23558

Species: Tetrahymena
Alias: 3813.m01511, 1079, TTHERM_00393350, 23558, PreTt23558, 42.m00292
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E6

Sequence

Name Sequence Type Origin Length Description Download
23558.AA Protein None 503 None Fasta, JSON
23558.kin_dom Protein Kinase Domain None 169 None Fasta, JSON
23558.NA RNA None 1512 None Fasta, JSON

Protein domain

Protein domains of 23558.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 23558.AA Ciliate-E6 57-166 39 1.1e-64 204.53 In-house 25-154 (154) Show / Hide
Range on Protein: 57-166
Range on HMM: 25-154/154
Sequence Identity: 39% (51 aa)

YTVLVEDLG--------------DIDDN-VFIDFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYF
|....|...              .|..| .|..|..||..|||||||||..|.|....|||||.|.|||..|||....|...|..|.|....||...||.
YFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIPNQQTKEFMAQKNQNKYHYC

APEQLN-----SSLETYVLQTAEADIWSVG
.|||..     .|....|..|.|.|||||.
PPEQFDYSKDQQSKHYKVNWTQEGDIWSVC

Kinase 23558.AA Ciliate-A2 67-226 35 5.5e-36 122.46 In-house 99-272 (272) Show / Hide
Range on Protein: 67-226
Range on HMM: 99-272/272
Sequence Identity: 35% (62 aa)

IDDNVFIDFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFN-IKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLET--------YVLQT
| | .|. ||.|.| |.||||.||  | . | .|| .| ... ||| |||| | ..  .....|...     | |. || ..  .|          . ||
IPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQT

AEADIWSVGISLYLLAGSNLDHIYLLT----RGLQQYQKQMQINEEMNLLLSQMLSQDPNKRP-QISHIKQQFE
 ..|||  || ||.|.| .. | | ||     .  |||.  .  |. | ...| |..||.|||  |  |.....
FMGDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH

Kinase 23558.AA TKL 70-225 15 1.9e-12 41.13 In-house 132-364 (364) Show / Hide
Range on Protein: 70-225
Range on HMM: 132-364/364
Sequence Identity: 15% (36 aa)

NVFIDFALQLLNAVEYLHS--------KNLYLSNFSNENIFLDENFN--------------IKLHDFGLRKSINTLQAYKLFQIG-------------AN
......||.   ...||||        ...   .   .||..|||..              .|. |||| ..... .  .  . .              .
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

QKG--FHYFAPEQLNSS--LETYV---------LQTAEADIWSVGISLYLLAG---SNLDHIYL------------LTRGLQQYQKQMQ-----------
 ..  . . ||| |. .  .. .|           .  .|..| || |. ..       |. |               ... ...  .            
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP

---INEEMNLLLSQMLSQDPNKRPQISHIKQQF
   . ..|  |. .  ..||.|||  . |....
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase 23558.AA PLK1 75-226 26 8.6e-12 34.77 In-house 104-253 (253) Show / Hide
Range on Protein: 75-226
Range on HMM: 104-253/253
Sequence Identity: 26% (43 aa)

FALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSVGISLY-LLA
.  |......||| ...    .   |.||......|. ||||   ..     |    |       | ||| ||    ..     | ||||.|  .| || 
YMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPN----YIAPEVLNKKGHSF-----EVDIWSIGCIMYILLF

GS------NLDHIYLLTRGLQQYQKQMQINEEMNLLLSQMLSQDPNKRPQISH-IKQQFE
|.       |.  |.  .   .|.   .|..  . |. .|| .||..||.|.. ....| 
GQPPFETKCLKETYSRIK-KNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF

Kinase 23558.AA C8 23-169 23 1.7e-10 32.75 In-house 66-226 (226) Show / Hide
Range on Protein: 23-169
Range on HMM: 66-226/226
Sequence Identity: 23% (38 aa)

KQIASLKGIQFQSYKQN-----KKDQRVFFLNS-----QNEGHGYTVLVEDLGDIDDNVFIDFALQLLNAVEYLHSKNLYLSNFSNENIF--LDENFN--
.... ..  .|.  |.        ... .|...     ||  . |  . .  . ....     |.|..  |.|.|.||        .|.   ||.| .  
YDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFE

IKLHDFGL----RKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSVGISL
||| |||.    .|. .  |  | ...|     . |||||... . . |   . . |..|||. |
IKLCDFGFASQVSKNKSHIQSKKMNTCGT----WAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL

Kinase 23558.AA Ciliate-C1 78-116 48 1.2e-09 20.61 In-house 137-175 (328) Show / Hide
Range on Protein: 78-116
Range on HMM: 137-175/328
Sequence Identity: 48% (19 aa)

QLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGL
|| |...|.|. |        |||.||||||.|. |||.
QLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGF

S_TKc 23558.AA S_TKc 4-228 17 2.1e-09 -39.14 SMART 1-231 (231) Show / Hide
Range on Protein: 4-228
Range on HMM: 1-231/231
Sequence Identity: 17% (48 aa)

FVIILII-----------------ILIYIKFMSSVLKQIASLKGIQFQSYKQNKKDQRVFFLNSQNEGHGYTVLVEDLGD--------------------
. |. .|                  .  || ..     .  .. ||  .    . .  | .. .  .  ..  .| .. |                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IDDNVFIDFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSV
 ..  .   .. |...|.||.||..        |||.|||  .||. |||| . .                  .| ||| |          ....|.||.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------GYGKCKCDWWSC

GISLYLLAGSNLDHIYLLTRGLQQYQKQMQINEEMNLLLSQMLSQDPNKRPQISHIKQ------QFEII
|. || ..       .     .|.  |..   .|.  .....|  ||.||| .  . |      . . .
GCILYEMLC--GYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 23558.AA MELK 78-227 28 2.4e-09 27.74 In-house 105-254 (254) Show / Hide
Range on Protein: 78-227
Range on HMM: 105-254/254
Sequence Identity: 28% (44 aa)

QLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSVGISLYLLAGSNL
|.. |. |.||.     ..  ||...||....|| ||||       . |   |         | ||| ..     |.   .|||.||.|| || |    |
QIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGS--PAYAAPELIQG--KQYI--GSEADVWSMGILLYVLMCGFL

----DHIYLLTRGLQQ--YQKQMQINEEMNLLLSQMLSQDPNKRPQISHIKQQFEI
    | . .. . ...  |..   .  |  .|| .||  ||.|| .. .. .   .
PFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV

Kinase 23558.AA Ciliate-E4 74-113 32 4.7e-09 26.8 In-house 111-150 (150) Show / Hide
Range on Protein: 74-113
Range on HMM: 111-150/150
Sequence Identity: 32% (13 aa)

DFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHD
. | .. ||  || ..|..  .    |||.|..| .|. |
QIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD

Kinase 23558.AA Ciliate-E9 75-116 32 4.6e-08 21.46 In-house 116-158 (298) Show / Hide
Range on Protein: 75-116
Range on HMM: 116-158/298
Sequence Identity: 32% (14 aa)

FALQLLNAVEYLHSKN-LYLSNFSNENIFLDENFNIKLHDFGL
...||. ..||.| .          ||. .|.|.|.|. |||.
YFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFGM

Kinase 23558.AA AMPK 78-116 43 5.6e-07 16.83 In-house 108-146 (254) Show / Hide
Range on Protein: 78-116
Range on HMM: 108-146/254
Sequence Identity: 43% (17 aa)

QLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGL
| ...|||.|  .        ||. ||.| |||. ||||
QIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGL

Kinase 23558.AA Pkinase 139-225 19 2e-06 23.53 Pfam 176-293 (293) Show / Hide
Range on Protein: 139-225
Range on HMM: 176-293/293
Sequence Identity: 19% (24 aa)

HYFAPEQLNSSLETYVLQTAEADIWSVGISLYLLAG-----SNL------DHIYLLTRGLQ-----QYQKQMQIN-----------------EEMNLLLS
.| ||| ..    ..   . ..|.||.|. || ..      ..       |..... | ..     ....   |                  ||.  ...
WYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

QMLSQDPNKRPQISHIKQQ--F
 .| .||.||| . .|.|   |
WCLCKDPKKRPTAEQILQHPWF

TyrKc 23558.AA TyrKc 6-225 16 0.000146 -148.85 SMART 1-280 (280) Show / Hide
Range on Protein: 6-225
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

IILIIIL-------IY------------------------IKFMSSV---------LKQIASLK------------------GIQFQSYKQNKKDQRVFF
| |. .|       .|                        .. |...         |  ... .                  .   ..| ......    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----

LNSQNEGHGYTVLVEDLGDIDDNVFIDFALQLLNAVEYLHSKNLYLSNFSN--------ENIFLDENFNIKLHDFGLRKSINTL-------QAYKLFQ-I
                   .    ...|..|  .  ||||||        |         |. ..||. .|  |||| . |          . |.  .  
-------------------LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

GANQ-KGFHYFAPEQLNSSLETYVLQTAEADIWSVGISLY--------LLAG------SNLDHIYLLTRGLQQYQKQM-------QINEEMNLLLSQMLS
|..        ||| .      |   | . |.|| |. ..           |      || . | .. .|    | .           .||  . .|   
GGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

QDPNKRPQISHIKQQF
 ||..||  | |...|
EDPEDRPTFSEIHECF

Kinase 23558.AA AMPK 196-223 35 0.000318 8.51 In-house 223-250 (254) Show / Hide
Range on Protein: 196-223
Range on HMM: 223-250/254
Sequence Identity: 35% (10 aa)

INEEMNLLLSQMLSQDPNKRPQISHIKQ
...|   |...||  ||.|| .|. |..
LSPEAKDLIKHMLQVDPMKRITIHDIRN

Kinase 23558.AA Ciliate-E9 203-222 40 0.007094 4.58 In-house 274-293 (298) Show / Hide
Range on Protein: 203-222
Range on HMM: 274-293/298
Sequence Identity: 40% (8 aa)

LLSQMLSQDPNKRPQISHIK
.. .|| ||| .|. |  |.
MMNWMLQQDPQNRISIQEIR

Kinase 23558.AA Pkinase 99-116 50 0.12528 6.84 Pfam 137-158 (293) Show / Hide
Range on Protein: 99-116
Range on HMM: 137-158/293
Sequence Identity: 50% (11 aa)

ENIFLDENFNI----KLHDFGL
|||..|.| .|    |. ||||
ENILIDNNGHIDACVKICDFGL

Kinase 23558.AA Pkinase 73-90 33 0.182775 6.26 Pfam 111-128 (293) Show / Hide
Range on Protein: 73-90
Range on HMM: 111-128/293
Sequence Identity: 33% (6 aa)

IDFALQLLNAVEYLHSKN
.....|.| ..||.||..
KFYMYQILRGLEYCHSMG

TPR_1 23558.AA TPR_1 315-348 26 4.6e-05 21.65 Pfam 1-34 (34) Show / Hide
Range on Protein: 315-348
Range on HMM: 1-34/34
Sequence Identity: 26% (9 aa)

YFAFNVKGYIYSMTNELQLAEECLKTTISLNPQF
. |.. .|..|   .... |.||..  ..|||..
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR 23558.AA TPR 315-348 23 0.001018 19.6 SMART 1-34 (34) Show / Hide
Range on Protein: 315-348
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

YFAFNVKGYIYSMTNELQLAEECLKTTISLNPQF
. |.. .| .|   .... |.||..  ..|.|..
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 23558.AA TPR_2 315-348 20 0.011488 13.52 Pfam 1-34 (34) Show / Hide
Range on Protein: 315-348
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

YFAFNVKGYIYSMTNELQLAEECLKTTISLNPQF
  | .  | .|   .... |.|...  ..|.|..
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_2 23558.AA TPR_2 281-314 20 0.067887 10.79 Pfam 1-34 (34) Show / Hide
Range on Protein: 281-314
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

DMYLAWKARNLARFDRYQESQELADKAVSINPKN
  .. . .. ...  .|.|  |. .||....|.|
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR 23558.AA TPR 383-416 20 0.151443 7.79 SMART 1-34 (34) Show / Hide
Range on Protein: 383-416
Range on HMM: 1-34/34
Sequence Identity: 20% (7 aa)

MQILINLSRIYLNNLKYENSMKYLQQNIKMYPYN
 ... ||  .|... .|.  ....|. ... | |
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 23558.AA TPR_2 383-416 23 0.282298 8.6 Pfam 1-34 (34) Show / Hide
Range on Protein: 383-416
Range on HMM: 1-34/34
Sequence Identity: 23% (8 aa)

MQILINLSRIYLNNLKYENSMKYLQQNIKMYPYN
  .. || ..|... .|.   .|... .| .| |
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR 23558.AA TPR 349-382 32 0.332368 4.79 SMART 1-34 (34) Show / Hide
Range on Protein: 349-382
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

ITAVQNICNNYEENGKISESLEMYEQSNLHNPNN
. |  |. | |. .|.. | .| |...  ..|||
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 23558.AA TPR_2 349-382 32 0.616367 7.4 Pfam 1-34 (34) Show / Hide
Range on Protein: 349-382
Range on HMM: 1-34/34
Sequence Identity: 32% (11 aa)

ITAVQNICNNYEENGKISESLEMYEQSNLHNPNN
  |  |. . |...|.  | .| ||..   .|||
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 23558.AA TPR_1 296-314 42 1.296118 6.13 Pfam 16-34 (34) Show / Hide
Range on Protein: 296-314
Range on HMM: 16-34/34
Sequence Identity: 42% (8 aa)

RYQESQELADKAVSINPKN
.|.|  |  .||...||.|
NYDEAIECYQKALELNPNN

TPR_2 23558.AA TPR_2 417-447 22 2.309488 5.37 Pfam 1-31 (34) Show / Hide
Range on Protein: 417-447
Range on HMM: 1-31/34
Sequence Identity: 22% (7 aa)

YYSLYYLGLICKATKFYNKSQLCYKKIIQND
 . .|.||... . . | .   .|.| .. |
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLD

TPR_1 23558.AA TPR_1 359-382 37 4.084036 4.39 Pfam 11-34 (34) Show / Hide
Range on Protein: 359-382
Range on HMM: 11-34/34
Sequence Identity: 37% (9 aa)

YEENGKISESLEMYEQSNLHNPNN
|.. |.  | .| |..   .||||
YYKMGNYDEAIECYQKALELNPNN

TPR_1 23558.AA TPR_1 392-416 20 18.366675 2.11 Pfam 10-34 (34) Show / Hide
Range on Protein: 392-416
Range on HMM: 10-34/34
Sequence Identity: 20% (5 aa)

IYLNNLKYENSMKYLQQNIKMYPYN
.|..  .|.   ...|. ... | |
CYYKMGNYDEAIECYQKALELNPNN

TPR_2 23558.AA TPR_2 247-280 17 32.178035 1.32 Pfam 1-34 (34) Show / Hide
Range on Protein: 247-280
Range on HMM: 1-34/34
Sequence Identity: 17% (6 aa)

EVEKFIKAQVMYQNDLNKESLQLLEELVENNQNN
    .  .|. |..   .| ....|.... . ||
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN

TPR_1 23558.AA TPR_1 456-489 17 2.1e-05 22.88 Pfam 1-34 (34) Show / Hide
Range on Protein: 456-489
Range on HMM: 1-34/34
Sequence Identity: 17% (6 aa)

VSILSQLGSIQFDKKQFEKSLKSYKKCQRLEPDE
. ....|| ... ...... .. |.|. .|.|. 
AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN

TPR 23558.AA TPR 456-489 17 2.8e-05 24.77 SMART 1-34 (34) Show / Hide
Range on Protein: 456-489
Range on HMM: 1-34/34
Sequence Identity: 17% (6 aa)

VSILSQLGSIQFDKKQFEKSLKSYKKCQRLEPDE
. ....|| . . ...... .. |.|. .|.|. 
AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN

TPR_2 23558.AA TPR_2 456-489 17 0.000351 18.88 Pfam 1-34 (34) Show / Hide
Range on Protein: 456-489
Range on HMM: 1-34/34
Sequence Identity: 17% (6 aa)

VSILSQLGSIQFDKKQFEKSLKSYKKCQRLEPDE
. .. .|| . . ...... .. |.|. .|.|. 
AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN