Gene 19630 (Tetrahymena)

19630

Species: Tetrahymena
Alias: TTHERM_00486990, 3680.m00857, PreTt19630, 1178, 19630, 59.m00268
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-E2
Subfamily: Ciliate-E2c

Sequence

Name Sequence Type Origin Length Description Download
19630.AA Protein None 350 None Fasta, JSON
19630.NA RNA None 1053 None Fasta, JSON
19630.kin_dom Protein Kinase Domain None 308 None Fasta, JSON

Protein domain

Protein domains of 19630.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 19630.AA Ciliate-E2c 144-330 43 3.4e-119 402.3 In-house 86-310 (310) Show / Hide 
Range on Protein: 144-330
Range on HMM: 86-310/310
Sequence Identity: 43% (97 aa)

SKKIYFILEYCEDGDLTKLLKYN-ELNEGQVLYLFGQLSRGMLELKKQ-NVFHRDLKPSNILIKEGTIKIADFGLSKICDPLHISNTQ-----VGTPYYM
.|.||.|.|||..|.|....... ..||.|.||.|.|..... .|.|. |.||||.||.||||..|.|||||||.||||....|.|||     .|||.||
DKHIYLIMEYCNGGTLEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYM

SPQALESKNYNLEKNDIWSAGVMLYQMLYRKFPWE---------------IQQIETHQKLIDVIKN--------------TTNIHFSNN--FSISEDTKD
.||.||.|||..||.||||.||.||.||..|.|||               .....|...|...|..              |.||||..|  ..||...|.
APQILEGKNYYTEKSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQ

LIKNMLEVEEANRFEWEEIINMNII
||..||.|.|..|..|.||.|. .|
LIHKMLQVDEEKRIDWDEIFNHECI
Kinase 19630.AA ULK 144-330 35 1.9e-69 237.07 In-house 87-324 (324) Show / Hide 
Range on Protein: 144-330
Range on HMM: 87-324/324
Sequence Identity: 35% (86 aa)

S--KKIYFILEYCEDGDLTKLLKYNE----------LNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIKEGT-------------IKIADFGLSK
|  . ||.|.|||..||| ...| |           |.| ...  | |.  |. || |.|. |||.||.||||..|.             .||||||..|
SNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

ICDP----LHISNTQV------GTPYYMSPQALE----SKNYNLEKNDIWSAGVMLYQMLYRKFP---W-EIQQIETHQKLID------VIKNTTNIHFS
..|       .  |.|      |||.||.|| |.     |.|.  | |||| |...|.||| | |   | . |..  .||||.      .. ....| | 
HVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFP

---NNFSISEDTKDLIKNMLEVEEANRFEWEEIINMNII
   ..  ||...||||. ||...|  |..||||.|. ..
KPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 19630.AA ULK 144-330 35 6.3e-69 235.31 In-house 90-329 (329) Show / Hide 
Range on Protein: 144-330
Range on HMM: 90-329/329
Sequence Identity: 35% (85 aa)

S--KKIYFILEYCEDGDLTKLLKYNE-----------LNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIKEG-------------TIKIADFGLS
|  . ||.|.|||..||| ...| |            |.| ...  | |.  |. || |.|. |||.||.||||..|             ..||||||..
SNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA

KICDP----LHISNTQV------GTPYYMSPQALE----SKNYNLEKNDIWSAGVMLYQMLYRKFP---W-EIQQIETHQKLID---VIK---NTTNIHF
| .|       .  |.|      |||.||.|| |.     |.|.  | |||| |...|.||| | |   | . |..  .||||.   ...   ..... |
KHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQF

S---NNFSISEDTKDLIKNMLEVEEANRFEWEEIINMNII
    |.  ||...||||. ||...|  |..|||..|. ..
PKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 19630.AA Ciliate-E2 145-330 26 3.9e-63 215.57 In-house 107-365 (365) Show / Hide 
Range on Protein: 145-330
Range on HMM: 107-365/365
Sequence Identity: 26% (72 aa)

KKIYFILEYCEDGDLTKLLKYN------------ELNEGQVLYLFGQLSR---------------GMLELKKQN-VFHRDLKPSNILIKEGTIKIADFGL
..||...|||. ||| ...| |             ..| ...|.. |. .               .. .|...| ..|||.||.|||.    |||.||||
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGL

SKICDPL--------------------------------HISNTQVGTPYYMSPQALESKNY--------NLEKNDIWSAGVMLYQMLYRKFPWEIQQIE
||..|.                                 .. ||..|||.||.|. |..|.|          .| ||||.||.||.||. |.|.      
SKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------

THQKLIDVIKNTT-NIHFS----------------NNFSISEDTKDLIKN----MLEVEEANRFE-WEEIINMNII
        ...   .| |.                .....|...|||||.    ||.... .|.  ||.|.|  ..
-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 19630.AA S_TKc 20-330 21 2.2e-53 184.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-330
Range on HMM: 1-231/231
Sequence Identity: 21% (71 aa)

LITNVTIGEGAFSKVYIAFYKKEFFEKKEKATKLCAKILQISNPTQLPYKQIQTEQQIMMSIQSPYVLRLLQFHQTINNVLFLILVSQPYRLINFL--LN
     .||.|||.||| .  ||          .   ||.                                                     ....  ..
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK----------------------------------------------------EHIRREIQ

ILINWISKHFLRLLFSFSSFFLQLKISKKIYFILEYCED--GDLTKLLKYNE-------LNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIKEGT
|| .   ..  .|. .| .        ...|...|||.   ||| ...| .        ..| .. ... |. ...  . .... ||||||.|||. | .
ILKK-HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-H

IKIADFGLSKICDPLHISNTQVGTPYYMSPQALESKNYNLEKNDIWSAGVMLYQMLYRKFPWEIQQIETHQKLIDVIKNTTNIHFSNNFSISEDTKDLIK
|||.||||...       .|..|||.||.|  |    |. .| |.|| |..|| ||... |..     ..|.....|.             |.. ||.|.
IKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIR

NMLEVEEANRFEWEEIIN-------MNII
..|... ..|    |. .       .  .
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 19630.AA CAMKL 145-326 29 5.5e-47 147.9 In-house 94-293 (297) Show / Hide 
Range on Protein: 145-326
Range on HMM: 94-293/297
Sequence Identity: 29% (59 aa)

KKIYFILEYCEDGD--LTKLLKYNE-----LNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIK-EG--TIKIADFGLSKICDP-----LHISNTQ
|||| ..|||. |.  |   .. ..     . |..   .| |.  ..  . .... |||.|| |||.   |  .|||.|||.| ...|      .  .|.
KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTF

VGTPYYMSPQALES--KNYNLEKNDIWSAGVMLYQMLYRKFPWEIQQIE----THQKLIDVIKNTTNIHFSNNFSISEDTKDLIKNMLEVEEANRFEWEE
 |.| ||.|  ...  | |.  | ||||.||.|| |.. ..|.. . ..    ... .   .....  ..   ...| | .|||. ||.|    |.  ..
CGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

IIN
| |
IMN
Kinase 19630.AA CAMK 145-319 22 1.1e-43 138.2 In-house 130-414 (425) Show / Hide 
Range on Protein: 145-319
Range on HMM: 130-414/425
Sequence Identity: 22% (63 aa)

KKIYFIL---EYCEDG----D-LTKLLKYNE---------------LNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIKE---------------
|..|...   |||. |    | . .. .                  ..| .. ..| |.  ..  . ..|. |||||| |||. .               
KHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD

---GTIKIADFGLSKICDPLH------------------------ISNTQVGTPYYMS-PQALES-------------KNYNLEKNDIWSAGVMLYQMLY
   ..|||.|||.....|| .                          .|..|||.||. |  |..             | |  .| |.||.||.|| || 
WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLC

RKFPWE---IQQIE-------THQKLIDVIKNTT-N-I--HFSN------------------NFSISEDTKDLIKNMLEVEEANRF
 ..|..    ..|.       . ..|   |..   . .  .||.                  .  .|.. ||||..||.|.  .|.
GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRM
Kinase 19630.AA Pkinase 144-330 28 1.7e-43 154.84 Pfam 72-293 (293) Show / Hide 
Range on Protein: 144-330
Range on HMM: 72-293/293
Sequence Identity: 28% (64 aa)

SKKIYFILEYCEDG----DLTKLLK---YNEL--NEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIK-EGTI----KIADFGLSKI--CDPLHISN
...||...|||| |    ||  ...   .. .   | ..   . |. ||.  . .... ||||||.||||. .|.|    ||.||||.|     . .  .
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT

TQVGTPYYMSPQALESKNYNLEKNDIWSAGVMLYQMLYRKFPWEIQ----QIETHQKLIDVIKNTTNIHFSNNF-SIS-----------------EDTKD
| .|||.||.|  . . .|   | |.||.|..||.|| ...|.  .       .....|. |. . .   . .  |||                 |. ||
TFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKD

LIKNMLEVEEANRFEWEEIINMNII
.||..|..  . |  .|.| .   .
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase 19630.AA Ciliate-E2-Unclassified 21-330 25 7.1e-40 136.0 In-house 2-352 (352) Show / Hide 
Range on Protein: 21-330
Range on HMM: 2-352/352
Sequence Identity: 25% (97 aa)

ITNVTIGEGAFSKVYIAFYKKEFFEKKEKATKLCAKILQISNPTQLPYK-QIQTEQQIMMSIQSPYVLRLLQFHQTINNVLFLILVSQPYRLINFLLN-I
. . .||.|.|.||| .  ||.   | ... .  .|  || .  |  .| .|  |...|..... |. |                       .|.... |
KIIKQIGQGGFGKVYKCQHKKQ---K-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K---------------------YNKIMQQI

LINWISKHFLRLLFSFSSFFLQLKISKKIYFILEYCEDGDLTKLLKY------------------NELNEGQVL-----YLFGQLSRGM-LELKKQNVFH
|.|  . . ..... |       .  ..||...||||.||| . .|                   ... | |..     ..| |.  |     .|.|. |
LLNHPHPFIVKMFYCF-------QDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIH

RDLKPSNILIKEG----TIKIADFGLSKICDPL----------------HISNTQVGTPYYM----SPQALESKNYNL---EKNDIWSAGVMLYQMLYRK
||.||.|||....     |||.|||.||  .                  ....|..|||.||    .|  |...||.    .| |||| || ||.||. .
RDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGY

FPWEIQQIETHQKLID------VIKNTTNIHFSNNFS------------ISEDTKDLIK----NMLEVEEANRFEWEEIINMNII
.| . .. | ||.||       ..|.  .. . .|..            .|.  ||.|.     ||..   .|  .|.|.|  ..
YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 19630.AA Ciliate-E2b 144-270 27 3.4e-37 110.66 In-house 72-210 (272) Show / Hide 
Range on Protein: 144-270
Range on HMM: 72-210/272
Sequence Identity: 27% (38 aa)

SKKIYFILEYCEDGDLTKLLKYNE---LNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIKE-GTIKIADFGLSKICDPLHI----SNTQVGTPYY
....||..|.|  ..|  ..       |.. ...  ....  .. .| .||. .||.||.||.. . | .|..|.|..|. .  .       | .|||.|
DQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHY

MSPQALE-----SKNYNLEKNDIWSAGVMLYQMLYRKFPW
| |. ..      | |. .  |||| |..|| ..  . ||
MAPEIIQSLQPGGKGYTYK-VDIWSVGICLYEFMCGYVPW
Kinase 19630.AA Ciliate-E2a 147-269 33 7.8e-36 102.98 In-house 74-215 (275) Show / Hide 
Range on Protein: 147-269
Range on HMM: 74-215/275
Sequence Identity: 33% (48 aa)

IYFILEYCEDGDLTKLLKYNE-LNEG--QVLYLFGQLS-RGMLELKKQNVFHRDLKPSNILIK----EG----TIKIADFGLSKIC--DPLHISNTQVGT
.|...|||| |.| . .|..  ..|   ..  .  ||   | . ....|..|||||| |||.|    ..     |||.||||.. .  |      ...||
YYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGT

PYYMS------PQALESKNYNLEKNDIWSAGVMLYQMLYRKFP
|.|.       .. |..|.|  .| |.||.||..| .|. | |
PGYVAPEVLNNKEVLKHKQYD-TKCDMWSCGVIFYILLCGKPP
Kinase 19630.AA NEK 144-263 34 1.7e-34 119.03 In-house 78-217 (286) Show / Hide 
Range on Protein: 144-263
Range on HMM: 78-217/286
Sequence Identity: 34% (49 aa)

SKKIYFILEYCE-DGDLTKL---LKYN-----ELNEGQVLYLFGQLSRGMLELKKQ-----NVFHRDLKPSNILIKE-GT----IKIADFGLSKICD-PL
. ... . ||||  ||| ..   .| .      . | |..  | |.. .. .. ..     .. |||.||.|| .   ..    .|| |||.||. .   
NNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTT

HISNT-QVGTPYYMSPQALESKNYNLEKNDIWSAGVMLYQM
   .| ||||||||||  ...| || .| |||| |. ||.|
DMAYTTQVGTPYYMSPEVCQNKPYN-NKSDIWSLGCVLYEM
Kinase 19630.AA TyrKc 20-330 17 5.6e-10 -61.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-330
Range on HMM: 1-280/280
Sequence Identity: 17% (62 aa)

LITNVTIGEGAFSKVYIAFYKKEFFEKKEKATKLCA-KILQISNPTQLPYKQIQTEQQIMMSI--QSPYVLRLLQFHQT--------INNVLFLILVSQP
.  . ..||||| .|| . .|             .| | |. .       . .  | .||...  . | ..||.    .            . . ...  
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-

YRLINFLLNILINWISKHFLRLLFSFSSFFLQLKISKKIYFILEYCEDGDLTKLLKYNELNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIKEGT
  | ..| .   .                                              |.  . |.   | ..||  | ..|. ||||   |.|..|. 
GDLKDYLRKHRPK----------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH

-IKIADFGLSKICDPL-HISNTQVGTPYYM-----SPQ--------ALESKNYNL--EKNDIWSAGVMLYQML---YRKFPWEIQQIETHQKLIDVIKNT
 .||.|||||.  .   .     . . ||.     .          |.|. ||.   .| |.|| ||... ..       | .|||     . ..||.. 
TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYV

TNIHFSNNFSI---------SEDTKDLIKNMLEVEEANRFEWEEIINMNII
 . .                ...  ...|   . . ..|   .||    ..
KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 19630.AA Pkinase_Tyr 144-218 33 1.3e-08 29.82 Pfam 80-159 (270) Show / Hide 
Range on Protein: 144-218
Range on HMM: 80-159/270
Sequence Identity: 33% (27 aa)

SKKIYFILEYCEDGDLTKLLKYN-----ELNEGQVLYLFGQLSRGMLELKKQNVFHRDLKPSNILIK-EGTIKIADFGLSK
. .|| ..||.. ||| . |. .      |.  . |    | ..||  |  .|  ||||   |.|.. ....||.||||..
N-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 19630.AA CAMK 25-104 12 2.5e-07 18.89 In-house 1-136 (425) Show / Hide 
Range on Protein: 25-104
Range on HMM: 1-136/425
Sequence Identity: 12% (18 aa)

TIGEGAFSKVYIAFYKKE---------FFEKKEKATKL----------------CAKILQISNPTQLP---------YKQIQTEQQIMMS-------IQS
|.|.|.|.||. .. |.           ..... | |                 |  . .|.. ..            |... | .||..       .. 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNC--Y-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDH

PYVLRLLQFHQ------------TINN-------VLFLIL
| ...|... .            | ..        .....
PNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVM
Kinase 19630.AA Ciliate-E2 20-104 15 0.000115 11.92 In-house 1-113 (365) Show / Hide 
Range on Protein: 20-104
Range on HMM: 1-113/365
Sequence Identity: 15% (18 aa)

LITNVTIGEGAFSKVYIA-------------------------------FYKKEFFEKKEKATKLCAKIL-QISNPTQLPYKQIQTEQQIMMSIQSPYVL
 . .  ||.|.|..|| .                               ...| . ... ...|   .|. .|    .   |.|  |..|. ....|...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FY---KKI-NEKNILEQLNHPNII

RLLQFHQT-INNVLFLIL
..  . |.  .| ..|..
KMYECFQEKDDNNIYLVM
Kinase 19630.AA Pkinase 20-104 16 0.000234 16.49 Pfam 1-79 (293) Show / Hide 
Range on Protein: 20-104
Range on HMM: 1-79/293
Sequence Identity: 16% (15 aa)

LITNVTIGEGAFSKVYIAFYKKE-------FFEKKEKATKLCAKILQISNPTQLPYKQIQTEQQIMMSIQSPYVLRLLQFHQTINNVLFLIL
. .  .||.|.|..||..  |..        ..|...  . .   . .            .| ||| ....|...||. . .. .. . ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL------------SEIQIMKRLNHPNIVRLYDWFED-KDHIYMVM
Kinase 19630.AA NEK 300-330 32 0.000298 11.33 In-house 256-286 (286) Show / Hide 
Range on Protein: 300-330
Range on HMM: 256-286/286
Sequence Identity: 32% (10 aa)

