Gene 2224 (Tetrahymena)

2224

Species: Tetrahymena
Alias: 2224, TTHERM_00473240, 428, 57.m00163, PreTt02224, 3709.m00024
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
2224.AA Protein None 2944 None Fasta, JSON
2224.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
2224.NA RNA None 8836 None Fasta, JSON

Protein domain

Protein domains of 2224.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2224.AA Ciliate-E2-Unclassified 2326-2586 30 1.3e-98 333.92 In-house 1-352 (352) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-352/352
Sequence Identity: 30% (108 aa)

YEVIEYIDKGGFGKVDKCIRKKDNLKVAIKTIPKRNIQNKERKMI----------ENELK-------------NMYRIDHKNVIKLISHFEDAINIYLVT
|..|. | .|||||| ||..||.... |.|.. | .|...  .|           .|..|              .. ..| ...|.. .|.|  |||.|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EFCEHGNLLQFLTNQGG----------------RFDERLCV-----FLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNH---IIKLIDFGSSK----
|.||.|.|.|.......                .|.|. ..     |...||.....|||. .  ||||||||||||. ||.    ||.||||.||    
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

------------AFEQSQVMNTMTGTPIYM----PPEIVQVGQQS----EKVDMWTLGVLIYEFLTGETPFDDKKDLDHNN---------RIEQIQQNIL
            .. ..| |.|..|||.||    .||. |  ...    .|.|.|.|||..||.|.|. ||.|... .|..         ...|..|||.
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

SNDIYFPP--------DFPPLAKTLVL----KLLNRRPEKRPNIKQIKEDPWL
 ..|.||.        . .| || ..     |.|. .|.||....||.. ||.
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 2224.AA AGC 2326-2586 25 1.8e-92 238.68 In-house 1-395 (395) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-395/395
Sequence Identity: 25% (103 aa)

YEVIEYIDKGGFGKVDKCIRKK-----DN-LKVAIKTIPKRN-IQNKERKMIENELKN---------------MYRID----------HKNVIK-LISHF
.|..  | ||.||||  . .|.     |.    |.| . |.  |. |...|.|. .                 . ...          | ...| | . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDAIN--IYLVTEFCE--------HGNLLQFLTNQG----GRFDERLCVFLLRQ-------IIDAIDYLHS-LKPPIIHRD-IKPENILIANNHIIKLID
.|  .  .|.| |...         | .  || .||    |||||  . | . .       |. |..|||| ..  ||||| .||||||. ..  ||| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMG--IIHRDYLKPENILLDEDGHIKLTD

FGSSKAFEQS---------------------------------------------------QVMNTMTG--TPIYMPPEIVQVGQQSEKVDMWT--LGVL
||..| . ..                                                   .  .|. |  || ||.|||.     .  .| |.  ||.|
FGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCL

IYEFLTGETPFDDKKDLDHNNR-----IEQIQQNIL------SNDIYFP----------PDFPPLAKTLVLKLLNRRPEKRPN----------IKQIKED
.||.||| .|| .. . . | |      ... |.|.      .... ||          . | | || |. |||.. ||||.           ...||. 
MYEMLTGYPPFYGDNPQE-N-RHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

PWL
|| 
PWF
Kinase 2224.AA CAMK 2331-2586 23 1.3e-91 295.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 2331-2586
Range on HMM: 1-425/425
Sequence Identity: 23% (102 aa)

YIDKGGFGKVDKCIRKKDN------------LKVAIKTIPKRNIQNKE--------------------------RKMIENELKNMYR-------IDHKNV
 . .|.|||| .||.|...             ||||| |.|. ...|.                          ||....|.. | .       .||.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLISHFED-------------------AINIYLVT---EFCEHG----NLLQFLTNQGG--------------RFDERLCVFLLRQIIDAIDYLHSLKP
|||. ..||                     ..|.|.   |.|. |     |..... .|.              ||.|| . .. |||..|..|.||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-

PIIHRDIKPENILIANNH-----------------IIKLIDFGSSKAFEQ------------------------SQVMNTMTGTPIYMP-PEIVQ-----
 |.|||.||||||. .|.                  ||.|||| .. |..                         | |.|. ||| ||. ||...     
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------VGQQSEKVDMWTLGVLIYEFLTGETPFDDKKDLDHNN------RIEQIQQNILSNDIYFPPDFPPL------------------------A
             ..|.||| .||. |  |.|. ||....| .  .       .... ..|.. . .|||.. .                         .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KTLVLKLLNRRPEKRPNIKQIKEDPWL
| |. |.|.. ||||..|.|....||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 2224.AA Pkinase 2326-2586 33 7.4e-90 309.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-293/293
Sequence Identity: 33% (99 aa)

