Gene 8030 (Tetrahymena)
8030
Sequence
Protein domains of 8030.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 8030.AA | Ciliate-E2a | 129-353 | 46 | 1.5e-140 | 416.41 | In-house | 43-275 (275) | Show / Hide |
Range on Protein: 129-353 Range on HMM: 43-275/275 Sequence Identity: 46% (109 aa) QKSLEKEIKIMQTVGSHPNLLEFIGSYEGENTYYVAMGLIEGNSLYNEIKKRKDEKFPIQKIKSFIQQIIS-GVLHFQKYGVMHRDLKPENIMFK--RKE ......||.||... .|||.. ... ||.||.|| | ..|| .||..||. |.... ||.|....||... |.........||||||||||.|| |. KEYFMNEINIMRQL-DHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKN N--LDELVIVDFGLAEFE--NEPQYLFSKCGTPGYVAPEVANYKEE-LQNRYTTKCDMFSVGVILHTLLYHSSVFYGKKFNDVLLKNKECKIDFNSKL-Y . . ...|.|||||.| .|..|.|.||||||||||||.|.||. ....|.|||||.|.|||...||.....|.||..|..| .||.||||||.. . SIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECW ENTSERTMNFMKGLLEKDPIKRLSAQQALNHEFF |. | ....||..|||||.||..||||||| .| EKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF |
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Kinase | 8030.AA | Ciliate-E2 | 130-353 | 24 | 6.5e-74 | 251.86 | In-house | 61-365 (365) | Show / Hide |
Range on Protein: 130-353 Range on HMM: 61-365/365 Sequence Identity: 24% (78 aa) KSLEKEIKIMQTVGS---------------HPNLLEFIGSYE--GENTYYVAMGLIEGNSLYNEIKKR----------KDEKFPIQKIKSFIQQIIS--- .....||.||... . |||..... ... .|..| | ...|..|. ||.. . ..| ...|| ...||.. EQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFK ------------GVLHFQKYG-VMHRDLKPENIMFKRKENLDELVIVDFGLAEFENEP-----------QYLFSK----------------------CGT .. . . . ..|||.|||||.| . |.||||. . ... |.| | ||| TKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGT PGYVAPEVANYKEEL----QNRYTTKCDMFSVGVILHTLLYHSSVFYGKKFNDVLLKNKECKIDFNSKL--------------YENTSERTMNFMKG--- |||.|||. |.|.. |..|..|||..|.||||. .|. | . ..|.|||||... ... |. .....| PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK -LLEKDPIKRLS-AQQALNHEFF .|.||| ||.. ..|.|||..| RMLQKDPEKRITGWEQILNHPWF |
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Kinase | 8030.AA | CAMK | 129-353 | 21 | 3e-62 | 199.08 | In-house | 75-425 (425) | Show / Hide |
Range on Protein: 129-353 Range on HMM: 75-425/425 Sequence Identity: 21% (75 aa) QKSLEKEIKIMQTVG------SHPNLLEFIGSYEG-------------------ENTYYVAM---GLIEGN----SLYNEIKKRKD-------------E .|....||.||... .|||.. .. || .. .| | ...| |.. |..... RKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERG KFPIQKIKSFIQQIISGVLHFQKYGVMHRDLKPENIMFKRKENLDE--------------LVIVDFGLA--EFENEPQY--------------------- .|. . . ...||.|.| . . ...|||||||||.. ... .. . |.|||.| ...| .. RFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQ -LFSKCGTPGYVA-PEVANYKE---------ELQNRYTTKCDMFSVGVILHTLLYHSSVFYGK-------------KFNDVLLKNKECKIDFNSKLYENT . ||||.|.| ||| |.| | . |. |||| |.|||| ..| . |||. .. . | ...| || .. .. KMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPI S--------------------ERTMNFMKGLLEKDPIKRLSAQQALNHEFF | . ... ...|..|| ||....|.|||... SCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | 8030.AA | CAMK1 | 194-353 | 38 | 2.8e-57 | 165.05 | In-house | 114-276 (276) | Show / Hide |
Range on Protein: 194-353 Range on HMM: 114-276/276 Sequence Identity: 38% (63 aa) IQQIISGVLHFQKYGVMHRDLKPENIMFKRKENLDELV--IVDFGLAEFENEPQ-YLFSKCGTPGYVAPEVANYKEELQNRYTTKCDMFSVGVILHTLLY ..||.| | . . |..||||||||. .. |.. ... | ||||. .... ... ||||||||||| ..|. | .|||.|.|||. .|| MKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK--DKPYDKACDMWSIGVITYILLC HSSVFYGKK-FNDVLLKNKECKIDFNSKLYENTSER-TMNFMKGLLEKDPIKRLSAQQALNHEFF . ||.. | . |.|.|...| |. | |. .| |..||.|| ||....|.||| .. GYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Pkinase | 8030.AA | Pkinase | 116-353 | 26 | 2.8e-52 | 184.8 | Pfam | 36-293 (293) | Show / Hide |
Range on Protein: 116-353 Range on HMM: 36-293/293 Sequence Identity: 26% (73 aa) RIQDEFFQQDIARQKSLEKEIKIMQTVGSHPNLLEFIGSYEGENTYYVAMGLIEGN----SLYNEIKKRKDEKF--PIQKIKSFIQQIISGVLHFQKYGV .. ... |... . ||.||. . .||| .......| .. .|. | . || .|. |. ... .| . . .|... ||..|. . . |. HEKSWKDQTHRRL-----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGI MHRDLKPENIMFKRKENL-DELVIVDFGLAEF--ENEPQYLFSKCGTPGYVAPEVANYKEELQ--NRYTTKCDMFSVGVILHTLLYHSSVFYGK----KF .|||||||||..... .. . . | |||||.. . . . . ||||.|.|||| .. . |..|.||.|.|.||. .| |.|. . IHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN- ND---VLLKNKECKIDFNSKLYENTS-----------------ERTMNFMKGLLEKDPIKRLSAQQALNHEFF .| .. ........|.. . | | |.|..|.||| ||..|.|.|.|..| HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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S_TKc | 8030.AA | S_TKc | 54-353 | 22 | 2.9e-52 | 180.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 54-353 Range on HMM: 1-231/231 Sequence Identity: 22% (74 aa) YDIVK----------WVVQKSDTQLTYTGMILTIRKEKEDKTFEKIEDFEFIGDSIILEQVKDYLRRYIFQTRIQDEFFQQDIARQKSLEKEIKIMQTVG |.|.. . ... . || | | . | .....||.|.. YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK------------------------------------------------EHIRREIQILKK-- SHPNLLEFIGSYEGENTYYVAMGLIEG--NSLYNEIKKRKDEK----FPIQKIKSFIQQIISGVLHFQKYGVMHRDLKPENIMFKRKENLDELVIVDFGL |||. ...... . .|. | ...| .|. ||||. .. || ......||.... . . |..|||||||||.. . .. | |||| HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGL AEFENEPQYLFSKCGTPGYVAPEVANYKEELQNRYTT-KCDMFSVGVILHTLLYHSSVFYGKKFNDVLLKNKECKIDFNSKLYENTSERTMNFMKGLLEK | . . |||| |.|||| |.. |||. |.|.|| .|. |. ....|. |. .|....|.| ARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQK DPIKRLSAQQALN-------HEFF || ||..| .||. |..| DPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 8030.AA | CDPK | 129-353 | 33 | 1.4e-40 | 122.32 | In-house | 45-271 (271) | Show / Hide |
Range on Protein: 129-353 Range on HMM: 45-271/271 Sequence Identity: 33% (78 aa) QKSLEKEIKIMQTVGSHPNLLEFIGSYEGENTYYVAMG--LIEGNSLYNEIKKRKDEKFPIQKIKSFIQQIISGVLHFQKYGVMHRDLKPENIMFKRKEN |... .||.|. . ||| . . |. |. ||. | . .| | |. .. |. .. . ..||.| | . . ...|||||||||.|. |.. QQQFFNEIEILKQL-DHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH--FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKD LD----ELVIVDFGLA-EFENE----PQYLFSKCGTPGYVAPEVANYKEELQNRYTTKCDMFSVGVILHTLLYHSSVFYGKKFNDVLLKNKECKIDFNSK . .....|.|.. .|. . ... .|||| |.|||| || .| ||| | |||| .|| . |||| .... | |..| .|. . DSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEV------LQKKYNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGP LYENTSERTMNFMKGLLEKDPIKRLSAQQALNHEFF .. |. .. . .|..|| ||.||||||.| | EWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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Kinase | 8030.AA | CAMKL | 127-353 | 24 | 5.9e-38 | 118.61 | In-house | 55-297 (297) | Show / Hide |
Range on Protein: 127-353 Range on HMM: 55-297/297 Sequence Identity: 24% (61 aa) ARQKSLEKEIKIMQTVG--SHPNLLEFIGSYEGENT------YYVAMGLIEGNS--LYNEIKKRKDEK--FPIQKIKSFIQQIISGVLHFQKYGVMHRDL ... ...||.||. . ||| . .| ... .| | ...| . |.. |.|... . .| . . .||.|.| . . |. |||. SDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDI KPENIMFKRKENLDELVIVDFGLAEFENE-----PQYLFSKCGTPGYVAPEVANY-KEELQNRYTTKCDMFSVGVILHTLLYHSSVFYGKKF------ND |||||.. . | . |.|||.. . . | | ||.| | |||. . ... . | |. | |||| .... | . | KPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKP---YDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI VLLKNKECKIDFNSKLYENTSERTMNFMKGLLEKDPIKRLSAQQALNHEFF .|..|. . .. . | . .. ...|...| || ...| .||... -YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | 8030.AA | Ciliate-E2-Unclassified | 123-353 | 23 | 6e-37 | 125.71 | In-house | 47-352 (352) | Show / Hide |
Range on Protein: 123-353 Range on HMM: 47-352/352 Sequence Identity: 23% (74 aa) QQDIARQKSLEKEIK---------IMQ---TVGSHPNLLEFIGSYEGENTYYVAMGLIEGNSLYNEIKKRKD---------------EKFPIQKIK---- . .| ... ....| ||| ||... .. . ... | | ..||..| . ||||| ..|. |..| D-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKA -SFIQQIISGV--LHFQKYGVMHRDLKPENIMFKRKENLDELVIVDFGLAEFENE----------------PQYLFSKCGTPGYV----APEVANY-KEE .. ||..| || .. .. |||.|||||.|. . . .. | |||.. . .. .| . ..||||.| |||| . . KFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYD LQNRYTTKCDMFSVGVILHTLLYHSSVFYGKKFND----------------VLLKNKECKIDFNSKLY----ENTSERTMNFMK----GLLEKDPIKRLS . |||..|.||||. .|. ||... .. .. . |...|.|.. . |. .| . .|.|.| ||.. HSKA--YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRIT AQQALNHEFF ..|.||| .| FEQILNHPWF |
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Kinase | 8030.AA | CAMK-Unique | 128-353 | 20 | 8.8e-37 | 118.81 | In-house | 59-363 (363) | Show / Hide |
Range on Protein: 128-353 Range on HMM: 59-363/363 Sequence Identity: 20% (63 aa) RQKSLEKEIKIMQTVGSHPNLLEFIGS----YEGEN---------------TYYVAMGLIEGNSLYNEIKK---RK---------------DEKFPI--Q | .|..|. |...| .|||.... . .. .. .| | ...|. |. .| | .. .| RDMKLKREHQIWKMV-DHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCW KIKSFIQQIISGVLHFQKYGVMHRDLKPENIMFKRKEN-------------LDELVIVDFGLAEFENEPQYLF---SKCGTPGYVAPEVANYK------- . . .|.. | | . . .. |||||.||||.. .. ... ||||. .|. . . |||| |.|||. | DTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTR -EELQ-NRYTTKC----DMFSVGVILHTLLYHSSVFYGKKFN--------DVLLKNKECKI-DFNSKLYEN---TSERTMNFMKGLLEKDPIKRLSAQQA | . .| .| | | |||....| .. |.. . . . . ... .| .| .. |. .| |.... || .|.|| .. DEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKEL LNHEFF | |... LEHQWI |
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Kinase | 8030.AA | RSK | 134-353 | 23 | 8.5e-35 | 121.93 | In-house | 49-278 (278) | Show / Hide |
Range on Protein: 134-353 Range on HMM: 49-278/278 Sequence Identity: 23% (55 aa) KEIKIMQTVGSHPNLLEFIGSYEGENTYYVAMGLIEGNSLYNEIKKRKD-EKFPIQKIKSFIQQIISGVLHFQKYGVMHRDLKPENIMFKRKENL-DELV .|..|......||.. . ... | | | ...| |. ..|.| | . . .|.. | | . |. |||||||||.. .. ... TERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIK IVDFGLAEF-ENE-PQYLFSKCGTPGYVAPEVANYKEELQNR-YTTKCDMFSVGVILHTLLYHSSVFYG---KKFNDVLLKNKECKIDFNSKLYENTSER ..|||.. .. | . . |.| |.|||. . . |.. .. || .| ||.....| . |.| . .... . ...|...... .. |. LTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQE TMNFMKGLLEKDPIKRLS-----AQQALNHEFF .. ...|..|| |||. |.. ..|..| AKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | 8030.AA | ULK | 130-353 | 25 | 1.6e-34 | 117.94 | In-house | 55-329 (329) | Show / Hide |
Range on Protein: 130-353 Range on HMM: 55-329/329 Sequence Identity: 25% (70 aa) KSLEKEIKIMQTVG-------SHPNLLEFIGSYEGE--NTYYVAMGLIEGNSLYNEIKKRKD--------EKFPIQKIKSFIQQIISGVLHFQKYGVMHR ..|..|||||.. .||| ... .| | .| | . .| | . |||.| ... |....|..||..| . .| ...|| QLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHR DLKPENIMFKRKENLD---------ELVIVDFGLAEFENEP------QYLFS----KCGTPGYVAPEVANYKEELQNRYTTKCDMFSVGVILHTLLYHSS |.||.||. . . | | |||.| . ... . .. |||| | ||.. . . | .. |. |||..|.|.|.. .|| DIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKP VFYGKKFNDVLLKNKECKID-----------FNSKLY-----ENTSERTMNFMKGLLEKDPIKRLSAQQALNHEFF ||. ||| |.... |. .. . . . |. . .. ...|..|. .| | .. .||..| PFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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TyrKc | 8030.AA | TyrKc | 115-353 | 17 | 3.9e-10 | -58.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 115-353 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) TRIQDEFFQ--------------------QDIARQKSLEKEIKIMQTVG-SHPNLLEFIGSYEGE-------NTYYVAMGLIEGNSLYNEIKKRKDEKFP . .. .. | .. . .|..|| .| .|||.. ..| . ... | . .. .| . ..|.... .. ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LC IQKIKSFIQQIISGVLHFQKYGVMHRDLKPENIMFKRKENLDELVIVDFGLAEFENEP-------QYLFSKC--GTPG-----YVAPEVANYKEELQNRY .. || || .| . . .. |||| |.. ... | ||||. . . .| .| |. . |||. ... MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKF TTKCDMFSVGVILHTLLYHSSVFYG------KKFNDVLLKNKECKIDFNSKLYE-----NTSERTMNFMKGLLEKDPIKRLSAQQALNHEFF ||| | .| || . .. | .. .|. . |. . . .. .. . || . || .| . .. ||.| TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 8030.AA | CAMK1 | 129-170 | 43 | 3.6e-08 | 19.79 | In-house | 49-92 (276) | Show / Hide |
Range on Protein: 129-170 Range on HMM: 49-92/276 Sequence Identity: 43% (19 aa) QKSLEKEIKIMQTVG--SHPNLLEFIGSYEGENTYYVAMGLIEG |..||.|| ||..|. .||| |. || .| .| | |. | QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTG |
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Kinase | 8030.AA | Pkinase_Tyr | 129-197 | 20 | 1.2e-05 | 19.81 | Pfam | 47-120 (270) | Show / Hide |
Range on Protein: 129-197 Range on HMM: 47-120/270 Sequence Identity: 20% (15 aa) QKSLEKEIKIMQTVGSHPNLLEFIGSYE-GENT--YYVAMGLIEGNSLYNEIKKR--KDEKFPIQKIKSFIQQI .... .|.||| . |.|||.. ..| . .|. | . .. .|.. .|. ....... . .. .|| REDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQI |