Gene 4723 (Tetrahymena)
4723
Sequence
Protein domains of 4723.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 4723.AA | CAMKL | 8-237 | 38 | 1e-104 | 335.15 | In-house | 1-269 (297) | Show / Hide |
Range on Protein: 8-237 Range on HMM: 1-269/297 Sequence Identity: 38% (106 aa) YELGQILGQGSFAIVREVTH-STTKQQFAMKIIDKDKVQRDDSIES------------LKKEISILMMAD---HQNIVKLVEVLASRTK------IYLVL |..|. ||.|||. |. || .||... |.|||||.| . |. ... ...||.|..| . |.||.|| ||. ... ||||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EYIRGGE--LWDLIKDRGQ----ISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHG--CIKVSDFGLSSLYQDP-NQIQNLLHTTCGTINYL ||. ||| | | |. .| ..|.| |.|||||. |..|| ...|.|||.||||||||..| ||..|||.| .|.. .. ..|.| ||. .| EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM APEVIQN--MGYDGHMADIWSLGVILFFTISGRLPFEDE--------NVAKLLEKIVSVEYTM-PKTKMSKE |||..| ||| .||||.||||.. . |.|||.|. |. .|..|| . | . . ..| . APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-D |
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Kinase | 4723.AA | AMPK | 8-231 | 43 | 1.9e-101 | 301.91 | In-house | 1-221 (254) | Show / Hide |
Range on Protein: 8-231 Range on HMM: 1-221/254 Sequence Identity: 43% (98 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIESLKKEISILMMADHQNIVKLVEVL-ASRTKIYLVLEYIRGGELWDLIKDRGQISED | .|. .| |.| | || .|... | ||..|.| . .| |....||.|| . |..|..| ||. . | |..|.||. ||||.| | .| ..|. YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER EMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGCIKVSDFGLSSLYQDPNQIQNLLHTTCGTINYLAPEVIQNMGYDGHMADIWSLGVILFFTISG | ...| ||| .. || . .|.||||||||.|||.. .||. ||||| ...| ..| | || .| |||.|.. | | |||| ||||. . | EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG----EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCG RLPFEDENVAKLLEKIVSVEYTMPK .|||.|||...| ||.. ||. || YLPFDDENTPTLYKKIKNGEYYIPK |
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Kinase | 4723.AA | CAMK | 13-235 | 26 | 8.5e-97 | 312.43 | In-house | 1-372 (425) | Show / Hide |
Range on Protein: 13-235 Range on HMM: 1-372/425 Sequence Identity: 26% (100 aa) ILGQGSFAIVREVTHS-TTK-----------QQFAMKIIDKDKVQ-------------------------RDDSIESLKKEISILMM-------ADHQNI .||.|||..|....| ||. |..|.|||||.|.. |. . .....||.|... || || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKLVEVLAS-------------------RTKIYLVL---EYIRGGEL----WDLIKDRGQ---------------ISEDEMRKYFRQIIKAIHYCKKKNI .|| || . ....|.|. ||. |||| | |...|. ..|.| |.|||||. |.||| ..|| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI AHRDLKPENILLDQH-----------------GCIKVSDFGLSSLYQD---------PNQIQNL------------LHTTCGTINYLA-PEVIQN----- .||||||||||||.. . ||..|||.. ... ... . . ..| ||| | | |||.. VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN --------MGYDGHMADIWSLGVILFFTISGRLPFEDE-------------NVAKLLEKIVSVEYTMPKTKMS |.| .|.||.||||.. .|..||... | .|.||| . .|..| ..| MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFS |
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Kinase | 4723.AA | MARK | 8-237 | 41 | 1.4e-85 | 279.68 | In-house | 1-234 (262) | Show / Hide |
Range on Protein: 8-237 Range on HMM: 1-234/262 Sequence Identity: 41% (99 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIESLKKEISILMMADHQNIVKLVEVLA--SRTK-IYLVLEYIRGGELWDLIKDR--GQ |.... .|.||.| |. ..| |....| ||..| | .. ...... ||.|... || ||.|| .| ... |||..||. |||| | || . | YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR ISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHG--CIKVSDFGLSSLYQDPNQI--QNLLHTTCGTINYLAPEVIQNMGYDGHMADIWSLGV ..|.| |..||||. |..|| .|||.|||.||||||.|..| || .|||.| ..| ..| | ||| | |||... ||| .||||||| LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFS------ICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGV ILFFTISGRLPFEDEN--VAKLLEKIVSVEYTMPKTKMSKE .|.| ..|..||.. . .| .||.. .|. | .||| VLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH-VSKE |
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Kinase | 4723.AA | CAMK1 | 8-231 | 40 | 5e-85 | 247.09 | In-house | 1-238 (276) | Show / Hide |
Range on Protein: 8-231 Range on HMM: 1-238/276 Sequence Identity: 40% (98 aa) YELGQILGQGSFAIVREVTHSTT---KQQFAMKIID-KDKVQRDDSI--ESLKKEISILM---MADHQNIVKLVEVLASRTKIYLVLEYIRGGELWDLIK ||.| ..| |.|..|...|| | ..|.|.|.|| |. .. .| |.|..||.|. ||.||.|. |. | ...|||.|.. |||| | | YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV DRGQISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILL---DQHGCIK--VSDFGLSSLYQ-DPNQIQNLLHTTCGTINYLAPEVIQN---MGYDGH ..|. .|.. |. .||..|..|. .|.|.||||||||.|. | . || ..||||| . | | |. | |||. | ||||. . .|| EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN----LMKTACGTPGYVAPEVLECKKDKPYDKA MADIWSLGVILFFTISGRLPFEDEN-VAKLLEKIVSVEYTMPK |.|| |||... | || ||| ..|.||| . ||..|. C-DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPS |
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Kinase | 4723.AA | Ciliate-E2-Unclassified | 8-222 | 29 | 4.2e-84 | 285.7 | In-house | 1-298 (352) | Show / Hide |
Range on Protein: 8-222 Range on HMM: 1-298/352 Sequence Identity: 29% (89 aa) YELGQILGQGSFAIVREVTHSTTKQQF-----AMKIIDKD--KVQRDDSIESLK-KEISILMMADHQN-----------------IVKLVEVLASRTKIY |......|||.|..|... |. .| |. ..||.... .... | ..... ||. .... .||. |||.... .. .|| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY LVLEYIRGGELWDLIKDRGQ-----------------ISEDEMR-----KYFRQIIKAI-HYCKKKNIAHRDLKPENILLDQHG---CIKVSDFGLSSLY .|.||..||.||. ||.|.. ..| ... .||.||.... ....|.|| |||.||||||.|. | .||..|||.|. | IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY QDPNQI------------QNLLHTTCGTINYL----APEVIQNMGYDG---HMADIWSLGVILFFTISGRLPFEDENVAK----------------LLEK |..|.. |....|.|||.||. ||||.|. .||. ...|||||||||.. . |..||.|.| . |... QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN I | I |
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Kinase | 4723.AA | Ciliate-E2 | 8-255 | 27 | 4.1e-83 | 282.44 | In-house | 1-331 (365) | Show / Hide |
Range on Protein: 8-255 Range on HMM: 1-331/365 Sequence Identity: 27% (96 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDK------------------VQRDDSIESLKKEISILM----------------MADHQNIVKLVE |.. ...|||.|..|..... ...|||.|||| .| ... . ||..|.||.|.. .| ||.|..| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE VLA--SRTKIYLVLEYIRGGELWDLIKDR-----------GQISEDEMRKYFRQIIK---------------AIHYCKKKN-IAHRDLKPENILLDQHGC . ....||||.||. ||.|.|.||.. ....| |......||.. |..|...|| | |||.||||||. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- IKVSDFGLSSLYQDPNQ----------------------------IQNLLHTTCGTINYLAPEVIQNMGYDG--------HMADIWSLGVILFFTISGRL ||..||||| |.|.|| .||. .|.||| .|.|||.... .||. ...|||||||||.. ..|.. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFEDENVAKLLEKIVSVEYTMPKTKMSKEEMEELQLEEKE--EIKQTSQ || ...| .. |. .. |. . . .. . |. || PF--------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQ |
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Kinase | 4723.AA | S_TKc | 8-359 | 25 | 5.8e-82 | 279.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-359 Range on HMM: 1-231/231 Sequence Identity: 25% (94 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIESLKKEISILMMADHQNIVKLVEVLASRTKIYLVLEYIRG--GELWDLIKDRGQ--- ||.....|.|.|. |. ..| |....|.|||. |....||.||.. .| ||||| .| . ...|.|.||. | |.| |.||.|| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---ISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGCIKVSDFGLSSLYQDPNQIQNLLHTTCGTINYLAPEVIQNMGYDGHMADIWSLGVI ..| . |.|..||..|. || ...| ||||||||||||. .||..||||. .. .| ||| .|.||||. ||.. .|.||.|.| RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI LFFTISGRLPFEDENVAKLLEKIVSVEYTMPKTKMSKEEMEELQLEEKEEIKQTSQYQRELSISSGSSELQNCESDLDGIIQDQHPTQLITKQISPIQLM |. ..|. ||. .......||. LYEMLCGYPPFP--QMQMMFKKIG---------------------------------------------------------------------------- SLLTSNILNKMFDVKGKNEQKHLQNTYQYTPITSDKPIEEIDQTLKK-------AFEALT----PKETSYI |. .. |.. |.| | |||. | .. ---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 4723.AA | RSK | 10-237 | 32 | 3.2e-74 | 252.87 | In-house | 1-245 (278) | Show / Hide |
Range on Protein: 10-237 Range on HMM: 1-245/278 Sequence Identity: 32% (81 aa) LGQI--LGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDS-IESLKKEISILMMAD-HQNIVKLVEVLASRTKIYLVLEYIRGGELWDLIKDRGQ--- | . .|.|.. ..|..||. |.|..|||...| |. . . .. ..|..||.. |..||.| .. .|.||..||.||||| . .. ... LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC ISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQ---HGCIKVSDFGLSSLYQDPNQIQNLLHTTCGTINYLAPEVIQ----NMGYDGHMADIWS .|||| . |...|..|. . .. | ||||||||||.|. .| ||..|||.. . ... ....| |.||.|.|||.. . |.| . .|.|| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHD-KACDWWS LGVILFFTISGRLPFED---ENVAKLLEKIVSVE--YTMP-KTKMSKE |||... .|..|| .| ......| . . ||| ..|.| LGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQE |
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Kinase | 4723.AA | Pkinase | 8-242 | 31 | 1.1e-72 | 252.57 | Pfam | 1-269 (293) | Show / Hide |
Range on Protein: 8-242 Range on HMM: 1-269/293 Sequence Identity: 31% (85 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIESLK-KEISILMMADHQNIVKLVEVLASRTKIYLVLEYIRGG----ELWDLIK--DR |..|...|.|||. |.. .| | ...|.|||.|.. . .. .. ||.|. . .| |||.| .. ....||.|.|| .|| .|.|.|. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GQI--SEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGCI----KVSDFGLSSLYQDPNQIQNLLHTTCGTINYLAPEVIQNMGYDGHMADIW | . ||.| ..|..||.... || ...| ||||||||||.|..| | |..||||. ... . . ..| |||..|.|||||. |.|. .|.| GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SLGVILFFTISGRLPFEDE------NVAKLLEKIVSVEYTMPKTKMSK-------------------EEMEEL |.|.||. ..||.|| .. . .....| . .. . . . ||. .. SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF |
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Kinase | 4723.AA | CAMK-Unique | 8-235 | 24 | 2.9e-72 | 237.8 | In-house | 1-327 (363) | Show / Hide |
Range on Protein: 8-235 Range on HMM: 1-327/363 Sequence Identity: 24% (81 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIE-----------------SLKKEISILMMADHQNIVKLVEV----LASRT------- |....|.|.|.| .|.|.. ..|. .|.|.. | ..... .. .||.|..|. | ||.||.||... |. YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI --------KIYLVLEYIRGGELWDLIKD--------------------RGQISE--DEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGC----- ..|.|.||. ||.| |.| . .|. || . . ..... |. | ...| |||||.|||.. . IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH -----------IKVSDFGLSSLYQDPNQIQNLLHTTCGTINYLAP--------------EVIQNMGYDGHMA---DIWSLGVILFFTISGRLPFEDENVA ||..||||. .|. |. ...|.|||. |.|| ||| . .||.. ||||||||... ..|..||. |. . RDFPYDWSNWHIKLCDFGLCCHYNH-NKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECED --------KLLEKIVSVEY-TMPKTKMS ...|.| . .| . .. ... RDYENHDKEIFECICKGDYCNFDWKMWH |
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Kinase | 4723.AA | QIK | 8-224 | 36 | 7.2e-71 | 241.75 | In-house | 1-232 (272) | Show / Hide |
Range on Protein: 8-224 Range on HMM: 1-232/272 Sequence Identity: 36% (86 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIESLKKEISILMMADHQNIVKLVEVLASRTKIYLVLEYIRGGELWDLIKDRGQ----- |.... .| | ||.|. .| ||.. | ||||| . ... .. .. |. |. | .| .|.|| .|. . .|.| || .||..| . |. YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEEN-LQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM ---------------ISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGCIKVSDFGLSSLYQDPNQIQNLLHTTCGTINYLAPEVIQNMGYD ..|.| |. | ||. |.||| |.||.||||| ||||||. ||. |||.| ... || | ||. | |||. . || VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQ----GQLLMTWCGSPPYAAPEMFEGKEYD GHMADIWSLGVILFFTISGRLPFEDENVAKLLEKIVS | .||||.||.|. ..| ||| ... .| ....| GPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLS |
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Kinase | 4723.AA | Pkinase_Tyr | 8-231 | 26 | 4.3e-18 | 61.91 | Pfam | 1-237 (270) | Show / Hide |
Range on Protein: 8-231 Range on HMM: 1-237/270 Sequence Identity: 26% (64 aa) YELGQILGQGSFAIVREVTHS----TTKQQFAMKIIDKDKVQRDD-SIESLKKEISILMMA-DHQNIVKLVEVLA-SRTK--IYLVLEYIRGGELWDLIK ..|. ||.|.| |.. | ||.. | |.. |.. .. .|.. .|..|.. .|.|||.|. | . ||.|.|| .| | | . ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR D----RGQISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGCIKVSDFGLSSLY-QDPNQIQNLLHTTCGTINYLAPEVIQNMGYDGHMADI . ..... .. .. .|| |. | ||. |||| |.|.. ...|..||||. . | . .. .. | .|||.|... . . |. KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFT-TKSDV WSLGVILFFTIS-GRLP-FEDENVAKLLEKIVSVEYTMPK || || .. .. |. | ... . ..|.| | ||. WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC |
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Kinase | 4723.AA | TyrKc | 8-250 | 22 | 1.9e-15 | 27.18 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 8-250 Range on HMM: 1-280/280 Sequence Identity: 22% (66 aa) YELGQILGQGSFAIVREVTHSTTKQQFAMKIIDKDKVQRDDSIESLKKEISILMMA--DHQNIVKLVEVLASR-------TKIYLVLEYIRGGELWDLIK .||..|| | | .|.. | . .| | | . .|. .| . .|..|... .|.|||.|. | . ...|.|| .| | | .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR DRGQ-ISEDEMRKYFRQIIKAIHYCKKKNIAHRDLKPENILLDQHGCIKVSDFGLSSLYQDP------NQIQNL----LHTTCGTINYLAPEVIQNMGYD ... .. ... .. || . | .||. |||| |.|.. ...|.|||||| | . | | .|||.|. . KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT GHMADIWSLGVILFFTIS-GRLPFEDE----NVAKLLEKIVSVEYTMPKTKM--------SKEEMEEL----------------QLEEKEEI . |.|| || .. . | | ... .. . . | | ||. . .|| .. .. .|.. -TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |