Gene 10523 (Tetrahymena)

10523

Species: Tetrahymena
Alias: 3810.m02083, 10523, PreTt10523, TTHERM_00571930, 243, 76.m00225
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
10523.AA Protein None 498 None Fasta, JSON
10523.kin_dom Protein Kinase Domain None 202 None Fasta, JSON
10523.NA RNA None 1497 None Fasta, JSON

Protein domain

Protein domains of 10523.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH_Akt_basal 10523.AA PH_Akt_basal 40-122 42 5.4e-44 152.47 In-house 1-90 (90) Show / Hide 
Range on Protein: 40-122
Range on HMM: 1-90/90
Sequence Identity: 42% (38 aa)

MIKINKKEKSQNRNFLLTSKRIMNVG----KKVKRSIDLMNLAGISLS-LESYEFVIHVKDEYDYRLL--SEEYRENFIYYLVEAYNNYM
.||.|...|.|.||...|||...|..    ...|..|.|....||..|  |..||||||.||||||.   ||..|...|..|..||..|.
VIKYNRYNKRQERNLMITSKHVYNCKPNKKHSIKWCIPLQKIYGIHQSTTEGCEFVIHVPDEYDYRYCMHSEDQRQCIIMVLCRAYCCYC
Myosin_TH1 10523.AA Myosin_TH1 31-98 26 3.8e-09 32.3 Pfam 50-150 (234) Show / Hide 
Range on Protein: 31-98
Range on HMM: 50-150/234
Sequence Identity: 26% (27 aa)

DE-------KIIFSCT----MIKINK--KEKSQNRNFLLTSKRIMNVG--------------KKVKRSIDLMNLAGISLSLESYE-FVIHV-----KDEY
.|       |..|...     .|.|.  . |...| .||| | |  ||              ..||| |.| .....|||  .   ||||.     ....
NELRKHPFMKVLFADHCECLVNKYNRFWFGKPSPRDLLLTDKHIYLVGREKKKKGPEKDQKTYQVKRRIPLNEITSVSLSPMQDDWFVIHCKESDNSQQH

D
|
D
Kinase 10523.AA Ciliate-E2-Unclassified 228-452 24 3.8e-67 229.39 In-house 34-352 (352) Show / Hide 
Range on Protein: 228-452
Range on HMM: 34-352/352
Sequence Identity: 24% (78 aa)

QNKHYAVRTV-------QCSTEEEENE-YIDR--------INRSINDPFVIPLEFCFKDNNDFYLVMQVL------------------GNDLFQRLYCSH
....|... .       .. .|..... |..|        | .....||.. ...||.| . .|.||. .                  |||||.......
KIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRK

NLSEMAAK-----YYFVQILCGLQLYHSKLHCHYGELKPENILLDEMG---RVFLTGYRS---------------------PKKNLTSE--TLEYT----
 ..| .||     .|| |||.||. .|.|... .  .||||||.|. |   .. .... .                     .......   |..|     
IFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYT

APELLRGEPKS----IASDFWCLGILLYEMLVGIPPFYYEGQES---------------IMIQLIIENNVQFPKFLN------ISQEAKSMILSLLKSNK
|||.|.|.  .    ...|.|.||..||||| | .|||.. .|.               ...| |...|.||||| .      .|.||| .|  ||... 
APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKML

NERIGVNSGLEEFKKHPWL
. ... . ..|. ..|||.
KKNPNKRITFEQILNHPWF
Kinase 10523.AA AGC 259-452 25 1.2e-62 159.81 In-house 90-395 (395) Show / Hide 
Range on Protein: 259-452
Range on HMM: 90-395/395
Sequence Identity: 25% (78 aa)

PFVIP-LEFCFKDNND--FYLVMQ----------VLGN-DLFQRLYC---SHNLSEMAAKYYFVQ-------ILCGLQLYHSKLHCHYGE-LKPENILLD
||..  | ..|.|..    |.||.          . |  .||..|.    .  ..| .|..|. .       |...|.  ||...  .   |||||||||
PFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLD

EMGRVFLT---------GYRSP----------------------------------------------KKNLTSE-----TLEYTAPELLRGEPKSIASD
| | . ||         .....                                              |...|.      | || ||| |     . | |
EDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACD

FWC--LGILLYEMLVGIPPFYYEG---------QESIMIQLII------ENNVQFPKF--------LNISQEAKSMILSLLKSNKNERIGVNS------G
 |.  ||.|.||||.|.|||| .          ..  | |.|.      ...|.||           ..|.|||. |  ||. . ..|.| .       |
WWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKG

LEEFKKHPWL
 || |.||| 
AEEIKNHPWF
Kinase 10523.AA Ciliate-E2 249-452 23 2.7e-47 160.41 In-house 66-365 (365) Show / Hide 
Range on Protein: 249-452
Range on HMM: 66-365/365
Sequence Identity: 23% (73 aa)

IDRINR----------------SINDPFVIPLEFCFK--DNNDFYLVMQ-VLGNDLFQRLY-----CSHN------LSEMAAKYYFVQILC---------
...|.|                ..| |..| .  ||.  |.| .||||  . |.|||....     . |.      ..|  .||.. |||          
EIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFY

------GLQLYHSKLHCHYGELKPENILLDEMGRVFLTGYRSPKKNLTSE---------------------------------------TLEYTAPELLR
      .|.  ||| .. .  .||||||.     ....     ||. ...                                       |..| ||| |.
IACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILN

GEP---------KSIASDFWCLGILLYEMLVGIPPFYYEGQESIMIQLIIENNVQFP----------------KFLNISQEAKSMILS----LLKSNKNE
|..          . ..|.|.||..||||| | |||         .| |......||                .....|||.| .|      .|. . ..
GKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEK

RIGVNSGLEEFKKHPWL
||.   | |. ..|||.
RIT---GWEQILNHPWF
Kinase 10523.AA SGK 354-452 39 3.4e-33 99.5 In-house 188-283 (283) Show / Hide 
Range on Protein: 354-452
Range on HMM: 188-283/283
Sequence Identity: 39% (39 aa)

TLEYTAPELLRGEPKSIASDFWCLGILLYEMLVGIPPFYYEGQESIMIQLIIENNVQFPKFLNISQEAKSMILSLLKSNKNERIGVNSGLEEFKKHPWL
|.|| ||| ||..| . . | ||||..||||..|.||||     ..| . ||    |.|..  .| .|...|  ||. .. .| | . . .| |.||. 
TPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSR-NKQQMYDNIINQPLQIPPQ--MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 10523.AA Akt 354-452 39 6.3e-32 99.28 In-house 165-264 (264) Show / Hide 
Range on Protein: 354-452
Range on HMM: 165-264/264
Sequence Identity: 39% (40 aa)

TLEYTAPELLRGEPKSIASDFWC-LGILLYEMLVGIPPFYYEGQESIMIQLIIENNVQFPKFLNISQEAKSMILSLLKSNKNERIG-VNSGLEEFKKHPW
| || ||| | |   . |.|.|  ||...|||. | |||| . ..  | ..| ...|.||.  .||.|.|. | .||. ....| |  .....| | |||
TPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQ-MFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPW

L
.
F
Kinase 10523.AA AktR 354-452 37 2.7e-28 100.35 In-house 167-268 (268) Show / Hide 
Range on Protein: 354-452
Range on HMM: 167-268/268
Sequence Identity: 37% (39 aa)

TLEYTAPELLRG-EPKSIASDFWCLGILLYEMLVGIPPFYYEGQESIMIQLIIENN-VQFPKFLNISQEAKSMIL-SLLKSNKNERIG-VNSGLEEFKKH
| || ||| ..  ..   ..|.|..||..|||..|.||| | ..  .|.|.|.. . ..||.  ..|...|. |   ||. | |.|.|  ..| || |.|
TPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPF-YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSH

PWL
|| 
PWF
Kinase 10523.AA Delta 259-452 30 3.7e-28 99.1 In-house 60-259 (259) Show / Hide 
Range on Protein: 259-452
Range on HMM: 60-259/259
Sequence Identity: 30% (62 aa)

PFVIPLEFCFKDNNDFYLVMQVL-GNDLFQRLYCSHNLSEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDEMGRVFLTGYRSPKKNLTSE----
||.  |   |. ..  . ||  | | ||   .  .|  .|  |..|   |.||||  |.|    | .|| .|.|||  | . .  .   |.|.. |    
PFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEKRARFYACEIICGLQFLHKK-GIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKAS

----TLEYTAPELLRGEPKSIASDFWCLGILLYEMLVGIPPFYYEGQESIMIQLIIENNVQFPKFLNISQEAKSMILSLLKSNKNERIGV-NSGLEEFKK
    | .| |||...|.  . . |.|  |.|.||||.|  ||  |. |  . . |....  .|..  |..|||...  |.. . ..|.|| ..   . ..
TFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGED-EDELFWSICNDRPWYPRW--ITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQ

HPWL
|.. 
HCFF
Kinase 10523.AA RSK-Unclassified 354-452 38 8.1e-28 84.03 In-house 185-283 (283) Show / Hide 
Range on Protein: 354-452
Range on HMM: 185-283/283
Sequence Identity: 38% (38 aa)

TLEYTAPELLRGEPKSIASDFWCLGILLYEMLVGIPPFYYEGQESIMIQLIIENNVQFPKFLNISQEAKSMILSLLKSNKNERIGVNSG-LEEFKKHPWL
| || |||..|.     | | | |||..||||.|.||.| . .. .    |  |.|.||.   ||......|  ||. |   | |  .|  .. |.||  
TEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYN-IEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
S_TKc 10523.AA S_TKc 199-452 25 2.3e-27 98.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 199-452
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

FIPDMKISQSKVGSKYHTIYYSRCTLKSLQNKHYAVRTVQCSTEEEENEYIDR---INRSINDPFVIPLEFCFKDNNDFYLVMQVLGN---DLFQRLYCS
.    || .   |. |  .  .        ....|.  .         | | |   | .. . |... |  .| | ...|.||  ...   |||...   
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

HN------LSEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDEMGRVFLT------GYRSPKKNLTSETLEYTAPELLRGEPKSI-ASDFWCLGI
        ..|  |..|. ||.|.|.  ||. .  .  ||||||||||  .. ..       .     .    |..| |||.|   . .  ..| | .|.
GRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LLYEMLVGIPPFYYEGQESIMIQLIIENNVQFPKFLNISQEAKSMILSLLKSNKNERIGVNSGLE---EFKKHPWL
.|||||.| |||.   |.  |...|             |.|||..|  .|. . ..|...   |.   . |.|||.
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10523.AA RSK 354-452 36 2.9e-24 85.8 In-house 171-278 (278) Show / Hide 
Range on Protein: 354-452
Range on HMM: 171-278/278
Sequence Identity: 36% (40 aa)

TLEYTAPELLR-GE-PK--SIASDFWCLGILLYEMLVGIPPFYY---EGQESIMIQLIIENN--VQFPKFLNISQEAKSMILSLLKSNKNERIGVN-SGL
|.|| |||.|. .. ..  . | | | ||.|.||||.| |||.    . .. || . | ...  . .|   ..|||||. |  .|. . . |.| . ...
TIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIM-KRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDA

EEFKKHPWL
|| |.|||.
EEIKQHPWF
Kinase 10523.AA RSK 354-452 31 5e-21 71.92 In-house 168-271 (271) Show / Hide 
Range on Protein: 354-452
Range on HMM: 168-271/271
Sequence Identity: 31% (33 aa)

TLEYTAPELLRGEPKSIASDFWCLGILLYEMLVGIPPFYYEGQESIMIQLIIENNVQ----FPKFLNISQEAKSMILSLLKSNKNERIGV-NSGLEEFKK
| .| ||| |.    . |.|.| .|.|.|||| | .||.    .. | ..    ...     .   .||.|||. .  .|. ... | |    | |. |.
TANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQ

HPWL
|||.
HPWF
Kinase 10523.AA Pkinase 354-452 26 1.4e-18 66.8 Pfam 174-293 (293) Show / Hide 
Range on Protein: 354-452
Range on HMM: 174-293/293
Sequence Identity: 26% (33 aa)

TLEYTAPELLR-GEPKSIASDFWCLGILLYEMLVGIPPFYYEG------QESIMIQLIIENNVQFPKFLNIS-------------------QEAKSMILS
|..| |||..| |.. . ..| | .|..||||| | |||. .        .  ||..| .  . |. .  .|                   .|.|. | .
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLKSNKNERIGVNSGLEEFKKHPWL
.|. . ..|..     |. ..|||.
CLCKDPKKRPT----AEQILQHPWF
Kinase 10523.AA AktR 256-334 41 4.7e-11 39.12 In-house 58-137 (268) Show / Hide 
Range on Protein: 256-334
Range on HMM: 58-137/268
Sequence Identity: 41% (33 aa)

INDPFVIPLEFCFKDNNDFYLVMQVL-GNDLFQRLYCSHNLSEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDE
.| || . |..||....  ...|.   | .||| |  .. .||. |. ||.||| .|.  |....  |  ||||||||||
CNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDE
Kinase 10523.AA RSK 259-341 31 6.4e-11 36.5 In-house 61-149 (278) Show / Hide 
Range on Protein: 259-341
Range on HMM: 61-149/278
Sequence Identity: 31% (28 aa)

PFVIPLEFCFKDNNDFYLVMQVL-GNDLFQRLYCSHN---LSEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDE---MGRVFLT
||.. |   |...  .||.|. . | .|| .|.       .||  |..|. .| . ..  |..    .  |||||||.|.    |.. ||
PFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQG-IIHRDLKPENILYDDESNEGHIKLT
Kinase 10523.AA RSK-Unclassified 257-341 31 9.8e-09 23.02 In-house 57-143 (283) Show / Hide 
Range on Protein: 257-341
Range on HMM: 57-143/283
Sequence Identity: 31% (28 aa)

NDPFVIPLEFCFKDNNDFYLVMQ-VLGNDLFQRLY--CSHNLSEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDEMGRVFLT
| ||.. | . |  .   ||.|.   | |.|. |    .  ..|  ...|   .   |   | |.   |  |||.||.|.  | | ||
NHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCEDDVRFYASEVTAALEYLH-KRDFIYRDLKPDNIVLHQEGHVMLT
Kinase 10523.AA RSK 229-336 31 2.9e-07 22.21 In-house 27-142 (271) Show / Hide 
Range on Protein: 229-336
Range on HMM: 27-142/271
Sequence Identity: 31% (37 aa)

NKHYAVRTVQCSTEEEE----NEYIDRINRSINDPFVIPLEFCFKDNNDFYLVMQVL-GNDLFQRLYCSHNLSEMAAKYYFVQILCGLQLYHSKLHCHYG
|.|||.  .. .|         | .. | | .. ||.. |   | |    |..|  . | ||| ||     .||  .| |   |.  ..  || .   . 
NQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHS-QGIVHR

ELKPENILLDEM----G
 |||||||.|..    |
DLKPENILYDDESGNPG
Kinase 10523.AA SGK 256-341 36 1e-06 16.26 In-house 82-167 (283) Show / Hide 
Range on Protein: 256-341
Range on HMM: 82-167/283
Sequence Identity: 36% (32 aa)

INDPFVIPLEFCFKDNNDFYLVMQ-VLGNDLFQRLYCSHNLSEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDEMGRVFLT
.. || . | . |      |.||  | | ..|  |     ..|  |. |  .| | |   ||.    |  ||||||||| .| . ||
MKHPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQ-DIIYRDLKPENILLDHQGHCCLT
Kinase 10523.AA Pkinase 259-338 33 5e-06 22.3 Pfam 60-147 (293) Show / Hide 
Range on Protein: 259-338
Range on HMM: 60-147/293
Sequence Identity: 33% (30 aa)

PFVIPLEFCFKDNNDFYLVMQVLGN-----DLFQRLY--CSHNL--SEMAAKYYFVQILCGLQLYHSKLHCHYGELKPENILLDEMGRV
|... |  .| |... |.||  ...     ||| ..    . ..  ||  .| |. |||.||.  ||   . .  |||||||.|. | .
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHI
Kinase 10523.AA Akt 259-336 35 2e-05 13.2 In-house 60-138 (264) Show / Hide 
Range on Protein: 259-336
Range on HMM: 60-138/264
Sequence Identity: 35% (28 aa)

PFVIPLEFCFKDNNDFYLVMQ-VLGNDLFQRLYCSHNLSEMAAKYYFVQILCGLQLYHSKLHCHYGE-LKPENILLDEMG
||.. | . | ...  |.||. . | .||. |.     ||  |..|  .| ....  ||     |   |||||||.|. |
PFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHS-KNIIYRDYLKPENILMDKDG