3995

Species: Tetrahymena
Alias: PreTt03995, 142.m00092, 645, 3995, TTHERM_00825310, 3683.m00025
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2

Sequence

Name Sequence Type Origin Length Description Download
3995.AA Protein None 375 None Fasta, JSON
3995.NA RNA None 1128 None Fasta, JSON
3995.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of 3995.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3995.AA AGC 19-277 27 4.1e-123 319.77 In-house 1-395 (395) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-395/395
Sequence Identity: 27% (108 aa)

YKFFELVGTGGFSKVWKVQKDG-----QT-SFRALKQMVKYR---IMSKNSVEAILNE------------RQILENLD----------HPFIIN-MYSAF
..|  ..|.|.|.||. |.| .     .|  . |.| . | .   |. || || ...|            |.|||...          ||||.. ....|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKYN--LYLIMDYLP---------GG-DLRYHIK---QTKIFSEQNAKFMMAC-------TLVALEYVHS-KNIIHRD-IKPENLVFDSQGYLRLTDFG
||| .  ||..|.|.|         || .| .|..   . ..|.|. |.|..|.       .. |||| || ..||||| .||||...|..|...|||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

ISRYTKTDN----------------------------------------------------SNETSG--TPGYLAPETLMRLNHGKESDFFG--LGVVLF
 .   ..|.                                                     .   |  || |.||| |    .||. |  .  ||....
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELIKGYRPYNVRS----------RKEMRDKIF------EKEIQLDPSHDH-----GEVSANCIDLINKLIKIKPFKRIGCN-------GIEEIFKHPWF
|.. || |..  .          ..|| .||       ........  |       ..| .. |||.||..  | ||.||.       |.||| .||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF

Kinase 3995.AA Ciliate-E2-Unclassified 19-277 30 4.4e-107 362.04 In-house 1-352 (352) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-352/352
Sequence Identity: 30% (109 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFRALKQMVKYRIMSKNSVEA---------ILNERQ-------------ILENLDHPFIINMYSAFQDKYNLYLIM
||. .  |.|||.||.|.|.. |  . |.|.| |..| ......          ..|...             || |..||||..|. .|||| |.|..|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DYLPGGDLRYHIKQT-----------------KIFSEQNAK-----FMMACTLVALEYVHSKN-IIHRDIKPENLVFDSQG---YLRLTDFGISR-----
.|..||||...||.                  |||.||.||     |..|. |..||| |.|| ||||||||||..||..|   |....|||||.     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------YTKTDNSNETSGTPGYL----APETLMRLNHG----KESDFFGLGVVLFELIKGYRPYNVRSRKE----------------MRDKIFE
            ..| .... ..|||.|.    ||| |.. |..    ...|...|||.|.|.. ||.|.. .....                ....|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KEIQLDPSH---DHGEVSANCIDLINKLIKIKPFKRIGCN-GIEEIFKHPWF
|.|| ...    ..  .| ...|.||.|.. .. |... . ..|.|..||||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase 3995.AA Ciliate-E2 19-277 29 9e-99 334.44 In-house 1-365 (365) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-365/365
Sequence Identity: 29% (113 aa)

YKFFELVGTGGFS-----KVWKVQK-----------------DGQT-SFRALKQMVKYRIMSKNSVEAIL----------NERQILENLDHPFIINMYSA
||| .. |.|.|.     |||||||                 .... .. |.|.| |. | ...... |.          ||..|||.|.||.||.|| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DKYNLYLIMDYLPGGDLRYHIK-------------------QTKIFSEQNAK-------FMMACTLVALEYVHSKN-IIHRDIKPENLVFDSQGYL
||  |. |.||.|.|. ||||...||                   . | ...| ..       |..|| ..|||| |||| ||||||||||..|     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RLTDFGISRYTKTDNSNET---------------------------------SGTPGYLAPETLMRLN---------HGKESDFFGLGVVLFELIKGYRP
 ..|||.|.. ..|| |.|                                  |||||.||| |.. .         .....|.. |||.|.|.. |..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

YNVRSRKEMRDKIFEKEIQLDPSH-------------DHGEVSANCIDLINK----LIKIKPFKRIGCNGIEEIFKHPWF
.         ..| ...|.... .             .. ..| .|.|||.|    ... .| |||.  |.|.|..||||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF

Kinase 3995.AA S_TKc 19-277 32 5.1e-84 286.34 SMART 1-231 (231) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFRALKQMVKYRIMSKNSVEAILNERQILENLDHPFIINMYSAFQDKYNLYLIMDYLPG--GDLRYHIKQTKI---
|.. ...| |.|.||.|... .     |.|..           | |..|.|||.. .||.|...| .|||  .||..|.|..|  |||. .||. .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEQNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFGISRYTKTDNSNETSGTPGYLAPETLMRLNHGK-ESDFFGLGVVLFELI
   |.|  |.|.|. .. |||| ||..|||||.||||. .|.   . ..|||..|       .   ||| |.||| |    .|| ..|   .|..|.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

KGYRPYNVRSRKEMRDKIFEKEIQLDPSHDHGEVSANCIDLINKLIKIKPFKRIGCNGIEE----IFKHPWF
 || |.     ..| .||                |  ..|.|.|. .  | ||...  . .    | .||||
CGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase 3995.AA SGK 19-277 35 9e-81 249.08 In-house 1-283 (283) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-283/283
Sequence Identity: 35% (104 aa)

YKFFELVGTGGFSKVWKVQKDGQ------------------TSFRALKQMVKYRIM-------SKNSVEAILNER-QILENLDHPFIINMYSAFQDKYNL
 .|  ..| |.| ||  |.. .                     | |.|   |  |         |...  |. ||  || |. ||||.|   ||| |  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLIMDYLPGGDLRYHIKQTKIFSEQNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFGISRYTKTDNSNETS---GTPGYLAPETLMR
|. |||. ||.. ||..  |.|.|  |.| .|    |||| ||..||.|| ||||.. |.||...||||| .   .   ...|.   ||| ||||| |  
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCK-EGIKTNDTTFTFCGTPEYLAPEVLRK

LNHGKESDFFGLGVVLFELIKGYRPYNVRSRKEMRDKIFEKEIQLDPSHDHGEVSANCIDLINKLIKIKPFKRIGCN-GIEEIFKHPWF
  |... | . || ||.|.. |  |.  | ...| |.|  ...|. |.     .|. . |||. | .  | || | . . .|| .||.|
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ-----MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF

Kinase 3995.AA AktR 19-277 38 2.6e-78 266.48 In-house 1-268 (268) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-268/268
Sequence Identity: 38% (104 aa)

YKFFELVGTGGFSKVWKVQKD-GQTSFRALKQMVKYRIMSKNSVEAILNERQILE-NLDHPFIINMYSAFQDKYNLYLIMDYLPGGDLRYHIKQTKIFSE
... .. | |.|.||  |||      . |.|   |  |  .|  .....||.|.|   .||||.... .||.|..|..||.| |||.| .|.|. | |||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

QNAKFMMACTLVALEYVHSK-NIIHRDIKPENLVFDSQGYLRLTDFGISR--YTKTDNSNETS--GTPGYLAPETLMR-LNHGKESDFFGLGVVLFELIK
. |.| .|  | |||| |.. ||| ||.||||.. |. |....|||| |.    . ..  ..|  ||| |.|||....   |.| .|.  .|....|.. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GYRPYNVRSRKEMRDKIFEKEIQLDPSHDHGEVSANCIDLIN-KLIKIKPFKRIG--CNGIEEIFKHPWF
|. | .. ....| .|| .|. |. .  .. ..| .| |||. || .  | ||.|  |||.||| .||||
GCPPFYHKNQNQMFQKIKIKQ-QNKF-PYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF

Kinase 3995.AA RSK 23-277 34 1.1e-75 257.71 In-house 3-278 (278) Show / Hide
Range on Protein: 23-277
Range on HMM: 3-278/278
Sequence Identity: 34% (97 aa)

EL--VGTGGFSKVWKV-QKDGQTSFRALKQMVKYRIMSKNS-VEAILNERQILENLD-HPFIINMYSAFQDKYNLYLIMDYLPGGDLRYHIKQTKI---F
.|   | | .. . |. ..| .. . | |.  |  |. ..  ..  . ||.|||    ||||.. . |||..  |||||.|..||.| .|... |.   |
VLGQGGYGKVFLCRKCTHHDTGQIY-AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCF

SEQNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDS---QGYLRLTDFGISRYTKTDNSNETS---GTPGYLAPETLM---RLN-HGKESDFFGLGVV
||  |.| ||   .|.|. |.. |||||.|||| ..|.   .| ..||||| ..... |... |    .|  |.||| |.   . . |.|  | . |||.
SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVL

LFELIKGYRPYNV---RSRKEMRDKIFEKEIQLDPSHDHGEVSANCIDLINKLIKIKPFKRIGCN--GIEEIFKHPWF
..|.  |..|.      .|||  ..| .... |.  ... ..|... |||.|. .  | ||.||.  ..||| .||||
MYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQ-YLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF

Kinase 3995.AA Pkinase 19-277 28 1.5e-75 262.06 Pfam 1-293 (293) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFRALKQMVKYRIMSKNSVEAIL-NERQILENLDHPFIINMYSAFQDKYNLYLIMDYLPGG----DLRYHIK--QT
|.. . .| |.|..|.| .. |     |.|.. | .. |.  ..... .| ||. .|.||.|. .| .|.|| ..|..|.|..||    ||  .|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KIF--SEQNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDSQGYL----RLTDFGISR---YTKTDNSNETSGTPGYLAPETLM-RLNHGKESDFFGL
. |  ||. .||.|  .| .||| ||..|||||.||||. .|..|..    ...|||...   | .    .   |||.|.||| .. .  .|...| ...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLFELIKGYRPYNVRS----RKEMRDKIFEKEIQLDPSHDHGEVS--------------------ANCIDLINKLIKIKPFKRIGCNGIEEIFKHPWF
|..|.|.. |. |.   .    .    ......  . ... |  . .                     .|.|.|..... .| ||..   .|.|..||||
GCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF





Kinase 3995.AA Akt 19-277 39 8.7e-69 218.99 In-house 1-264 (264) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-264/264
Sequence Identity: 39% (105 aa)

YKFFELVGTGGFSKVWKVQKDG-QTSFRALKQMVKYRIMSKNSVEAILNERQILENLDHPFIINMYSAFQDKYNLYLIMDYLPGGDLRYHIKQTKIFSEQ
  | .. | | | ||  |.|   |  . |.|   | .|  || || .. || ||.. .||||.|.. .||.. .||..||| .||.| ||... ..|||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

NAKFMMACTLVALEYVHSKNIIHRD-IKPENLVFDSQGYLRLTDFGISRYT-KTDNSNETS--GTPGYLAPETLMRLNHGKESDFFG-LGVVLFELIKGY
 |.|  |    |.|. |||||| ||  ||||.. |..|...||||| ..   ..|.   ..  ||| ||||| |    |.| .|. | ||.|..|.. | 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

RPYNVRSRKEMRDKIFEKEIQLDPSHDHGEVSANCIDLINKLIKIKPFKRIG--CNGIEEIFKHPWF
 |.  . ...| .||......  .      .| .| |||..| .  | || |   |...||  ||||
PPFYNQDHHQMFKKIKNQPVKFPDK---DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF

Kinase 3995.AA RSK-Unclassified 19-277 32 5.1e-66 206.17 In-house 1-283 (283) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-283/283
Sequence Identity: 32% (94 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFRALKQMVKYRIMSKNSVEAILNERQILENLDHPFIINMYSAFQDKYNLYLIMDYLPGGDLRYHIK--QTKIFSE
.    |.| | | ||. |.| .     |.| . | ... .| .  .. |. |.   .||||. .| .|| .  |||.|.| .|||.  |     .| |.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

QNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFGISRYT--------K------------TDNSNETS---GTPGYLAPETLMRLNHG
  ..| .. . .|||| | . .| || ||.| | .  |  .||||. |           |             | .  |    ||  ||||| . |  |.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KESDFFGLGVVLFELIKGYRPYNVRSRKEMRDKIFEKEIQLDPSHDHGEVSANCIDLINKLIKIKPFKRIGC-NG-IEEIFKHPWF
|  | . ||.|..|.  |  ||    . |.   |  ..... |  .  ..| || ||| || .  | || ||  |  ..| .|| |
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKF-P--HDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF

Kinase 3995.AA PKA 19-277 36 3.2e-62 213.04 In-house 1-263 (263) Show / Hide
Range on Protein: 19-277
Range on HMM: 1-263/263
Sequence Identity: 36% (98 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFRALKQMVKYRIMSKNSVEAILNERQILENLDHPFIIN-MYSAFQDKYNLYLIMDYLPGGDLRYHIKQTKIFSEQ
.... ..||| | .|  ... . . . |.|.. | .|   . || ..||..|| |..||||.. ||. |||  .||..|.| |||.. ...   . ||..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

NAKFMMA-CTLVALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFGISRYTKTDNSNETS---GTPGYLAPETLMRL-NHGKESDFFGLGVVLFELIKGY
 |||  |     |||| ||.|||.|| ||||.  |..|.. .|||| . ....    .|.   ||| ||||| . .   |||  |   ||.. .|.  ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD----RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGY

RPYNVR--SRKEMRDKIFEKEIQLDPSHDHGEVSANCI-DLINKLIKIKPFKRIGC--NGIEEIFKHPWF
 | .    .  .. .|| . .|.  |.|..  .  | . |||.||.   . ||.|.  ||.. | .|.||
PPFYDHNRDPMQIYEKICNGKIKF-PRHFDSDA--NYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF

Kinase 3995.AA NDR 19-162 39 8.3e-51 154.58 In-house 1-149 (350) Show / Hide
Range on Protein: 19-162
Range on HMM: 1-149/350
Sequence Identity: 39% (59 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFRALKQMVKYRIMSKNSVEAILNERQILENLD--HPFIINMYSAFQDKYNLYLIMDYLPGGDLRY---HIKQTKI
... ...| |.| .|| |.|  .  . |.| | |  .| || |  ...||.|.   |  .|..  .| .|||| .|||.|.|.||||..     .....|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FSEQNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFG
|.|. |.| .| . .|.|.||. ..|||||||.|.. |..| . |||||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG

Kinase 3995.AA NDR 177-277 29 1.8e-21 62.38 In-house 243-350 (350) Show / Hide
Range on Protein: 177-277
Range on HMM: 243-350/350
Sequence Identity: 29% (32 aa)

GTPGYLAPETLMR-LNHGKESDFFGLGVVLFELIKGYRPYNVRSRKEMRDKIFEKEIQL--DPSHDH--GEVSANCIDLINKLIKIKPFKRIGCNG--IE
||| |.||| ...  ..... |.  ||....|.. || | .  . .| ..||   ....  .. |.    ..|  . ||| .|.   | .|.| .|  ..
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EIFKHPWF
|| .||.|
EIKSHPFF

Kinase 3995.AA TyrKc 19-272 20 1.9e-13 -5.28 SMART 1-280 (280) Show / Hide
Range on Protein: 19-272
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YKFFELVGTGGFSKVWKVQKDGQTSFR-ALKQMVKYRIMSKNSVEAILNERQILENL--DHPFIINMYSAFQDK-------YNLYLIMDYLPGGDLRYHI
 .. .  | | | .|.| . .       | | . ..       .|....| .|. .|  .|| |...| .  ..         |...| | |.|||. ..
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KQTKI-FSEQNAKFMMACTLVALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFGISRYTKTD-----NSNETS-----GTPG-----YLAPETLMRLNH
. ..  .. .    ..       || ||||.||||.   |   ....  . .||| ||. . |     ..   .     |. .      .|||...    
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GKESDFFGLGVVLFELI-KGYRPYNV-----RSRKEMRDKIFEKEIQLDPSHDHGE-----VSANCIDLINKLIKIKPFKRIGCNGIEEIF
  .|| .  ||...|.   |  ||        | .|.. .. . .    | .|  .      ..   ... .  . .| .|   . | |.|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase 3995.AA Pkinase_Tyr 62-105 31 0.000924 13.36 Pfam 48-95 (270) Show / Hide
Range on Protein: 62-105
Range on HMM: 48-95/270
Sequence Identity: 31% (15 aa)

EAILNERQILENL-DHPFIINMYSAFQ-DKYN--LYLIMDYLPGGDLR
|. ..| .|. .| .|| |...| .   ..    .|..| | |.|||.
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

Kinase 3995.AA Pkinase_Tyr 129-182 29 0.471385 4.19 Pfam 123-176 (270) Show / Hide
Range on Protein: 129-182
Range on HMM: 123-176/270
Sequence Identity: 29% (16 aa)

ALEYVHSKNIIHRDIKPENLVFDSQGYLRLTDFGISRYTKTDNSNE-TSGTPGYL
..|| .|||.||||.   |   ....  . .||| .|.  .. ..  .... | |
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKL