Gene 2332 (Tetrahymena)
2332
Sequence
Protein domains of 2332.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 2332.AA | Ciliate-E2c | 24-279 | 36 | 2.1e-149 | 502.66 | In-house | 1-310 (310) | Show / Hide |
Range on Protein: 24-279 Range on HMM: 1-310/310 Sequence Identity: 36% (113 aa) YEIFEILGKGSFGQVFKAKKNG-----------------KIYALKLLDLHMIKQRNIERFVSNEINLMKKMNHKNIVKIYETFQTTSVIFLVLEYCNQGT .....|||.||.|.|.||.... |...||..|.|||....|......|||.||.|||..|.|.|...||...|.|..||||.|| IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT LLSYISKK-KPKVEECVDLFIQILAGVKHIHEK-GILHRDLKPENMFLHDGVLKIADFGLAQFEQDDFVY--------CGTSFYMAPEVLER-RQVTYKS |..||..| ||....|...|.||....|..|.. .|.|||.||||...|.|..||||||.....|||... |||..||||..||. ...|.|| LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS DLWSLGIVLFYMIFRRLPFY----------------SKQNLLKIIKEHTDPYFN----------IRRYFKGNDAYLNMIDLELDDFFQKVLVFDINKRIQ |.||||..|.||....||.. ..||..|..|.|...||| |.........|...|..|......|.|..|..|||. DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID FKELFNLSLI ..|.||...| WDEIFNHECI |
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| Kinase | 2332.AA | Ciliate-E2 | 24-279 | 23 | 2.9e-86 | 292.88 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 24-279 Range on HMM: 1-365/365 Sequence Identity: 23% (89 aa) YEIFEILGKGSFGQVFKA--KKNGKIYALKLLDLHM-----------IKQRNIERF-------VSNEINLMKKMN----------------HKNIVKIYE |.. ...|.|.||.|.|. .|..| .|.|. | .. ||. ..... ...||..|...| |.||.|.|| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE TFQ--TTSVIFLVLEYCNQGTLLSYISKK------------KPKVEECVDLFIQILA---------------GVKHIHEKG-ILHRDLKPENMFLHDGVL .|| ... |.||.|||..|.|..|| .. ... .|. ... ||| .....|.|. |.|||.|||| .. . CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I KIADFGLAQFEQDD-----------------------------------FVYCGTSFYMAPEVLERRQ---------VTYKSDLWSLGIVLFYMIFRRLP ||.||||... .|| . .||| |||||.|.. . .||.|.||||..|..|.| ..| KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP FYSKQNLLKIIKEHTDPYFNIRRYFKGNDAYLNMIDLELD------------DFFQK----VLVFDINKRIQ-FKELFNLSLI | .... . .... .....| .. .| . .. |...| |. | .|||. .....| . F---------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 2332.AA | S_TKc | 24-279 | 30 | 9.6e-82 | 278.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-279
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)
YEIFEILGKGSFGQVFKAKKNG--KIYALKLLDLHMIKQRNIERFVSNEINLMKKMNHKNIVKIYETFQTTSVIFLVLEYCNQ--GTLLSYISKKKP---
||| ...|||.||.|.|..... .|.|.| .. . . .||...|| .|.||||.|..||. . ...|.|||.. |.|..|| |...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL
----KVEECVDLFIQILAGVKHIHEKGILHRDLKPENMFLHDGVLKIADFGLAQFEQDDFVYCGTSFYMAPEVLERRQVTY-KSDLWSLGIVLFYMIFRR
.. .. ||. .....|..||.|||||||| .| . ..||.||||| . .||| .||||||| . .. |.| ||.|..|. |. ..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY
LPFYSKQNLLKIIKEHTDPYFNIRRYFKGNDAYLNMIDLELDDFFQKVLVFDINKRIQFKELFN-------LSLI
||. .. ...| . |. || .| |..| .||. |... .
PPFP---QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 2332.AA | ULK | 24-279 | 30 | 3.1e-81 | 276.19 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 24-279
Range on HMM: 1-329/329
Sequence Identity: 30% (102 aa)
YEIFEILGKGSFGQVFKA--KKN----GKIYALKLLD---LHMIKQRN----IERFVSNEINLMKKMN----HKN----IVKIYETFQTT--SVIFLVLE
|.. ..|||||||.|.|. ||. ....| | .| . .... . . .. ||| .|||.. ||| ||| |. |.|. |....|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME
YCNQGTLLSYISKKKPKVE-----------ECVDLFIQILAGVKHIHEKGILHRDLKPENMFLHDG-------------VLKIADFGLAQFEQDD-----
|||.|.| .||.|.|.. | |.. |.|||.| |..|...| |||.||.| .|.| ||||||||.|.. ..|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ
----FV----YCGTSFYMAPEVLERR----QVT-YKSDLWSLGIVLFYMIFRRLPFYSKQNLLKIIKEHTDPYFN-------IRRYFKG-NDA-YLNMID
.| .||| ||||..|... . . ||.|.||||.....|.. . |||. . ... ... . | |. ... . . |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS
LELDDFFQKVLVFDINKRIQFKELFNLSLI
|. |.... |..| ..|| . |||| ..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
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| Kinase | 2332.AA | ULK | 24-279 | 30 | 1.5e-79 | 270.63 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 24-279
Range on HMM: 1-324/324
Sequence Identity: 30% (98 aa)
YEIFEILGKGSFG-QVFKA--KKN---GKIYALKLLD---LHMIKQRN----IERFVSNEINLMKKMN---HKN--IVKIYETFQTT--SVIFLVLEYCN
|.. ..||||||| .|.|. ||. ....| | | . ..|... . . |||..|||.. |.| ||| |. |.|. |....||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN
QGTLLSYISKKKPKVEE----------CVDLFIQILAGVKHIHEKGILHRDLKPENMFLHDG-------------VLKIADFGLAQFEQDD---FVYC--
.|.| .|| |.|.. |. .. |.||..| |..|...| |||.||.| .|.| ||||||||.|.. ... |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT
--------GTSFYMAPEVLERR----QVT-YKSDLWSLGIVLFYMIFRRLPF---YSKQNLLKIIKEHTD----PYFNIRRYFKGNDA-YLNMIDLELDD
|| ||||..|... . . ||.|.||||.....|.. . || ...|.| |.|. ... . .. .. . . | |. |
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD
FFQKVLVFDINKRIQFKELFNLSLI
.... |..| ..|| . |.|| ..
LIRRMLQYDEKDRISWEEIFNHPWF
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| Kinase | 2332.AA | CAMK | 29-226 | 21 | 1.1e-69 | 223.54 | In-house | 1-361 (425) | Show / Hide |
Range on Protein: 29-226
Range on HMM: 1-361/425
Sequence Identity: 21% (77 aa)
ILGKGSFGQVFKAKK--NG------------KIYALKLLDLHMIK-------------------------QRNIERFVSNEINLMKK-------MNHKNI
.||.||||.|.... .. . .| | .| .| . . ...| .||..||| ..|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VKIYETFQ------------TTSV--------IFLVL---EYCNQG----TLLSYISKKKP----------------KVEECVDLFIQILAGVKHIHEKG
.|.||... | | ...|. ||| | |..|| .... . .|. .| ||. .|...|...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
ILHRDLKPENMFL-HD-----------------GVLKIADFGLAQFEQDDF---------------------------VYCGTSFYMA-PEVLER-----
| |||||||| | .. . .||.|||.|.. ... .||| ||| ||||..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
---------RQVTYKSDLWSLGIVLFYMIFRRLPFYSK---------------QNLLKIIKE
. ...|.| ||.|..|. | ..|||.. ..|.. |..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMK
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| Kinase | 2332.AA | Ciliate-E2a | 24-217 | 35 | 2e-68 | 200.54 | In-house | 1-219 (275) | Show / Hide |
Range on Protein: 24-217 Range on HMM: 1-219/275 Sequence Identity: 35% (78 aa) YEIFEILGKGSFGQVFKA--KKNGKIYALKLLDLHMIKQRNIERFVSNEINLMKKMNHKNIVKIYETFQTTSVIFLVLEYCNQGTLLSYISKKK-PKVE- |.. ..|||.||.|..| |..|| .| | .. .| | . .... ||||.|....|.|| |.||.... . ..||.|||. |.|...|...| . | YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI -ECVDLFIQIL-AGVKHIHEKGILHRDLKPENMFLH----DG----VLKIADFGLAQFEQDD-----FVYCGTSFYMA------PEVLERRQVTYKSDLW | |. |.| |. ..| ..|.|||||||| .. .. .||.|||||.| ..| |. ||| |.| .|||...| ..| |.| QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW SLGIVLFYMIFRRLPFYSK |.|.... ... ..||. | SCGVIFYILLCGKPPFKGK |
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| Kinase | 2332.AA | Pkinase | 24-226 | 34 | 9.2e-68 | 236.23 | Pfam | 1-229 (293) | Show / Hide |
Range on Protein: 24-226 Range on HMM: 1-229/293 Sequence Identity: 34% (80 aa) YEIFEILGKGSFGQVFKAKKNGK--IYALKLLDLHMIKQRNIERFVS-NEINLMKKMNHKNIVKIYETFQTTSVIFLVLEYCNQG----TLLSYIS---K |.| ...|.||||.|.|... | |.|.| .... .| .. . .|| .||..||.|||..|..|.. . | .|.|||. | | .||| . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH KKP--KVEECVDLFIQILAGVKHIHEKGILHRDLKPENMFLH-DGVL----KIADFGLA----QFEQDDF-VYCGTSFYMAPEVLE-RRQVTYKSDLWSL .. .|| . . ||| |....|..||.|||||||| ... .|.. ||.||||| . . ..|||..||||||. .. ..|.| ||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GIVLFYMIFRRLPFYSK-----QNLLKIIKE |..|..|...|.||... . ...|.. GCILYEMLCGRPPFPGHCWHDNHDQMQMICR |
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| Kinase | 2332.AA | CAMKL | 24-231 | 30 | 5.1e-67 | 212.87 | In-house | 1-261 (297) | Show / Hide |
Range on Protein: 24-231 Range on HMM: 1-261/297 Sequence Identity: 30% (80 aa) YEIFEILGKGSFGQVFKAKK---NGKIYALKLLDLHMIK-QRNIERF-----------VSNEINLMKKMN---HKNIVKIYETFQTTSV------IFLVL |.| . |||||||.| |. .|. .| | .| |. .... . ||..||..| |.||.|.||...| . |.||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM EYCNQGT--LLSYISKK-----KPKVEECVDLFIQILAGVKHIHEKGILHRDLKPENMFLH-DG--VLKIADFGLA-QFE-Q----DDF--VYCGTSFYM ||| | |. || |. . . .|. .| ||...|...|..|| |||.|||| | .| ..||.|||.. ... . ... ||. || EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM APEVLER--R-QVTYKSDLWSLGIVLFYMIFRRLPFY----------SKQNLLKIIKEHTDPY |||.... . .| | ||.|..|. |.. .||| . .|...|... . APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYP |
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| Kinase | 2332.AA | Ciliate-E2-Unclassified | 24-279 | 25 | 2.1e-64 | 220.3 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 24-279
Range on HMM: 1-352/352
Sequence Identity: 25% (93 aa)
YEIFEILGKGSFGQVFKA--KKNGKIYALKLLDLHMIKQRNIERFV---------SNEIN-------------LMKKMNHKNIVKIYETFQTTSVIFLVL
|.| ...|.|.||.|.|. ||....||.| . ..|. ... ... |... ... ..| .||| ...||.. |..|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM
EYCNQGTLLSYISKKKP---------------K---VEECV-----DLFIQILAGVKHIHEKG-ILHRDLKPENMFLHDG----VLKIADFGLAQFEQDD
|||..|.|. ||.|.| | .... ..| ||| | ...|.|. |.|||.|||| ..... .||.|||.. . |..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN
---FVY-----------------CGTSFYM----APEVLERRQVT----YKSDLWSLGIVLFYMIFRRLPFYSKQ------------------NLLKIIK
. ||| || |||||.. . ||.| ||||..|..|.| ..|||... .|...||
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK
EH--TDPYFNIRRYFKGNDAYLNMIDLELD--------DFFQKVLVFDINKRIQFKELFNLSLI
. | |. . |. .. |..|| |. ..||||.|....| ..
QKNIQFPKFPWQQ-----------IPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
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| Kinase | 2332.AA | NEK | 24-205 | 33 | 4e-54 | 186.13 | In-house | 1-215 (286) | Show / Hide |
Range on Protein: 24-205 Range on HMM: 1-215/286 Sequence Identity: 33% (72 aa) YEIFEILGKGSFGQVFKAKKN--GKI-----YALKLLDLHMIKQRNIERFVSNEINLMKKMNHKNIVKIYETFQTTS--VIFLVLEYCN-QGTLLSY--- ||| . .|.||||.|.|... ||. |..| .. . .... . ..||... |...| |||| |. |. .. | |||. |.| YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS ISKKK----PKVE-ECVDLFIQILAGVKHIHEK-----GILHRDLKPENMFLH-DGV----LKIADFGLAQFEQDD--FVYC---GTSFYMAPEVLERRQ | |.| . | . .| |||.. ..|..|.. |||||.|| | || .. .|| |||.. ... . | || ||.|||.. . IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP VTYKSDLWSLGIVLF ..||| |||| ||. YNNKSDIWSLGCVLY |
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| Kinase | 2332.AA | MARK | 24-214 | 34 | 2.5e-52 | 169.46 | In-house | 1-206 (262) | Show / Hide |
Range on Protein: 24-214 Range on HMM: 1-206/262 Sequence Identity: 34% (72 aa) YEIFEILGKGSFGQVFKA--KKNGKIYALKLLD---LHM-IKQRNIERFVSNEINLMKKMNHKNIVKIYETFQ--TTSV-IFLVLEYCNQGTLLSYISKK |.. .|.||...| .| |. |. .|.| .. | . .|..| ||..|||..|.||.| ..... |.. |.|..||. | |..|| .. YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMR----EIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAH --KPKVE-ECVDLFIQILAGVKHIHEKGILHRDLKPENMFL-HDG--VLKIADFGLA-QFEQDD--FVYCGTSFYMAPEVLERRQVT-YKSDLWSLGIVL . | |. .| ||. .|. |.|.| |||.|||| . ..| ||.|||.. ... . ||| |||||..... . .| | ||||.|| PNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVL FYMIFRRLPF ..|. ..|| YFMVCGYFPF |
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| Kinase | 2332.AA | Pkinase_Tyr | 24-205 | 28 | 6.8e-23 | 78.15 | Pfam | 1-205 (270) | Show / Hide |
Range on Protein: 24-205 Range on HMM: 1-205/270 Sequence Identity: 28% (59 aa) YEIFEILGKGSFGQVFKAKKN------GKIYALKLLDLHMIKQRN--IERFVSNEINLMKKM-NHKNIVKIYETFQ-TTSV--IFLVLEYCNQGTLLSYI .. . ||.|.||.|.|.. . . | | | . ... .| | . |...||.. .|.|||. | |..|.||. | ||.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL SKK-----KPKVEECVDLFIQILAGVKHIHEKGILHRDLKPENMFLH-DGVLKIADFGLAQFEQDDFVY-CGTS------FYMAPEVLERRQVTYKSDLW |. ...... .. .|| .| . ..|.. |||| | .. ..| ||.||||| ..| | .. . ||||.. . | ||| | RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW SLGIVLF | |.... SFGVLMW |
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| Kinase | 2332.AA | TyrKc | 24-279 | 22 | 1.3e-15 | 29.74 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 24-279 Range on HMM: 1-280/280 Sequence Identity: 22% (68 aa) YEIFEILGKGSFGQVFKAKKNGKIYALKLLDLHMIKQRNIERFVSNEINLMKKM--NHKNIVKIYETFQTT-------SVIFLVLEYCNQGTLLSYISKK . ..|| | ||.|.|.. . | | | . .| | . |...|.| .|.|||..| . ...|.||. | |..|. |. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMR-EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH K--PKVEECVDLFIQILAGVKHIHEKGILHRDLKPENMFLHDGV-LKIADFGLAQFEQDD-------FVYC-----GTS-----FYMAPEVLERRQVTYK . .... .. .|| .| ..|.|.. |||| | .... ||.||||. . || .| |. ||||.. . | | RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK SDLWSLGIVLF---------Y-------MIFRRLPFYSKQNLLKIIKEH----TDPYFNIRRYFKGNDAYLNMIDLELDDFFQKVLVFDINKRIQFKELF || || |.... | | ... | || . .. . |. . .. .| ..| |.|. SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI- NLSLI ... -HECF |
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