Gene 11833 (Tetrahymena)

11833

Species: Tetrahymena
Alias: 932, PreTt11833, 1.m00881, 11833, TTHERM_00013270
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AGC-Sar
Subfamily: Ciliate-E2b

Sequence

Name Sequence Type Origin Length Description Download
11833.AA Protein None 1219 None Fasta, JSON
11833.kin_dom Protein Kinase Domain None 311 None Fasta, JSON
11833.NA RNA None 3660 None Fasta, JSON

Protein domain

Protein domains of 11833.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP 11833.AA cNMP 449-565 25 1.1e-14 56.07 SMART 1-123 (123) Show / Hide 
Range on Protein: 449-565
Range on HMM: 1-123/123
Sequence Identity: 25% (32 aa)

IFSNLEEQHMNQVVNKMFACTCKQGEFIFEQNDEASLFFFIEQGNVNIKIN---------KEFKKCLDEFTSFGELALLYNSPRSASAQAAQDG-VQLIL
.|.||.||.. .....|.   .. || ||.|.| .. |..|..| | .              . . |    .|||||||    |.. . ||    .   .
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL----RRPRTAAARACCECCTI

WAIDRVTFLNVIKHINQQDLEVNRKFL
| ||.  |.. . .. |  ... ....
WRIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 11833.AA cNMP_binding 467-555 27 4.4e-13 47.54 Pfam 1-91 (91) Show / Hide 
Range on Protein: 467-555
Range on HMM: 1-91/91
Sequence Identity: 27% (26 aa)

ACTCKQGEFIFEQNDEASLFFFIEQGNVNIKINKEFKK-----CLDEFTSFGELALLYNS-PRSASAQAAQDGVQLILWAIDRVTFLNVIKHINQ
  ..| ||.||.|.|... |.....| | .    |  .      | .   |||.||..|. ||.|...|     .  .|.|.| .|.....   .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVA---LTDCECWRIPREDFRQLMQQHPE
CNMP_binding 11833.AA cNMP_binding 588-676 30 2.3e-18 65.66 Pfam 1-91 (91) Show / Hide 
Range on Protein: 588-676
Range on HMM: 1-91/91
Sequence Identity: 30% (28 aa)

YQKFHKGETIVNIGDDANSFYIIKSGQVSIISQNQIEERQ----LQSGDWFGESSLYLNKSIRTRTVQAKSFDVILLALSRKATQEILGDKIQ
 ....|||.|.  || ...|||..||.|...  ..  ..|    |. ||.||| .|  |.. || ||.|   |. .....|.. .... .  .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE
CNMP 11833.AA cNMP 570-686 21 2.3e-15 58.31 SMART 1-123 (123) Show / Hide 
Range on Protein: 570-686
Range on HMM: 1-123/123
Sequence Identity: 21% (27 aa)

FFSNFTHEQKDLLASQFTYQKFHKGETIVNIGDDANSFYIIKSGQVSIISQ--------NQIEERQLQSGDWFGESSLYLNKSIRTRTVQAKSFDVILLA
.|.| . ..   |...   ... .||.|.  || ...|||| ||.| .. .        .... . |. || ||| .|    . || .. |.. .. .. 
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL--RRPRTAAARACCECCTIWR

LSRKATQEILGDKIQYLAFRNLMRW
....  ...|..  | .. . . . 
IDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding 11833.AA cNMP_binding 750-793 22 17.138449 0.83 Pfam 48-91 (91) Show / Hide 
Range on Protein: 750-793
Range on HMM: 48-91/91
Sequence Identity: 22% (10 aa)

QVVGSMCLIANQYTDNQLVFSEKESLIAEISKEQIETLLGGSYE
...| |.|. || .    | .. .. ...|..|... |.  . |
DFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
Kinase 11833.AA Ciliate-E2b 834-1144 46 2.4e-191 586.43 In-house 1-272 (272) Show / Hide 
Range on Protein: 834-1144
Range on HMM: 1-272/272
Sequence Identity: 46% (148 aa)

LVYIKELGRGNFGSVNLVFNNIQTQDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIFQRGIEKYILREKS
..|||.||.|.||||.||.|.                                                |......|||....|.|.|...||..|.||.
MIYIKKLGFGQFGSVYLVWNT------------------------------------------------KNTKQYYAMKCISKNQIIQQNMEKHMLQEKN

TLQKCNFPFIMRYYRSFYDNYHIYFMNEFINGMDFFTVMREVG--LFNKQQAQFYTAFIILTLQYLNNQGIVYRDLKPENILIDHEGWPKLVDMGTAKYL
.|.|||.||||...|||.|..|.|||.||.|||..|.|.||.|  |......|||.|.|.|.|.||.||.|.|||.|||||..||.|..||.||||||..
VLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHM

YDKNQQLTRTYSLVGTPHYMAPEVIQ-----QKGYGFAVDIYSLGVILYELLVGYLPYGEDVDDPIEVYQLILEG--RLGFPNHMKNRLSDKKLISQLMA
|.||.|.|||....|||||||||.||     .|||...|||.|.|..|||...||.|..|||.||.|.|| |...  ...||...|....||||..|...
YKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQ

KSPEVRLGGSYGALKSHEWF
|.|||||||||..||||.||
KMPEVRLGGSYSWLKSHPWF
Kinase 11833.AA AGC 834-1144 24 3.7e-101 261.69 In-house 1-395 (395) Show / Hide 
Range on Protein: 834-1144
Range on HMM: 1-395/395
Sequence Identity: 24% (109 aa)

LVYIKELGRGNFGSVNLVFNNIQTQDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNY-IFQRG--IEKYILR
   .| .|.| || | ||  .  .                                            .|. ....||||    . | ..    ......
FEFLKVIGKGSFGKVYLVRKKDGCH-------------------------------------------KKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMT

E------------KSTLQKCN----------FPFIMR-YYRSFYDNYH--IYFMNE----FIN------GMDFFTVMR---EVGLFNKQQAQFYTAF---
|            .  |.|||           ||| .  . || |. |  .||  |    ..|      |...|. ..     | |. ..|.||.|    
EHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQK

----IILTLQYLNN-QGIVYRD-LKPENILIDHEGWPKLVDMGTAKYL-------------------------------------YDKNQ----------
    |.| |.|| . .||..|| |||||||.|..|  ||.| | .| .                                      ..|.          
ICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRK

QLTRTYSLVG--TPHYMAPEVIQQKGYGFAVDIYS--LGVILYELLVGYLP-YGEDVD-------DPIEVYQLIL------EGRLGFPNHMK------NR
.  ||....|  ||.|||||..    ||.|.|..|  ||...||.|.|| | ||....       .| |..|.|.      . .. ||...         
KRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRW

LSD--KKLISQLMAKSPEVRLG--GS------YGALKSHEWF
.|.  | ||..|. | || |||  |.      .  .|.|.||
FSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 11833.AA Ciliate-E2 834-1144 25 9.2e-91 307.84 In-house 1-365 (365) Show / Hide 
Range on Protein: 834-1144
Range on HMM: 1-365/365
Sequence Identity: 25% (107 aa)

LVYIKELGRGNFG-----SVNLVFNNIQTQDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIFQRGIEKYI
   || .|.||||     .| .| .... .... ... ...|    |                          ||.|  ..|||... | |.|   |..|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQM---Q--------------------------EKVKIKIYAMKIMKKNQIEQIKQEIHI

L----------REKSTLQKCNFPFIMRYYRSFY--DNYHIYFMNEFINGMDFFT-------------------VMREVGLFNKQQAQ-------FYTAFI
.           ||. |.. |.|.|...| .|.  |. .||.  |...|.| |                    ...|.. . ||..|       || | |
MREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACI

ILTLQYLNNQG-IVYRDLKPENILIDHEGWPKLVDMGTAKYLYDKNQQLT----------------------------RTYSLVGTPHYMAPEVIQ----
|| |.|| ... |..||.||||||.     .|..|.|..|.. |.||. |                             .....|||.|||||...    
ILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

-----QKGYGFAVDIYSLGVILYELLVGYLPYGEDVDDPIEVYQLILEGRLGFP----------------NHMKNRLSDKKLISQ----LMAKSPEVRLG
     ||||....||.||||||||.| |..|.          .| |... . ||                .. |  .. | ||..    .. | || |..
DNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT

GSYGALKSHEWF
 ..  .. |.||
-GWEQILNHPWF
Kinase 11833.AA PKA 902-1144 38 7.2e-66 225.15 In-house 20-263 (263) Show / Hide 
Range on Protein: 902-1144
Range on HMM: 20-263/263
Sequence Identity: 38% (95 aa)

EKQKDRLFAMKVFISNYIFQRGIEKYILREKSTLQKCNFPFIMR-YYRSFYDNYHIYFMNEFINGMDFFTVMREVGLFNKQQAQFYTA-FIILTLQYLNN
.|.  . .|||.   ..| ..  .  .. ||. || ...||| .  | .| |. ..|.  |...| . |. .| .| |. ..|.|| |  |.|.|.|| .
HKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHS

QGIVYRDLKPENILIDHEGWPKLVDMGTAKYLYDKNQQLTRTYSLVGTPHYMAPEVIQQK-GYGFAVDIYSLGVILYELLVGYLPYGEDVDDPIEVYQLI
| |.|||||||||||| .|  |. | | ||.. |      ||..| ||| |.|||.|| | |.| .||  .||.. ||.|.|| |  ..  ||.. |. |
QNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD------RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKI

LEGRLGFPNHMKNRL-SDKKLISQLMAKSPEVRLGGSYG---ALKSHEWF
..|.. ||.|. ...   | ||..|... .. |.|   .     | |.||
CNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 11833.AA S_TKc 834-1144 25 2.9e-65 224.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 834-1144
Range on HMM: 1-231/231
Sequence Identity: 25% (83 aa)

LVYIKELGRGNFGSVNLVFNNIQTQDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIFQRGIEKYILREKS
   ....|.| ||.| .. ..                                                   .|..|.|.            . |.|| .
YEILRKIGKGAFGKVYKCRHKK-------------------------------------------------TGRIVAIKIIK----------EHIRREIQ

TLQKCNFPFIMRYYRSFYDNYHIYFMNEFING--MDFFTVMREVGL------FNKQQAQFYTAFIILTLQYLNNQGIVYRDLKPENILIDHEGWPKLVDM
 |.| . |.| ..| .|.|  |.|.  |...|   | |..... |       |.  .|.||.. |.. |.|. ..||..|||||||||.|.    |. | 
ILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDF

GTAKYLYDKNQQLTRTYSLVGTPHYMAPEVIQQKGYGF-AVDIYSLGVILYELLVGYLPYGEDVDDPIEVYQLILEGRLGFPNHMKNRLSDKKLISQLMA
| |. |          ....|||.||||||.   |||. ..|..|.|.||||.|.|| |.     .. .....|.              . | .|.... 
GLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQ

KSPEVRLGGSYGAL-----KSHEWF
| || |..           |.|.||
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11833.AA Akt 902-1144 34 9.8e-60 189.6 In-house 20-264 (264) Show / Hide 
Range on Protein: 902-1144
Range on HMM: 20-264/264
Sequence Identity: 34% (88 aa)

EKQKDRLF-AMKVFISNYIFQRGIEKYILREKSTLQKCNFPFIMRYYRSFYDNYHIYFMNEFINGMDFFTVMREVGLFNKQQAQFYTAFIILTLQYLNNQ
.|. .... ||||   .|| |..  .... |.  ||.||.|||   . || .. ..||. ...|| . |. ..  . |. ..| || | ||| ...| ..
KKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSK

GIVYRD-LKPENILIDHEGWPKLVDMGTAKYLYDKN--QQLTRTYSLVGTPHYMAPEVIQQKGYGFAVDIYS-LGVILYELLVGYLPYGEDVDDPIEVYQ
.|.||| |||||||.|..|  .| | | .|    .|  ..  .|... ||| |.|||.....|.. |||... ||...||.. | .|. .  .|  . ..
NIIYRDYLKPENILMDKDGHICLTDFGLCK----ENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYN--QDHHQMFK

LILEGRLGFPNHMKNRLSD--KKLISQLMAKSPEVRLGGSYG---ALKSHEWF
.|... . ||.   ...|.  | |||.|  | |. |||| ..    .|.|.||
KIKNQPVKFPDK--DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 11833.AA RSK 899-1144 33 1.2e-58 201.19 In-house 17-278 (278) Show / Hide 
Range on Protein: 899-1144
Range on HMM: 17-278/278
Sequence Identity: 33% (90 aa)

KFNEKQKDRLFAMKVFISNYIFQRGI-EKYILREKSTLQKCN-FPFIMRYYRSFYDNYHIYFMNEFINGMDFFTVMREVGL---FNKQQAQFYTAFIILT
| . .......||||   . | ||    .. ..| . |. |.  ||| ... .| .. ..|   |...| ..||  .. .    |    |.|| | |.|.
KCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLA

LQYLNNQGIVYRDLKPENILIDH---EGWPKLVDMGTAKYLYDKNQQLTRTYSLVGTPHYMAPEVIQ----QKGYGFAVDIYSLGVILYELLVGYLPYGE
...|  |||..||||||||| |.   ||  ||.| | .|..  ....  .|.. ..| .|||||..     |.|.. |.|..||||..||.|.|..|.  
VEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG

DVD-DPIEVYQLILEGR--LGFPNHMKNRLSD--KKLISQLMAKSPEVRLG-GSYGA--LKSHEWF
. | .. |. . |..|.  |..||   . ||.  | ||.... . |. ||| |  .|  .|.|.||
PNDNNRKEIMKRIQKGKFSLTMPNW--QYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 11833.AA AktR 902-1144 33 5.6e-57 195.61 In-house 20-268 (268) Show / Hide 
Range on Protein: 902-1144
Range on HMM: 20-268/268
Sequence Identity: 33% (86 aa)

EK-QKDRLFAMKVFISN-YIFQRGIEKYILREKSTLQ-KCNFPFIMRYYRSFYDNYHIYFMNEFINGMDFFTVMREVGLFNKQQAQFYTAFIILTLQYLN
.| . ....|||. |..  | .|  ......|.  .. .||.||| . . .| ......|  |.. | . |.. .  . |. .||.|| | |.| |.|| 
KKRDNQKQYAMKM-IKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLH

NQ-GIVYRDLKPENILIDHEGWPKLVDMGTAKYLYDKNQQLTRTYSLVGTPHYMAPEVIQQ-KGYGFAVDIYSLGVILYELLVGYLPYGEDVDDPIEVYQ
..  |.||||||||||.| .|  |..| | .| |  ..    ..||..|||.|||||.|.. ||....||....|. .||...|. |   . .  .  ..
QHMNIIYRDLKPENILLDEDGHVKITDFGLSK-LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKI

LILEGRLGFPNHMKNRLSD--KKLIS-QLMAKSPEVRLG-GSYGA--LKSHEWF
.| .  . || ...  .|.  |.||  .|. | |. ||| .. |.  .||| ||
KIKQ-QNKFPYPSY--FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 11833.AA Ciliate-E2-Unclassified 835-1144 23 1.7e-53 183.91 In-house 2-352 (352) Show / Hide 
Range on Protein: 835-1144
Range on HMM: 2-352/352
Sequence Identity: 23% (93 aa)

VYIKELGRGNFGSVNLVFNNIQTQDF----TTNNKRISTQQDINQN---------FNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIFQ
  || .|.|.||.| .. .. |   .    . . ..|  |. |...          |..|. |.|.                                  
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQR-K--------------------------------

RGIEKYILREKSTLQKCNFPFIMRYYRSFYDNYHIYFMNEFINGMDFFTVMREV-----------------GLFNKQQAQ-----FYTAFIILTLQYLNN
  . . |. .   |. .. |||....  | |  .||.  |...| | .  ...                    |  |||.     ||.| |.. |.||  
--Y-NKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH

QG-IVYRDLKPENILIDHEG---WPKLVDMGTAKYLYDKNQ-QLTR------------TYSLVGTPHYM----APEVIQQKGYG----FAVDIYSLGVIL
.. |..||.||||||.| .|    .|. | | .|.. . |. . |.            ... .||| ||    ||||.|...|.    ...||.||||||
KNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL

YELLVGYLPYG--EDVDDPI------------EVYQLILEGRLGFPNHMK----NRLSDKK--LIS----QLMAKSPEVRLGGSYGALKSHEWF
||.| ||.|..   . .. .            ..|| |... . ||.. .     ..|..   .|.    ... | |. |.  ..  .. | ||
YEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI--TFEQILNHPWF
Kinase 11833.AA Pkinase 834-1144 23 2.7e-52 184.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 834-1144
Range on HMM: 1-293/293
Sequence Identity: 23% (83 aa)

LVYIKELGRGNFGSVNLVFNNIQTQDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIFQRGIEKYIL-REK
.. .. .|.|.||.| .  .    .                                                 ..|.|..    .     .  .. .| 
YHIGRKIGSGSFGCVYKCHHKGTGK-------------------------------------------------IVAVKIIKKRHEKSWKDQTHRRLSEI

STLQKCNFPFIMRYYRSFYDNYHIYFMNEFINGM----DFFTVMR--EVGLF--NKQQAQFYTAFIILTLQYLNNQGIVYRDLKPENILIDHEGWP----
. ....| |.| |.|..|.|. |||.  |. .|     | |....  . | |    ....||   |.  |.|. ..||..|||||||||||..| .    
QIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV

KLVDMGTAKYLYDKNQQLTRTYSLVGTPHYMAPEVIQ-QKGYGFAVDIYSLGVILYELLVGYLPYG-E----DVDDPIEVYQLILEGRLGFPNHMKNR--
|. | | || ..  .   . .....|||.|||||||. ...|| .||..|.|.||||.| |..|.  .    . .|.......|....| |.   ...  
KICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSIS

-----------------LSDKKLISQLMAKSPEVRLGGSYGALKSHEWF
                  . |..|. . .| |. |..     .. |.||
YFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT--AEQILQHPWF
Kinase 11833.AA PKG 902-1144 35 7.7e-50 171.89 In-house 21-260 (260) Show / Hide 
Range on Protein: 902-1144
Range on HMM: 21-260/260
Sequence Identity: 35% (87 aa)

EKQKDRLFAMKVFISNYIFQRGIEKYILREKSTLQKCNFPFIMRYYRSFYDNYHIYFMNEFINGMDFFTVMREVGLFNKQQAQFYTAFIILTLQYLNNQG
..|| | ||.|.     |     .  |  ||  ...|. .|| | || | |.  .|.  |   | .  |..|. | |  . ..||.| ..  . || ...
NHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDKTTRFYCACVVEAFDYLHRKN

IVYRDLKPENILIDHEGWPKLVDMGTAKYLYDKNQQLTRTYSLVGTPHYMAPEVIQQKGYGFAVDIYSLGVILYELLVGYLPYGEDVDDPIEVYQLILEG
|.||||||||.. |..|..|||| | || .    .|  .|.   ||| | |||.|  ||  ..||. .||.  .|||.|  |.     ||. .|..|| |
IIYRDLKPENLMLDNRGYCKLVDFGFAKKI----GQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPF--SGSDPMKTYNIILKG

--RLGFPNHMKNRLSDKKLISQLMAKSPEVRLGGS---YGALKSHEWF
   . || .   . ..  .| .|    |  |||      .  | | ||
IDMWEFPRKITRWAQN--MIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase 11833.AA CAMK 839-1144 18 4.5e-49 155.85 In-house 1-425 (425) Show / Hide 
Range on Protein: 839-1144
Range on HMM: 1-425/425
Sequence Identity: 18% (86 aa)

ELGRGNFGSVNLVFNNIQT------QDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIF------------
.||||.|| | |...   |                                                       . .|.|.   . .             
TLGRGSFGKVKLCIHKNTTGKERVHH-----------------------------------------I-YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYK

-------------QRGIEKYILREKSTLQKCN-------FPFIMRYYRSFYD-------------------NYHIYFMN---EFINGM----DFFTVMRE
             .   .| ..|| . ..|..        | | . |  . |                   . |.|.     |.. |     | |   .|
IDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVE

VGL---------------FNKQQAQFYTAFIILTLQYLNNQGIVYRDLKPENILIDHEG----------------W-PKLVDMGTAKYL-----------
 |                |. ..|..|   |.  ..|. ...|| |||||||||.|. .                .  |..| | |...           
HGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSD

YDKNQQLTR-----------TYSLVGTPHYMA-PEVIQQ--------------KGYGFAVDIYSLGVILYELLVGYLPYGED-----------VDDPIEV
|. .. . .            .  .|||.||| |||...              ..||...|. |.||||| .|.||.|. .|            ... | 
YKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYEL

YQLILEGRLGFPNHMKNRLS----------------------DKKLISQLMAKSPEVRLGGSYGALKSHEWF
.. |..|.  || ..   .|                       | ||.... . || |.  .    ..|.|.
FEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRM--TIEQCLNHPWM
Kinase 11833.AA TyrKc 834-1122 15 3.7e-11 -42.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 834-1122
Range on HMM: 1-280/280
Sequence Identity: 15% (53 aa)

LVYIKELGRGNFGSVNLVFNNIQTQDFTTNNKRISTQQDINQNFNIRKSKYSQKNPEIQIQKKSNKFNEKQKDRLFAMKVFISNYIFQRGIEKYILREKS
.. .|.||.|.|| | .   .                                                    .  | |.  ..       .. ..|| .
ITLGKKLGEGAFGEVYKGTWK----------------------------------------------------IQVAVKMLKEDA------REDFMREAR

TLQKC--NFPFIMRYYRSFYDN-------YHIYFMNEFINGMDFFTVMREVGL-FNKQQAQFYTAFIILTLQYLNNQGIVYRDLKPENILIDHEGWPKLV
 . |   . | | | |    .          ..   |.  . |     |. .  .. ..   .   |    .||  .... |||   |.|.....  |  
IMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKIS

DMGTAKYLYDK-----NQQLTRTYSLVGTP-----HYMAPEVIQQKGYGFAVDIYSLGVILYELL-VGYLPYGEDV---DDPIEVYQLILEG-RLGFPNH
| | ....||.     ...  |. .  |.        ||||.|. . . .. |..| || ..|..  |  || ...    ...||.... .| |.  | .
DFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPN

------------------------MKNRLSDKKLISQL
                         ..| . . .....
DYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 11833.AA Pkinase_Tyr 1051-1102 32 0.000931 13.35 Pfam 181-233 (270) Show / Hide 
Range on Protein: 1051-1102
Range on HMM: 181-233/270
Sequence Identity: 32% (18 aa)

MAPEVIQQKGYGFAVDIYSLGVILYELLV-GYLP-YGEDVDDPIEVYQLI-LEGR
||||.|. . .  . |..| || ..|..  |  | | ... .. |||..|  .|.
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY-PGM-SNEEVYEYIYEDGY
Kinase 11833.AA Pkinase_Tyr 834-848 46 0.002444 11.93 Pfam 1-15 (270) Show / Hide 
Range on Protein: 834-848
Range on HMM: 1-15/270
Sequence Identity: 46% (7 aa)

LVYIKELGRGNFGSV
.. .|.||.|.||.|
ITFGKKLGEGAFGEV
Kinase 11833.AA AktR 835-851 52 0.107214 2.85 In-house 2-18 (268) Show / Hide 
Range on Protein: 835-851
Range on HMM: 2-18/268
Sequence Identity: 52% (9 aa)

VYIKELGRGNFGSVNLV
...| ||.|.|| | ||
HVYKCLGKGAFGKVYLV
Kinase 11833.AA RSK 837-851 46 0.149896 1.89 In-house 1-15 (278) Show / Hide 
Range on Protein: 837-851
Range on HMM: 1-15/278
Sequence Identity: 46% (7 aa)

IKELGRGNFGSVNLV
.|.||.| .|.| |.
LKVLGQGGYGKVFLC
Kinase 11833.AA PKG 834-851 55 0.331703 1.12 In-house 1-18 (260) Show / Hide 
Range on Protein: 834-851
Range on HMM: 1-18/260
Sequence Identity: 55% (10 aa)

LVYIKELGRGNFGSVNLV
|  |  || | || | ||
LKIIATLGVGGFGRVELV