGGRNGVLQAYFYSIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSL ||| || |. .| | | | | .| .||||..|| . |.|| | .|. ||.| . ||||||| || .|| . DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGV----LGSPSQDDLNCIIN-EKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITV KECFLHPYF | ||| EEALAHPYL |
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| Kinase | 17883.AA | MAPK-Unclassified | 122-189 | 31 | 1.4e-12 | 41.28 | In-house | 79-150 (575) | Show / Hide |
Range on Protein: 122-189 Range on HMM: 79-150/575 Sequence Identity: 31% (23 aa) KNLYIVKELMDI---NLKDVTFSRQ-ELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKI . .||| ..| . .|. . |.| . ..||. | ||||. | ||| .. | | .|. ..| ..| DDIYIVMDYMQTSLFDLHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRI |
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| Kinase | 17883.AA | ERK7 | 107-192 | 31 | 5.2e-12 | 37.05 | In-house | 57-144 (292) | Show / Hide |
Range on Protein: 107-192 Range on HMM: 57-144/292 Sequence Identity: 31% (28 aa) QHENINSNLHIMMESKN--LYIVKELMDINLKDVTFSRQELTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGF .|.|| . . .. . . .|.| | |. | | . | | | . .||.|.|. ..|| || | | . ||| .| .|. | CHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDF |
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| Kinase | 17883.AA | Pkinase | 69-171 | 21 | 2.1e-11 | 41.4 | Pfam | 18-131 (293) | Show / Hide |
Range on Protein: 69-171 Range on HMM: 18-131/293 Sequence Identity: 21% (25 aa) AIDREYGQKVFIKVIKLEECILKYIIQAIR--SIKIENHFQHENINSNLHIMMESKNLYIVKELMDI-----NLKDVTF--SRQEL--TDEHIKWFVYQI .... .|..| .|.||... . ....| |.| ....|.|| ..........|.| |... |.|. .. . .....| ..||| CHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQI LKALNFLHSQNVYH |..|...||... | LRGLEYCHSMGIIH |
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| Kinase | 17883.AA | ERK7 | 226-333 | 28 | 2.3e-10 | 31.32 | In-house | 189-292 (292) | Show / Hide |
Range on Protein: 226-333 Range on HMM: 189-292/292 Sequence Identity: 28% (31 aa) DIWHVGVIILQLLYGYPFFEKRNRGGRNGVLQ--AYFYSIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFS | | .| |. ..| | | | | . | .|. |..||. . |...|| .|. .. .|.. . ||| ..|||| .|| . DMWSIGCILGEMLRGKPMFP-----GTSTMNQIEKILETIPKPTQEDIEAIGSHY-AWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLT LKECFLHPYF ... ||| AEQALQHPYV |
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| Kinase | 17883.AA | Pkinase | 223-333 | 17 | 2.7e-10 | 37.51 | Pfam | 191-293 (293) | Show / Hide |
Range on Protein: 223-333 Range on HMM: 191-293/293 Sequence Identity: 17% (20 aa) SKTDIWHVGVIILQLLYGYPFFEKR-NRGGRNGVLQAYFYSIG----SPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFPNANPLLCDLLDKMLVFN .| |.| .|.|. ..| |.| | . . . . .| .. | ...... | . .. .. . . . . .|... ..|.....| .. PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTF-HNWSEECKDFIKWCLCKD EDKRFSLKECFLHPYF || . .... ||.| PKKRPTAEQILQHPWF |
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| Kinase | 17883.AA | nmo | 308-333 | 50 | 8.6e-09 | 22.52 | In-house | 267-292 (292) | Show / Hide |
Range on Protein: 308-333 Range on HMM: 267-292/292 Sequence Identity: 50% (13 aa) DLLDKMLVFNEDKRFSLKECFLHPYF .|| .||.|. ||| | |. ||| HLLCRMLHFDPDKRISCKDALAHPYL |
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| Kinase | 17883.AA | MAPK-Unclassified | 290-333 | 38 | 1.2e-08 | 26.83 | In-house | 532-575 (575) | Show / Hide |
Range on Protein: 290-333 Range on HMM: 532-575/575 Sequence Identity: 38% (17 aa) YCKKSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF .|| . || |.. |...|||.|| ||.. . .|||| FCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF |
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| Kinase | 17883.AA | TyrKc | 63-333 | 16 | 8e-06 | -128.68 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 63-333
Range on HMM: 1-280/280
Sequence Identity: 16% (56 aa)
ISF------------CLAAIDREYGQKVFIKVIKLEECILKYIIQAIRS-IKIENHF--QHENINSNLHIMMES-------KNLYIVKELMD-INLKDVT
|.. ... . ..| .|..| . ...... ..| .. .|.|| . . ... . |.|| |.|. .|||
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL
FSRQE-LTDEHIKWFVYQILKALNFLHSQNVYHTELTARDILLKENCDLKITGFIHSNFPHEVNYYNK------KGYYPPQR--ILE--LP------ENL
.... |. .. | .|| . ..|||.|. | | || .|..|| ||. | | . |.. | || .. || | .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS-----RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI
------SKTDIWHVGVII-------LQLLYG-----YPFFEKRNRGGRNGVLQAYFY----SIGSPSEEDLSQYKDYTEQYEQLKSLNQYCKKSWQDQFP
.|.|.| || . | .| . .| ... . . . . | |.
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------FV
NANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF
. . . .. . .. ..| . .|. | .|
CCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
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| Kinase | 17883.AA | ERK5 | 293-333 | 31 | 1.9e-05 | 15.78 | In-house | 255-295 (295) | Show / Hide |
Range on Protein: 293-333 Range on HMM: 255-295/295 Sequence Identity: 31% (13 aa) KSWQDQFPNANPLLCDLLDKMLVFNEDKRFSLKECFLHPYF | |. .| | . ||| .||.| .| . . ||. KDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL |
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