Gene 20456 (Tetrahymena)
20456
Sequence
Protein domains of 20456.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 20456.AA | Ciliate-E2-Unclassified | 12-275 | 24 | 6.9e-77 | 261.75 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 12-275 Range on HMM: 1-352/352 Sequence Identity: 24% (85 aa) YEILLTKGNGNIGSVFQAKKDKEY------YAIKMINKNQLESMESFYNLMQKMEHLDYGG-------------------NNNVVRIYEFFQNPFNIFIS |.|. . |.|. |.|......|.. |..|.....|. |.. ..|..|... . ..|. .. ||. .||.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV MEYCNQGNLLQYMLKQPE---------------KRLDCFKAI-----ELFAHILNGFKFLHKNN-IQHRNLKPQNILMHNN----KPKITDYGLYMLYN- ||||..|.|.||. |.. |......|. .||.||.|...||..| | ||..||.|||..|| ..||.|.|. . |. MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ -------------------GKQQYQMREFM----APENYERTSDQGS--HLCDIWGLGVLLFFMIFNTWPFKDFDEIKKYTYSKQ-------FALDLFLK ... . ..| ||| ... .| . ||||.|||.|..|.|...||.| ..........| . | | NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK EKEIQKPSTL------QTNQQAMNMLTEIFQGLFAYQSKNRMSFWKLCNHEIF .|.||.|. . ...| .......| .. .. ..|..|....|| .| QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 20456.AA | Ciliate-E2 | 12-275 | 20 | 4.9e-72 | 245.62 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 12-275 Range on HMM: 1-365/365 Sequence Identity: 20% (80 aa) YEILLTKGNGNIGSVFQAKKDKE-------------------------YYAIKMINKNQLESMESFYNLMQKMEHLD-----------YGGNNNVVRIYE |... |.|| |||...|..|. .||.|...|||.|.... ..|..... . ..|....|| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE FFQ--NPFNIFISMEYCNQGNLLQYMLKQPEKR---------LDCFKAIELFAHILN---------------GFKFLHKNN-IQHRNLKPQNILMHNNKP .|| . ||.. ||||..|.|..|. ... || ............||. ....||..| | ||..||.|||. . CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I KITDYGLYMLYNGKQQ------------------------------------YQMREFMAPENYERTSDQ-------GSHLCDIWGLGVLLFFMIFNTWP ||.| || |. ..| . . ..||||.... ... .. |||| |||.|..|.|. .| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FKDFDEIKKYTYSKQFALDLFLKEKEIQKP---------STLQTNQQAMNMLTEIFQG--LFAYQSKNRMS-FWKLCNHEIF | . .. .. . ..| ||. |... |...... | | .. .. ..|.. .... ||..| F----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKK-F-GKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 20456.AA | CAMK | 17-208 | 17 | 1.6e-35 | 111.44 | In-house | 1-336 (425) | Show / Hide |
Range on Protein: 17-208 Range on HMM: 1-336/425 Sequence Identity: 17% (60 aa) TKGNGNIGSVFQAKK--DK------------EYYAIKMINKNQLE----------------------------SMESFYNLMQKMEHLDYGG----NNNV | | |. | |. .. .. . .|||.|.|..| ....... .. | .| .| |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VRIYEFFQNPFN-------------------IFISM---EYCNQG----NLLQYMLKQPE-------------KRLDCFKAIELFAHILNGFKFLHKNNI ...||....|.. ... | ||| | |..| ... .|.. | .| |. . ...|..|| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI QHRNLKPQNILM-HN-----------------NKPKITDYGLYMLYNGKQ----------------------------QYQMREFMA-PENYER-T---- || ||| |||. .| |. ||.| |. ..... . |.|| || .. . VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM -------SDQGSHLCDIWGLGVLLFFMIFNTWPFKD . . ||.| .||.|..| . || . QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYG |
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Kinase | 20456.AA | ULK | 19-155 | 35 | 9.9e-34 | 117.08 | In-house | 8-184 (324) | Show / Hide |
Range on Protein: 19-155 Range on HMM: 8-184/324 Sequence Identity: 35% (64 aa) GNGNIG-SVFQA--KKD---KEYYAIKMIN-----KNQLE--------SMESFYNLMQKMEHLDYGGNNN--VVRIYEFFQNP--FNIFISMEYCNQGNL | | | |... ||. ..|.|.|||. |...| . .. ..|.|. .| ..| .|. |..|... ||.| |||||.|.| GKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKEL---KHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDL LQYMLKQPE-------KRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNKPK-------------ITDYGL ||. |. . ||| .||. | .|.||||.|||.|| || .||||||.||..|| |.| |. EQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF |
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Kinase | 20456.AA | ULK | 19-155 | 35 | 5.2e-33 | 112.62 | In-house | 8-188 (329) | Show / Hide |
Range on Protein: 19-155 Range on HMM: 8-188/329 Sequence Identity: 35% (65 aa) GNGNIGSVFQA--KKDK----EYYAIKMINKNQLESMESFYN-------------LMQKMEHLDYGGNN---NVVRIYEFFQNP--FNIFISMEYCNQGN | | | |... ||.| |..|.||| |... . .. .|.|. . ...| |.|. |..|... ||.| |||||.|. GKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPN-RHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGD LLQYMLKQPE--------KRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNKPK-------------ITDYGL | ||. |. . ||| .||. | .||||||.|||.|| || .||||||.||..|| |.| |. LEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF |
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Kinase | 20456.AA | S_TKc | 12-275 | 21 | 1.2e-30 | 109.1 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-275 Range on HMM: 1-231/231 Sequence Identity: 21% (61 aa) YEILLTKGNGNIGSVFQAKKDK--EYYAIKMINKNQLESMESFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQ--GNLLQYMLKQPEKR- |||| . | | |.|..... | ...|||.|. |.... .| ... . |.|..|..||. .... ||||.. |.|..|. |.. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNKPKITDYGLYMLYNGKQQYQMREFMAPENYERTSDQGSH-LCDIWGLGVLLFFMIFN .. | ... |... ...|...| || |||.|||. . ||.| || .. . . ...|||| . .. ||.| .|..|. |. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCG TWPFKDFDEIKKYTYSKQFALDLFLKEKEIQKPSTLQTNQQAMNMLTEIFQGLFAYQSKNRMSFWKLCN-------HEIF || .. |. .. . .... . ..|.. .. . |. | YPPFP-----QMQMMFKKIG---------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 20456.AA | Pkinase | 12-208 | 25 | 2.4e-25 | 90.69 | Pfam | 1-214 (293) | Show / Hide |
Range on Protein: 12-208 Range on HMM: 1-214/293 Sequence Identity: 25% (57 aa) YEILLTKGNGNIGSVFQAKKDKEY--YAIKMINKNQLESME-------SFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQG----NLLQY |.|. . | |. |.|..... .. .|.| |.| .| . | .|... | |.||.|..|... .| . ||||. | | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNH------PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-D MLK-QPEKRL--DCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMH-NNKP----KITDYGL-YML-YNGKQQYQM----REFMAPENYERTSDQGS ... . .... . .. . || | ...|...| || |||.|||.. |. . ||.| || . | .. .. ...|||| .. . YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYG HLCDIWGLGVLLFFMIFNTWPFKD . .|.|..|..|. |.. ||.. PKVDMWSCGCILYEMLCGRPPFPG |
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Kinase | 20456.AA | Ciliate-E2b | 19-206 | 24 | 3.3e-23 | 67.53 | In-house | 8-210 (272) | Show / Hide |
Range on Protein: 19-206 Range on HMM: 8-210/272 Sequence Identity: 24% (49 aa) GNGNIGSVFQAKK---DKEYYAIKMINKNQLESMESFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQGNLLQYMLKQPEKRLDCFKAIEL |.|. |||.. .. .|.|||.| |.|||. . ..| . | .... . |. .. ||.|| . |. .. . | . GFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFY FAHILNGFKFLHKNNIQHRNLKPQNILMHN-NKPKITDYGLYMLYNGKQQ-----YQMR---EFMAPENYE--RTSDQG-SHLCDIWGLGVLLFFMIFNT .| |. ... ||..|| .| .|| ||. .. .|. | |. . .|.. . .. ..|||| . . .| . ||| .|. |..... IASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGY WPF |. VPW |
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Kinase | 20456.AA | CAMKL | 12-155 | 26 | 9.2e-21 | 62.85 | In-house | 1-175 (297) | Show / Hide |
Range on Protein: 12-155 Range on HMM: 1-175/297 Sequence Identity: 26% (48 aa) YEILLTKGNGNIGSVFQAKKD---KEYYAIKMIN--KNQL-ESMESF---------------YNLMQKME---HLDYGGNNNVVRIYEFFQNPFN----- |.|. | | |. | | |. .| .|||.|. | .. . |.. ...|... | |....|| ...| . YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHP------NIIKLYEVIETPEHDIETK -IFISMEYCNQGN--LLQYMLKQPEKR--LDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNK---PKITDYGL |.. |||| |. |..| |....| .. | .| |. . ...|...| || .|| ||| .|. ||.| |. KIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGF |
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Kinase | 20456.AA | MELK | 12-208 | 27 | 2.1e-20 | 66.18 | In-house | 1-202 (254) | Show / Hide |
Range on Protein: 12-208 Range on HMM: 1-202/254 Sequence Identity: 27% (56 aa) YEILLTKGNGNIGSVFQAKK--DKEYYAIKMINKNQLESMESFYNLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCNQGNLLQYMLKQPEKRLDC ||. . | | . | | . |||...|||| . . . |. | .. ..| . . ||. |||| |... |...| .||. YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHD--LPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQ--DRLEE FKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNN-KPKITDYGLYMLYNGKQQYQ-------MREFMAPENYERTSDQGSHLCDIWGLGVLLFFMIF . .| |. ..| ||.|||.|.|. .. . |. |.|| |.. | . ||| . . || |.| .|.||. .. EETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSE-ADVWSMGILLYVLMC NTWPFKD || | GFLPFDD |
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Kinase | 20456.AA | Ciliate-E2c | 9-155 | 28 | 6.9e-19 | 62.9 | In-house | 1-160 (310) | Show / Hide |
Range on Protein: 9-155 Range on HMM: 1-160/310 Sequence Identity: 28% (47 aa) INGYEILLTKGNGNIGSVFQAKKDK------EY------YAIKMINKNQL----ESMESFY-NLMQKMEHLDYGGNNNVVRIYEFFQNPFNIFISMEYCN |. .|| | |. |.|. |.. . . .||||. . . . . ... . . . .....|...| .|.. ||||| IDRNNIL---GSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCN QGNLLQYMLKQPEKRLDCFKAIELFAHILNGFKFLHKN-NIQHRNLKPQNILMHNNKPKITDYGL .|.|.|| . | .. . .| |...|| |||. || || .|| ||| || .|| | |. GGTLEQYIYHKP--KPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGF |
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Kinase | 20456.AA | MARK | 12-155 | 29 | 2.1e-17 | 53.62 | In-house | 1-152 (262) | Show / Hide |
Range on Protein: 12-155 Range on HMM: 1-152/262 Sequence Identity: 29% (46 aa) YEILLTKGNGNIGSVFQA--KKDKEYYAIKMINKNQL---ESMESFY---NLMQKMEHLDYGGNNNVVRIYEFFQ--NPFN-IFISMEYCNQGNLLQYML |..| | | |. . | | |. .. .|||...|..| ..|.... ..|.|..| |... .. .. .. . |.. |||. |.|..|. YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHP------NIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIK KQPEKRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNN---KPKITDYGL ..| || | .| |. . ...|..|| || .||.|||. | . ||.| |. AHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGF |
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Kinase | 20456.AA | TyrKc | 12-275 | 21 | 1.7e-10 | -53.07 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 12-275 Range on HMM: 1-280/280 Sequence Identity: 21% (65 aa) YEILLTKGNGNIGSVFQAKKDKEYYAIKMINKNQLESMESFYNLMQKMEHLDYG-GNNNVVRIYEFFQNP-------FNIFISMEYCNQGNLLQYMLKQP . . . |.|. | |.... . . |.||.... .| |.. .. | .| | . |.||.| . ..| |||. |.|..| | ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKL--GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR EKRLDCFKAIELFAHILNGFKFLHKNNIQHRNLKPQNILMHNNK-PKITDYGL-YMLYNG------KQQYQM-----REF------MAPENYERTSDQG- .| | . .. | .| .||..|. || | |.| ..|. ||.| || .|.. |. | . . . |||| . | PK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGK -SHLCDIWGLGVLLFFMIFNTWPFKDFDE-IKKYTYSKQFALDLFLKEKEIQKPSTLQTNQQ----AMNMLTEIFQGLFAYQSKNRMSFWKLCNHEIF .. |.| ||... . | . . |.. | | .. . . . .| . . .| . ... ..| .|. . ||.| FTTKSDVWSFGVCMWEIF--TYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 20456.AA | ULK | 170-275 | 22 | 2e-06 | 19.1 | In-house | 213-324 (324) | Show / Hide |
Range on Protein: 170-275 Range on HMM: 213-324/324 Sequence Identity: 22% (26 aa) FMAPENYE---RTSDQGSHLCDIWGLGVLLFFMIFNTWPFKDFDEIKKYTYSKQFALDL------FLKEKEIQKPSTLQTNQQAMNMLTEIFQGLFAYQS .|||. . ..... |||| ||.... |... ||. . | | .| .. . | . ||.|. ... . . ....... |. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDE KNRMSFWKLCNHEIF | |.|. . ||..| KDRISWEEIFNHPWF |
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Kinase | 20456.AA | MARK | 188-214 | 41 | 2e-06 | 17.3 | In-house | 188-218 (262) | Show / Hide |
Range on Protein: 188-214 Range on HMM: 188-218/262 Sequence Identity: 41% (13 aa) DIWGLGVLLFFMIFNTWPFK--D--FDEIKK ||| |||.|.||. ..||. . . |..| DIWSLGVVLYFMVCGYFPFDGDTQDYKELYK |
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Kinase | 20456.AA | CAMKL | 188-220 | 33 | 1.2e-05 | 13.8 | In-house | 218-255 (297) | Show / Hide |
Range on Protein: 188-220 Range on HMM: 218-255/297 Sequence Identity: 33% (13 aa) DIWGLGVLLFFMIFNTWPFKDFDE------IKKYTYSKQ ||| .||.|..|.. ..||.| . . | | |. DIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKI |
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Kinase | 20456.AA | Ciliate-E2c | 188-220 | 31 | 1.9e-05 | 15.12 | In-house | 201-238 (310) | Show / Hide |
Range on Protein: 188-220 Range on HMM: 201-238/310 Sequence Identity: 31% (12 aa) DIWGLGVLLFFMIFNTWPFK-----DFDEIKKYTYSKQ ||| |||.|..|.. |.. | | . |. . DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWW |
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Kinase | 20456.AA | ULK | 170-207 | 29 | 3.3e-05 | 14.21 | In-house | 217-257 (329) | Show / Hide |
Range on Protein: 170-207 Range on HMM: 217-257/329 Sequence Identity: 29% (12 aa) FMAPENYE-R--TSDQGSHLCDIWGLGVLLFFMIFNTWPFK .|||. . . ..... |||| ||.... |... ||. YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFY |
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Kinase | 20456.AA | ULK | 250-275 | 30 | 0.009918 | 5.46 | In-house | 304-329 (329) | Show / Hide |
Range on Protein: 250-275 Range on HMM: 304-329/329 Sequence Identity: 30% (8 aa) EIFQGLFAYQSKNRMSFWKLCNHEIF ....... |. | |.|. | ||..| DLIRRMLQYDEKDRISWEELFNHPWF |