Gene 5444 (Tetrahymena)

5444

Species: Tetrahymena
Alias: 3708.m00065, PreTt05444, 5444, TTHERM_00438870, 49.m00216, 435
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
5444.AA Protein None 836 None Fasta, JSON
5444.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
5444.NA RNA None 2511 None Fasta, JSON

Protein domain

Protein domains of 5444.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5444.AA ULK 19-279 30 5.7e-92 311.86 In-house 1-324 (324) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-324/324
Sequence Identity: 30% (100 aa)

YLFNKQIGRGNQG-AIYLATVLNQKPVIQGEEQAQVAIKVVQHQALKAKEKE--------LLQNEIQALKEID---SNY--VVKCIECLNDQ--ENTYIV
|  |...| |  |   | ..  ...       . .||.|... . .. |..|        ||.|||| .|...   ...  .|| .......   |.||.
YCLNHCLGKGSFGVKVYKGRNKKTNT-----QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII

LEYCQYGSLEEYLRKN-SF------KFISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAK------------EFKIADLGFCKKLA---EDQ
.|||. | ||.|. ||  .      |..||   . .||||. |..|||.. | |||||..|||..| .             .|||| ||.|..    ..|
MEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

NICQTVL------GTKMYMAPELLK----MEKYG-IEAELFSVGVLFYLLSQGRFPFEANSPPQLLKA--------------IENQQLKFDD------IS
..||| .      || .||||..|.     ..|. ... ..|.|..|| .  |. ||... . .. .               |.||...|..      ||
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

NELQDLLRKMLKYEPKERIQFKDIFNQPFF
.|..||.|.||.|..|.|| . .||| |.|
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 5444.AA Ciliate-E2-Unclassified 19-279 27 1.8e-90 306.86 In-house 1-352 (352) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-352/352
Sequence Identity: 27% (97 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQALKAKEKELLQNEIQALK----------------EIDSNYVVKCIECLNDQENTYIV
| ..||||.|..| .|..   .||  ..  ... ..... |.| .. .|. . ..|.. .|                 ... ..||...| .|..| |||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LEYCQYGSLEEYLRKNSF---------------KFISERFLK-----DYFKQILFGLQELHSK-RILHRDIKLSNILVKNAK---EFKIADLGFCKKLAE
.|||..|.|..|..|...               | ..|.  |     .||.||| ||. ||.|  |.|||||..|||..| .   . ||.|.|..||. .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

D---------------QNICQTVLGTKMYM----APELLKMEKYG----IEAELFSVGVLFYLLSQGRFPFEANSPPQ----------------LLKAIE
.               |....|. || .||    |||.|. ..|.    ...  .|.||..| .  |..||..|.  |                |.. | 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NQQLKFD---------DISNELQDLLR----KMLKYEPKERIQFKDIFNQPFF
.....|.         ..|.| .|...    ||||. |..||.|..|.| |.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5444.AA ULK 19-279 30 8.4e-90 304.65 In-house 1-329 (329) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-329/329
Sequence Identity: 30% (102 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQALKAKEKE--------LLQNEIQALKEID----SNY----VVKCIECLNDQ--ENTY
|  |...| |  |  | ..  ..|   .   . .||.|... | .. |..|        ||.|||. .|...    ...    .|| .......   |.|
YCLNHCLGKGSFGKVYKGRNKKTK-D-Y--VNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIY

IVLEYCQYGSLEEYLRKN--------SFKFISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAK------------EFKIADLGFCKKLAED-
|..|||. | ||.|. ||          |..||   . .||||| |..|||...| |||||..|||..| .             .|||| ||.|.. .| 
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

--QNICQTVL------GTKMYMAPELLK----MEKYG-IEAELFSVGVLFYLLSQGRFPFEANSPPQLL-----KA----------IENQQLKFDD----
  |.. .| .      || .||||..|.     ..|.  .. ..|.|..|| .  |. ||.|. . ..      |           |..|.|.|..    
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

--ISNELQDLLRKMLKYEPKERIQFKDIFNQPFF
  ||.|..||.|.||.|..|.|| . ..|| |.|
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 5444.AA Ciliate-E2 19-279 25 1.5e-86 293.83 In-house 1-365 (365) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-365/365
Sequence Identity: 25% (95 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQ---------------GEEQAQVAIKVVQHQALKAKEKELLQN-EIQ----------ALKEIDSNYVVKCIEC
| |.|.||.||.| .|...| ...  ..               .  . ..|.|..... ......|. .. ||.           |.........|..||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LN--DQENTYIVLEYCQYGSLEEYLRKNSFKF---------ISERFLKDYFKQILF---------------GLQELHSKR-ILHRDIKLSNILVKNAKEF
    |..| |.|.||||.|.|..|...|. |.         ..|.  |...||||                .|..||||  |.|||||..|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIADLGFCKKLAED-------------------------------QNICQTVLGTKMYMAPELLKMEK---------YGIEAELFSVGVLFYLLSQGRFP
||.|.|..||. .|                               ||. .|..|| .||||| |...|         |. .. ..|.||..| .  |..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEANSPPQLLKAIENQQLKFD-------------------DISNELQDLLRK----MLKYEPKERIQ-FKDIFNQPFF
|        .. |......|.                   ..|.| .||..|    ||...|..||. ...|.| |.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5444.AA S_TKc 19-279 28 6.5e-69 236.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-231/231
Sequence Identity: 28% (77 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQALKAKEKELLQNEIQALKEIDSNYVVKCIECLNDQENTYIVLEYCQY--GSLEEYLR
| . ..||.|  |  |...  .         . .||||..          | ...||| ||. .  ..||....  | .. |.|.|||    |.| .|..
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

KNSFKF----ISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAKEFKIADLGFCKKLAEDQNICQTVLGTKMYMAPELLKMEKYGI-EAELFS
|.  .     ..|   . |..||. .|. .||..|.|||.| .|||. .  . ||.| |....|        |. ||  |||||.|   .||  ..   |
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWS

VGVLFYLLSQGRFPFEANSPPQLLKAIENQQLKFDDISNELQDLLRKMLKYEPKERIQFKDIFN-------QPFF
.|...| .  |. ||.   . ...| |          | |. |..||.|...|..|.   ....        |.|
CGCILYEMLCGYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5444.AA CAMK 24-279 19 2.1e-61 196.3 In-house 1-425 (425) Show / Hide 
Range on Protein: 24-279
Range on HMM: 1-425/425
Sequence Identity: 19% (85 aa)

QIGRGNQGAIYLATVLNQKPVIQ-----GEEQAQVAIKVVQHQALK--------------------------AKEKELLQNEIQALKE-------IDSNY
..|||. |  .|..  | .  ..      . . .||||..  . ||                          .| .. ...||. .|        .|   
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VVKCIECLND-------------------QENTYIVL---EYCQYG----SLEEYLRKNSF-------------KFISERFLKDYFKQILFGLQELHSKR
..|..|   |                   ... |.|.   |||. |     | .|.....              . ..||  . ||.||. ... .||. 
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

ILHRDIKLSNILVKNAK-----------------EFKIADLGFCKKLAEDQN-----------------------ICQTVLGTKMYMA-PELLKM-----
| |||.|. |||. . .                   ||.| || .|. ...|                        ..|. ||  ||| ||.|.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------EKYGIEAELFSVGVLFYLLSQGRFPFEAN-------------SPPQLLKAIENQQLKFDD-----------------ISNE--------LQ
         . || ..   |.||. | .  |..||..              ....|.. | . .  |..                 ||.|         .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLLRKMLKYEPKERIQFKDIFNQPFF
||.||||...|..|.  ... | |..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5444.AA Pkinase 19-279 27 6.2e-60 210.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YLFNKQIGRGNQGAIYLATVLNQ-KPVIQGEEQAQVAIKVVQHQALKAKEKELLQN--EIQALKEIDSNYVVKCIECLNDQENTYIVLEYCQYG----SL
| . ..||.|. |  |...  .  |         .||.|..  .  | .... . .  ||| .|.... ..|.....  |  . |.|.|||. |    .|
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDL

EEYLR---KNSFKFISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAKEF----KIADLGFCKKL-AEDQNICQTVLGTKMYMAPELLK-MEK
 .|..   ...|   ||. .|.|..||| ||. .||..|.|||.|..|||..|  .     ||.| |..|..    .  ..|. ||  |||||...  ..
FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YGIEAELFSVGVLFYLLSQGRFPFEAN------SPPQLLKAIENQQLKFDDI----------------------SNELQDLLRKMLKYEPKERIQFKDIF
|| ..  .|.|...| .  ||.||         .. |... |   .|.||                        | |..|.....|.. ||.|. ...|.
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

NQPFF
. |.|
QHPWF
Kinase 5444.AA AGC 19-279 20 2.4e-59 151.05 In-house 1-395 (395) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-395/395
Sequence Identity: 20% (81 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQA---LKAK-EKELLQNE------------IQALKEID----------SNYVVK-CIE
. | | ||.|  |  ||.   . .   .   . . |.||.. .    .| | . |  ..|             . |....          . ..||    
FEFLKVIGKGSFGKVYLVRKKDGCH--KKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHY

CLNDQEN--TYIVLEYCQ----------YGSLEEYLRKN-SFKFISERFLKDYFKQ-------ILFGLQELHS-KRILHRD-IKLSNILVKNAKEFKIAD
.  |...   |.|.||..           . |  .|..    .  .|   . |. .       |. .|. ||| . | ||| .|. |||  .    |..|
SFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD

LGFCKKLAEDQ--------------------------------------------------NICQTVLG--TKMYMAPELLKMEKYGIEAELFS--VGVL
 |.||..  |.                                                  . ..|  |  |  ||||| |    || ..   |  .|.|
FGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

FYLLSQGRFPFEANSPP----------QLLKAIE------NQQLKF-----------DDISNELQDLLRKMLKYEPKERIQ----------FKDIFNQPF
.| .  |. || ...|           .. . |.      |...||           . .|.|..||..|.|. .|..|.           ...| | |.
MYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPW

F
|
F
Kinase 5444.AA STE 19-279 20 1.4e-54 187.69 In-house 1-359 (359) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-359/359
Sequence Identity: 20% (73 aa)

YLFNKQIGRGNQGAIYLATVLNQKPV-IQGEE------QAQVAIKVVQHQALKA---------------KEKELLQNEIQALKEID--SNYVVKCIECLN
. . ..||.|. |  |.|   .. .    ||.      .  .|||.. ..  ..               .|.. ...||. .|. .  . ..||.. |  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DQ-------ENTYIVLEYCQYGSLEEYLR-KNSFKF-----------ISERFLKDYFKQILFG-LQELHSKRILHRDIKLSNILVKNAKEFKIADLGFCK
.        .. .|..||. .|||.. .. | . ..           ..|  .. . .||| | |. |||..| ||||| .|||.      |..| |.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLAED----------------QNICQTVLGTKMYMAPELLKM------EKYGIEAELFSVGVLFYLLSQGRFPFEANSPPQLLKAIE-------------
.|...                |  ..|. ||  .|||| ..        .|.. .   |.| .   .  |. |.   .|.. . .|              
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NQQLKFDD--------------------ISNELQDLLRKMLKYEPKERIQFKDIFN--QPFF
   ..  .. |                     | |..| ..| |...|..|   ..  .   ||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 5444.AA CAMKL 19-279 25 1.8e-52 165.7 In-house 1-297 (297) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-297/297
Sequence Identity: 25% (78 aa)

YLFNKQIGRGNQGAIYLATV-LNQKPVIQGEEQAQVAIKVVQHQALKAKEKEL-------------LQNEIQALKEID---SNYVVKCIECLNDQEN---
| . |..|.|. |   |||  ...        . .||||..  . .. ... .             .. ||| .| ..      ..|  |.. ..|.   
YRIGKTLGKGSFGKVKLATHIRTT--------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIE

---TYIVLEYCQYGS--LEEYLRKNSFKF--ISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAK--EFKIADLGFCKKLAE----DQNICQT
    |.|.|||. |.  | .|..|.  .   ..|.  . ||.||. ... .||..| |||||. |||. . .    ||.| ||. .  .    . . . |
TKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKT

VLGTKMYMAPELLKM--E-KYGIEAELFSVGVLFYLLSQGRFPFEANSPP-------QLLKAIENQQLKFD---DISNELQDLLRKMLKYEPKERIQFKD
  |.  |||||...   .  .| ..   | ||. | .  |..||.. . .        |.. |  .  ...   ..| ...||.||||.  |..|.  ..
FCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

IFNQPFF
| | |..
IMNHPWM
Kinase 5444.AA Ciliate-E2c 19-279 25 6.1e-42 144.81 In-house 1-310 (310) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-310/310
Sequence Identity: 25% (81 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGE-EQAQV-AIKVVQHQAL-----KAKEKE-LLQNEIQALKEIDSNYVVKCIECLNDQENTYIVLEYCQYGS
.  |.  | |..|  |.|     .  .. .  . |. |||  . . .     . |...  . .||. .|. .. ...|...      . |...|||  |.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LEEYLRKN-SFKFISERFLKDYFKQILFGLQELHSK-RILHRDIKLSNILVKNAKEFKIADLGFCKKLAEDQ-NICQ---TVLGTKMYMAPELLKMEKYG
|| |....     ..|.   .||.||. ....||.. .|.||||| .||| .|  . |||| || |. ..|  .. |   |. || |||||. |.  .| 
LEQYIYHKPK---PNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNG-MIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYY

I-EAELFSVGVLFYLLSQGRFPFE------------------ANSPPQLLKAIE---------------NQQLKFDDI-----SNELQDLLRKMLKYEPK
   ... | ||. |     ..|.|                  .|.  .| ..|.               .|...| .      | |...|..||| ....
TEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEE

ERIQFKDIFNQPFF
 ||....||| . .
KRIDWDEIFNHECI
Kinase 5444.AA PLK-Unclassified 19-279 31 5.8e-41 142.4 In-house 1-264 (264) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-264/264
Sequence Identity: 31% (86 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQAL-KAKEKELLQNEIQALKEIDSNYVVKCIECLNDQENTYIVLEYCQYGSLEEYLRK
|   . .| |     |... .           .. |.|..  . | | . .. | .||.  |  . . .|| . |  |.|| ||.|||| .|.| ||...
YHRGHFLGKGGFAKCYQVKNIET--------KKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKR

N-----SFKFISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAKEFKIADLGFCKKLAEDQNICQTVLGTKMYMAPELLKMEK--YGIEAELF
        | ..|   |.|  ||. .|. ||..|| ||| || ||..    | ||.| |   ||. |    .|. ||  | ||| |   .  ...|    
RNFQLFEKKRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCW

SVGVLFYLLSQGRFPFEANSPPQLLKAIENQQLKFDD---ISNELQDLLRKMLKYEPKERIQFKDIFNQPFF
| |.  | |  |. |||...  | .| | ..| .| .   || .. ||... |.  |..|     |.. ||.
SFGCILYTLLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase 5444.AA Pkinase_Tyr 19-181 25 4.8e-22 75.29 Pfam 1-166 (270) Show / Hide 
Range on Protein: 19-181
Range on HMM: 1-166/270
Sequence Identity: 25% (44 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQALKAK--EKELLQNEIQALKEI-DSNYVVKCIECLN-DQEN--TYIVLEYCQYGSLE
  |.|..|.|. | .|..|        ..... .||.|.. ..| .     ..... |.. .|.. .   .|... .   ..|    |||.||...|.| 
ITFGKKLGEGAFGEVYKGTWKG----DPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

EYLRKN---SFKFISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAKEFKIADLGFCKKLAEDQN
.||||.     ..  .. | ..  ||  |.. |.||.. |||.   |.||.. .  ||.| | .. . .| .
DYLRKHREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDY
Kinase 5444.AA TyrKc 19-279 21 1.7e-18 68.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YLFNKQIGRGNQGAIYLATVLNQKPVIQGEEQAQVAIKVVQHQALKAKEKELLQNEIQALKEI--DSNYVVKCIECLNDQ-------ENTYIVLEYCQYG
  ..|..|.|. | .|..|              |||.|.... |     .| . .|.. ....  .   .|... .  .|       |  .||.||. .|
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

SLEEYLRKNSFKFISERFLKDYFKQILFGLQELHSKRILHRDIKLSNILVKNAKEFKIADLGFCKKLAED-------QNICQTV--LGTKM----YMAPE
.| .||||.  | .. . | ..  ||  | . ||||.. |||.   |.||.. .  ||.| | .... .|       . . ..    |  |     ||||
DLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

LLKMEKYGIEAELFSVGVLFY-LLSQGRFPFEA-----NSPPQLLKAIENQ--QLKFDD--------ISNELQDLLRKMLKYEPKERIQFKDIFNQPFF
 ..  |. ..   .| ||. . ... |  | .       |. .... ...     . ..         . |. .. ..  ...|..|  |..|    .|
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF