Gene 23558 (Tetrahymena)
23558
Group:
Other
Family:
Ciliate-E6
Sequence
Protein domains of 23558.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 23558.AA | Ciliate-E6 | 57-166 | 39 | 1.1e-64 | 204.53 | In-house | 25-154 (154) | Show / Hide |
Range on Protein: 57-166 Range on HMM: 25-154/154 Sequence Identity: 39% (51 aa) YTVLVEDLG--------------DIDDN-VFIDFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYF |....|... .|..| .|..|..||..|||||||||..|.|....|||||.|.|||..|||....|...|..|.|....||...||. YFIVMERCEMNLQDWIHQHKNKKQINQNDQFFKFCCQLFHAVEYLHSKNYVLQNITLKNIFLDKNMNIKICDFGFQQCIIPNQQTKEFMAQKNQNKYHYC APEQLN-----SSLETYVLQTAEADIWSVG .|||.. .|....|..|.|.|||||. PPEQFDYSKDQQSKHYKVNWTQEGDIWSVC |
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Kinase | 23558.AA | Ciliate-A2 | 67-226 | 35 | 5.5e-36 | 122.46 | In-house | 99-272 (272) | Show / Hide |
Range on Protein: 67-226 Range on HMM: 99-272/272 Sequence Identity: 35% (62 aa) IDDNVFIDFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFN-IKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLET--------YVLQT | | .|. ||.|.| |.||||.|| | . | .|| .| ... ||| |||| | .. .....|... | |. || .. .| . || IPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLAKKYQPEINSQMFYTSCPKGVFFYYPPECHFQCFEMNGEQNKKQQIKQT AEADIWSVGISLYLLAGSNLDHIYLLT----RGLQQYQKQMQINEEMNLLLSQMLSQDPNKRP-QISHIKQQFE ..||| || ||.|.| .. | | || . |||. . |. | ...| |..||.||| | |..... FMGDIWAFGICLYQLGGADQQHCYKLTQCNQKKWWQYQDYPNLDEKCNQIIQQILNCDPKKRPSSIQQIRHHWH |
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Kinase | 23558.AA | TKL | 70-225 | 15 | 1.9e-12 | 41.13 | In-house | 132-364 (364) | Show / Hide |
Range on Protein: 70-225 Range on HMM: 132-364/364 Sequence Identity: 15% (36 aa) NVFIDFALQLLNAVEYLHS--------KNLYLSNFSNENIFLDENFN--------------IKLHDFGLRKSINTLQAYKLFQIG-------------AN ......||. ...|||| ... . .||..|||.. .|. |||| ..... . . . . . HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM QKG--FHYFAPEQLNSS--LETYV---------LQTAEADIWSVGISLYLLAG---SNLDHIYL------------LTRGLQQYQKQMQ----------- .. . . ||| |. . .. .| . .|..| || |. .. |. | ... ... . TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP ---INEEMNLLLSQMLSQDPNKRPQISHIKQQF . ..| |. . ..||.||| . |.... CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 23558.AA | PLK1 | 75-226 | 26 | 8.6e-12 | 34.77 | In-house | 104-253 (253) | Show / Hide |
Range on Protein: 75-226 Range on HMM: 104-253/253 Sequence Identity: 26% (43 aa) FALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSVGISLY-LLA . |......||| ... . |.||......|. |||| .. | | | ||| || .. | ||||.| .| || YMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPN----YIAPEVLNKKGHSF-----EVDIWSIGCIMYILLF GS------NLDHIYLLTRGLQQYQKQMQINEEMNLLLSQMLSQDPNKRPQISH-IKQQFE |. |. |. . .|. .|.. . |. .|| .||..||.|.. ....| GQPPFETKCLKETYSRIK-KNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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Kinase | 23558.AA | C8 | 23-169 | 23 | 1.7e-10 | 32.75 | In-house | 66-226 (226) | Show / Hide |
Range on Protein: 23-169 Range on HMM: 66-226/226 Sequence Identity: 23% (38 aa) KQIASLKGIQFQSYKQN-----KKDQRVFFLNS-----QNEGHGYTVLVEDLGDIDDNVFIDFALQLLNAVEYLHSKNLYLSNFSNENIF--LDENFN-- .... .. .|. |. ... .|... || . | . . . .... |.|.. |.|.|.|| .|. ||.| . YDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEMELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFE IKLHDFGL----RKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSVGISL ||| |||. .|. . | | ...| . |||||... . . | . . |..|||. | IKLCDFGFASQVSKNKSHIQSKKMNTCGT----WAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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Kinase | 23558.AA | Ciliate-C1 | 78-116 | 48 | 1.2e-09 | 20.61 | In-house | 137-175 (328) | Show / Hide |
Range on Protein: 78-116 Range on HMM: 137-175/328 Sequence Identity: 48% (19 aa) QLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGL || |...|.|. | |||.||||||.|. |||. QLINVIQYIHQNNICHRDLKPENILLDENFNLKIADFGF |
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S_TKc | 23558.AA | S_TKc | 4-228 | 17 | 2.1e-09 | -39.14 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 4-228 Range on HMM: 1-231/231 Sequence Identity: 17% (48 aa) FVIILII-----------------ILIYIKFMSSVLKQIASLKGIQFQSYKQNKKDQRVFFLNSQNEGHGYTVLVEDLGD-------------------- . |. .| . || .. . .. || . . . | .. . . .. .| .. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -IDDNVFIDFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSV .. . .. |...|.||.||.. |||.||| .||. |||| . . .| ||| | ....|.||. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------GYGKCKCDWWSC GISLYLLAGSNLDHIYLLTRGLQQYQKQMQINEEMNLLLSQMLSQDPNKRPQISHIKQ------QFEII |. || .. . .|. |.. .|. .....| ||.||| . . | . . . GCILYEMLC--GYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 23558.AA | MELK | 78-227 | 28 | 2.4e-09 | 27.74 | In-house | 105-254 (254) | Show / Hide |
Range on Protein: 78-227 Range on HMM: 105-254/254 Sequence Identity: 28% (44 aa) QLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGLRKSINTLQAYKLFQIGANQKGFHYFAPEQLNSSLETYVLQTAEADIWSVGISLYLLAGSNL |.. |. |.||. .. ||...||....|| |||| . | | | ||| .. |. .|||.||.|| || | | QIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGS--PAYAAPELIQG--KQYI--GSEADVWSMGILLYVLMCGFL ----DHIYLLTRGLQQ--YQKQMQINEEMNLLLSQMLSQDPNKRPQISHIKQQFEI | . .. . ... |.. . | .|| .|| ||.|| .. .. . . PFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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Kinase | 23558.AA | Ciliate-E4 | 74-113 | 32 | 4.7e-09 | 26.8 | In-house | 111-150 (150) | Show / Hide |
Range on Protein: 74-113 Range on HMM: 111-150/150 Sequence Identity: 32% (13 aa) DFALQLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHD . | .. || || ..|.. . |||.|..| .|. | QIAFCCINAMYYLQQVNITHGDLKPSNIFFDQYFMVKIAD |
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Kinase | 23558.AA | Ciliate-E9 | 75-116 | 32 | 4.6e-08 | 21.46 | In-house | 116-158 (298) | Show / Hide |
Range on Protein: 75-116 Range on HMM: 116-158/298 Sequence Identity: 32% (14 aa) FALQLLNAVEYLHSKN-LYLSNFSNENIFLDENFNIKLHDFGL ...||. ..||.| . ||. .|.|.|.|. |||. YFKQLIDSIEYMHQYQNICHRDLKPENMLIDKNYNMKICDFGM |
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Kinase | 23558.AA | AMPK | 78-116 | 43 | 5.6e-07 | 16.83 | In-house | 108-146 (254) | Show / Hide |
Range on Protein: 78-116 Range on HMM: 108-146/254 Sequence Identity: 43% (17 aa) QLLNAVEYLHSKNLYLSNFSNENIFLDENFNIKLHDFGL | ...|||.| . ||. ||.| |||. |||| QIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGL |
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Kinase | 23558.AA | Pkinase | 139-225 | 19 | 2e-06 | 23.53 | Pfam | 176-293 (293) | Show / Hide |
Range on Protein: 139-225 Range on HMM: 176-293/293 Sequence Identity: 19% (24 aa) HYFAPEQLNSSLETYVLQTAEADIWSVGISLYLLAG-----SNL------DHIYLLTRGLQ-----QYQKQMQIN-----------------EEMNLLLS .| ||| .. .. . ..|.||.|. || .. .. |..... | .. .... | ||. ... WYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK QMLSQDPNKRPQISHIKQQ--F .| .||.||| . .|.| | WCLCKDPKKRPTAEQILQHPWF |
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TyrKc | 23558.AA | TyrKc | 6-225 | 16 | 0.000146 | -148.85 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 6-225 Range on HMM: 1-280/280 Sequence Identity: 16% (52 aa) IILIIIL-------IY------------------------IKFMSSV---------LKQIASLK------------------GIQFQSYKQNKKDQRVFF | |. .| .| .. |... | ... . . ..| ...... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---- LNSQNEGHGYTVLVEDLGDIDDNVFIDFALQLLNAVEYLHSKNLYLSNFSN--------ENIFLDENFNIKLHDFGLRKSINTL-------QAYKLFQ-I . ...|..| . |||||| | |. ..||. .| |||| . | . |. . -------------------LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK GANQ-KGFHYFAPEQLNSSLETYVLQTAEADIWSVGISLY--------LLAG------SNLDHIYLLTRGLQQYQKQM-------QINEEMNLLLSQMLS |.. ||| . | | . |.|| |. .. | || . | .. .| | . .|| . .| GGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH QDPNKRPQISHIKQQF ||..|| | |...| EDPEDRPTFSEIHECF |
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Kinase | 23558.AA | AMPK | 196-223 | 35 | 0.000318 | 8.51 | In-house | 223-250 (254) | Show / Hide |
Range on Protein: 196-223 Range on HMM: 223-250/254 Sequence Identity: 35% (10 aa) INEEMNLLLSQMLSQDPNKRPQISHIKQ ...| |...|| ||.|| .|. |.. LSPEAKDLIKHMLQVDPMKRITIHDIRN |
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Kinase | 23558.AA | Ciliate-E9 | 203-222 | 40 | 0.007094 | 4.58 | In-house | 274-293 (298) | Show / Hide |
Range on Protein: 203-222 Range on HMM: 274-293/298 Sequence Identity: 40% (8 aa) LLSQMLSQDPNKRPQISHIK .. .|| ||| .|. | |. MMNWMLQQDPQNRISIQEIR |
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Kinase | 23558.AA | Pkinase | 99-116 | 50 | 0.12528 | 6.84 | Pfam | 137-158 (293) | Show / Hide |
Range on Protein: 99-116 Range on HMM: 137-158/293 Sequence Identity: 50% (11 aa) ENIFLDENFNI----KLHDFGL |||..|.| .| |. |||| ENILIDNNGHIDACVKICDFGL |
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Kinase | 23558.AA | Pkinase | 73-90 | 33 | 0.182775 | 6.26 | Pfam | 111-128 (293) | Show / Hide |
Range on Protein: 73-90 Range on HMM: 111-128/293 Sequence Identity: 33% (6 aa) IDFALQLLNAVEYLHSKN .....|.| ..||.||.. KFYMYQILRGLEYCHSMG |
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TPR_1 | 23558.AA | TPR_1 | 315-348 | 26 | 4.6e-05 | 21.65 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 315-348 Range on HMM: 1-34/34 Sequence Identity: 26% (9 aa) YFAFNVKGYIYSMTNELQLAEECLKTTISLNPQF . |.. .|..| .... |.||.. ..|||.. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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TPR | 23558.AA | TPR | 315-348 | 23 | 0.001018 | 19.6 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 315-348 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) YFAFNVKGYIYSMTNELQLAEECLKTTISLNPQF . |.. .| .| .... |.||.. ..|.|.. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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TPR_2 | 23558.AA | TPR_2 | 315-348 | 20 | 0.011488 | 13.52 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 315-348 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) YFAFNVKGYIYSMTNELQLAEECLKTTISLNPQF | . | .| .... |.|... ..|.|.. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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TPR_2 | 23558.AA | TPR_2 | 281-314 | 20 | 0.067887 | 10.79 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 281-314 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) DMYLAWKARNLARFDRYQESQELADKAVSINPKN .. . .. ... .|.| |. .||....|.| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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TPR | 23558.AA | TPR | 383-416 | 20 | 0.151443 | 7.79 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 383-416 Range on HMM: 1-34/34 Sequence Identity: 20% (7 aa) MQILINLSRIYLNNLKYENSMKYLQQNIKMYPYN ... || .|... .|. ....|. ... | | AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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TPR_2 | 23558.AA | TPR_2 | 383-416 | 23 | 0.282298 | 8.6 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 383-416 Range on HMM: 1-34/34 Sequence Identity: 23% (8 aa) MQILINLSRIYLNNLKYENSMKYLQQNIKMYPYN .. || ..|... .|. .|... .| .| | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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TPR | 23558.AA | TPR | 349-382 | 32 | 0.332368 | 4.79 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 349-382 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) ITAVQNICNNYEENGKISESLEMYEQSNLHNPNN . | |. | |. .|.. | .| |... ..||| AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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TPR_2 | 23558.AA | TPR_2 | 349-382 | 32 | 0.616367 | 7.4 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 349-382 Range on HMM: 1-34/34 Sequence Identity: 32% (11 aa) ITAVQNICNNYEENGKISESLEMYEQSNLHNPNN | |. . |...|. | .| ||.. .||| AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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TPR_1 | 23558.AA | TPR_1 | 296-314 | 42 | 1.296118 | 6.13 | Pfam | 16-34 (34) | Show / Hide |
Range on Protein: 296-314 Range on HMM: 16-34/34 Sequence Identity: 42% (8 aa) RYQESQELADKAVSINPKN .|.| | .||...||.| NYDEAIECYQKALELNPNN |
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TPR_2 | 23558.AA | TPR_2 | 417-447 | 22 | 2.309488 | 5.37 | Pfam | 1-31 (34) | Show / Hide |
Range on Protein: 417-447 Range on HMM: 1-31/34 Sequence Identity: 22% (7 aa) YYSLYYLGLICKATKFYNKSQLCYKKIIQND . .|.||... . . | . .|.| .. | AEAWYNLGQCYYKQGDYDEAIEYYEKALKLD |
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TPR_1 | 23558.AA | TPR_1 | 359-382 | 37 | 4.084036 | 4.39 | Pfam | 11-34 (34) | Show / Hide |
Range on Protein: 359-382 Range on HMM: 11-34/34 Sequence Identity: 37% (9 aa) YEENGKISESLEMYEQSNLHNPNN |.. |. | .| |.. .|||| YYKMGNYDEAIECYQKALELNPNN |
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TPR_1 | 23558.AA | TPR_1 | 392-416 | 20 | 18.366675 | 2.11 | Pfam | 10-34 (34) | Show / Hide |
Range on Protein: 392-416 Range on HMM: 10-34/34 Sequence Identity: 20% (5 aa) IYLNNLKYENSMKYLQQNIKMYPYN .|.. .|. ...|. ... | | CYYKMGNYDEAIECYQKALELNPNN |
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TPR_2 | 23558.AA | TPR_2 | 247-280 | 17 | 32.178035 | 1.32 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 247-280 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) EVEKFIKAQVMYQNDLNKESLQLLEELVENNQNN . .|. |.. .| ....|.... . || AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |
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TPR_1 | 23558.AA | TPR_1 | 456-489 | 17 | 2.1e-05 | 22.88 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 456-489 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) VSILSQLGSIQFDKKQFEKSLKSYKKCQRLEPDE . ....|| ... ...... .. |.|. .|.|. AEAWYNLGNCYYKMGNYDEAIECYQKALELNPNN |
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TPR | 23558.AA | TPR | 456-489 | 17 | 2.8e-05 | 24.77 | SMART | 1-34 (34) | Show / Hide |
Range on Protein: 456-489 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) VSILSQLGSIQFDKKQFEKSLKSYKKCQRLEPDE . ....|| . . ...... .. |.|. .|.|. AEAWYNLGNCYYKMGDYDEAIECYQKALELDPNN |
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TPR_2 | 23558.AA | TPR_2 | 456-489 | 17 | 0.000351 | 18.88 | Pfam | 1-34 (34) | Show / Hide |
Range on Protein: 456-489 Range on HMM: 1-34/34 Sequence Identity: 17% (6 aa) VSILSQLGSIQFDKKQFEKSLKSYKKCQRLEPDE . .. .|| . . ...... .. |.|. .|.|. AEAWYNLGQCYYKQGDYDEAIEYYEKALKLDPNN |