YEVIEYIDKGGFGKVDKCIRKKDNLKVAIKTIPKRNIQNKERKMIEN--ELKNMYRIDHKNVIKLISHFEDAINIYLVTEFCEHG----NLLQFLT-NQG
|.... | .|.||.| ||..|... .||.|.|.||..  ....   .  |.. | |..|.|...|.  |||  .||.|.|.||.|     |  ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--DERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNHII----KLIDFGSSKAF-EQSQVMNTMTGTPIYMPPEIVQ-VGQQSEKVDMWT
|.|  .|. | | ..||. ...|.||    |||||.||||||| ||  |    |..|||..| | . ...|.| .||| ||.||...     . ||||| 
GCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLIYEFLTGETPFDDK----KDLDHNNRIEQIQQNILSNDIYFPPDFP-----------------PLAKTLVLKLLNRRPEKRPNIKQIKEDPWL
.|...||.|.|..||...    . .|.. .|..| . .|. |.. . . .                 . .| .. ..|.. |.|||...||...||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 2224.AA S_TKc 2326-2586 32 7.6e-88 299.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

YEVIEYIDKGGFGKVDKCIRKKDNLKVAIKTIPKRNIQNKERKMIENELKNMYRIDHKNVIKLISHFEDAINIYLVTEFCEH--GNLLQFLTNQGGR---
||... | ||.|||| ||. ||.. .|||| |.         ..|..|.. . . .|.|..||. .|.|  ..|.|.|.|..  |.|.... ..|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FDERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNHIIKLIDFGSSKAFEQSQVMNTMTGTPIYMPPEIVQVGQQSE-KVDMWTLGVLIYE
  |.|  . |...||..|..|.||.   |||||.||||||. .   ||..|||... .      .|. ||| ||.||..   . .  |.|.| .|...||
FPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

FLTGETPFDDKKDLDHNNRIEQIQQNILSNDIYFPPDFPPLAKTLVLKLLNRRPEKRPNIKQIKE-------DPWL
.|.|..||.          .... ..|.          .| || .. |.|.. ||||| . .. .       .||.
MLCGYPPFP---------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2224.AA Ciliate-E2 2326-2586 25 1.8e-86 293.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-365/365
Sequence Identity: 25% (99 aa)

YEVIEYIDKGGFG-----KVDKCIR------------------KKDNLKVAIKTIPKR--NIQNKERKMIE---------NELKNMYRIDHKNVIKLISH
|..|. | .|.||     ||.|  .                  | .. ..|.|.. |.  .....| ...          ||.... ...|.|.||.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--DAINIYLVTEFCEHGNLLQFLTNQ----------GGRFDERLCVFLLRQIID---------------AIDYLHSLKPPIIHRDIKPENILIANNHI
|.  |  |||||.|.|..|.|.... |.          ...|.|. . .. .||..               |. |||| .. ||||||||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

IKLIDFGSSK-----------------AFEQSQVMNTMTG----------------TPIYMPPEIVQVGQ---------QSEKVDMWTLGVLIYEFLTGE
||.|||| ||                   . .. .....|                || ||.|||.. ..          ..|.|.| |||..||.|.|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

TPFDDKKDLDHNNRIEQIQQNILSNDIYFPPD------------------FPPLAKTLVLK----LLNRRPEKRPN-IKQIKEDPWL
.||               ||.|. ..| ||.                    .. .| |  |    .|.. ||||.. ..||.. ||.
PPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2224.AA Aur 2334-2586 36 3.6e-84 221.82 In-house 9-257 (257) Show / Hide 
Range on Protein: 2334-2586
Range on HMM: 9-257/257
Sequence Identity: 36% (94 aa)

KGGFGKVDKCIRKKDNLKVAIKTIPKRNI-QNKERKMIENELKNMYRIDHKNVIKLISHFEDAINIYLVTEFCEHGNLLQFLTNQG-GRFDERLCVFLLR
|| ||.|   . || . ..|.| . | .| ...  . ...| | ... .| |..|.  .|.|. .|||. |. ..|.| . |..|. .|||| .  .  .
KGKFGNVYLARHKKTHFIFALKVMFKEQIKKYCMEHQLRREIKIQSHLNHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDEQRAAKYMY

QIIDAIDYLHSLKPPIIHRDIKPENILIAN-NHIIKLIDFGSSKAFEQ-SQVMNTMTGTPIYMPPEIVQVGQQSEKVDMWTLGVLIYEFLTGETPFDDKK
||..|.||.|| .  ||||||||||||.   |  ||. ||| | .. . ..  .|. ||  |||||.|.  .  .||| | ||||.||...|  ||  . 
QICNALDYCHSKN--IIHRDIKPENILLDQCNGNIKICDFGWS-VHCPNNNRRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESN-

DLDHNNRIEQIQQNIL-SNDIYFPPDFPPLAKTLVLKLLNRRPEKRPNIKQIKEDPWL
     .   .. ..|.  .||.||. ... || |. |.| . |..| ...||.. || 
-----ENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase 2224.AA CAMKL 2326-2586 32 2.6e-81 259.22 In-house 1-297 (297) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-297/297
Sequence Identity: 32% (99 aa)

YEVIEYIDKGGFGKVDKCIR-KKDNLKVAIKTIPKRNIQNKERKM-------------IENELKNMYRID---HKNVIKLISHFEDAIN------IYLVT
|.... . ||.||||  ..  .  . ||||| | |. |.|.. ..             |. | . | ...   |.|.|||  ..|.  .      ||||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCEHGN--LLQFLTNQG---GRFDERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNH--IIKLIDFGSSKAFE-Q----SQVMNTMTGTPI
| |. |.  |.... ..|   ||..|. . .. |||..|..|.||..  |.||||||||||. .|.   ||.|||| |  .. .     | ..|  |.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YMPPEIVQV---GQQSEKVDMWTLGVLIYEFLTGETPFDDKKD---LDHNNRIEQIQQNILSNDIYFPPDFPPLAKTLVLKLLNRRPEKRPNIKQIKEDP
||.|||.|         |||.| .||. |  ..|. ||||  .    . |.  .  .....   .  ... .  .. |  |.|.. |||||.|.||...|
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WL
|.
WM
Kinase 2224.AA ULK 2326-2586 29 2.9e-74 253.03 In-house 1-329 (329) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-329/329
Sequence Identity: 29% (97 aa)

YEVIEYIDKGGFGKVDKCIRKKD----NLKVAIKTIPKRNIQNKERK--------MIENELKNMYRID----HKN----VIKLISHFEDA--INIYLVTE
|.... . || |||| | . ||.    | |||.| |.|  ...|.          ...|| |.| ...    |||    ..||.  ||..   |||...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCEHGNLLQFLTNQGG---------RFDERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNH------------IIKLIDFGSSKAFEQS---
.|..|.| |.. ....         |. |  ..  ..||. .  .||. .  ||||||||.|||| |.             ..|. ||| .| .. .   
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

-QVMNTMT------GTPIYMPPEIVQ----VGQQS-EKVDMWTLGVLIYEFLTGETPFDDKKDLDHN-NRIEQIQQN-------ILSNDIYFPPD-----
 |.| |..      |||.|| |.|.|      ...  |.|.| ||...|| |.|..||      | . . |..  .|       | .. . ||.|     
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQ

FPPLAKTLVLKLLNRRPEKRPNIKQIKEDPWL
. |  | |  ..| . ...| .. .. . ||.
ISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 2224.AA ULK 2326-2586 28 7.4e-73 248.36 In-house 1-324 (324) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-324/324
Sequence Identity: 28% (95 aa)

YEVIEYIDKGGFG-KVDKCIRKKD---NLKVAIKTIPKRNIQNKERK--------MIENELKNMYRID---HKN--VIKLISHFEDA--INIYLVTEFCE
|.... . || || || | . ||.   | .||.| |.| ....|. .        ...|| ..|  ..   |.|  ..||.  ||..   |||...|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

HGNLLQFLTNQGG--------RFDERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNH------------IIKLIDFGSSKAFEQS----QVM
.|.| |.. ....        |. |  ..  ..||. .  .||. .  ||||||||.|||| |.             ..|. ||| .| ..      |..
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

NTMT------GTPIYMPPEIVQ----VGQQS-EKVDMWTLGVLIYEFLTGETPFDDKKDLDHN-NRIEQIQQN-------ILSNDIYFP---PDFP--PL
 |.       |||.|| |.|.|      ...  |.|.| ||...|| |.|..||      | . . |.. ..|       |  . | ||   .| .  | 
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE

AKTLVLKLLNRRPEKRPNIKQIKEDPWL
 | |  ..| . ...| .. .| . ||.
CKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 2224.AA MARK 2326-2586 35 1e-67 220.46 In-house 1-262 (262) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-262/262
Sequence Identity: 35% (95 aa)

YEVIEYIDKGGFGKVDKCIRKKDNLKVAIKTIPKRNIQN-KERKMIENELKNMYRIDHKNVIKLISHFE--DAIN-IYLVTEFCEHGNLLQFLTNQ-GGR
|... .| .|...|| ... |. . |||||...| ...  ...|... |.. | ..||.|.|||   .|  .  . |||. | .. |.|.... .. .||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

FDERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNH--IIKLIDFGSSKAFEQSQVMNTMTGTPIYMPPEIVQVGQQS-EKVDMWTLGVLIYE
  |...  . |||. |. |.||    |.|||||||||||  |    ||.|||| |  ..  |  ||  ||| ||.|||..       |||.|.|||. | 
LHEEEARRIFRQIVSAVNYCHSKN--IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYF

FLTGETPFDDKKDLDHNNRIEQIQQNILSNDIYFPPDFPPLAKTLVLKLLNRRPEKRPNIKQIKEDPWL
 ..|  |||     . .. .......||. .  .|.  .. .. |. .||.  ||.|| |..| ..||.
MVCGYFPFD-----GDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase 2224.AA STE 2326-2586 23 2.6e-66 226.61 In-house 1-359 (359) Show / Hide 
Range on Protein: 2326-2586
Range on HMM: 1-359/359
Sequence Identity: 23% (88 aa)

YEVIEYIDKGGFGKVDKCIRK------KDNLK---------VAIKTIPKRNIQN---------------KERKMIENELKNMYRID--HKNVIKLISHFE
.| || | ||.||.| |....      | . .         .||| ....| .|               .|.. |..|.| | . .  |.|..| . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DA-------INIYLVTEFCEHGNLLQFLTNQG-------------GRFDERLCVFLLRQIIDA-IDYLHSLKPPIIHRDIKPENILIANNHIIKLIDFGS
.         ..... |... | | ... . .             .||.| .  . .|||. .  .||||..  |||||||| |||.     .||.||| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

SKAFEQ-----------------SQVMNTMTGTPIYMPPEIVQVGQQS------EKVDMWTLGVLIYEFLTGETPF---DDKKDLDHNNRIEQIQQ----
.. ...                 .|  ||..||| .| ||..| ..|.      .|.|.| || .| | .||. |.    . . . . ..   .||    
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ

-NILSNDIY-FPP-------------------DFPPLAKTLVLKLLNRRPEKRPNIKQIKE--DPWL
 .|. ...  .|.                    . |  |  . | |.. |.|||. .|  .   |..
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 2224.AA Pkinase_Tyr 2337-2530 27 4.1e-26 89.06 Pfam 12-221 (270) Show / Hide 
Range on Protein: 2337-2530
Range on HMM: 12-221/270
Sequence Identity: 27% (58 aa)

FGKVDKCIRK----KDNLKVAIKTIPKRNIQNKE--RKMIENELKNMYRI-DHKNVIKLISHFE-DAIN--IYLVTEFCEHGNLLQFLTNQ---GGRFDE
||.| |.. |    .....||.|.. | .   ..  |..  .|.| |  . .|.|...|.     .     ||.|.|...||.|| .| ..   ..... 
FGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTM

RLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNHIIKLIDFGSSKAF--EQSQ-VMNTMTGTPI-YMPPEIVQVGQQSEKVDMWTLGVLIYEFL
   .   .|| .. .||.| .  .||||.   |.|...|...|  ||| ...   .    .. . .  ||  |.||  . |  ..| | |  |||..| .
KDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF

T-GETP-FDDKKD
| ||.| . . ..
TYGEQPTYPGMSN
Kinase 2224.AA TyrKc 2326-2589 21 9.2e-26 92.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 2326-2589
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YEVIEYIDKGGFGKVDKCIRKKDNLKVAIKTIPKRNIQNKERKMIENELKNMYRI--DHKNVIKLISHFEDA-------INIYLVTEFCEHGNLLQFLTN
 . .. .  | ||.| |.. |   ..||.|.. .       |... .|.. | ..  .|.|...|.    .          ...|.|...||.|...| .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

QGGRFDERLCVFLLRQIIDAIDYLHSLKPPIIHRDIKPENILIANNHIIKLIDFGSSKAFEQS-------QVMNTMT--GTP--I---YMPPEIVQVGQQ
 ....  .  .    || .  .||||   ..||||.   |.|...||..|  ||| |.. .         ..  ...  |.   .    |.||  . |  
HRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SEKVDMWTLGVLIYEFLT-GETPFDD-----------KKDLDHNNRIEQIQQNILSNDIYFPPDFPPLAKTLVLKLLNRRPEKRPNIKQIKEDPWLKQF
..| | |  ||...| .| |..|  .            ..... .| .| . .     . |.   . . . . ..  .. ||.||. ..|      ..|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-----HECF