Gene 5729 (Tetrahymena)
5729
Sequence
Protein domains of 5729.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
---|---|---|---|---|---|---|---|---|---|
Kinase | 5729.AA | AGC | 211-385 | 29 | 6.8e-112 | 290.08 | In-house | 127-395 (395) | Show / Hide |
Range on Protein: 211-385 Range on HMM: 127-395/395 Sequence Identity: 29% (82 aa) G-DLYMNMK---YKQKFTDREVLFYCSE-------IIVALEYLHS-KGIIYRD-LKPENVLLTKQGHIKLADFGLSKIKNYKD----------------- | .|.. .. ...|. .. ||..| |. ||||||| .|||.|| |||||.||...|||||.||||.|. . .. GCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNK ---------------------------------ERSQSKCG--TPDYIAPEIVLGQNGHDESCDFWS--LGSVIYELYHGYPPFFCK------------- .| .. || ||.|.||||. .. .|| || || ..||. |||||. . KYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPM DKQKQIIDSM---NKEVLIS----------KKLSEEAQDLIRKFLQPNPENRIGSQG------GFQEIKSHPFF .. ..|.. . |..| . ...|.||.|||.|.|...||.|.|..| |..|||.||.| EMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
|||||||||
Kinase | 5729.AA | Ciliate-E2-Unclassified | 57-385 | 27 | 2.6e-105 | 356.16 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 57-385 Range on HMM: 1-352/352 Sequence Identity: 27% (111 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQH---------ALNEKN-------------ILASNNHPFLLKLYYSFQDDQKLYLIT .||.|.||||.||.||..... .|. ||||...|..|.. ||... ..|.|. || ...|||..|..| |||.|..|... YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EYVQGGKLIINQSFGATQKLFYPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQKFTDREVL----- ||..||.|. . .|| ....||..|||....||..... EYCEGGDLWQYIKKRKKQK------------------------------------------------------QKGNDLFHNMKQRKIFTEQQAKYKKAK FYCSEIIVALEYLHSKG-IIYRDLKPENVLLTKQG---HIKLADFGLSK---------------IKNYKDERSQSKCGTPDYI----APEIVLG-QNGHD ||. .|...|||||.|. ||.||.||||.|....| .||..|||.|| ....|.......|||| |. |||. | ...| FYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHS --ESCDFWSLGSVIYELYHGYPPFFCKDKQK----------------QIIDSMNKEVLISK--------KLSEEAQDLIRKFLQPNPENRIGSQGGFQEI ..||.|||| ..||. ||.||..... . .. . ..|.. ..| ..|.||.|.|...|| ........ .|..| KAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI KSHPFF . ||.| LNHPWF |
|||||||||
Kinase | 5729.AA | Ciliate-E2 | 57-385 | 28 | 1.5e-96 | 327.04 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 57-385 Range on HMM: 1-365/365 Sequence Identity: 28% (124 aa) FKIVKKIGQGNFG-----TVYHVYC------------------EADKKDYAMKIIHKNRIRDEKQKQHAL----------NEKNILASNNHPFLLKLYYS .|..||||||||| .|. | . ....| |||||..|| |. ||..| . |||||| ..|||...|.|.. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FQ--DDQKLYLITEYVQGGKLIINQSFGATQKLFYPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQ || ||...||..||.||| | ..... . . . .|...| . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE--------------------------------------------------K-D-KYFTEKEIK KFTDREVL-------FYCSEIIVALEYLHSKG-IIYRDLKPENVLLTKQGHIKLADFGLSKI--------------KNYKDER----------------- ... . ||. .||.||||||||. ||.||.||||.|. ||..||||||. |.|.. . YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQN -SQSKCGTPDYIAPEIVLG--------QNGHDESCDFWSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLIS------------------KKLSEEAQ .. |||| | ||||. | |.|.|..||.|||| ..||. |.||| .. ..... .. ||.|.|.. MFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECK DLIRK----FLQPNPENRIGSQGGFQEIKSHPFF |||.| || .||.||. |...|. ||.| DLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF |
|||||||||
Kinase | 5729.AA | Akt | 211-385 | 45 | 7.4e-79 | 251.69 | In-house | 85-264 (264) | Show / Hide |
Range on Protein: 211-385 Range on HMM: 85-264/264 Sequence Identity: 45% (83 aa) GDLYMNMKYKQKFTDREVLFYCSEIIVALEYLHSKGIIYRD-LKPENVLLTKQGHIKLADFGLSKIKN-YKD-ERSQSKCGTPDYIAPEIVLGQNGHDES |.|. ...|..|. . |||.||| |.|.||||.||||| |||||.|. |.|||.|.||||.| .| || .. .. |||| |.|||| .| |||. . GELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK-ENIIKDHDKTKTFCGTPEYLAPEILNG-NGHTKA CDFWS-LGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLIS--KKLSEEAQDLIRKFLQPNPENRIG-SQGGFQEIKSHPFF .|.|. || |.||...| |||. .|... .|..| . ...| |..|||.. |. .|..| | .. ||||.||.| VDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
|||||||||
Kinase | 5729.AA | S_TKc | 57-385 | 30 | 7.4e-73 | 249.28 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 57-385 Range on HMM: 1-231/231 Sequence Identity: 30% (102 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQG-GKLIINQSFGATQKLF ..|..|||.| ||.|| .. ... .|.|||. .|...| .|| . .||.. |||..||| ..||...||. | . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDL--------------- YPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQK------FTDREVLFYCSEIIVALEYLHSKGIIY |||. .| ... |. .. ||. .|. ||||.||.|||. -------------------------------------------------------GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIH RDLKPENVLLTKQGHIKLADFGLSKIKNYKDERSQSKCGTPDYIAPEIVLGQNGHDE-SCDFWSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLISK |||||||.||.. |||..||||... . ||||.|.|||.. |.. .|| ||.| ..||.. ||||| ...... . RDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------- KLSEEAQDLIRKFLQPNPENRIGSQGGFQ---EIKSHPFF |.|| |.||| || .||.|.. .| .||.||.| --SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
Kinase | 5729.AA | AktR | 211-385 | 44 | 7.5e-73 | 248.34 | In-house | 86-268 (268) | Show / Hide |
Range on Protein: 211-385 Range on HMM: 86-268/268 Sequence Identity: 44% (82 aa) GDLYMNMKYKQKFTDREVLFYCSEIIVALEYLHSK-GIIYRDLKPENVLLTKQGHIKLADFGLSK--IKNYKDERSQSKCGTPDYIAPEIVLGQNGHDES |.|. | |.||. ...|| ..|. ||||||.. |||||||||| || . ||.|..|||||| ... .||. .| |||| |.|||... . ||. | GELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKS CDFWSLGSVIYELYHGYPPFFCKD----KQKQIIDSMNKEVLISKKLSEEAQDLIR-KFLQPNPENRIG-SQGGFQEIKSHPFF .|.|..| .|||. |.|||. |. ||..| .... .....|....||| | |. ||..|.| . |..||||||.| VDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
|||||||||
Kinase | 5729.AA | SGK | 211-385 | 44 | 6.4e-72 | 221.25 | In-house | 110-283 (283) | Show / Hide |
Range on Protein: 211-385 Range on HMM: 110-283/283 Sequence Identity: 44% (78 aa) GDLYMNMKYKQKFTDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKDERSQSKCGTPDYIAPEIVLGQNGHDESCDF |.. .. ..| .. || .||. |||||||. ||||||||||.|| |||..| ||||.| . . . . |||| | |||. ..| .|| . | GEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ-PHDRTVDW WSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLISKKLSEEAQDLIRKFLQPNPENRIGSQGGFQEIKSHPFF |.||.| ||. .| |||....|| .|.. | . | .| ||| || .|..| |. .| |||.|||| WCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF |
|||||||||
Kinase | 5729.AA | RSK | 211-385 | 40 | 8.9e-70 | 238.13 | In-house | 86-278 (278) | Show / Hide |
Range on Protein: 211-385 Range on HMM: 86-278/278 Sequence Identity: 40% (78 aa) GDLYMNMKYKQK---FTDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTK---QGHIKLADFGLSKI-KNYKDERSQSKCGTPDYIAPEIVL---G |.|.. . .. |. .|. || .||..|.|.||..|||.|||||||.|.. .||||| |||..|. .. . .. .. |.| .|.|||.. . GELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQ QNGHDESCDFWSLGSVIYELYHGYPPFFC-KD-KQKQIIDSMNKEV--LISK---KLSEEAQDLIRKFLQPNPENRIGS-QGGFQEIKSHPFF |.|||..|| |||| ..||. |.||| | .|.|.. . | | .. .||.||.||||| |. .|..|.|. .. .|||.||.| QGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
|||||||||
Kinase | 5729.AA | MAST | 230-385 | 34 | 3.7e-68 | 218.71 | In-house | 103-334 (334) | Show / Hide |
Range on Protein: 230-385 Range on HMM: 103-334/334 Sequence Identity: 34% (79 aa) FYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKI---------------------------KNYKDERS------------------- .| .|.. .||||||.||. |||||.|.|... |||||.||||||. || .| .. MYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQQQ -------------------QSKCGTPDYIAPEIVLGQNGHDESCDFWSLGSVIYELYHGYPPFFCKDKQ---KQIIDSM-N-KEVLIS------KKLSEE .. ||||||||||. ||| | . | ||.| ..||. |.|||. .. . .|. . | .| ...|.| QEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPE AQDLIRKFLQPNPENRIGSQGGFQEIKSHPFF |||||.|.|||.|. |.|...| .|.|.|||| AQDLIEKLLQPDPRKRLGANNGADEVKQHPFF |
|||||||||
Kinase | 5729.AA | Pkinase | 211-385 | 29 | 1.9e-55 | 195.34 | Pfam | 85-293 (293) | Show / Hide |
Range on Protein: 211-385 Range on HMM: 85-293/293 Sequence Identity: 29% (64 aa) G----DLYMNMK--YKQKF--TDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHI----KLADFGLSKIK-NYKDERSQSKCGTPDYIAPEI | ||. .. .. .| ...|. ||. .|. .|||.||.|||.|||||||.|. ..||| |..||||.| . . ... .. ||||.|.|||. GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV VLGQNGHDESCDFWSLGSVIYELYHGYPPFFCKDKQKQIIDSMNKEVLISKKLS-------------------------------EEAQDLIRKFLQPNP ..|..... ..| ||.| ..||.. |.||| .. . .. ... ..| .... ||..|.|.. |...| IRGGQYYGPKVDMWSCGCILYEMLCGRPPFP--GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP ENRIGSQGGFQEIKSHPFF . |.. ...|. ||.| KKRPT----AEQILQHPWF |
|||||||||
Kinase | 5729.AA | PKA | 210-328 | 49 | 4.7e-48 | 165.96 | In-house | 84-200 (263) | Show / Hide |
Range on Protein: 210-328 Range on HMM: 84-200/263 Sequence Identity: 49% (59 aa) KGDLYMNMKYKQKFTDREVLFYCS-EIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKDERSQSKCGTPDYIAPEIVLGQNGHDESC .|.. . ...|. . .|| .|. |||||||. |||||||||| |. |.||||..||| . |. .| |... ||||.|.||||... ||| | GGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFA--KKVDD-RTWTLCGTPEYLAPEIIQSKNGHGKSV DFWSLGSVIYELYHGYPPFF | |.|| .|||. |||||. DWWALGILIYEMLAGYPPFY |
|||||||||
Kinase | 5729.AA | AGC | 57-142 | 30 | 6.9e-43 | 107.52 | In-house | 1-130 (395) | Show / Hide |
Range on Protein: 57-142 Range on HMM: 1-130/395 Sequence Identity: 30% (40 aa) FKIVKKIGQGNFGTVYHVYCE------ADKKDYAMKIIHKNR---IRDEKQKQHALNE------------KNILASNN----------HPFLLK-LYYSF |...| ||.| ||.|| | . .| ||||.. | . |..... .|...| .|||. | |||. | |.||| FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF QDDQK--LYLITEYVQ---------GG-KL ||... ||.. ||.. || | QDKDHTYLYFVMEYMPRYVNDLYCGGGCEL |
|||||||||
Kinase | 5729.AA | AktR | 57-142 | 44 | 1.6e-32 | 114.37 | In-house | 1-88 (268) | Show / Hide |
Range on Protein: 57-142 Range on HMM: 1-88/268 Sequence Identity: 44% (39 aa) FKIVKKIGQGNFGTVYHVYCE-ADKKDYAMKIIHKNRIRDEKQKQHALNEKNILA-SNNHPFLLKLYYSFQDDQKLYLITEYVQGGKL |.. | .|.|.||.|| | ..| ||||.|.| |....|..|...|.||.. .||||. ||.|.||.. ||..| ||..||.| FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGEL |
|||||||||
Kinase | 5729.AA | SGK | 57-142 | 33 | 1.7e-31 | 94.2 | In-house | 1-112 (283) | Show / Hide |
Range on Protein: 57-142 Range on HMM: 1-112/283 Sequence Identity: 33% (37 aa) FKIVKKIGQGNFGTVYHVYCEAD------------------KKDYAMKIIHKNRIR-------DEKQKQHALNEK-NILASNNHPFLLKLYYSFQDDQKL |.. |.||.|.|| || | ..| .| ||||.. |. |. |. | . |. .|| .|||. .| |.|| ..|| FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL YLITEYVQGGKL |. .||.|| . YFVMDYVNGGEM |
|||||||||
Kinase | 5729.AA | Akt | 57-140 | 42 | 2.7e-30 | 93.99 | In-house | 1-85 (264) | Show / Hide |
Range on Protein: 57-140 Range on HMM: 1-85/264 Sequence Identity: 42% (36 aa) FKIVKKIGQGNFGTVYHVYCEADKKDY-AMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQGG | ..| .|.| || |. | ...| | |||.. |..| . .|..|.. |.||| ||||. .|.||||. .|||....|..|| FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGG |
|||||||||
Kinase | 5729.AA | PKA | 57-140 | 44 | 3.7e-29 | 103.2 | In-house | 1-85 (263) | Show / Hide |
Range on Protein: 57-140 Range on HMM: 1-85/263 Sequence Identity: 44% (38 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLL-KLYYSFQDDQKLYLITEYVQGG |.|.. .|.| ||.|. . ... ||||.. |..| ..||..| .|||||| . .|||. |.|..||||..||.. |||.|| FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGG |
|||||||||
Kinase | 5729.AA | NDR | 57-140 | 44 | 1.9e-26 | 78.05 | In-house | 1-86 (350) | Show / Hide |
Range on Protein: 57-140 Range on HMM: 1-86/350 Sequence Identity: 44% (38 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNN--HPFLLKLYYSFQDDQKLYLITEYVQGG |.|.| ||.| || |. | . .. |||||. | . . | | ..|. |.|. . .|. ||||||||.| |||. ||. || FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGG |
|||||||||
Kinase | 5729.AA | NDR | 220-274 | 47 | 1.2e-25 | 75.48 | In-house | 98-152 (350) | Show / Hide |
Range on Protein: 220-274 Range on HMM: 98-152/350 Sequence Identity: 47% (26 aa) KQKFTDREVLFYCSEIIVALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSK .. ||. . || .|...|.|..|. |.| ||.||.| |. |.||||| ||||.. MDIFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT |
|||||||||
Kinase | 5729.AA | Pkinase | 57-142 | 35 | 2.3e-23 | 83.67 | Pfam | 1-91 (293) | Show / Hide |
Range on Protein: 57-142 Range on HMM: 1-91/293 Sequence Identity: 35% (32 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHAL-NEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQGG----KL ..|..|||.|.||.||. . . | .|.||| | .....|...|.. .| |... |||. ..||..|.|....|...||..|| | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL |
|||||||||
Kinase | 5729.AA | RSK | 60-140 | 39 | 7.6e-23 | 80.55 | In-house | 1-86 (278) | Show / Hide |
Range on Protein: 60-140 Range on HMM: 1-86/278 Sequence Identity: 39% (34 aa) VKKIGQGNFGTVYHVYCE---ADKKDYAMKIIHKNRIRD-EKQKQHALNEKNILASNN-HPFLLKLYYSFQDDQKLYLITEYVQGG .| ||| .| |. . . .. ||||...|. |. .| |.. | |||. . |||. .|.|.||...|||||.||. || LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGG |
|||||||||
Kinase | 5729.AA | NDR | 285-328 | 52 | 3.6e-22 | 64.61 | In-house | 240-283 (350) | Show / Hide |
Range on Protein: 285-328 Range on HMM: 240-283/350 Sequence Identity: 52% (23 aa) SKCGTPDYIAPEIVLGQNGHDESCDFWSLGSVIYELYHGYPPFF | |||||.|||......|....||.|||| . ||. |||||. STVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFC |
|||||||||
Kinase | 5729.AA | NDR | 349-385 | 60 | 4e-22 | 64.45 | In-house | 313-350 (350) | Show / Hide |
Range on Protein: 349-385 Range on HMM: 313-350/350 Sequence Identity: 60% (23 aa) KLSEEAQDLIRKFLQPNPENRIGSQG-GFQEIKSHPFF .||.||.||||... |.|..|.||.| |..|||||||| NLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF |
|||||||||
Kinase | 5729.AA | MAST | 57-140 | 35 | 2.5e-21 | 65.2 | In-house | 1-84 (334) | Show / Hide |
Range on Protein: 57-140 Range on HMM: 1-84/334 Sequence Identity: 35% (30 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASNNHPFLLKLYYSFQDDQKLYLITEYVQGG |...| |. | .| || | .. .|||.| |. . .. .. |.|||| || |..|||| ...|... ||..|| FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGG |
|||||||||
Kinase | 5729.AA | TyrKc | 57-385 | 17 | 2.2e-13 | -6.27 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 57-385 Range on HMM: 1-280/280 Sequence Identity: 17% (66 aa) FKIVKKIGQGNFGTVYHVYCEADKKDYAMKIIHKNRIRDEKQKQHALNEKNILASN--NHPFLLKLYYSFQDD-------QKLYLITEYVQGGKL----I . ||.| |.||.||. . | | .... .. ..| .|. . .|| ...|| .. . |....||. .| | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR INQSFGATQKLFYPLILFFLIGFIYFGGSPNFSRNLLFIQFFTSKSIDIVTNQQQLSCIQLFLKIIKGDLYMNMKYKQKFTDREVLFYCSEIIVALEYLH .. .. .. | .| | |||| KHRPK--------------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLH SKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKD---ERSQSKC-----GTPD-----YIAPEIVLGQNG-HDESCDFWSLGSVIYELY-HGYPPFF ||..| ||| |.|.......| .|||||. .| |... . |. . ||| . | . | || | ...|.. | .| SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYP C----KDKQKQIIDSMNKE-VLISKKL---------SEEAQDLIRKFLQPNPENRIGSQGGFQEIKSHPFF . . ...| . . . ..| ..... . .||.| |.|| | .| GMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR----PTFSEI--HECF |
|||||||||
Kinase | 5729.AA | Pkinase_Tyr | 57-140 | 24 | 7.5e-09 | 30.61 | Pfam | 1-92 (270) | Show / Hide |
Range on Protein: 57-140 Range on HMM: 1-92/270 Sequence Identity: 24% (23 aa) FKIVKKIGQGNFGTVYHVYCE----ADKKDYAMKIIHKNRIRDEKQ--KQHALNEKNILASN-NHPFLLKLYYSFQ-DDQK--LYLITEYVQGG .. ||.|.|.||.||. .. .| . | |.. |. ...| .. ..| .|. . .|| ...|| ... .|...||...| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG |
|||||||||
Kinase | 5729.AA | Pkinase_Tyr | 238-290 | 37 | 4.2e-07 | 24.68 | Pfam | 123-175 (270) | Show / Hide |
Range on Protein: 238-290 Range on HMM: 123-175/270 Sequence Identity: 37% (20 aa) ALEYLHSKGIIYRDLKPENVLLTKQGHIKLADFGLSKIKNYKDERS-QSKCGTP ..|||.||..| ||| |.|.|.....| .||||.. |.|. ... |.. GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK |
|||||||||
Kinase | 5729.AA | PKA | 350-385 | 35 | 6e-06 | 23.74 | In-house | 224-263 (263) | Show / Hide |
Range on Protein: 350-385 Range on HMM: 224-263/263 Sequence Identity: 35% (14 aa) LSEEA---QDLIRKFLQPNPENRIGSQG-GFQEIKSHPFF .. | |||.| ||.... |.|.. | . || |..| FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF |