Gene 20262 (Tetrahymena)

20262

Species: Tetrahymena
Alias: TTHERM_00455330, 53.m00164, 3712.m00025, 416, 20262, PreTt20262
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
20262.AA Protein None 604 None Fasta, JSON
20262.kin_dom Protein Kinase Domain None 274 None Fasta, JSON
20262.NA RNA None 1815 None Fasta, JSON

Protein domain

Protein domains of 20262.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20262.AA Ciliate-E2 8-283 24 2.1e-84 286.73 In-house 1-365 (365) Show / Hide 
Range on Protein: 8-283
Range on HMM: 1-365/365
Sequence Identity: 24% (96 aa)

YILLEVAGRGQFGEVYQARHKETSELFAIKMFDSTKLLKSP----------VYQEMLI-DEIQCLRKISHQR-----------------------IVRFH
|..... |.|.|| ||....... ..||||..| .|. ...          .. .... ..|. . .. |.                        |....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

EWFK--TSNHIYLAYEYCFGGNLDEVIKHY--KFLQE--------DVVLSHVFKQIIE---------------GFLIIKKSH-IIHNDIKPSNILFKKTN
|.|.  . |.|||  ||| ||.| . ||.   |...|        .   ....|||..               ..  ... . ||| ||||.||||    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

MSTESQSQLLKNDICIADFGFCKYVGEFDKDESK----------------------IISQELTTAIRGSPIYMAPEIIQGST---------IDYSSDVYS
             |.|.|||..|.. .. .....                      ||.|...  | |.| ||||||..|            ||..|..|
-------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

LGVVFYEMLQGVCPFEDTVIESLLIKKKECKLAFP------------------HPISDFAQQLCRS----MLEVDPKKRIT-IEEVANLIGV
|||..|||| |  ||        ....|.||. ||                  . .|. ...|..     ||..||.|||| .|.. |    
LGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20262.AA Ciliate-E2-Unclassified 8-283 26 3.2e-84 286.09 In-house 1-352 (352) Show / Hide 
Range on Protein: 8-283
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YILLEVAGRGQFGEVYQARHKETSELF-----AIKMFDST-KLLKSPVYQEMLI-DEIQCLRKISHQR-----------------IVRFHEWFKTSNHIY
|..... |.|.||.||...||..  ..     ..|. .   |. ..   ..|.. .|.... | .|||                 ||.....|.. ..||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LAYEYCFGGNLDEVIKHYKF-----------------LQEDVVLS----HVFKQIIEGF-LIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICI
. .||| ||.| . ||..|.                 ..|  ...    . |.||..|.  ...| .||| ||||.||||.. ..         .. |.|
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------NYYIKI

ADFGFCKYVGEFDKDESK-------IISQELTTAIRGSPIYM----APEIIQGSTID----YSSDVYSLGVVFYEMLQGVCPFEDTVIES----------
.|||..|. ....... .       |..|.... . |.|.||    |||..||   |    |..|..||||..|||| | .||.|.  |.          
IDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWIN

------LLIKKKECKLAFPH-------PISDFAQ-----QLCRSMLEVDPKKRITIEEVANLIGV
      |. ..|.... ||.        .... .     .|...||...|.||||.|.. |    
NAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20262.AA ULK 8-279 35 2.5e-77 263.2 In-house 1-320 (324) Show / Hide 
Range on Protein: 8-279
Range on HMM: 1-320/324
Sequence Identity: 35% (114 aa)

YILLEVAGRGQFG-EVYQARHKET---SELFAIKMFDSTKLLKSPVYQE------MLIDEIQCLRKIS---HQR--IVRFHEWFKTS--NHIYLAYEYCF
|.| .. | |.||  ||..|.|.|    ...|.|| |  |. |..  ||      .|. ||| ..|.    |.   ||....||.||  |.||. .||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGNLDEVIKHY---------KFLQEDVVLSHVFKQIIEGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQ-SQLLKNDICIADFGFCKYVGEFDKDESKI
||.|.. || .         |.| |. .. ..||||..||  . |  ||| ||||.||| .. . .|.|. ..  .. . ||||||.| | . .... ..
GGDLEQYIKKNKKLPETEEKKRLSEQEAI-QFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMC

ISQE-LTTAIRGSPIYMAPEIIQGS--TIDYS---SDVYSLGVVFYEMLQGVCP----FEDTV--IESLLIK-------KKECKLAFP-----HPISDFA
 ..    . |.|.|.||||.|.||    ..|.   .|..|||..||||| | .|    |.|..  |..|. .        |  .. ||      .||.  
QTCVNE-KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

QQLCRSMLEVDPKKRITIEEVAN
..| | ||..|.|.||..||. |
KDLIRRMLQYDEKDRISWEEIFN
Kinase 20262.AA ULK 8-279 33 1.3e-76 260.81 In-house 1-325 (329) Show / Hide 
Range on Protein: 8-279
Range on HMM: 1-325/329
Sequence Identity: 33% (112 aa)

YILLEVAGRGQFGEVYQARHKET----SELFAIKMFDSTKLLKSPVYQE------MLIDEIQCLRKIS----HQR----IVRFHEWFKTS--NHIYLAYE
|.| .. | |.|| ||..|.|.|     |..|.|| |. |. ...  ||      .|. ||. ..|.     |.     ||....||.||  |.||. .|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCFGGNLDEVIKHY----------KFLQEDVVLSHVFKQIIEGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQ-SQLLKNDICIADFGFCKYVGEF--D
|| ||.|.. || .          |.| |. .. ..||||..||  . |  ||| ||||.||| .. . .|.|. ..  .. . ||||||.| | ..  .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAI-QFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNME

KDESKIIS-QELTTAIRGSPIYMAPEIIQGS--TIDYS---SDVYSLGVVFYEMLQGVCP----FEDTV---IESLLIKKKECK-------LAFP-----
..  .  . .   . ..|.|.||||.|.||    ..|.   .|..|||..||||| | .|    |.|..   |..|. ......       | ||     
QQMMMTCVNE---KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

HPISDFAQQLCRSMLEVDPKKRITIEEVAN
 .||.  ..| | ||..|.|.||..||. |
PQISPECKDLIRRMLQYDEKDRISWEELFN
Kinase 20262.AA S_TKc 8-287 28 1.2e-68 235.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-287
Range on HMM: 1-231/231
Sequence Identity: 28% (83 aa)

YILLEVAGRGQFGEVYQARHKETSELFAIKMFDSTKLLKSPVYQEMLIDEIQCLRKISHQRIVRFHEWFKTSNHIYLAYEYCFG--GNLDEVIKHYKF--
| .|.. |.| ||.||..|||.| ...|||. .           |... |||.|.|  |  ||.....| . .|.|.  ||| |  |.| ..||...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LQEDVVLSHVFKQIIEGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICIADFGFCKYVGEFDKDESKIISQELTTAIRGSPIYMAPE
    . |  .  ....||...   . . .||| |.||.|||. .               | |.|||... .                | . |.| |||||
LRFPFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL----------------TTFCGTPWYMAPE

IIQGSTIDY-SSDVYSLGVVFYEMLQGVCPFEDTVIESLLIKKKECKLAFPHPISDFAQQLCRSMLEVDPKKRITIEEVAN---LIGVDILK
..     .. ..|..|.|...|||| |  ||.    . ...||           |. | .. | .|..||.||.|. |. .   .|  .   
VL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20262.AA Pkinase 8-281 25 3.9e-62 217.55 Pfam 1-293 (293) Show / Hide 
Range on Protein: 8-281
Range on HMM: 1-293/293
Sequence Identity: 25% (81 aa)

YILLEVAGRGQFGEVYQARHKETSELFAIKMFDSTKLLKSPVYQEMLIDEIQCLRKISHQRIVRFHEWFKTSNHIYLAYEYCFGG----NLDEVIK--HY
| .... |.| ||.||...|| |....|.| ..  .  ..  ..  .. ||| .....|  |||...|| ...|||.  ||| ||     | ..|.   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KFL--QEDVVLSHVFKQIIEGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICIADFGFCKYVGEFDKDESKIISQELTTAIRGSPIYMAPE
. .  .|...  ....||..|   . .  ||| |.||.|||..  |. ...       ...|.|||..| .         . ... .| . |.| |||||
GCFYFSEWECK-FYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA-------CVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPE

IIQ-GSTIDYSSDVYSLGVVFYEMLQGVCPFEDT------VIESLLIKKKECKLAFPHPIS---------------------DFAQQLCRSMLEVDPKKR
.|. |. .....|..|.|...|||| |  || .           .. ......| |. | .                     . ........|..|||||
VIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKR

ITIEEVANL--I
.|.|.. .   .
PTAEQILQHPWF
Kinase 20262.AA Ciliate-E2a 8-276 30 7.3e-61 177.89 In-house 1-268 (275) Show / Hide 
Range on Protein: 8-276
Range on HMM: 1-268/275
Sequence Identity: 30% (88 aa)

YILLEVAGRGQFGEVYQARHKETSELFAIKMFDSTKLLKSPVYQEMLIDEIQCLRKISHQRIVRFHEWFKTSNHIYLAYEYCFGGNLD-EVIKHYKFLQE
| .. . | |.|| || |.||.| . ||.| |.  |.  .   .| ...||. .|...|  | ...| ... |..|| .||| || |  . ... .| .|
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE

DVVLSHVFKQII-EGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICIADFGFCKYV--GEFDKDESKIISQELTTAIRGSPIYMA------
. . ... .|.. .|.. ... .|.| |.|| |||||.   |..|.    . ||.|.|||. ...             ...    . |.| |.|      
IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKN--CSKNSI---QNSDIKIIDFGLATFIDKD----------EKKYMFQKCGTPGYVAPEVLNN

PEIIQGSTIDYSSDVYSLGVVFYEMLQGVCPFEDTVIESLLIKKKECKLAFPHPI-----SDFAQQLCRSMLEVDPKKRITIEE
.|....   |.. |. |.||.|| .| |  ||.    .  |.. |.||. |  |.     |. ...| . |||.|||||||...
KEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQ
Kinase 20262.AA CAMK 13-279 22 2.2e-60 192.98 In-house 1-421 (425) Show / Hide 
Range on Protein: 13-279
Range on HMM: 1-421/425
Sequence Identity: 22% (95 aa)

VAGRGQFGEVYQARHKETS------------ELFAIKMFDSTKLLK------------------------SPVYQEMLIDEIQCLRK-------ISHQRI
. |||.||.|. ..||.|             . .|||. | .|| .                        .|. ....  ||....|       ..|  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFHEWFK------------TSNH--------IYLAY---EYCFGG----NLDEVIKHYKF---------------LQEDVVLSHVFKQIIEGFLIIKKS
....|..             | ..        .|.     ||| ||     | . |.  .                ..|. . ...|.||...   . . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREA-RRYFRQICSAVHYCHSH

HIIHNDIKPSNILFKKTN------------MSTESQSQLLKNDICIADFGFCKYV--GEFDKDESKIISQELTTA-------------IRGSPIYMA-PE
.|.| |.|| |||. . |                    . .|.| |.|||| ...  || ....|.. . |.                  |.| ||| ||
NIVHRDLKPENILLDDNNDDSDPVEHDEIFD-------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEM-HNQWTTPTEGQKMKTFCGTPEYMAAPE

IIQGST--------------IDYSSDVYSLGVVFYEMLQGVCPFEDT-------------VIESLLIKKKECKLAFPHP----------------ISDF-
...|..              .....|. |.||. | || |  ||..               .. |. | ...|  ||.|                |||  
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEF

-------AQQLCRSMLEVDPKKRITIEEVAN
       ...| |.||.|||.||.|||.. |
HHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase 20262.AA AGC 8-277 20 3.8e-58 147.88 In-house 1-389 (395) Show / Hide 
Range on Protein: 8-277
Range on HMM: 1-389/395
Sequence Identity: 20% (83 aa)

YILLEVAGRGQFGEVYQARHK------ETSELFAIKMFD-ST-KLLKSPVYQEMLIDE------------IQCLRKIS----------HQRIVR-FHEWF
. .| | |.| ||.||..|.|       | ...|.|. . ..  ..|    .|. . |             . | |..          |. ||.  |  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KTSNH--IYLAYEY---------CFGG-NLDEVIK---HYKFLQEDVVLSHVFKQ-------IIEGFLIIKK-SHIIHND-IKPSNILFKKTNMSTESQS
.. .|  .|.  ||         | ||  |   ..   ... . |...  . . .       |. ..  . .  .||| | .|| |||. .         
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERAR-FYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED--------

QLLKNDICIADFGFCKYVG-------------------------------------------EFDKDESKIIS-QELTTAIRG--SPIYMAPEIIQGSTI
      |...|||.|| .                                            . . | ... . ...|. . |  .| ||||||.     
----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQ-E-DDTTR-KKRDRTWTFCGPCTPEYMAPEIL----Y

DYSSDVYS--LGVVFYEMLQGVCPFEDT----------VIESLLIKKK------ECKLAFP----------HPISDFAQQLCRSMLEVDPKKRIT-----
... | .|  ||...|||| |  || .             . .  | .      ..|. ||            .|. |. |.. .|..||.||..     
GKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGND

-----IEEV
     .||.
FGDKGAEEI
Kinase 20262.AA STE 8-276 20 3.2e-48 166.52 In-house 1-350 (359) Show / Hide 
Range on Protein: 8-276
Range on HMM: 1-350/359
Sequence Identity: 20% (75 aa)

YILLEVAGRGQFGEVYQARHK------ETSEL---------FAIKMFDSTK-------------LLKSPVYQEMLIDEIQCLRKIS--HQRIVRFHEWFK
. ..|. |.| ||.||.|...      .| |.         .|||  .  .               | .  .. .. ||. ..| .  |. ||...  . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS-------NHIYLAYEYCFGGNLDEVIK-HYKFLQE------------DVVLSHVFKQIIEG-FLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLK
         ...... ||. || ||..||  |. ...              ..... .||..|    . . |||| ||||.|||.               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

NDICIADFGFCKYVGE-FDKDESKI--------ISQELTTAIRGSPIYMAPEIIQG------STIDYSSDVYSLGVVFYEMLQGVCPF---EDT-VIESL
  . ..|||.|. . .  ... . .         .|. .. . |.| .||||.||.      .  |...|..||| .  ||. |  |.    .. ..   
--VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMI

LIK--------------KKECKLAF-----------------PHPISDFAQQLCRSMLEVDPKKRITIEE
...              ..  .|                   ||  |.  ..  .  |. ||.|| | ..
PFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase 20262.AA CAMKL 8-279 29 8.8e-48 150.48 In-house 1-293 (297) Show / Hide 
Range on Protein: 8-279
Range on HMM: 1-293/297
Sequence Identity: 29% (92 aa)

YILLEVAGRGQFGEVYQARH-KETSELFAIKMFDSTKLLKSPVYQEM-----------LIDEIQCLRKIS---HQRIVRFHEWFKTSNH------IYLAY
|..... |.| ||.|  |.| . | |  |||. |  |. . |. . .           .  |||......   |. |....| . |..|      |||  
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCFGGN--LDEVI--KHYKF--LQEDVVLSHVFKQIIEGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICIADFGFCKY---VGEFDKDE
||| ||.  | . |  . ..   ..|.    . |.||...   . . .|.| |||| |||. . ...           | |.||||. .   .       
EYCSGGEMDLFDYIVKHGHRRGRMPEHEA-RRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN----------NIKIIDFGFSNMYRPC-------

SKIIS-QELTTAIRGSPIYMAPEIIQG--STID-YSSDVYSLGVVFYEMLQGVCPFEDT--------VIESLLIKKKECKLAFPHP--ISDFAQQLCRSM
  |.   .. .   ||| ||||||.||     | .  |. |.||. | |. |  ||.|          |  |. |....   .|..  .|  ...| |.|
--IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKM

LEVDPKKRITIEEVAN
|.|.|.||.||... |
LQVNPEKRPTIHQIMN
Kinase 20262.AA RSK 11-277 27 1.1e-39 138.19 In-house 1-272 (278) Show / Hide 
Range on Protein: 11-277
Range on HMM: 1-272/278
Sequence Identity: 27% (81 aa)

LEVAGRGQFGEVYQARHK---ETSELFAIKMFDSTKLLKSPVYQEMLIDEIQCLRKIS-HQRIVRFHEWFKTSNHIYLAYEYCFGGNLDEVIKHYKF---
|.|.|.| .|.|.. | .    |  ..| |  .  |. .. . ..    |...|  .  |. ||. |. |.|  ..||  ||| || | . ... |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LQEDVVLSHVFKQIIEGFLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICIADFGFCKYVGEFDKDESKIIS-QELTTAIRGSPIYMAPEIIQ
. || . . .. .|.     . . .||| |.||.|||.   . . ..        | . ||||||.           ..  ..|   ...  |||||.. 
FSEDEA-CFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGH--------IKLTDFGFCKQF---------RCDHNQWTMTFCYTIEYMAPEMLK

----GSTIDYSSDVYSLGVVFYEMLQGVCPFED---TVIESLLIKKKECK--LAFP--HPISDFAQQLCRSMLEVDPKKRIT-----IEEV
    ... | . |..||||. |||| |  ||        . .. . ...|  | .|  . .|. |. | | ||..||.||..     .||.
RANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEI
Kinase 20262.AA TyrKc 8-281 21 1.7e-14 11.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-281
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YILLEVAGRGQFGEVYQARHKETSELFAIKMFDSTKLLKSPVYQEMLIDEIQCLRKI--SHQRIVRFHEWFKTS-------NHIYLAYEYCFGGNLDEVI
  |... |.|.|||||... |   .  |.||  . .       .|....|.. ..|.  .|. |||..    ..         ...  ||. .|.|.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KHYK--FLQEDVVLSHVFKQIIEG--FLIIKKSHIIHNDIKPSNILFKKTNMSTESQSQLLKNDICIADFGFCKYVGEFDKDESKIISQELTTA----IR
. ..  .  .| .  .   || .|  .|  |  ..|| |.   |.| .. .             . |.||| ...... |.      |..  ..     .
RKHRPKLCMKDLL--SFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGG

G--SPI-YMAPEIIQGSTIDYSSDVYSLGVVFYEML-QGVCPFED-----TVIESLLIKKKEC-KLAFPHP--------ISDFAQQLCRSMLEVDPKKRI
    ||  |||| |. ..    |||.| ||. .|..  |  | ..        . .. . |.   .  |.          .|   |. ..  . ||..| 
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP

TIEEVANLI
| .|.  ..
TFSEIHECF
Kinase 20262.AA Pkinase_Tyr 8-96 24 3.2e-13 45.42 Pfam 1-96 (270) Show / Hide 
Range on Protein: 8-96
Range on HMM: 1-96/270
Sequence Identity: 24% (24 aa)

YILLEVAGRGQFGEVYQARHK----ETSELFAIKMF--DSTKL-LKSPVYQEMLIDEIQCLRKI-SHQRIVRFHEWFK-TSNH--IYLAYEYCFGGNLDE
 ..... |.|.|||||... |    .|    |.||   ....  .    ..|... |.. .... .|. |||..      . .  ||.  ||. .|.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN----CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase 20262.AA Pkinase_Tyr 196-231 36 0.025509 8.48 Pfam 181-218 (270) Show / Hide 
Range on Protein: 196-231
Range on HMM: 181-218/270
Sequence Identity: 36% (14 aa)

MAPEIIQGSTIDYSSDVYSLGVVFYEMLQ-GVCP-FED
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MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG