Gene 11509 (Tetrahymena)
11509
Sequence
Protein domains of 11509.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 11509.AA | Ciliate-E2 | 128-379 | 20 | 1.1e-49 | 168.7 | In-house | 1-360 (365) | Show / Hide |
Range on Protein: 128-379 Range on HMM: 1-360/365 Sequence Identity: 20% (75 aa) YTLQKPISQDQNVQITQVIRKSDGSTY-ISRNYQKN-----------------KVNIAKEKKQFFNEVKMLR----------------TLNHKLIIQGID | ..| | | . .. .. ..... . | ... .. |... ....|...| ...| .|||. ||. .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE YFE--SDNTYKIVVQNFEGKKLSDKLRVT-----------KSLTLQEVCVIIEQICQ---------------ALKYLHSNN-IIVRNLNLESIQFKYNNS .|. .||.. .| ..|. | | .. |..|..|.. |..||.| ||.||||.| || |.. .| | | CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- YNLLITCTRDFQRIGDE-----------IIPFDS-----------------------DPNGFQAPEVAFANN------QKDITTKCDIYSCGSIFYRLVA . |. ... |. ...| . |..|||. . ||. ..||||.|.| |.|... --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GKTYQQSLTSQVEYLNQKSNFFSEE--------------FKTVPIQVQKLIKQ----MLDNNPDKRPS-ADDIL ||. | . ...| .|...| .| .. ... |||. ||. .|.||.. ...|| GKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL |
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| Kinase | 11509.AA | Ciliate-E2-Unclassified | 128-379 | 17 | 1.6e-47 | 162.9 | In-house | 1-347 (352) | Show / Hide |
Range on Protein: 128-379
Range on HMM: 1-347/352
Sequence Identity: 17% (62 aa)
YTLQKPISQDQNVQITQVIRKSDGSTY-------ISRNYQKNKVNI---------AKEKKQFFNEVK--------MLRTLNHKLIIQGIDYFESDNTYKI
|...| | | .. .. ....|... | ...| ..... . ..|. . .. |. ..| .|. ...|..... |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI
VVQNFEGKKLSDKLRVTKS-----------------LTLQEVC-----VIIEQICQALKYLHSNN-IIVRNLNLESIQFKYNNS-YNLLITCTRDFQ---
| . .||..|.. .. |. .| |... .. ||.|.|.|||..| || |.. .| | |. |.. |.. |.. .
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ
--------------RIGDEIIPFDSDPNGFQ----APEVAFANNQKDIT-TKCDIYSCGSIFYRLVAGKTYQQSLT-------------------SQVEY
.. .... . .... |||| .|. . . ||||.|.| |.| .. |. .. . . .
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI
LNQKSNFFSEEF----KTVPIQVQKLIK----QMLDNNPDKRPSADDIL
.... .|..... |... ... .|. .||..||.||.....||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
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| Kinase | 11509.AA | Ciliate-E2a | 161-248 | 34 | 5.9e-24 | 67.42 | In-house | 34-124 (275) | Show / Hide |
Range on Protein: 161-248 Range on HMM: 34-124/275 Sequence Identity: 34% (32 aa) KNKVNIAK-EKKQFFNEVKMLRTLNHKLIIQGIDYFESDNTYKIVVQNFEGKKLSDKLRVTKSLTLQ--EVCVIIEQIC-QALKYLHSNNII | | .. | .|..|.||.. .|.|.|. ||. ....|..|.|..| .||. | ||.. |... |.| |. |. |.| |.|..||. K-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIM |
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| Kinase | 11509.AA | Ciliate-E2a | 291-379 | 33 | 2.9e-19 | 53.38 | In-house | 175-270 (275) | Show / Hide |
Range on Protein: 291-379 Range on HMM: 175-270/275 Sequence Identity: 33% (32 aa) GFQAPEVAFANN---QKDITTKCDIYSCGSIFYRLVAGKT-YQQSLTSQVEYLNQKS--NFFSEE-FKTVPIQVQKLIKQMLDNNPDKRPSADDIL |. ||||. .|. .||||. ||| |||.|. ||. ... .... ..| | .| . | .. .. . . |.|.||. .| ||..| ..| GYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQAL |
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| Kinase | 11509.AA | CAMK | 160-248 | 16 | 3.1e-14 | 41.57 | In-house | 57-201 (425) | Show / Hide |
Range on Protein: 160-248 Range on HMM: 57-201/425 Sequence Identity: 16% (24 aa) QKNKVN--------IAKEKKQFFNEVKMLRT-------LNHKLIIQGIDYFE------------SDNT--------YKIVV---QNFEGK----KLSDKL ...| . .| .|....|...... |.|. ||. ....| . .. . .| .| | |.. KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYI RVTKS---------------LTLQEVCVIIEQICQALKYLHSNNII . .. .| .|.. .. |||.|..|.||.||. VEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIV |
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| Kinase | 11509.AA | Pkinase | 168-248 | 24 | 3.2e-14 | 51.36 | Pfam | 40-130 (293) | Show / Hide |
Range on Protein: 168-248 Range on HMM: 40-130/293 Sequence Identity: 24% (22 aa) KEKKQFFN--EVKMLRTLNHKLIIQGIDYFESDNTYKIVVQNFEGK----KLSDKLR--VTKSL--TLQEVCVIIEQICQALKYLHSNNII ..... .. |..... |||. |.. .|.||... . .| || |.| .. ... . .|.. .. ||...|.|.||..|| WKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGII |
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| Kinase | 11509.AA | S_TKc | 128-386 | 18 | 5.8e-14 | 27.82 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 128-386 Range on HMM: 1-231/231 Sequence Identity: 18% (53 aa) YTLQKPISQDQNVQITQVIRKSDGSTYISRNYQKNKVNIAKEKKQFFNEVKMLRTLNHKLIIQGIDYFESDNTYKIVVQNFEG--KKLSDKLRVTKS--- |.. ..| . . ... |..| . ... .|...|. .|. |.. .|.|.. . . .| .| | | .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LTLQEVCVIIEQICQALKYLHSNNIIVRNLNLESIQFKYNNSYNLLIT---CTRDFQRIGDEIIPFDSDPNGFQ------APEVAFANNQKDITT-K .. ... .. |||.||.|.||..|| | | | | . .. |. | . . | |||| .. | RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------GYGKCK CDIYSCGSIFYRLVAGKT-YQQSLTSQVEYLNQKSNFFSEEFKTVPIQVQKLIKQMLDNNPDKRPSADDILI-----KLTNLL ||..||| |.| ...|.. .. . . ... . .. .|...|. .|.|||.| ..| |. . CDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 11509.AA | TKL | 294-382 | 18 | 1.6e-11 | 37.81 | In-house | 241-364 (364) | Show / Hide |
Range on Protein: 294-382 Range on HMM: 241-364/364 Sequence Identity: 18% (23 aa) APEVAFANNQ-------------KDITTKCDIYSCGSIFYRLVAGKTYQQSLT--------------SQVEYLNQKSNFFSEEF--------KTVPIQVQ |||| ... .. ..|||.|| | ... ...... . . ..| . ... .. ...| .. APEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMK KLIKQMLDNNPDKRPSADDILIKL ||... | .|.||||...|| .| KLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 11509.AA | Pkinase | 294-382 | 19 | 2.5e-10 | 37.6 | Pfam | 179-293 (293) | Show / Hide |
Range on Protein: 294-382 Range on HMM: 179-293/293 Sequence Identity: 19% (23 aa) APEVAFANN-QKDITTKCDIYSCGSIFYRLVAGKTYQQSL------TSQVEYLNQKS---NFFSEEFKTVP-----------------IQVQKLIKQMLD |||| . ......|.|..||| |.| .. |.. .. . .. . . .. | ... ... ...|| .|. APEV---IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC NNPDKRPSADDILIK--L .| |||.|..|| . KDPKKRPTAEQILQHPWF |
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| Kinase | 11509.AA | DCAMKL | 175-248 | 29 | 1.8e-09 | 25.07 | In-house | 64-137 (279) | Show / Hide |
Range on Protein: 175-248 Range on HMM: 64-137/279 Sequence Identity: 29% (22 aa) NEVKMLRTLNHKLIIQGIDYFESDNTYKIVVQNFEGKKLSDKLRVTKSLTLQEVCVIIEQICQALKYLHSNNII |||.... ..| ||| .. .. .. | .| .| | | .. . | . ... ..|.||||||. ||. NEVSIMQKIKHPHIIQLYEHWDTETHYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIV |
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| Kinase | 11509.AA | ULK | 294-372 | 24 | 5.1e-08 | 24.19 | In-house | 219-317 (329) | Show / Hide |
Range on Protein: 294-372 Range on HMM: 219-317/329 Sequence Identity: 24% (24 aa) APEVAFAN-NQKDIT-TKCDIYSCGSIFYRLVAGKTY--QQSLTSQVEYLNQKSNF-----------FSEEFK------TVPIQVQKLIKQMLDNNPDKR ||.. . ||. . ||||.| | ||| .. ||.. . ..|... .|| . .|. .. ... ||..|| ....| APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR |
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| Kinase | 11509.AA | ULK | 294-372 | 26 | 6e-08 | 24.36 | In-house | 215-312 (324) | Show / Hide |
Range on Protein: 294-372 Range on HMM: 215-312/324 Sequence Identity: 26% (26 aa) APEVAFAN-NQKDIT-TKCDIYSCGSIFYRLVAGKTY--QQSLTSQV----EYLN-----------QKSNFFSEEFKTVPI--QVQKLIKQMLDNNPDKR ||.. . ||. . ||||.| | ||| .. ||.. . ..|. . .| |. .| . . | ..| ... ||..|| ....| APQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDR |
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| Kinase | 11509.AA | ULK | 170-257 | 25 | 7.7e-08 | 23.54 | In-house | 54-161 (329) | Show / Hide |
Range on Protein: 170-257 Range on HMM: 54-161/329 Sequence Identity: 25% (28 aa) KKQFFNEVKMLRTLN----HKL----IIQGIDYFESD--NTYKIVVQNFEGKKLSDKLRVTKS----------LTLQEVCVIIEQICQALKYLHSNNIIV .... ||.| ...|. || |.. .|.||.. | . |.. .| |.. . | |. ||. .. ||....|.||..||| WQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIH RNLNLESI | . .. | RDIKPQNI |
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| Kinase | 11509.AA | PLK1 | 168-254 | 27 | 8.9e-08 | 21.37 | In-house | 41-127 (253) | Show / Hide |
Range on Protein: 168-254 Range on HMM: 41-127/253 Sequence Identity: 27% (24 aa) KEKKQFFNEVKMLRTLNHKLIIQGIDYFESDNTYKIVVQNFEGKKLSDKLRVTKSLTLQEVCVIIEQICQALKYLHSNNIIVRNLNL ... . |... | |.|. |.. ..|| .. ||. . . | . . |..| .| . || .. .||| |.|| | | | HQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPECRYYMYQIVEGCQYLHNNKIIHRDLKL |
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| Kinase | 11509.AA | CAMK1 | 231-247 | 47 | 1e-06 | 15.23 | In-house | 113-129 (276) | Show / Hide |
Range on Protein: 231-247 Range on HMM: 113-129/276 Sequence Identity: 47% (8 aa) IIEQICQALKYLHSNNI |..||..|..|.||..| IMKQILSAVEYMHSKGI |
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| Kinase | 11509.AA | ULK | 160-257 | 25 | 2e-06 | 18.66 | In-house | 37-157 (324) | Show / Hide |
Range on Protein: 160-257 Range on HMM: 37-157/324 Sequence Identity: 25% (31 aa) QKNKVNIAKEK-------KQFFNEVKMLRTLN---HKL--IIQGIDYFESD--NTYKIVVQNFEGKKLSDKLR---------VTKSLTLQEVCVIIEQIC .|.| |. | . ... ||.. ...|. |. |.. .|.||.. | . |.. .| |.. . | |. ||. .. ||| DKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQIC QALKYLHSNNIIVRNLNLESI ...|.||..||| | . .. | NGFKELHKHNIIHRDIKPQNI |
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| Kinase | 11509.AA | TyrKc | 159-382 | 17 | 3e-06 | -122.53 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 159-382 Range on HMM: 1-280/280 Sequence Identity: 17% (54 aa) YQKNKV------------------------NIAKEKKQFFNEVKMLRTL--NHKLIIQGIDYFESD-------NTYKIVVQNFEGKKLSDKLRVTKS-LT ...|. . | .. | .| .... | .|. |.. . . .. . ||. .. | | || .. |. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC LQEVCVIIEQICQALKYLHSNNIIVRNLNLESIQFKYNNSYNLLITCTR-----DF---QRIGDE--------IIPFDSDPNGFQ-------APEVAFAN ... . . ||.. ||||.|.| | | | |.. . || |.|. . . .| |||. MKDLLSFCWQIACGMEYLHSKNCIHRDLAAR----------NCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--- NQKDITTKCD----------IYSCGSIFYRLV--AGKTYQQSLTSQVE---YLNQKSN-----FFSEEFKTVPIQVQKLIKQMLDNNPDKRPSADDILIK | . ||| | |.. | | . . | . .|. .. | | | . | . ...|| . .|..||. .| . NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC L . F |
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| Kinase | 11509.AA | PLK1 | 311-384 | 27 | 6e-06 | 15.35 | In-house | 181-253 (253) | Show / Hide |
Range on Protein: 311-384 Range on HMM: 181-253/253 Sequence Identity: 27% (20 aa) DIYSCGSIFYRLVAGKTYQQSLTSQVEYLNQKSNFFSEEFKTVPIQVQKLIKQMLDNNPDKRPSADDILIKLTN ||.| | |.| |. |. . . . |. | | .. . . ..||..|||..|..|| .. .| . DIWSIGCIMYILLFGQPPFETKCLKETYSRIKKNEYRIP-SHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF |
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| Kinase | 11509.AA | CAMK1 | 162-206 | 22 | 2.4e-05 | 11.45 | In-house | 36-88 (276) | Show / Hide |
Range on Protein: 162-206 Range on HMM: 36-88/276 Sequence Identity: 22% (12 aa) N-KVNIAKEK----KQFFNEVKMLRT---LNHKLIIQGIDYFESDNTYKIVVQ . | ...|.. ... ||. .... ..| ||. ....|||| . .|.. DKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME |
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| Kinase | 11509.AA | CAMK1 | 360-379 | 40 | 2.5e-05 | 11.36 | In-house | 252-271 (276) | Show / Hide |
Range on Protein: 360-379 Range on HMM: 252-271/276 Sequence Identity: 40% (8 aa) LIKQMLDNNPDKRPSADDIL .||.||...| ||......| FIKHMLEVDPKKRYTCEQCL |
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| Kinase | 11509.AA | CAMK | 345-379 | 18 | 3.2e-05 | 11.99 | In-house | 366-420 (425) | Show / Hide |
Range on Protein: 345-379 Range on HMM: 366-420/425 Sequence Identity: 18% (10 aa) FFSEEFKTVP--------------------IQVQKLIKQMLDNNPDKRPSADDIL | ...|.... ... ||..|| .|.||......| FPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCL |
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| Kinase | 11509.AA | DCAMKL | 360-379 | 45 | 7.9e-05 | 10.36 | In-house | 255-274 (279) | Show / Hide |
Range on Protein: 360-379 Range on HMM: 255-274/279 Sequence Identity: 45% (9 aa) LIKQMLDNNPDKRPSADDIL ||..|| .|.||..| .|. LISHMLQVDPEKRYTAEQIM |
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| Kinase | 11509.AA | TKL | 213-257 | 26 | 0.002226 | 8.04 | In-house | 125-171 (364) | Show / Hide |
Range on Protein: 213-257 Range on HMM: 125-171/364 Sequence Identity: 26% (14 aa) LSDKLRVTKSLTLQEVCVIIEQICQALKYLHSNN--------IIVRNLNLESI | . | .. | .. .|.... ||||.| || |.|. . | LLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI |
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