Gene 23052 (Tetrahymena)
23052
Sequence
Protein domains of 23052.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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CNMP_binding | 23052.AA | cNMP_binding | 120-205 | 31 | 2.2e-21 | 76.06 | Pfam | 1-91 (91) | Show / Hide |
Range on Protein: 120-205 Range on HMM: 1-91/91 Sequence Identity: 31% (29 aa) YCELQEGETIIKEEDNASTFFILEQGRIQVSVKDNVKR-----DIVPGEGFGELALLYNA-PRSASCKALQKCHLWGIDRATFRRVVEEMIT ....||.|... | .. |.|...|...|.. | | . ||. |||.||..| ||.|...|| |..| |.|..||..... VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE |
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CNMP | 23052.AA | cNMP | 102-215 | 26 | 1.8e-20 | 75.24 | SMART | 1-123 (123) | Show / Hide |
Range on Protein: 102-215 Range on HMM: 1-123/123 Sequence Identity: 26% (33 aa) VFYNLQDSQLETLVNEMFYCELQEGETIIKEEDNASTFFILEQGRIQVSVK---------DNVKRDIVPGEGFGELALLYNAPRSASCKAL-QKCHLWGI .| || ...|. |.. |. ... ||.|... | ...|.|...|...| .. . . . . ||. ||||||| ..||.|...|. . | .| | MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI DRATFRRVVEEMITKEYEQNRKFI |. |.. .... . |. .... DFQHFMQQLQQHPQHMYRMLQQLA |
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CNMP_binding | 23052.AA | cNMP_binding | 260-346 | 29 | 4.1e-23 | 82.02 | Pfam | 1-91 (91) | Show / Hide |
Range on Protein: 260-346 Range on HMM: 1-91/91 Sequence Identity: 29% (27 aa) DQKFQKDQIIVSEDDPASSFYIIKEGSVSVMRGGAEVR-----TLQGGDSFGETALLQGVHKRAMTVKAQSDVKCLALGRDVLTRILGDQVE ....|...|....||...|||...|.|.| . . . | .|. || ||| ||... ..|. ||.|..|..|... |... ... . | VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE |
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CNMP | 23052.AA | cNMP | 242-356 | 20 | 5.9e-17 | 63.57 | SMART | 1-123 (123) | Show / Hide |
Range on Protein: 242-356 Range on HMM: 1-123/123 Sequence Identity: 20% (26 aa) SKKNLTVEQKNSVAGVLIDQKFQKDQIIVSEDDPASSFYIIKEGSVSVMRG---------GAEVRTLQGGDSFGETALLQGVHKRAMTVKAQ-SDVKCLA |||. .. ... .. ..... ..|. . ||...|||| .|.| |.. . .|..|. ||.||| ||| |. ...| ...... MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL--RRPRTAAARACCECCTIWR LGRDVLTRILGDQVEVIIYKNISKW . .. . ..|... . .. .. IDFQHFMQQLQQHPQHMYRMLQQLA |
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CNMP_binding | 23052.AA | cNMP_binding | 381-410 | 40 | 0.402441 | 6.43 | Pfam | 1-29 (91) | Show / Hide |
Range on Protein: 381-410 Range on HMM: 1-29/91 Sequence Identity: 40% (12 aa) INHHKDGEVVIQQGTPIKNAIIILLEGQIK . | | |||...|| | . . |.|.|..| VRHYKKGEVIFHQGDP-CDHFYIVLSGKVK |
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Kinase | 23052.AA | Ciliate-E2b | 499-759 | 68 | 3.1e-209 | 641.63 | In-house | 1-272 (272) | Show / Hide |
Range on Protein: 499-759 Range on HMM: 1-272/272 Sequence Identity: 68% (186 aa) LIVIKKLGFGQFGSVFLVKE-KGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIG--LLS .|.||||||||||||.||.. | .|..|..||.||.|...|..|||...||.|.|..|.||.|||.||||||...||..||..|||||||||||| ||| MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS TYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVIS-----GKGYNFLVDLWSVGICL ||||||||.|..|.|||||...|||||||||||||||.||.|||||||||.|..|....||||||||||||||||.|. ||||.. ||.||||||| TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL YEFMCGYVPFAEEAEDPYEIYEEIIKK--EIQFPAYMKDAVA-KQLMLQLLNKIPEIRLGGSYNALKSNAWF |||||||||.||...||||||.||||| |||||.|.||..| |.||||.|.|.||.||||||..|||..|| YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF |
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Kinase | 23052.AA | AGC | 499-759 | 24 | 7.79999999999e-107 | 276.7 | In-house | 1-395 (395) | Show / Hide |
Range on Protein: 499-759 Range on HMM: 1-395/395 Sequence Identity: 24% (99 aa) LIVIKKLGFGQFGSVFLVKEK------GKKKLYGLKCVSKAQ-VVEQS--LEKHIQNE------------KQVMEFNN----------FPFVMK-FLRSF ..| .| | || |.||..| . .|.| .|...|. .|. ..|...| ....| | ||. | || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF KDDRC--IYFLLEFIQ----------GMELFDVIR---EIGLLSTYDSQFYIGS-------LILTLEYLHS-NYIIYRD-IKPENIMVDHAGYLKLIDMG .|.. .||..|... |.||| .. | .. ..||. ..| |||||| . ||.|| .|||||. |. |..|| | | QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG TAKIMKSKAGT-----------------------------------------------VTRTFTIIG--TPHYMAPEVISGKGYNFLVDLWS--VGICLY .|..... . || |. | ||.|||||.. |.. .| || .|...| LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY EFMCGYVPFAEEA--------EDPYEIYEEII------KKEIQFPAYM---------KDAVAKQLMLQLLNKIPEIRLG--GS------YNALKSNAWF |...|| || . ..|.|... |. .....|| .. . || |. .||.| || ||| |. .. .|. || EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | 23052.AA | Ciliate-E2 | 499-759 | 27 | 1.9e-94 | 320.09 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 499-759 Range on HMM: 1-365/365 Sequence Identity: 27% (105 aa) LIVIKKLGFGQFGSVFLVKE-----------------------KGKKKLYGLKCVSKAQVVEQSLEKHIQ----------NEKQVMEFNNFPFVMKFLRS ..|||.|.|.||||...| | |.|.| .|...| |. ... |.|| |||...|..|.|...|. . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FK--DDRCIYFLLEFIQGMELFD-------------------VIREIGLLSTYDSQ-------FYIGSLILTLEYLHSNY-IIYRDIKPENIMVDHAGYL |. || .||. .|..||..||| ...||. .... | |||...|| ||||||. ||.||||||||.. . FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I KLIDMGTAK----------------IMKSKAGTVTRTFT-------------IIGTPHYMAPEVISGKG---------YNFLVDLWSVGICLYEFMCGYV |.||.|..| ... . .||.. |.|||.|||||...||. |.. .|.||.|..|||...|. KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP PFAEEAEDPYEIYEEIIKKEIQFP----------------AYMKDAVA-KQLMLQ----LLNKIPEIRLGGSYNALKSNAWF || ...|....|.|| . | |.|. . .|.| || |.. ... .. . || PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT-GWEQILNHPWF |
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Kinase | 23052.AA | PKA | 499-759 | 37 | 8.3e-78 | 264.81 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 499-759 Range on HMM: 1-263/263 Sequence Identity: 37% (101 aa) LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVM-KFLRSFKDDRCIYFLLEFIQGMELFDVIREIGLLSTY |. || | || | |...|. .. | .|. .|...| . |. |||... ..||. | .|.||| .|...|...| |.|. .| | .| . FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP DSQFYIG-SLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVISGK-GYNFLVDLWSVGICLYEFMC ...||. .|.|||||| ||||| |||||. | |..|. | | || ... ||.|. ||| |.|||.|..| |.. || |. || ||.. HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD------RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLA GYVPFAEEAEDPYEIYEEIIKKEIQFPAYMKDAV--AKQLMLQLLNKIPEIRLGGSYN---ALKSNAWF || || .. || .||| |.. .|.|| .. .. | | .||.. .. |.| | | || GYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF |
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Kinase | 23052.AA | S_TKc | 499-759 | 29 | 1.7e-71 | 244.78 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 499-759 Range on HMM: 1-231/231 Sequence Identity: 29% (80 aa) LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQG--MELFDVIREIGL--- ...|.| | ||.|.....|. .... .|... .||..| |... . |.. |.. .| | ..|. .|.. | .|||.|.. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVISGKGYNF-LVDLWSVGIC .. . .||. ... |||.||. ||.||.|||||..|. .|..| | |... |..|||.||||||. ||.. .| ||.|.. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI LYEFMCGYVPFAEEAEDPYEIYEEIIKKEIQFPAYMKDAVAKQLMLQLLNKIPEIRLGGSYNAL-----KSNAWF |||..||| || ....... | . ||... ..|.| || |.. |. || LYEMLCGYPPFP----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 23052.AA | AktR | 500-759 | 35 | 5.6e-70 | 238.79 | In-house | 2-268 (268) | Show / Hide |
Range on Protein: 500-759 Range on HMM: 2-268/268 Sequence Identity: 35% (96 aa) IVIKKLGFGQFGSVFLVKEK-GKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVME-FNNFPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIGLLSTY |.| || | || |.||..| .|.| .| ..| .|. ...|...|...|| .|.|| |. .|.......|..|...| |||.... .. .| HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE DSQFYIGSLILTLEYLHSN-YIIYRDIKPENIMVDHAGYLKLIDMGTAK--IMKSKAGTVTRTFTIIGTPHYMAPEVISG-KGYNFLVDLWSVGICLYEF ...||. .| |||||.. |||||.|||||. | |..|..| | .| .|... . . .. |||.|||||.| ||.|. ||.|..|| .|| QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEK---AYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM MCGYVPFAEEAEDPYEIYEEIIKKE-IQFPAYMKD-AVAKQLML-QLLNKIPEIRLG-G--SYNALKSNAWF . |. || .... .... |..|. ..|| ... .| | .||.| |. ||| . . .|| || VTGCPPF--YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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Kinase | 23052.AA | Ciliate-E2-Unclassified | 500-759 | 25 | 3e-64 | 219.75 | In-house | 2-352 (352) | Show / Hide |
Range on Protein: 500-759 Range on HMM: 2-352/352 Sequence Identity: 25% (89 aa) IVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKH----IQNEKQVMEFN------------------NFPFVMKFLRSFKDDRCIYFLLE ..||..| |.||.|.....| .|..| .| .|.|.. | . .. ....|.... . . ||..|.. |.|. .||. .| KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME FIQGMELFDVIREI-----------------GLLSTYDSQ-----FYIGSLILTLEYLHSNY-IIYRDIKPENIMVDHAG---YLKLIDMGTAKIMKS-- ...| .|.. |.. .. . .. ||. ... |||||.. ||.||||||||..| | |.|.|| | .| .. YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN --KAGT---------VTRTFTIIGTPHYM----APEVISGKGYN----FLVDLWSVGICLYEFMCGYVPF-AEEAEDPY-------------EIYEEIIK . .. .. |..||| || ||||. |..|. . .| ||.|..|||.. || || .. |. . ..|..|.. NCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ KEIQFPA-------YMKDAVAKQLMLQLLNKIPEIRLG--GSYNALKSNAWF |.|||| . . || . .|| |... ... ... .. || KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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Kinase | 23052.AA | SGK | 500-759 | 31 | 1.1e-63 | 195.39 | In-house | 2-283 (283) | Show / Hide |
Range on Protein: 500-759 Range on HMM: 2-283/283 Sequence Identity: 31% (91 aa) IVIKKLGFGQFGSVFLVKEKGK------------------KKLYGLKCVSKAQVV-------EQSLEKHIQNEK-QVMEFNNFPFVMKFLRSFKDDRCIY . .|..| | || |..|| |.. .|.| .| .|.... ..|||. |. .. . || . .| . | DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY FLLEFIQGMELFDVIREIGLLSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAK-IMKSKAGTVTRTFTIIGTPHYMAPEVI | .....| |.| .. . .. . || ... |||||| ||||| |||||. || |...| | | .| .| | . |||. ||| |.||||. FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIK----TNDTTFTFCGTPEYLAPEVL SGKGYNFLVDLWSVGICLYEFMCGYVPFAEEAEDPYEIYEEIIKKEIQFPAYMKDAVAKQLMLQLLNKIPEIRLGGS--YNALKSNAWF .... || |. |. |||.| | || . . . |. ||....|.| .| . |. |. .||.| |. ||| |. .| RKQPHDRTVDWWCLGCVLYEMMYGLPPF--YSRNKQQMYDNIINQPLQIPPQMS-NDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF |
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Kinase | 23052.AA | RSK | 502-759 | 29 | 1.8e-61 | 210.57 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 502-759 Range on HMM: 1-278/278 Sequence Identity: 29% (83 aa) IKKLGFGQFGSVFLVKEK---GKKKLYGLKCVSKAQVVEQSL-EKHIQNEKQVMEFNN-FPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIGL--- .| || | .|.|||.... ....| | ..|| .| .| | ...| . ||. . .|... .| .|.. | |||. ... . LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDH---AGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVIS----GKGYNFLVDLWSV .| . .||. ..|..|.||. ||.||.|||||. |. | .||.| | .|.. .. .| | ..| .|||||.. ..|.. .|.|| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL GICLYEFMCGYVPFAE-EAEDPYEIYEEIIKKE--IQFP--AYMKDAVAKQLMLQLLNKIPEIRLG---GSYNALKSNAWF |. .|| |..||. . ... || . | |.. .| .|. . || | ..| . |. ||| . . .|...|| GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL-SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | 23052.AA | PKG | 499-716 | 38 | 2.7e-59 | 203.29 | In-house | 1-213 (260) | Show / Hide |
Range on Protein: 499-716 Range on HMM: 1-213/260 Sequence Identity: 38% (85 aa) LIVIKKLGFGQFGSVFLVKEKGKK-KLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQGMELFDVIREIGLLSTY | .| || | || | ||. .. | . . ||| |...|.. . || .||..|. . .|. . | |.|.. .|.|.| | || ..|. | . LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK DSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVISGKGYNFLVDLWSVGICLYEFMCGY ..||.. . ..|||. ||||| ||||.| |. ||.||.| | || | |. .| | ||| | |||.| || . || |. || .| . | TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAK----KIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGN VPFAEEAEDPYEIYEEIIK || .. || .| | | PPF--SGSDPMKTYNIILK |
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Kinase | 23052.AA | CAMK | 504-759 | 19 | 3e-56 | 179.39 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 504-759 Range on HMM: 1-425/425 Sequence Identity: 19% (82 aa) KLGFGQFGSVFLVKEKGKK------------KLYGLKCVSKAQVVE-------------------------QSLEKHIQNEKQVMEF-------NNFPFV .|| |.|| |.|...| . . . | ..| .. . .. .| ...| ..| . | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI MKFLRSFKD-------------------DRCIYFLL---EFIQGMEL----FDVIREIGL---------------LSTYDSQFYIGSLILTLEYLHSNYI |.. . | |...|. . |...| || || |.| | .. . ..|. .. ..|.||. | IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI IYRDIKPENIMVDHAG----------------Y-LKLIDMGTAKIMKSKAGTVTR--------------------TFTIIGTPHYMA-PEVISG------ . ||.|||||..|. . . .|.|| | |...... . . | |||.||| |||..| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM --------KGYNFLVDLWSVGICLYEFMCGYVPFAEEAE-----------DPYEIYEEIIKKEIQFPAYMKDAV-----------------------AKQ ..|.. .| ||.|. || ||| || .. . ..||..| |.| . .|| .. . . .|. QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD LMLQLLNKIPEIRLGGSYNALKSNAWF | ..|.. || |. . .. |. LIRKMLQVDPEKRM--TIEQCLNHPWM |
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Kinase | 23052.AA | Pkinase | 499-759 | 29 | 7.8e-55 | 193.29 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 499-759 Range on HMM: 1-293/293 Sequence Identity: 29% (87 aa) LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQ-NEKQVMEFNNFPFVMKFLRSFKDDRCIYFLLEFIQGM----ELFDVIR--EI . ...|.| | ||.|.. ..|| |.. .|...| .. .. |. .| |.| | |.. .....| |.. ||. .|. .| .|||.|. . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GLL--STYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYL----KLIDMGTAKIMKSKAGTVTRTFTIIGTPHYMAPEVIS-GKGYNFLVDLW | . | . .||. .. |||.||. ||.||.|||||..|. |.. |..| | || .. . . |. |||.||||||| |..| || | GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW SVGICLYEFMCGYVPFAEE----AEDPYEIYEEIIKKEIQFPAYMKD--------------------AVAKQLMLQLLNKIPEIRLGGSYNALKSNAWF |.|. |||..||. || .. |.......| .... |. . .. .|... .|.| |. |.. .. || SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF |
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Kinase | 23052.AA | TyrKc | 499-757 | 19 | 2.5e-10 | -55.61 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 499-757 Range on HMM: 1-280/280 Sequence Identity: 19% (57 aa) LIVIKKLGFGQFGSVFLVKEKGKKKLYGLKCVSKAQVVEQSLEKHIQNEKQVMEFN--NFPFVMKFLRSFKDD-------RCIYFLLEFIQGMELFDVIR . .|||| |.|| |.. . | ... | . .. . .| ..| . | . ... .. .. ..|. . | | .| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR EIGL-LSTYDSQFYIGSLILTLEYLHSNYIIYRDIKPENIMVDHAGYLKLIDMGTAKIMKSK--------AGTV-----TRT-FTIIGTPHYMAPEVISG . . |.. | . |||||. .| ||. |..|.. . | | | .. ... .. ..| . | ||||.| KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI----RWMAPECINY KGYNFLVDLWSVGICLYE-FMCGYVPFAEEAE---DPYEIYEEIIKK-EIQFPAY--------MKDAVAKQLMLQLLNKIPEIRLGGSYNALKSNA . ... | || |.|..| | | | .... ...|..| . . |.. . |.. . .|.| . || | . ..... GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP--TFSEIHECF |
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Kinase | 23052.AA | Pkinase_Tyr | 667-702 | 31 | 0.002762 | 11.75 | Pfam | 181-218 (270) | Show / Hide |
Range on Protein: 667-702 Range on HMM: 181-218/270 Sequence Identity: 31% (12 aa) MAPEVISGKGYNFLVDLWSVGICLYEFMC-GYVP-FAE ||||.|. . .. | || |....| . | | ... MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPG |
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Kinase | 23052.AA | Pkinase_Tyr | 499-515 | 47 | 0.105632 | 6.39 | Pfam | 1-17 (270) | Show / Hide |
Range on Protein: 499-515 Range on HMM: 1-17/270 Sequence Identity: 47% (8 aa) LIVIKKLGFGQFGSVFL .. .|||| |.||.|.. ITFGKKLGEGAFGEVYK |