Gene 9395 (Tetrahymena)
9395
Group:
Other
Family:
Ciliate-E6
Sequence
Protein domains of 9395.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9395.AA | Ciliate-E6 | 68-220 | 50 | 1.3e-99 | 317.1 | In-house | 1-154 (154) | Show / Hide |
Range on Protein: 68-220 Range on HMM: 1-154/154 Sequence Identity: 50% (78 aa) AKLLQECNHENIPKYIDQFQIKQFYLILMESFDTTLFNWSQQVENFYYIKND-LFIKFSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFGEG .. |..|||.||.||.|.|||...|.|.||.....|..|..|..|...|... .|.||...||..|||.|||||.|||.||.||..||||..||.|||.. IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ QSIIPSIETKKFLAQQPGNEYIYLPPEFFDYSKKHDQKNEQVKWTQCADIWMLG |.|||...||.|.||...|.|.|.|||.|||||....|...|.|||..|||... QCIIPNQQTKEFMAQKNQNKYHYCPPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
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| Kinase | 9395.AA | Ciliate-A2 | 29-281 | 31 | 5.8e-36 | 122.37 | In-house | 8-272 (272) | Show / Hide |
Range on Protein: 29-281 Range on HMM: 8-272/272 Sequence Identity: 31% (85 aa) ILFVQN---ENQEEYVMRIFNLQSDDDQSKICDQKLNQAQNFAKLLQECNHENIPKYIDQFQIKQFYLILMESF-DTTLFNWSQQVEN-FYYIKNDLFIK ..||. .| |.| |.... | .||. ||| ... |..|..|||.|| || | |||. .| | || . | | . .| | .|.. VIFVEHMDNHNNEKYAIKIQSII-DGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDHQFVH FSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMK-LKILDFGEGQSIIPSIETKKFLAQQPGNEYIYLPPEFFDY---SKKHDQKNEQVKWTQCADIWML | . . . .||.|.||| | .| |.|| ||.. .| ||| . |.|... |....| . .| ||| . . .|..|.| | .||| . FACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQTFMGDIWAF GICLYALAGADLFQIQQFT---QGKDFFQYNLNKVDLELRKFVMNILCFNTNQRP-QASQLIERLS |||||.|.|||. . ..| |.|.. ....| .. . .|| ..|| |... . GICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
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| S_TKc | 9395.AA | S_TKc | 24-281 | 15 | 4.2e-11 | -14.07 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-281
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)
INREDIL----------FVQNENQEEYVMRIFNLQSDDDQSKICDQKLNQAQNFAKLLQECNHENIPKYIDQFQIKQFYLILMESFDT---TLFNWSQQV
... . .. .... . | . ..... ..|.. .|.|| |..| || ... . || |. .|| ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR
ENF---YYIKNDLFIKFSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFGEGQSIIPSIETKKFLAQQPGNEYI----YLPPEFFDYSKKHDQ
... .. ..... .||.||.. . | .|| .|. .|| ||| . . .. |..|| .
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL--------
KNEQVKWTQ-CADIWMLGICLYALAGADL-FQIQQFTQGKDFFQYNLNKVDLELRKFVMNILCFNTNQRPQASQLIE--------RLS
... .|.| .|..|| .. |. | . |. . . |.. |....|... ..|| | .. .
-----GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 9395.AA | Ciliate-E2 | 69-278 | 17 | 2.2e-10 | 31.86 | In-house | 84-361 (365) | Show / Hide |
Range on Protein: 69-278 Range on HMM: 84-361/365 Sequence Identity: 17% (51 aa) KLLQECNHENIPKYIDQFQ--IKQFYLILMESFDT-TLFNWSQQVENFY--------YIKNDLFIKFSQELFS---------------IVEYIHSKN-YL ..|.. || || |... || .. . . || .. .|| . .. . |.. ......... .||.|||| . NILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNII LQNLTLQNIYIDKNMKLKILDFGEGQSIIPSIETKK-----FLAQQPGN-----------------------EYIYLPPEFFDYSKKHDQKNEQVKWTQC .. ..|| . .|| ||| . . .. . . . .. .| . |..|| . . | | ..| .. HRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYK ADIWMLGICLYALAGADL-FQIQQFTQGKDFFQYNL---------------NKVDLELRKFVMN----ILCFNTNQRPQ-ASQLIE .||| ||..|| . . | .|| |.| |. . .|...| . . .|. . ..|.. ..|... CDIWSLGVILYEMLFGKPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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| Kinase | 9395.AA | Kin4 | 124-164 | 43 | 9.5e-07 | 16.09 | In-house | 116-155 (273) | Show / Hide |
Range on Protein: 124-164 Range on HMM: 116-155/273 Sequence Identity: 43% (18 aa) FSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFG |.| | | |.|.|.| | | |. .||. | | ||| FAQ-LISGVHYMHYKGLVHRDLKLENLLLDKHENLVITDFG |
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| Kinase | 9395.AA | TKL | 132-227 | 15 | 4e-06 | 17.98 | In-house | 145-283 (364) | Show / Hide |
Range on Protein: 132-227 Range on HMM: 145-283/364 Sequence Identity: 15% (21 aa) VEYIHS--------KNYLLQNLTLQNIYIDKNMK--------------LKILDFGEGQSIIPSIE---------------TKKFLAQQPGNEYIYLPPEF ..| || .. . .|. .|| .|.|.. .|| ||| ... .| . . . .. . ...|| MNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV FDYSKKHDQKN------EQVKWTQCADIWMLGICLYALA .. . . ..|. .. . .. .|.. ||.|. .. LRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL |
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| Kinase | 9395.AA | SAK | 134-164 | 45 | 5e-06 | 16.27 | In-house | 115-145 (254) | Show / Hide |
Range on Protein: 134-164 Range on HMM: 115-145/254 Sequence Identity: 45% (14 aa) YIHSKNYLLQNLTLQNIYIDKNMKLKILDFG |.|| . . ||| || . ..|..|| ||| YLHSHGIMHRDLTLSNILLTRDMHCKIADFG |
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| Kinase | 9395.AA | TKL-ciliate1 | 254-280 | 29 | 7e-06 | 16.15 | In-house | 253-279 (279) | Show / Hide |
Range on Protein: 254-280 Range on HMM: 253-279/279 Sequence Identity: 29% (8 aa) ELRKFVMNILCFNTNQRPQASQLIERL .. .. | .| | |.|| ....|..| NFHNLMMRCWCQNPNKRPNFNEIIQIL |
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| Kinase | 9395.AA | PHK | 128-164 | 45 | 2.4e-05 | 13.92 | In-house | 118-154 (273) | Show / Hide |
Range on Protein: 128-164 Range on HMM: 118-154/273 Sequence Identity: 45% (17 aa) LFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFG ||. |.|.|..| | . || | ||. || ||| LFEGVCYMHAHNIVHRDLKPENILCDDNMNIKISDFG |
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| Kinase | 9395.AA | MELK | 123-164 | 33 | 6.4e-05 | 12.41 | In-house | 101-142 (254) | Show / Hide |
Range on Protein: 123-164 Range on HMM: 101-142/254 Sequence Identity: 33% (14 aa) KFSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNMKLKILDFG .| ... | . |.||. | ..| .|. .| ...||..||| HFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFG |
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| Kinase | 9395.AA | CAMK | 70-172 | 15 | 0.000129 | 10.01 | In-house | 84-249 (425) | Show / Hide |
Range on Protein: 70-172 Range on HMM: 84-249/425 Sequence Identity: 15% (26 aa) LLQECN-------HENIPKYIDQFQIKQ--------------------FYLIL--MESFDTT-----LFNWSQQVENF------------YYIKNDLFIK ... .. |.|| | .. .. .. .|... || . ||.. .. ... ... . . IMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARR FSQELFSIVEYIHSKNYLLQNLTLQNIYIDKNM-----------------KLKILDFGEGQSIIPS . . . | |.|.||.| | . || .|.|. ..|| ||| . ..|. YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPG |
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| Kinase | 9395.AA | TKL | 268-280 | 30 | 0.216945 | 0.78 | In-house | 352-364 (364) | Show / Hide |
Range on Protein: 268-280 Range on HMM: 352-364/364 Sequence Identity: 30% (4 aa) NQRPQASQLIERL ..|| ......|| EKRPSFQEILKRL |
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| Kinase | 9395.AA | MELK | 214-226 | 61 | 0.220737 | 0.12 | In-house | 181-193 (254) | Show / Hide |
Range on Protein: 214-226 Range on HMM: 181-193/254 Sequence Identity: 61% (8 aa) ADIWMLGICLYAL ||.| .|| ||.| ADVWSMGILLYVL |
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| TPR | 9395.AA | TPR | 339-372 | 20 | 5.5e-08 | 33.77 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 339-372 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) YEVLNLIAQIYLQKNQFEQAEIILNQALKINPEN .|... ....|........|. ...||...|.| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 9395.AA | TPR_2 | 339-372 | 26 | 2.6e-07 | 29.93 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 339-372 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) YEVLNLIAQIYLQKNQFEQAEIILNQALKINPEN |......|.|........|. ...|||..|.| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 9395.AA | TPR_1 | 339-372 | 23 | 4e-07 | 28.85 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 339-372 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) YEVLNLIAQIYLQKNQFEQAEIILNQALKINPEN .|... ....|........|. ...||..||.| AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 9395.AA | TPR_2 | 305-338 | 11 | 0.008572 | 13.97 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 305-338
Range on HMM: 1-34/34
Sequence Identity: 11% (4 aa)
LITQIQEGKKCLHNKQYEEALQKFNQVIEKNSED
. |. ......|.||.. ...... . ..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN
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| TPR | 9395.AA | TPR | 305-338 | 14 | 0.028984 | 14.1 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 305-338 Range on HMM: 1-34/34 Sequence Identity: 14% (5 aa) LITQIQEGKKCLHNKQYEEALQKFNQVIEKNSED . . | ......|.||.. .....| . .. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 9395.AA | TPR_1 | 312-338 | 22 | 0.107793 | 9.9 | Pfam | 8-34 (34) | Show / Hide |
Range on Protein: 312-338 Range on HMM: 8-34/34 Sequence Identity: 22% (6 aa) GKKCLHNKQYEEALQKFNQVIEKNSED | ... ..|.||.. .....| | .. GNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_1 | 9395.AA | TPR_1 | 394-407 | 21 | 12.12424 | 2.74 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 394-407 Range on HMM: 21-34/34 Sequence Identity: 21% (3 aa) INHYERCIKNHPEY | .|..... |.. IECYQKALELNPNN |
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| TPR_2 | 9395.AA | TPR_2 | 394-407 | 35 | 66.166769 | 0.21 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 394-407 Range on HMM: 21-34/34 Sequence Identity: 35% (5 aa) INHYERCIKNHPEY |..||...| |.. IEYYEKALKLDPNN |
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| TPR_1 | 9395.AA | TPR_1 | 443-473 | 29 | 0.000109 | 20.35 | Pfam | 4-34 (34) | Show / Hide |
Range on Protein: 443-473 Range on HMM: 4-34/34 Sequence Identity: 29% (9 aa) LKKLGMIYATQKKEQKALNQFKKAIALNPFD .. ||..| ... ..|. ..||..||| . WYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 9395.AA | TPR_2 | 440-473 | 26 | 0.000134 | 20.36 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 440-473 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) NMGLKKLGMIYATQKKEQKALNQFKKAIALNPFD .. ||..|. |.. ..|.. ..||..|.| . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 9395.AA | TPR | 440-473 | 23 | 0.000233 | 21.73 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 440-473 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) NMGLKKLGMIYATQKKEQKALNQFKKAIALNPFD .. ||..| ... ..|.. ..||..|.| . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR | 9395.AA | TPR | 474-507 | 23 | 0.000303 | 21.35 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 474-507 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) FECQNLIGKINYVLQNKDQAINDFNLSLTINPDQ |. . .| . | . . |.||.... .|...|. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 9395.AA | TPR_1 | 474-507 | 29 | 0.000569 | 17.85 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 474-507 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) FECQNLIGKINYVLQNKDQAINDFNLSLTINPDQ | . .| . | ..| |.|| ... | .||. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 9395.AA | TPR_2 | 474-507 | 23 | 0.001931 | 16.26 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 474-507 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) FECQNLIGKINYVLQNKDQAINDFNLSLTINPDQ .|. ...|.. | ... |.||.... .| ..|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 9395.AA | TPR_1 | 539-572 | 29 | 0.002771 | 15.45 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 539-572 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) YEAFEQIGNELNFDQKFLSAIQYYKKTIQIKPNI .||. ..|| . ... ||..|.| ... || AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 9395.AA | TPR | 539-572 | 29 | 0.015092 | 15.71 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 539-572 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) YEAFEQIGNELNFDQKFLSAIQYYKKTIQIKPNI .||. ..|| . .. ||..|.| ... || AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 9395.AA | TPR_2 | 539-572 | 29 | 1.18924 | 6.39 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 539-572 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) YEAFEQIGNELNFDQKFLSAIQYYKKTIQIKPNI || ..|. . ... ||.||.| ... || AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 9395.AA | TPR_1 | 525-538 | 35 | 1.925432 | 5.53 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 525-538 Range on HMM: 21-34/34 Sequence Identity: 35% (5 aa) ISYFKKACLIDPNY | ...|| ..||. IECYQKALELNPNN |
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| TPR_2 | 9395.AA | TPR_2 | 525-538 | 50 | 6.414248 | 3.8 | Pfam | 21-34 (34) | Show / Hide |
Range on Protein: 525-538 Range on HMM: 21-34/34 Sequence Identity: 50% (7 aa) ISYFKKACLIDPNY | |..|| .|||. IEYYEKALKLDPNN |
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