SEDTKDLIKNMLEVEEANRFEWEEIINMNII
|.| ..|| .|| ..  .|   ..|..| .|
SQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 19630.AA Ciliate-E2a 299-313 53 0.004812 4.83 In-house 244-258 (275) Show / Hide 
Range on Protein: 299-313
Range on HMM: 244-258/275
Sequence Identity: 53% (8 aa)

ISEDTKDLIKNMLEV
.| ..|||.| |||.
CSKECKDLMKKMLEK
Kinase 19630.AA ULK 20-104 18 0.021205 4.4 In-house 1-96 (324) Show / Hide 
Range on Protein: 20-104
Range on HMM: 1-96/324
Sequence Identity: 18% (19 aa)

LITNVTIGEGAFS-KVYIAF-YKKEFFEKKEKATKLCAKILQISNPTQLPYK--------QIQTEQQIMMSIQ---SPY--VLRLLQFHQTIN-NVLFLI
 . |  .|.|.|  ||| ..  |..      .  .  .|. ....  . ...        ... | |||  .    .|.  . .|. . .| | | ...|
YCLNHCLGKGSFGVKVYKGRNKKTNT-----QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYII

L
.
M
Kinase 19630.AA Pkinase_Tyr 20-90 21 0.02351 8.6 Pfam 1-70 (270) Show / Hide 
Range on Protein: 20-90
Range on HMM: 1-70/270
Sequence Identity: 21% (16 aa)

LITNVTIGEGAFSKVYIAFYKKEFFEKKEKATKLCAKILQISNPTQLPY---KQIQTEQQIMMSI-QSPYVLRLL
.. . ..||||| .|| . .|    ..... ..   |.|   . .  .    .    | .||... . | ..||.
ITFGKKLGEGAFGEVYKGTWKG---DPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 19630.AA ULK 20-104 18 0.035046 3.52 In-house 1-99 (329) Show / Hide 
Range on Protein: 20-104
Range on HMM: 1-99/329
Sequence Identity: 18% (19 aa)

LITNVTIGEGAFSKVYIAFYKKEFFEKKEKATKLCAKIL--QISNPTQLPY-----KQIQTEQQIMMSI----QSPY----VLRLLQFHQTIN-NVLFLI
 . |  .|.|.| ||| .. ||     . .    | .|.  ....  .. .     .... | .||  .    ....    . .|. . .| | | ...|
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

L
.
M
Kinase 19630.AA CAMKL 19-91 21 0.041922 2.34 In-house 1-82 (297) Show / Hide 
Range on Protein: 19-91
Range on HMM: 1-82/297
Sequence Identity: 21% (19 aa)

VLITNVTIGEGAFSKVYIAFYKKEFFEKKEKATKLCAKILQISNPTQLPYKQ-------------IQTEQQIMMSIQ---SPYVLRLLQ
  |   |.|.|.|.||  |  ..         .|   ||. ..  .  |...             |. | |||....    | . .|..
YRIGK-TLGKGSFGKVKLATHIRTT------GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYE
Kinase 19630.AA Ciliate-E2c 22-99 20 0.130794 1.52 In-house 3-89 (310) Show / Hide 
Range on Protein: 22-99
Range on HMM: 3-89/310
Sequence Identity: 20% (18 aa)

TNVTIGEGAFSKVYIAFYKKEFFEKKEK--------ATKLCAKILQISNPTQLPYK-QIQTEQQIMMSIQSPYVLRLLQFHQTINNV
.|   | | . ||| | | ..    ...           .|.|.. |.  .. . |  |  | ..|..  .|....   . || ...
RNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHI
Kinase 19630.AA Ciliate-E2a 21-37 41 0.194639 0.02 In-house 2-18 (275) Show / Hide 
Range on Protein: 21-37
Range on HMM: 2-18/275
Sequence Identity: 41% (7 aa)

ITNVTIGEGAFSKVYIA
 ..  ||.|.| .||.|
KFIKKIGKGNFGSVYLA
Kinase 19630.AA NEK 25-35 63 0.208973 1.19 In-house 6-16 (286) Show / Hide 
Range on Protein: 25-35
Range on HMM: 6-16/286
Sequence Identity: 63% (7 aa)

TIGEGAFSKVY
.||.|.|.|||
KIGQGSFGKVY