Gene 10107 (Tetrahymena)

10107

Species: Tetrahymena
Alias: 3828.m01369, TTHERM_00077610, PreTt10107, 10107, 138, 5.m00458
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
10107.AA Protein None 534 None Fasta, JSON
10107.kin_dom Protein Kinase Domain None 260 None Fasta, JSON
10107.NA RNA None 1605 None Fasta, JSON

Protein domain

Protein domains of 10107.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 10107.AA AGC 58-317 27 6.2e-133 345.74 In-house 1-395 (395) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-395/395
Sequence Identity: 27% (111 aa)

YIFNQVIGKGGFGKVWNVQKR------KNKEVLAMKIMS---KVKILSKKSVNSVLNE------------RKILSHLN----------HPLIVN-MHNSF
. |  |||||.||||. |.|.       .... |||...   |..|. |. |  ...|            |.||...|          || ||. .| ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDREN--LYLTMD----FIG----GGDLRYHLIHQ---TEP-FSETQAQFIACC-------IVSALEYIHS-QNILHRD-IKPENLIFDESGYLKVTDFG
|| ..  ||. |.    ...    ||.. ..|. |    |  |.| .|.|.|..       ||.||||.|| ..| ||| .||||. .|| |..| ||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

ISRI--------------------------------------WKPDN--------------SNETSG--TPGYIAPEILMRQNYGVAVDYYA--LGIIMY
 . .                                      |. .|               .   |  || |.|||||    || |.|...  ||..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMAMGKRPYKAK----------DRKELREQILAKQ-VQIKREEIP----------KGWSLEAIDFINRLIQRKPSNRLGVN-------GPQEVKDHVWI
||  |. |. ..          ...|. ..|.  . .. .....|          . .| || |.|..|... |..||| .       | .|.|.| | 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 10107.AA Ciliate-E2-Unclassified 58-317 31 5.4e-118 398.3 In-house 1-352 (352) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-352/352
Sequence Identity: 31% (110 aa)

YIFNQVIGKGGFGKVWNVQKRKNKEVLAMKIMSKVKILSKKSVNSV---------LNERK-------------ILSHLNHPLIVNMHNSFQDRENLYLTM
|.....||.||||||. .|..|.|.. |||.|.|..| ..|.....         .|..|             ||....||.||.|.  |||..|.|. |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

DFIGGGDLRYHLIHQTE----------------PFSETQAQ-----FIACCIVSALEYIHSQN-ILHRDIKPENLIFDESG---YLKVTDFGISR-----
... ||||.... ..                   |.| ||.     |.. .|...|||.|..| |.||||||||..||..|   |.|..|||||.     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

------------IWKPDNSNETSGTPGYI----APEILMRQNYG----VAVDYYALGIIMYEMAMGKRPYKAKDRKE----------------LREQILA
            |||..... ..|||.|.    |||.|..|||.     ..|...||.|.||| .|..|........                |...|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KQVQIKREE---IPKGWSLEAIDFINRLIQRKPSNRLGVN-GPQEVKDHVWI
|..|.. ..   |||.|| ||.||||.|.|... .... . ...... | |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 10107.AA Ciliate-E2 58-317 28 3.8e-101 342.34 In-house 1-365 (365) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-365/365
Sequence Identity: 28% (108 aa)

YIFNQVIGKGGFG-----KVWNVQKRK------------------NKEVLAMKIMSKVKILSKKSVNSVL----------NERKILSHLNHPLIVNMHNS
|.|...||.|.||     |||.|||..                  ..   |||||.| .| ..|......          ||..||..|||| |..|. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DRENLYLTMDFIGGGDLRYHLI------------------HQTEPFSETQAQ-------FIACCIVSALEYIHSQN-ILHRDIKPENLIFDESGYL
||  |..|.|| |... ||||.....                   .   ... ..|       |...||..||||.||.| |.||||||||..|     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVTDFGISRIWKPDNSNET---------------------------------SGTPGYIAPEILMRQN---------YGVAVDYYALGIIMYEMAMGKRP
|..|||.|.. ..|| |.|                                  ||||| |||||....         |. ..|...||.|.||| .||.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

YKAKDRKELREQILAKQVQIKREE-------------IPKGWSLEAIDFINR----LIQRKPSNRLGVNGPQEVKDHVWI
.         .||. .....  .|             ..| ||.|..|.|..    ..|..|..|..  |......| |.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase 10107.AA SGK 58-317 35 2.2e-94 291.86 In-house 1-283 (283) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-283/283
Sequence Identity: 35% (103 aa)

YIFNQVIGKGGFGKVWNVQKRKN------------------KEVLAMKIMSKVKIL-------SKKSVNSVLNER-KILSHLNHPLIVNMHNSFQDRENL
 .| .|||||.||||  |.. .                   . . |||. .|  |.        ||... .. || .||. ..|| ||| | .||  . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLTMDFIGGGDLRYHLIHQTEPFSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDESGYLKVTDFGISR--IWKPDNSNETSGTPGYIAPEILMR
|. ||.. ||.. |||      |.| .| | |  ||.|||| |||.| .|| ||||.  |  |... |||| .   | . |      ||| | |||.|  
YFVMDYVNGGEMFYHLQREKH-FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

QNYGVAVDYYALGIIMYEMAMGKRPYKAKDRKELREQILAKQVQIKREEIPKGWSLEAIDFINRLIQRKPSNRLGVN-GPQEVKDHVWI
| .. .|| . ||...||| .|. |.  ...... ..|. .  |     ||.. | .| | |. | |. |..||| . .  |.|.|.. 
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQ-----IPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 10107.AA S_TKc 58-317 31 3.3e-93 316.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

YIFNQVIGKGGFGKVWNVQKRKNKEVLAMKIMSKVKILSKKSVNSVLNERKILSHLNHPLIVNMHNSFQDRENLYLTMDFIGG--GDLRYHLIHQTEP--
| . ..||||.||||. ....| ... |.||..          .....|..||.. .|| ||... .||| ..||. |....|  |||. .. ..  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDESGYLKVTDFGISRIWKPDNSNETSGTPGYIAPEILMRQNYGV-AVDYYALGIIMYEMA
   |.| .|.|... |..||||.||..|.|||.||||. .||   .|..|||..|.      .   ||| |.|||.|    ||  ..| ...|.|.|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

MGKRPYKAKDRKELREQILAKQVQIKREEIPKGWSLEAIDFINRLIQRKPSNRLGVNGPQE----VKDHVWI
 |. |.   . ... ..|.               | ||.|||... |. |..|...    .    .| | |.
CGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 10107.AA Akt 60-317 39 4.3e-86 275.19 In-house 1-264 (264) Show / Hide 
Range on Protein: 60-317
Range on HMM: 1-264/264
Sequence Identity: 39% (107 aa)

FN--QVIGKGGFGKVWNVQKRKNKEVL-AMKIMSKVKILSKKSVNSVLNERKILSHLNHPLIVNMHNSFQDRENLYLTMDFIGGGDLRYHLIHQTEPFSE
|.   |.||| ||||  |.| .....  |||. .| .|. |. |  .. ||.|| | ||| |||.| |||. ..||. ||...||.| ||| .. . |||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRK-RRFSE

TQAQFIACCIVSALEYIHSQNILHRD-IKPENLIFDESGYLKVTDFGISR-I-WKPDNSNET-SGTPGYIAPEILMRQNYGVAVDYYA-LGIIMYEMAMG
 .| | .. |..|.|. ||.||  ||  ||||.  |. |....|||| .. .  | .    |  ||| |.|||||  . .. ||| .. ||..||||  |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

KRPYKAKDRKELREQILAKQVQIKREEIPKGWSLEAIDFINRLIQRKPSNRLG--VNGPQEVKDHVWI
  |. ..|.... ..|. ..|....    . .| |. |.|..| .. |..|||   |. ||.|.| | 
RPPFYNQDHHQMFKKIKNQPVKFPDK---DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 10107.AA RSK 61-317 34 1.9e-81 276.92 In-house 1-278 (278) Show / Hide 
Range on Protein: 61-317
Range on HMM: 1-278/278
Sequence Identity: 34% (98 aa)

NQVIGKGGFGKVWNVQKR---KNKEVLAMKIMSKVKILSK-KSVNSVLNERKILSHLN-HPLIVNMHNSFQDRENLYLTMDFIGGGDLRYHLIHQTEP--
 .| |.||.|||  ..|    ... . |||. .| ||  . |..  .. ||.||.. . || ||. | .||. . ||| |... ||.| .|| ..     
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDE---SGYLKVTDFGISRIWKPDNSNETS---GTPGYIAPEILM---RQN-YGVAVDYYALGI
|||. |.|..  ||.|.|..|.| | |||.|||| ..|.   .| .|.|||| ... ..|... |    .|  |.|||.|.   .|. .. |.|.. ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

IMYEMAMGKRPYKA---KDRKELREQILAKQ--VQIKREEIPKGWSLEAIDFINRLIQRKPSNRLG--VNGPQEVKDHVWI
.|||| .|..|...   ..|||. ..|. ..  . ...   ..  | || |.|... .| |..|||   .. .|.|.| |.
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPN---WQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 10107.AA Pkinase 58-317 28 8.9e-81 279.46 Pfam 1-293 (293) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YIFNQVIGKGGFGKVWNVQKRKNKEVLAMKIMSKVKILSKKSVNSVL-NERKILSHLNHPLIVNMHNSFQDRENLYLTMDFIGGG----DLRYHLI-HQT
| . ..||.|.||.|.  ..... .. |.||..|... |.| .. .. .| .|. .|||| || .. .|.|. ..|. |.. .||    ||  ..  .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EPF--SETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDESGYL----KVTDFGISR---IWKPDNSNETSGTPGYIAPEILM-RQNYGVAVDYYAL
 .|  || ...|..  |...|||.||..|.|||.||||. .|. |..    |..|||...   . .    .   |||.|.|||... .| || .|| ...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIIMYEMAMGKRPYKAK------DRKELREQILAKQVQIKREEIPK----------------GWSLEAIDFINRLIQRKPSNRLGVNGPQEVKDHVWI
|.|.|||. |. |.. .      | ... ..|. ...   ...                    || |..|||.......|. |..   ..... | |.
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 10107.AA AktR 58-317 36 1.1e-80 274.42 In-house 1-268 (268) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-268/268
Sequence Identity: 36% (100 aa)

YIFNQVIGKGGFGKVWNVQKR-KNKEVLAMKIMSKVKILSKKSVNSVLNERKILS-HLNHPLIVNMHNSFQDRENLYLTMDFIGGGDLRYHLIHQTEPFS
. . ...|||.||||  |||. .|... |||. .| ||  ..    ...||.|.  . ||| ||..| .||..|.|.. |... ||.| .. . . . ||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGEL-FQHLKKKKKFS

ETQAQFIACCIVSALEYIHSQ-NILHRDIKPENLIFDESGYLKVTDFGISR--IWKPDNSNETS--GTPGYIAPEILMR-QNYGVAVDYYALGIIMYEMA
| ||.|... |. |||| |.. ||  ||.||||.  || |..| |||| |.  . . ..  ..|  ||| |.|||.... . .. .||..|.||  ||| 
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

MGKRPYKAKDRKELREQILAKQ-VQIKREEIPKGWSLEAIDFIN-RLIQRKPSNRLG--VNGPQEVKDHVWI
.|  |  .|..... . |. || ...   ..|.  | .. |.|. .| .. | .|||   ||..|.|.| | 
TGCPPFYHKNQNQMFQKIKIKQQNKF---PYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 10107.AA CAMK 63-317 18 1.7e-77 249.13 In-house 1-425 (425) Show / Hide 
Range on Protein: 63-317
Range on HMM: 1-425/425
Sequence Identity: 18% (81 aa)

VIGKGGFGKVWNVQKRKNK------------EVLAMKIMSKVKILS-------------------------KKSVNSVLNERKILSH-------LNHPLI
..|.|.||||  .. ....            .  |.||..| |. .                          |.  .|..| .|...       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNMHNSFQD-------------------RENLYLTM---DFIGGGDL--R-YHLIHQTEP---------------FSETQAQFIACCIVSALEYIHSQNI
....  ..|                   ....|. |   ... ||.|  . .  | . ..               |.| .|...   |.||..|.||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKPENLIFDESG----------------Y-LKVTDFGISRIWKPDN-------------------------SNETSGTPGYIA-PEILMRQN----
 |||.||||. .|...                . .|..||| ... .|..                          ..  |||.|.| ||.| ..     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YGVAVDYYALGIIMYEMAMGKRPYKAKDRKELRE---------QILAKQVQIKREEIPKGWSL-----------------------EAID
          || ..|  ..|.|.| |  |. |. .....| .|         ... |  . | . .|. .|                        |..|
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FINRLIQRKPSNRLGVNGPQEVKDHVWI
.|... |. |..|. .   .....| |.
LIRKMLQVDPEKRMTI---EQCLNHPWM
Kinase 10107.AA PKA 58-317 35 1.5e-70 240.68 In-house 1-263 (263) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-263/263
Sequence Identity: 35% (98 aa)

YIFNQVIGKGGFGKVWNVQKRKNKEVLAMKIMSKVKILSKKSVNSVLNERKILSHLNHPLIVN-MHNSFQDRENLYLTMDFIGGGDLRYHLIHQTEPFSE
. . |..|.| ||.|  ........  |||...| .|   | |  |.||..||. ..|| ||. |  .|||. .||. |....||.. ..| .    ||.
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGR-FSN

TQAQFIAC-CIVSALEYIHSQNILHRDIKPENLIFDESGYLKVTDFGISRIWKPDNSNETS---GTPGYIAPEILMRQ-NYGVAVDYYALGIIMYEMAMG
 .|.|.|.  ||.||||.||||| .|| ||||.  |. |..|.|||| .   .     .|.   ||| |.||||. .   .| .||  ||||. |||. |
PHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD----RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAG

KRPYKAK--DRKELREQILAKQVQIKREEIPKGWSLEA---IDFINRLIQRKPSNRLGV--NGPQEVKDHVWI
. |  ..  |  .. | |.. ...      |   .  |    |.|..|.|. .. |.|   || . .|.| | 
YPPFYDHNRDPMQIYEKICNGKIK-----FPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 10107.AA RSK 58-317 35 3.4e-69 236.21 In-house 1-271 (271) Show / Hide 
Range on Protein: 58-317
Range on HMM: 1-271/271
Sequence Identity: 35% (97 aa)

YIFNQVIGKGGFGKVWNVQKR---KNKEVLAMKIMSKVKILSKKSVNSVLNERKILSHLNHPLIVNMHNSFQDRENLYLTMDFIGGGDLRYHLIHQTEPF
|.. ..||.| |.||. ..|     ..   ||||  | ..  |       .||.||.. .|| ||  | .||| ...|. |||  ||||  .|  |   |
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQ-KMF

SETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDES----GYLKVTDFGISRIWKPDNSNETS--GTPGYIAPEILMRQNYGVAVDYYALGIIMYEM
||  . |... | .|.|| ||| | ||| |||| ..|.     | .|..||| .   . .|    .  .|  |.|||.|.|| ...|.|.. .|..||||
SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

AMGKRPYKAKDRKELREQILAKQVQIK---REEIPKGWSLEAIDFINRLIQRKPSNRLGV--NGPQEVKDHVWI
  |  |. .|.|... ..|....   .      ..   | || | . ..  | | ||||   || ...| | |.
LTGCTPFQNKPRDTP-MNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 10107.AA TyrKc 58-315 19 5.3e-14 3.77 SMART 1-280 (280) Show / Hide 
Range on Protein: 58-315
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

YIFNQVIGKGGFGKVWNVQKRKNKEVLAMKIMSKVKILSKKSVNSVLNERKILSHL--NHPLIVNMHNSFQDR-------ENLYLTMDFIGGGDLRYHLI
  .....| | ||.|.  . .   .  | | . . .      .   ..| .|...|  .|| ||...    .        | |.. | .  .|||. .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

HQTEPFSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDESGYLKVTDFGISRIWKPD-----NSNETS-----GTPG-----YIAPEILMRQNYG
   . ..  .   ..  | .  ||.||.|. |||.   |   .| .  |..||| || .. |     ..   .     |. .       ||| ..   . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VAVDYYALGIIMYEMA-MGKRPYKA-----KDRKELREQILAKQVQIKREEIPKG--------WSLEAIDFINRLIQRKPSNRLGVNGPQEVKDHV
 . | .. |. |.|.   |. ||       .. .|..|..     | .| ..|.          . |  . . .  ...|..|      .|...  
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV----KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF---SEIHECF
Kinase 10107.AA Pkinase_Tyr 58-267 23 2.2e-09 32.39 Pfam 1-228 (270) Show / Hide 
Range on Protein: 58-267
Range on HMM: 1-228/270
Sequence Identity: 23% (54 aa)

YIFNQVIGKGGFGKVWNVQKR----KNKEVLAMKIMSKVKILSKKS--VNSVLNERKILSHL-NHPLIVNMHNSFQ-DREN--LYLTMDFIGGGDLRYHL
 .|....|.| ||.|.    .    ..|   | |..      ...     . ..| ||...| .|| ||...     ..|   .|. | .  .|||. .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

IHQ---TEPFSETQAQFIACCIVSALEYIHSQNILHRDIKPENLIFDESGYLKVTDFGISRIWKPDNSNE-TSGTPGYI-----APEILMRQNYGVAVDY
  .    .|..  .   ..  | ...|| .|.|. |||.   |   .|..  |..||| .|    . ..  .... | .     ||| ..   . .. | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YALGIIMYEMAM-GKRP-YKAKDRKELREQI
.. |. |.|.   |. | |.  .  |. |.|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI