Gene 26506 (Tetrahymena)
26506
Group:
Other
Family:
Ciliate-E6
Sequence
Protein domains of 26506.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26506.AA | Ciliate-E6 | 74-196 | 44 | 4.3e-60 | 189.75 | In-house | 1-125 (154) | Show / Hide |
Range on Protein: 74-196 Range on HMM: 1-125/154 Sequence Identity: 44% (56 aa) VNRLKQCSHKNILRYYDSFQIEDSFFIVMEKVEFSLQQWIN--DNRRNLIQKEQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRDLNIKLSTFTVQ ...||.|.|.|||.|.||||||...|||||..|..||.||. .|.....|..||.||..|......|||...|.|.||.|||||||...|||.. | | IQNLKNCNHPNILKYMDSFQIENYYFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQ QEVSVKYLLDKQIYA-LENNQLIYFP |.. .. . |.. | . |...|.| QCI-IPNQQTKEFMAQKNQNKYHYCP |
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| Kinase | 26506.AA | Ciliate-A2 | 34-165 | 40 | 3.4e-32 | 109.12 | In-house | 4-144 (272) | Show / Hide |
Range on Protein: 34-165 Range on HMM: 4-144/272 Sequence Identity: 40% (57 aa) GFGKYLFAKYQ--QNSC--MIKIISIQSDEQLS--QQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVMEKV-EFSLQQWIN--DNRRNLIQKE .||. .|.. .|. |||.||. |. . |.||| . .. || |.|.|| .|.|.||| ||.||| |.|||.|| | .. |... CFGCVIFVEHMDNHNNEKYAIKIQSII-DGIDQKISQQKLQECKHEAQFLKNCNHPNIVKYHDEFQIGFYYFIQMEKCPECSLQDWIDKFQNQQKFIPDH QFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRDLN-IKL ||..||.|. . .||| . |.| ..||.|| .| | . ||| QFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKL |
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| Kinase | 26506.AA | STE | 48-146 | 17 | 1.7e-09 | 29.84 | In-house | 42-174 (359) | Show / Hide |
Range on Protein: 48-146
Range on HMM: 42-174/359
Sequence Identity: 17% (24 aa)
CMIKIISIQSDEQLSQQ------------KKLQKAMEKVNRLKQCS--HKNILRYYDSFQIE-------DSFFIVMEKVEF-SLQQWINDN-RRNLIQK-
. ||......... . . ...|. .. .. .|.|. |.|| .||... | |. .|.|| .. || . |. . .. ..
MAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNH
---------EQFL-KFAQQMVEV-ADYLHHQKYI
|. . ....| .. .||| ...|
NRQHQHRFPESQIAYICRQILKGLLYYLHSHHII
|
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| Kinase | 26506.AA | STE20 | 50-103 | 28 | 2.2e-08 | 27.07 | In-house | 33-88 (288) | Show / Hide |
Range on Protein: 50-103 Range on HMM: 33-88/288 Sequence Identity: 28% (17 aa) IKIISIQSDE--QLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIE----DSFFIVME ||.... ... | .... . .. .||| |.|| .||.|.. . |. .|||| IKKMNLEKCDNEQ----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVME |
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| S_TKc | 26506.AA | S_TKc | 28-275 | 14 | 6.5e-08 | -60.89 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 28-275
Range on HMM: 1-231/231
Sequence Identity: 14% (41 aa)
IRKDKE----GFGKYLFAKYQQ--NSCMIKIISIQSDEQLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVMEKVEF---SLQQWINDNRR
.. .. .||| .. . ||||. .... .. ||. |.|| ..||.|| |....||| .. .| . | ...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR
NL----IQKEQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRDLNIKL-----STFTVQQEVSVKYLLDKQIYALENNQLIYFPIC---------LI
. . . ....|... .|.| .. | . ||.||. .||. ... .| ..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------TTFCGTPWYMAPEVL
EEGGNQNMVALSN-KQDMYTIGLCLYCLTG----VSYMEVLNYIQGGKFQVNISLGVDINQLLQLMLFRNTY-----SSVP-------SPCY
. | |.. .| .|| . . .. .. . . .... .| .. |
---------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
|
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| Kinase | 26506.AA | SLK | 60-170 | 20 | 1.3e-07 | 21.64 | In-house | 33-143 (259) | Show / Hide |
Range on Protein: 60-170 Range on HMM: 33-143/259 Sequence Identity: 20% (23 aa) QLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVMEKVEFSLQQWINDNRRNLIQKEQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDR .. .. .|. | .. | .| | ||.. |... ... ....| . | . .. .| ...|.| ..||..| | .. || . EIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTM DLNIKLSTFTV | ...| | | DGDVRLADFGV |
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| Kinase | 26506.AA | Ciliate-E2-Unclassified | 49-168 | 20 | 2.3e-07 | 21.61 | In-house | 29-191 (352) | Show / Hide |
Range on Protein: 49-168 Range on HMM: 29-191/352 Sequence Identity: 20% (34 aa) MIKIISIQSDEQLSQQK-----KLQKAMEKVN-------------RLKQCSHKNILRYYDSFQIEDSFFIVMEKVE-FSLQQWIND-------------- | ...||.. |..... .|.|.. . |... | .|..... || .. ..||||..| .|.|.|.. MKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHN -NRRNLIQKEQFL-----KFAQQMVEVADYLHHQK-YILSNISLKNIFLDRDL---NIKLSTF ..|. .. .| . ... | .. .||||.. | .| . ||..| . .||.. | MKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF |
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| Kinase | 26506.AA | Jak | 72-160 | 22 | 3e-07 | 21.76 | In-house | 58-154 (299) | Show / Hide |
Range on Protein: 72-160 Range on HMM: 58-154/299 Sequence Identity: 22% (22 aa) EKVNRLKQCSHKNILRYYDSF--QIEDSFFIVMEKVEF-SLQQWIN---DNRRNLIQK--EQFLKFAQQMVEVADYLHHQKYILSNISLKNIFLDRD . . ...|.|||.|..|. ...|. .||| ... .| . . ..... . . ..||.| .....||. ..|| ... .|| .||. REISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDWKMQFAKQICWGMHYLEDKRYIHGDVCARNILVDRE |
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| Kinase | 26506.AA | Ciliate-E2 | 49-166 | 19 | 1e-06 | 18.58 | In-house | 48-198 (365) | Show / Hide |
Range on Protein: 49-166 Range on HMM: 48-198/365 Sequence Identity: 19% (31 aa) MIKIISIQSDEQLSQQKKLQKAMEKVN----------RLKQCSHKNILRYYDSFQ--IEDSFFIVMEKVEF-SLQQWINDNRRNL---------IQKEQF .|. . |.. |. |.|. .. | ..| |.| .|.||...|..|| ......||| .. .|...|..|. . . .. KIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI LKFAQQMVEVA---------------DYLHHQK-YILSNISLKNIFLDRDLNIKLS ... .| ... ||| .. | .| . ||.. ||.. KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII |
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| Kinase | 26506.AA | PAKA | 60-103 | 34 | 3e-06 | 17.97 | In-house | 35-78 (260) | Show / Hide |
Range on Protein: 60-103 Range on HMM: 35-78/260 Sequence Identity: 34% (15 aa) QLSQQKKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDSFFIVME ....| | .. . .|.| |||| .|.||. ..| ..||| NMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVME |
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| Kinase | 26506.AA | NEK1 | 60-103 | 29 | 5e-06 | 17.04 | In-house | 33-80 (276) | Show / Hide |
Range on Protein: 60-103 Range on HMM: 33-80/276 Sequence Identity: 29% (14 aa) QLSQQ--KKLQKAMEKVNRLKQCSHKNILRYYDSFQIEDS--FFIVME ..... | ...|. |. |. | || .|..||. . . .|||| NVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVME |
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| Kinase | 26506.AA | Pkinase | 77-166 | 23 | 3.5e-05 | 19.39 | Pfam | 54-154 (293) | Show / Hide |
Range on Protein: 77-166 Range on HMM: 54-154/293 Sequence Identity: 23% (25 aa) LKQCSHKNILRYYDSFQIEDSFFIVMEKVEF-----SLQQWINDNRRNLI--QKEQFLKFAQQMVEVADYLHHQKYILSNIS-----LKNIFLDRDLNI- .| ..|.||.|.||.|. .|. .||| .| .| .| |.. . . .. ... |... .|.| . .| . ||..|.. .| MKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHID ---KLS |.. ACVKIC |
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| TPR_1 | 26506.AA | TPR_1 | 427-460 | 26 | 1e-06 | 27.41 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 427-460 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DEVYNNIGDIYLKQNDFNTSKSYFEKSIEFNPRQ |...|.| .|.|..... ...| .| || AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR | 26506.AA | TPR | 427-460 | 26 | 1.1e-05 | 26.19 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 427-460 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DEVYNNIGDIYLKQNDFNTSKSYFEKSIEFNPRQ |...|.| .|.|..|.. ...|..| .| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 26506.AA | TPR_2 | 427-460 | 32 | 2.1e-05 | 23.23 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 427-460 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) DEVYNNIGDIYLKQNDFNTSKSYFEKSIEFNPRQ |...|.|..|.||.|. . |.||... .|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 26506.AA | TPR_1 | 461-494 | 20 | 8.3e-05 | 20.77 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 461-494 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) YIAYYNLAQVYFEQKMFQKGSYYLKKAKKIEQDD . |.|||...|.... ... ...|| ... .. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 26506.AA | TPR_2 | 461-494 | 32 | 0.000123 | 20.49 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 461-494 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) YIAYYNLAQVYFEQKMFQKGSYYLKKAKKIEQDD |.|||.|.|..|. ... |..|| |.. .. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 26506.AA | TPR | 461-494 | 20 | 0.000311 | 21.31 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 461-494 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) YIAYYNLAQVYFEQKMFQKGSYYLKKAKKIEQDD . |.|||...|. .. ... ...|| ... .. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_2 | 26506.AA | TPR_2 | 393-426 | 26 | 0.115001 | 9.98 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 393-426 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) DVAMFGLGSAYEDLGFIQESLSCYDKYINLNSFD | . || .|. .| .| . .|.| . |. . AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR | 26506.AA | TPR | 393-426 | 29 | 0.252432 | 5.84 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 393-426 Range on HMM: 1-34/34 Sequence Identity: 29% (10 aa) DVAMFGLGSAYEDLGFIQESLSCYDKYINLNSFD | . || .|. .| ..| . ||.| . |. . AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR | 26506.AA | TPR | 495-527 | 24 | 0.40242 | 4.06 | SMART | 2-34 (34) | Show / Hide |
Range on Protein: 495-527 Range on HMM: 2-34/34 Sequence Identity: 24% (8 aa) DSYELLGYFYEQKQEYEKSLKCYEKLSMNIQNH . . || |... .|.. ..||.| |. EAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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| TPR_1 | 26506.AA | TPR_1 | 393-426 | 32 | 0.481861 | 7.63 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 393-426 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) DVAMFGLGSAYEDLGFIQESLSCYDKYINLNSFD | . || .|. .| .| . ||.| . || . AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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| TPR_2 | 26506.AA | TPR_2 | 495-527 | 24 | 0.494029 | 7.74 | Pfam | 2-34 (34) | Show / Hide |
Range on Protein: 495-527 Range on HMM: 2-34/34 Sequence Identity: 24% (8 aa) DSYELLGYFYEQKQEYEKSLKCYEKLSMNIQNH . . .|| |.....|.. ...|||. |. EAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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| TPR_1 | 26506.AA | TPR_1 | 495-519 | 28 | 0.711127 | 7.04 | Pfam | 2-26 (34) | Show / Hide |
Range on Protein: 495-519 Range on HMM: 2-26/34 Sequence Identity: 28% (7 aa) DSYELLGYFYEQKQEYEKSLKCYEK . . ||. |.....|.. ..||.| EAWYNLGNCYYKMGNYDEAIECYQK |
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| TPR_2 | 26506.AA | TPR_2 | 377-392 | 37 | 55.530135 | 0.48 | Pfam | 19-34 (34) | Show / Hide |
Range on Protein: 377-392 Range on HMM: 19-34/34 Sequence Identity: 37% (6 aa) QAFYSYKKAFELNDKN .| |.|| .|. .| EAIEYYEKALKLDPNN |
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| TPR_1 | 26506.AA | TPR_1 | 382-392 | 63 | 57.028244 | 0.39 | Pfam | 24-34 (34) | Show / Hide |
Range on Protein: 382-392 Range on HMM: 24-34/34 Sequence Identity: 63% (7 aa) YKKAFELNDKN |.|| ||| .| YQKALELNPNN |
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