Gene 6653 (Tetrahymena)

6653

Species: Tetrahymena
Alias: 16.m00309, TTHERM_00193700, PreTt06653, 6653, 886
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AGC-Sar
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
6653.AA Protein None 756 None Fasta, JSON
6653.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
6653.NA RNA None 2271 None Fasta, JSON

Protein domain

Protein domains of 6653.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP_binding 6653.AA cNMP_binding 77-162 31 5.9e-19 67.72 Pfam 1-91 (91) Show / Hide 
Range on Protein: 77-162
Range on HMM: 1-91/91
Sequence Identity: 31% (29 aa)

YCEVNQGEQVIKQGDDAFCFFLLEKGEIEVQVNQQKVR-----KLKDGEGFGELALLYNA-PRSATCVALSKSYFWMIERNTFRKAVEEMIT
  ..  || ...||| . .|.....|...| .  .. |      |. |. |||.||..|  ||.||.|||. .  | |.|..||. ...   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 6653.AA cNMP 59-172 26 2e-14 55.18 SMART 1-123 (123) Show / Hide 
Range on Protein: 59-172
Range on HMM: 1-123/123
Sequence Identity: 26% (33 aa)

VFYNLQDSQLETLVNEMSYCEVNQGEQVIKQGDDAFCFFLLEKGEIEVQVN---------QQKVRKLKDGEGFGELALLYNAPRSATCVAL-SKSYFWMI
.| || ...|. |.. |   ..  || ...||| .  |.....|...| .          .| |. |. |. ||||||| ..||.|...|. . . .| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

ERNTFRKAVEEMITQEYQQNRKFI
... |. .....    |.  ....
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 6653.AA cNMP_binding 195-281 33 1.5e-23 83.52 Pfam 1-91 (91) Show / Hide 
Range on Protein: 195-281
Range on HMM: 1-91/91
Sequence Identity: 33% (31 aa)

DQRFLKEQNIVNKDDPASSFYIIKEGKVSVMLGDKEVR-----TLGQGESFGETALLQGDQTRTMTIKALEDTTCLALGRDVLTKLLGDKVE
 ... | . |. ..||...|||...|||.|   |.. |     .||.|. ||| ||......|| |..||.|..|... |... .|. .  |
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP 6653.AA cNMP 177-291 23 1.1e-18 69.27 SMART 1-123 (123) Show / Hide 
Range on Protein: 177-291
Range on HMM: 1-123/123
Sequence Identity: 23% (29 aa)

FFQNLTSNQKDAIAGVLIDQRFLKEQNIVNKDDPASSFYIIKEGKVSVMLG---------DKEVRTLGQGESFGETALLQGDQTRTMTIKAL-EDTTCLA
.|.||.  .  ... ..  ... . . |. . ||...|||| .|.| |.           ...|..||.|..||| |||  ...|| ...|. |. |.. 
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL--RRPRTAAARACCECCTIWR

LGRDVLTKLLGDKVEMIIYRNISKW
. .. .  .|..  .. ... ..  
IDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 6653.AA cNMP_binding 316-345 40 0.26922 7.03 Pfam 1-29 (91) Show / Hide 
Range on Protein: 316-345
Range on HMM: 1-29/91
Sequence Identity: 40% (12 aa)

ISHITKGRVIIPKGTQKAQQLYIILKGSVK
. |. || ||. .| . .. .||.|.|.||
VRHYKKGEVIFHQGDP-CDHFYIVLSGKVK
Kinase 6653.AA Ciliate-E2b 432-692 66 8.9e-209 640.2 In-house 1-272 (272) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-272/272
Sequence Identity: 66% (180 aa)

LEVVKKLGNGQFGSVYLVKN-KDTKQIYALKCVSKSSVVETSLEKHLIQEKKVMQTVNYPFIMRFFRSFKDDYYIYFLLEFIQGQELFEVIREIG--LLS
....||||.|||||||||.| |.|||.||.||.||........|||..|||.|....|.||||.|.||||||...||..||..|.|||.||||||  |||
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

TWDSQFYIGSIILALEYLHSRKIIYRDIKPENIMITHKGYLKLIDMGTAKIMQTNAGTMTRTFTIIGTPHYMAPEVIS-----GKGYSYLVDLWSVGICL
|.||||||.||.|.|||||...||||||||||||..||||.|||||||||.|......|||||||||||||||||.|.     ||||.| ||.|||||||
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

YEFMCGYVPFGEEAEDPYEIYEEIIKK--EINFPNYLSDPMA-KSLMEQLLSRVPEMRTGGSYSSLKSHQFF
|||||||||..|...||||||.|||||  ||.||.|..| || |.||.|.|...||.|.|||||.||||..|
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 6653.AA AGC 432-692 25 9.3e-120 310.89 In-house 1-395 (395) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-395/395
Sequence Identity: 25% (102 aa)

LEVVKKLGNGQFGSVYLVKNK------DTKQIYALKCVSKSS-VVETS--LEKHLIQE------------KKVMQTVN----------YPFIMR-FFRSF
 |..| .| | || ||||. |      ||...||.|...|.  .|..    ..| . |            .......|           ||| .  . ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

KDDYY--IYFLLEFIQ---------GQ-ELFEVIR---EIGLLSTWDSQFYIGS-------IILALEYLHS-RKIIYRD-IKPENIMITHKGYLKLIDMG
.|. .  .||..|...         |  |||  ..     | ..   ..||.         |.|||||||| ..||.|| .|||||.....|..|| | |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TAKIMQTNAGT-----------------------------------------------MTRTFTIIG--TPHYMAPEVISGKGYSYLVDLWS--VGICLY
 .|.. .. .                                                . || |. |  ||.|||||..    |.. .| ||  .|...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EFMCGYVPFGEEA--------EDPYEIYEEII------KKEINFP----------NYLSDPMAKSLMEQLLSRVPEMRTG--GS------YSSLKSHQFF
|...|| ||  .         ..|.|... |.      .... ||           ..|.  ||.|...|| . || | |  |.      .. .|.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPE-AKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 6653.AA Ciliate-E2 432-692 26 6.7e-101 341.52 In-house 1-365 (365) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

LEVVKKLGNGQFGSVYLVKN-----------------------KDTKQIYALKCVSKSSVVETSLEKHLI----------QEKKVMQTVNYPFIMRFFRS
 ...||.|.|.|||||..|.                       |....|||.|...|. . ... |.|..          .||......| |.|.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FK--DDYYIYFLLEFIQGQELFE-------------------VIREIGLLSTWDSQ-------FYIGSIILALEYLHSRK-IIYRDIKPENIMITHKGYL
|.  || .||. .|..||..||.                   ...||. ...   |       |||..||||||||||.. ||.||||||||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLIDMGTAK----------------IMQTNAGTMTRTFT-------------IIGTPHYMAPEVISGKG---------YSYLVDLWSVGICLYEFMCGYV
|.||.|..|                ...   . ..||..             |.|||.|||||...||.         |.| .|.||.|..|||...|. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFGEEAEDPYEIYEEIIKKEINFP----------------NYLSDPMA-KSLMEQ----LLSRVPEMRTGGSYSSLKSHQFF
||          ...|....|.||                .... .   | |. .    .| . || | . ... .. |..|
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF
Kinase 6653.AA S_TKc 432-692 30 8.7e-86 292.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

LEVVKKLGNGQFGSVYLVKNKDTKQIYALKCVSKSSVVETSLEKHLIQEKKVMQTVNYPFIMRFFRSFKDDYYIYFLLEFIQG--QELFEVIREIGL---
 |...|.| | ||.||....|.|..|.|.|...          .|...| ....  . |.| ... .| |  ..|. .|.. |   .||..|.. |    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSTWDSQFYIGSIILALEYLHSRKIIYRDIKPENIMITHKGYLKLIDMGTAKIMQTNAGTMTRTFTIIGTPHYMAPEVISGKGYSY-LVDLWSVGIC
   ..  . .||.  |..||||.||..||.||.|||||....   .|..| | |...           |..|||.||||||.   ||..  .| ||.|..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

LYEFMCGYVPFGEEAEDPYEIYEEIIKKEINFPNYLSDPMAKSLMEQLLSRVPEMRTGGSYSSL-----KSHQFF
|||..||| ||     ....... |            .| ||......| . || | .           |.|..|
LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6653.AA PKA 432-692 38 2.1e-85 290.02 In-house 1-263 (263) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-263/263
Sequence Identity: 38% (105 aa)

LEVVKKLGNGQFGSVYLVKNKDTKQIYALKCVSKSSVVETSLEKHLIQEKKVMQTVNYPFIMR-FFRSFKDDYYIYFLLEFIQGQELFEVIREIGLLSTW
 | .. ||.| || |.|...|.....||.|. .|. .| .  . | . ||...| .. ||| .    .|.|| |.|...|...| |.|  .|  | .|  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

DSQFYIG-SIILALEYLHSRKIIYRDIKPENIMITHKGYLKLIDMGTAKIMQTNAGTMTRTFTIIGTPHYMAPEVISGK-GYSYLVDLWSVGICLYEFMC
...||.   |.||||||||  ||||| |||||.|  .|..|. | | || ...      ||.|. ||| |.|||.|..| |.   || |. ||  ||.. 
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD------RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLA

GYVPFGEEAEDPYEIYEEIIKKEINFPNYLSDPMA---KSLMEQLLSRVPEMRTGGSYS---SLKSHQFF
|| || ..  || .||| |.. .|.||... |. |   |.| ..||.. .. | |   .   . | | .|
GYPPFYDHNRDPMQIYEKICNGKIKFPRHF-DSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 6653.AA AktR 433-692 35 9.3e-81 274.61 In-house 2-268 (268) Show / Hide 
Range on Protein: 433-692
Range on HMM: 2-268/268
Sequence Identity: 35% (96 aa)

EVVKKLGNGQFGSVYLVKNK-DTKQIYALKCVSKSSVVETSLEKHLIQEKKVMQ-TVNYPFIMRFFRSFKDDYYIYFLLEFIQGQELFEVIREIGLLSTW
.| | ||.| || ||||. | |....||.| ..|.  .|  ...|.|.|...|.  .| ||| ... .|.......|..|...| ||| ... .. .|  
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

DSQFYIGSIILALEYLHSR-KIIYRDIKPENIMITHKGYLKLIDMGTAK---IMQTNAGTMTRTFTIIGTPHYMAPEVISG-KGYSYLVDLWSVGICLYE
...||.  |.|||||||.. .|||||.|||||..   |..|..| | .|   .|  .  .     .. |||.|||||.|   ||. . ||.|..|| .||
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAY----SFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYE

FMCGYVPFGEEAEDPYEIYEEIIK-KEINFPNYLSDPMAKSLME-QLLSRVPEMRTG-G--SYSSLKSHQFF
 . |. ||  .      ... |.  .....| |.| . .|.| . .|| . |..| | .  . . .||| .|
MVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFS-SQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 6653.AA Pkinase 432-692 30 6.2e-78 270.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

LEVVKKLGNGQFGSVYLVKNKDTKQIYALKCVSKSSVVETSLEKHLI-QEKKVMQTVNYPFIMRFFRSFKDDYYIYFLLEFIQGQ----ELFEVIR--EI
.....|.| | ||.||. ..|.| .|.|.|...|..  .  .. |.  .| ..|. .| |.| |....| |. .||. .|. .|     .||..|.  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GLL--STWDSQFYIGSIILALEYLHSRKIIYRDIKPENIMITHKGYL----KLIDMGTAKIMQTNAGTMTRTFTIIGTPHYMAPEVIS-GKGYSYLVDLW
| .  | |. .||.  |. .|||.||..||.||.|||||.| ..|..    |..| | || ..      . . |. |||.|||||||  |..|.. || |
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SVGICLYEFMCGYVPFGEE----AEDPYEIYEEIIKKEINFPNYLSD--------------------PMAKSLMEQLLSRVPEMRTGGSYSSLKSHQFF
|.|. |||..||. || ..      |.......| .... |. . ..                    . .|.... .| . |. | .     .. | .|
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase 6653.AA SGK 433-692 32 1.2e-76 236.08 In-house 2-283 (283) Show / Hide 
Range on Protein: 433-692
Range on HMM: 2-283/283
Sequence Identity: 32% (93 aa)

EVVKKLGNGQFGSVYLVKNKDT------------------KQIYALKCVSKSSVV-------ETSLEKHLIQEK-KVMQTVNYPFIMRFFRSFKDDYYIY
.  |..| | || ||.|| ||.                  ...||.|  .| ...          ..||   |. .... .. |||     .|  . . |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

FLLEFIQGQELFEVIREIGLLSTWDSQFYIGSIILALEYLHSRKIIYRDIKPENIMITHKGYLKLIDMGTAK-IMQTNAGTMTRTFTIIGTPHYMAPEVI
| .....| |.|  ..  . ..   . ||   |..||||||| .||||| |||||.  |.|...| | | .|  ..||    . |||. ||| |.||||.
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTN----DTTFTFCGTPEYLAPEVL

SGKGYSYLVDLWSVGICLYEFMCGYVPFGEEAEDPYEIYEEIIKKEINFPNYLSDPMAKSLMEQLLSRVPEMRTGGS--YSSLKSHQFF
 .....  || |. |. |||.| |  ||  .  .  . |. ||......| . | . |..|...|| . |. | |        |.|.||
RKQPHDRTVDWWCLGCVLYEMMYGLPPF--YSRNKQQMYDNIINQPLQIPPQMS-NDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 6653.AA RSK 435-692 32 7.2e-75 255.04 In-house 1-278 (278) Show / Hide 
Range on Protein: 435-692
Range on HMM: 1-278/278
Sequence Identity: 32% (90 aa)

VKKLGNGQFGSVYLVKNK---DTKQIYALKCVSKSSVVETSL-EKHLIQEKKVMQTVN-YPFIMRFFRSFKDDYYIYFLLEFIQGQELFEVIREIGL---
.| || | .|.|.|.. .   ||.|||| | ..|. .| .    .|  .| .......  ||| . . .|... ..|  .|.. | |||. ... .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LSTWDSQFYIGSIILALEYLHSRKIIYRDIKPENIMITH---KGYLKLIDMGTAKIMQTNAGTMTRTFTIIGTPHYMAPEVIS----GKGYSYLVDLWSV
.|  . .||.  |.||.|.||...||.||.|||||. ..    | .||.| | .|..  . . .| ||  ..| .|||||..     ..|..  .|.|| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTF--CYTIEYMAPEMLKRANQQGGHDKACDWWSL

GICLYEFMCGYVPFGE-EAEDPYEIYEEIIKKE--INFP--NYLSDPMAKSLMEQLLSRVPEMRTG---GSYSSLKSHQFF
|. .||   |..||   . ... || . | |..   ..|  .|||.. ||.|  ..| | |..| |   .  . .|.|..|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQE-AKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 6653.AA Ciliate-E2-Unclassified 433-692 26 2.2e-72 246.76 In-house 2-352 (352) Show / Hide 
Range on Protein: 433-692
Range on HMM: 2-352/352
Sequence Identity: 26% (95 aa)

EVVKKLGNGQFGSVYLVKNKDTKQIYALKCVSKSSVVE---------TSLEKHLIQEKK-------------VMQTVNYPFIMRFFRSFKDDYYIYFLLE
...|..|.|.||.||....|..||.||.|  .|. ..           ..|.. ...||              ..  . |||...|  |.|. .||. .|
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

FIQGQELFEVIREI-----------------GLLSTWDSQ-----FYIGSIILALEYLHSRK-IIYRDIKPENIMITHKG---YLKLIDMGTAKIMQTNA
...|..|.. |..                    ..   ..     ||.  |...|||||. . ||.||||||||... .|   |.|.|| | .|  |.| 
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

G-TMTR------------TFTIIGTPHYM----APEVISGKGYS----YLVDLWSVGICLYEFMCGYVPF-GEEAEDPY-------------EIYEEIIK
. . |.            . |..||| ||    ||||. |..|.    | .| ||.|..|||.. || || ..  |. .             ..|..|..
NCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

KEINFPNYL-------SDPMAKSLMEQLLSRVPEMRTG--GSYSSLKSHQFF
|.|.||..        ..| || . ..||.. .. . .   ... .. |..|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6653.AA Akt 433-692 35 5.7e-72 229.34 In-house 2-264 (264) Show / Hide 
Range on Protein: 433-692
Range on HMM: 2-264/264
Sequence Identity: 35% (96 aa)

EVVKKLGNGQFGSVYLVKNKDTKQIY-ALKCVSKSSVVETSLEKHLIQEKKVMQTVNYPFIMRFFRSFKDDYYIYFLLEFIQGQELFEVIREIGLLSTWD
...| || | || |.||| |||...| |.|  .|.  ..    .| ..|... |..| |||     || .  ..|| .....| |||  ..  .  |   
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

SQFYIGSIILALEYLHSRKIIYRD-IKPENIMITHKGYLKLIDMGTAK-I-MQTNAGTMTRTFTIIGTPHYMAPEVISGKGYSYLVDLWS-VGICLYEFM
  ||.  ||||.|.|||. |||||  |||||.. ..|...| | | .| . .. .  |.    |. ||| |.|||...|.|..  || |. .|. .||.|
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTK----TFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

CGYVPFGEEAEDPYEIYEEIIKKEINFP--NYLSDPMAKSLMEQLLSRVPEMRTG---GSYSSLKSHQFF
||  || .  .|  . .. |  ....||  ...| | .|.| ..||.. |..| |   .    .|.| .|
CGRPPFYN--QDHHQMFKKIKNQPVKFPDKDWIS-PECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 6653.AA PKG 432-649 39 3.1e-66 226.35 In-house 1-213 (260) Show / Hide 
Range on Protein: 432-649
Range on HMM: 1-213/260
Sequence Identity: 39% (86 aa)

LEVVKKLGNGQFGSVYLVKNKDTK-QIYALKCVSKSSVVETSLEKHLIQEKKVMQTVNYPFIMRFFRSFKDDYYIYFLLEFIQGQELFEVIREIGLLSTW
|...  || | || | ||. .  | ...||||  |. .|.|  . | . ||..|.  . .|| | .| |.|. |.|.|.|   | ||  ..|. |     
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

DSQFYIGSIILALEYLHSRKIIYRDIKPENIMITHKGYLKLIDMGTAKIMQTNAGTMTRTFTIIGTPHYMAPEVISGKGYSYLVDLWSVGICLYEFMCGY
 ..||.. .. |..|||.. ||||| ||||.|  ..||.||.| | || ....     .| |  ||| | |||.|  ||    || |. ||  .| . | 
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGR----KTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGN

VPFGEEAEDPYEIYEEIIK
 ||  .. ||  .|  | |
PPF--SGSDPMKTYNIILK
Kinase 6653.AA TyrKc 432-692 21 3.6e-13 -9.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 432-692
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

LEVVKKLGNGQFGSVYLVKNKDTKQIYALKCVSKSSVVETSLEKHLIQEKKVMQTV--NYPFIMRFFRSFKDD-------YYIYFLLEFIQGQELFEVIR
..  ||||.|.|| ||. . |       ...  |.   ..  .. ...| ..|  .  . | | |..    ..         .. ..|.  .  | . .|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EIGL-LSTWDSQFYIGSIILALEYLHSRKIIYRDIKPENIMITHKGYLKLIDMGTAKIMQTN--------AGTM-----TRT-FTIIGTPHYMAPEVISG
. .  |.. |   .   |    |||||...| ||.   |.......  |  | | ..               ..     ..| . |      ||||.|  
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECINY

KGYSYLVDLWSVGICLYE-FMCGYVPFGEEAE---DPYEIYEEIIKK-EINFPNY--------LSDPMAKSLMEQLLSRVPEMRTGGSYSSLKSHQFF
. ..   | || |.|..| |  |  |  ....   ...|..| . .      | .         .| | . .|.|   . ||.|   |      |..|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI----HECF
Kinase 6653.AA Pkinase_Tyr 432-448 52 0.001787 12.39 Pfam 1-17 (270) Show / Hide 
Range on Protein: 432-448
Range on HMM: 1-17/270
Sequence Identity: 52% (9 aa)

LEVVKKLGNGQFGSVYL
..  |||| |.||.||.
ITFGKKLGEGAFGEVYK
Kinase 6653.AA Pkinase_Tyr 600-635 31 0.002916 11.67 Pfam 181-218 (270) Show / Hide 
Range on Protein: 600-635
Range on HMM: 181-218/270
Sequence Identity: 31% (12 aa)

MAPEVISGKGYSYLVDLWSVGICLYEFMC-GYVP-FGE
||||.|. . ..   | || |....| .  |  | . .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG