Gene 1090 (Tetrahymena)
1090
Sequence
Protein domains of 1090.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 1090.AA | Ciliate-E2a | 1-214 | 50 | 1.2e-147 | 437.67 | In-house | 53-275 (275) | Show / Hide |
Range on Protein: 1-214 Range on HMM: 53-275/275 Sequence Identity: 50% (113 aa) MRNLRDHPNVIKLYEVFEGEHTFYFVMEIVEGTSLYEEIKKHAQNPYKDEEVRDIMSMLI-DGIAYCASKNIMHRDIKPENLLFG-KVGNQ---KILKIV ||.| ||||.||||||.|.|...|.||| .|| .||..||.. .. ....|..||| .|. .|..|. ..||||||.||||.|| . | . .||. MRQL-DHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKII DFGLGTYA--DENPYIFPKCGTPGFVAPEIANLVDK-AQP-YSTVCDMFSVGVIFHILLTGEAVFPGKKFNEVLKKNKLCEIDLEKKE-YENLSDPAKDL ||||.|.. ||. |.|.||||||.||||..|. .. .. |.| |||.|.||||.|||.|. .|.||..||.|..|| |.||.. .| .|..|...||| DFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDL LRRMLEKDPQKRITAAEALQHHYF ...||||||.|||||..||.|..| MKKMLEKDPKKRITAQQALNHPWF |
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| Kinase | 1090.AA | Ciliate-E2 | 6-214 | 29 | 1e-83 | 284.41 | In-house | 90-365 (365) | Show / Hide |
Range on Protein: 6-214 Range on HMM: 90-365/365 Sequence Identity: 29% (86 aa) DHPNVIKLYEVFE--GEHTFYFVMEIVEGTSLYEEIKKH----------AQNPYKDEEVRDIMSMLID---------------GIAYCASKN-IMHRDIK .|||.||.||.|. ....|.||| ..| .|.. ||.. . ......|...|| ... .. |. ||| |.||||| NHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK PENLLFGKVGNQKILKIVDFGLGTYADEN-----------PYIFPK----------------------CGTPGFVAPEIANLVD-----KAQPYSTVCDM |||.|| .||.|||| ...|.. |.| | |||||..|||| | . | ..|.. ||. PENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDI FSVGVIFHILLTGEAVFPGKKFNEVLKKNKLCEIDLEKKE--------------YENLSDPAKDLLRR----MLEKDPQKRIT-AAEALQHHYF .|.|||....|.|. | ....| |.||. ..| ....|. .|||... ||.|||.|||| . ..|.|..| WSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | 1090.AA | CAMK | 1-214 | 24 | 7.6e-68 | 217.45 | In-house | 85-425 (425) | Show / Hide |
Range on Protein: 1-214
Range on HMM: 85-425/425
Sequence Identity: 24% (82 aa)
MRNLR------DHPNVIKLYEVFEGEHT-------------------FYFVM---EIVEGT----SLYEEIKKHAQ-------------NPYKDEEVRDI
|..|. ||||.||||||.| .| .|.|| | ..| |.. |..| . .. .|.| .
MKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRY
MSMLIDGIAYCASKNIMHRDIKPENLLFGKVG--------------NQKILKIVDFGLGTYADE------------------------NPYIFPKCGTPG
. ......|| |.||.|||.||||.|. . . |. .||.|||. .. |. .. ||||.
FRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPE
FVA-PEIANL----------VDKAQPYSTVCDMFSVGVIFHILLTGEAVFPGK-------------KFNEVLKKNKLCEIDLEKKEYEN-----------
..| ||. | .. ..|. ||| |.||| |.|.|. | |. .| ..| . .. | . .. .
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWD
---------LSDPAKDLLRRMLEKDPQKRITAAEALQHHYF
.|. .|||.|.||..||.||.|....|.| .
DISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 1090.AA | CAMK1 | 53-214 | 40 | 3e-62 | 179.75 | In-house | 111-276 (276) | Show / Hide |
Range on Protein: 53-214 Range on HMM: 111-276/276 Sequence Identity: 40% (68 aa) RDIMSMLIDGIAYCASKNIMHRDIKPENLLFGKVGNQKILK--IVDFGLGTYADENP-YIFPKCGTPGFVAPEIANLVDKAQPYSTVCDMFSVGVIFHIL |.|| ... . |. ||.|.|||.||||||. .. ..| | |||| .. |.. . . |||||.||||. . ..||. |||.|.|||. || RHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKACDMWSIGVITYIL LTGEAVFPGKK-FNEVLKKNKLCEIDLEKKEYENLSDP-AKDLLRRMLEKDPQKRITAAEALQHHYF |.| | .. || ..|.| ||.. ... | || |||... |||.||.||.|....|.| . LCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | 1090.AA | Pkinase | 1-214 | 29 | 8e-61 | 213.18 | Pfam | 54-293 (293) | Show / Hide |
Range on Protein: 1-214 Range on HMM: 54-293/293 Sequence Identity: 29% (73 aa) MRNLRDHPNVIKLYEVFEGEHTFYFVMEIVEGT----SLYEEIKKHAQNPY--KDEEVRDIMSMLIDGIAYCASKNIMHRDIKPENLLFG-KVGNQKILK |..| .|||...||..|| . |.||| .||. .|.. |. ...... ..|....| .. |..|| |..|.|||.||||.|. . . ..| MKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVK IVDFGLG----TYADENPYIFPKCGTPGFVAPEIANLVDKAQPYSTVCDMFSVGVIFHILLTGEAVFPGK------KFNEVLKKNKLCEIDLEKKEYENL | |||| . .. .. | ||||...|||. . ..|.|.. .||.|.|.|....|.|. |||. ........ .... . . . ICDFGLAKQFDY-NNS-MTTF--CGTPWYMAPEVIR---GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSI S-----------------DPAKDLLRRMLEKDPQKRITAAEALQHHYF | ...||.....|.|||.||.||...||| .| SYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 1090.AA | CDPK | 1-214 | 37 | 8e-61 | 185.36 | In-house | 55-271 (271) | Show / Hide |
Range on Protein: 1-214 Range on HMM: 55-271/271 Sequence Identity: 37% (85 aa) MRNLRDHPNVIKLYEVFEGEHTFYFVME--IVEGTSLYEEIKKHAQNPYKDEEVRDIMSMLIDGIAYCASKNIMHRDIKPENLLFGKVGNQK----ILKI ...| ||||.||.||... | .|.||| ...| | . |. ...... | ..|| .. ..|| |.||.|||.||||.|| . . ..|. LKQL-DHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYII--EKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKV VDFGLGTYADEN-----PYIFPKCGTPGFVAPEIANLVDKAQPYSTVCDMFSVGVIFHILLTGEAVFPGKKFNEVLKKNKLCEIDLEKKEYENLSDPAKD .|.|. .. | | .. .|||| .|||. .| | || | ||| ||| |. | || .|...| | .. ..|..| .. || ||| IDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEV---LQKK--YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKD LLRRMLEKDPQKRITAAEALQHHYF | |.||..||.||..|..|||| .| LIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | 1090.AA | Ciliate-E2-Unclassified | 6-214 | 25 | 2.8e-53 | 183.18 | In-house | 79-352 (352) | Show / Hide |
Range on Protein: 6-214 Range on HMM: 79-352/352 Sequence Identity: 25% (72 aa) DHPNVIKLYEVFEGEHTFYFVMEIVEGTSLYEEIKKHAQ---------------NPYKDEEVR-----DIMSMLIDGIAYCASKN-IMHRDIKPENLLFG .||...|....|. . ..|.||| .|| .| . ||| . . ..... ... ...|. |. .|| | ||||||||.|| PHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFD KVGNQKILKIVDFGLGTYADENPYIFPK-----------------CGTPGFV----APEIANLVDKAQPYSTV----CDMFSVGVIFHILLTGEAVFPGK . |. .|| |||. . ..|... . ||||.. |||. . | |.. ||..|.|||.. .|.|. |... NNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL----QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDN KFNE----------------VLKKNKLCEIDLEKKEY----ENLSDPAKDLLR----RMLEKDPQKRITAAEALQHHYF . .. .... | ..|. | . ..|. |||... .||.|.| ||||. ..|.|..| NCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 1090.AA | S_TKc | 1-214 | 30 | 1.5e-52 | 181.85 | SMART | 18-231 (231) | Show / Hide |
Range on Protein: 1-214
Range on HMM: 18-231/231
Sequence Identity: 30% (76 aa)
MRNLR-----------------------DHPNVIKLYEVFEGEHTFYFVMEIVEG--TSLYEEIKKHAQNP----YKDEEVRDIMSMLIDGIAYCASKNI
|. . .|||..|||.||. . .|.||| ..| .|.. |||. .. . ..| .| ......|| |..|
CRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGI
MHRDIKPENLLFGKVGNQKILKIVDFGLGTYADENPYIFPKCGTPGFVAPEIANLVDKAQPYST-VCDMFSVGVIFHILLTGEAVFPGKKFNEVLKKNKL
.|||.||||.|. . .|| |||| . |||| ..|||. .|.. ||. |.|.|. ..|.|. || ....|| .
IHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-
CEIDLEKKEYENLSDPAKDLLRRMLEKDPQKRITAAEALQ-------HHYF
|..|||..|..|.|||.||.|| |||| | .|
-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 1090.AA | CAMKL | 1-214 | 29 | 1.1e-46 | 146.92 | In-house | 66-297 (297) | Show / Hide |
Range on Protein: 1-214 Range on HMM: 66-297/297 Sequence Identity: 29% (71 aa) MRNLR--DHPNVIKLYEVFEGEHT------FYFVMEIVEGTS--LYEEIKKHAQ--NPYKDEEVRDIMSMLIDGIAYCASKNIMHRDIKPENLLFGKVGN |. |. |||.||||||.| . . .| ||| ..| . |.. |.|| . . .| | . ......|| |..| ||||||||.|. . || MKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGN QKILKIVDFGLGTYADE-----NPYIFPKCGTPGFVAPEIANL--VDKAQPYSTVCDMFSVGVIFHILLTGEAVFPGKKF------NEVLKKNKLCEIDL . .||.|||.... .. . ||.| . |||| . . | |. | ||| ...|. | . | ....| . N-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKV---DIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-Y EKKEYENLSDPAKDLLRRMLEKDPQKRITAAEALQHHYF . . .| ...||.|.||...| ||.|. . ..| . YPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | 1090.AA | CAMK-Unique | 6-214 | 23 | 5.9e-44 | 142.87 | In-house | 74-363 (363) | Show / Hide |
Range on Protein: 6-214 Range on HMM: 74-363/363 Sequence Identity: 23% (69 aa) DHPNVIKLYEV----FEGEH---------------TFYFVMEIVEGTSLYEEIKK------------------HAQNPYKD--EEVRDIMSMLIDGIAYC |||| ||||.. |. . .| |||...| |...| | | .. ... || | .|| DHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYM ASKNIMHRDIKPENLLFGKVGN-------------QKILKIVDFGLGTYADENPYIF---PKCGTPGFVAP--------------EIANLVDKAQPYSTV |..| |||.|.||... . .. .. .|. |||| .. ..| |||| ..|| |. | .|.|. HSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN----MQCYDQQ C----DMFSVGVIFHILLTGEAVFPGKKFN--------EVLKKNKLCEI-DLEKKEYEN---LSDPAKDLLRRMLEKDPQKRITAAEALQHHYF | | | ||| ...|.|. | . . | ... . ... ....| .. |. |||.. . .. || .|..|.|.|.| .. CSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | 1090.AA | RSK | 7-214 | 29 | 2.4e-43 | 150.32 | In-house | 60-278 (278) | Show / Hide |
Range on Protein: 7-214 Range on HMM: 60-278/278 Sequence Identity: 29% (66 aa) HPNVIKLYEVFEGEHTFYFVMEIVEGTSLYEEIKKHAQ-NPYKDEEVRDIMSMLIDGIAYCASKNIMHRDIKPENLLFGK-VGNQKILKIVDFGLGTY-- ||....|...|. | .| .|| ..| |.. ..|. . .|....|. .. . . .. | |||.|||| |. |. .|..|||. . HPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFR ADENPYIFPKCGTPGFVAPEIANLVDKAQP-YSTVCDMFSVGVIFHILLTGEAVFPG---KKFNEVLKKNKLCEIDLEKKEYENLSDPAKDLLRRMLEKD .|.| |.| ..|||. . . | .. || .| ||. . .||| | | . .|..|. . ....|. .. ..||..||||.|.||..| CDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRD PQKRIT-----AAEALQHHYF |.||.. |.| .|| .| PHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 1090.AA | CMGC | 1-108 | 18 | 6.1e-30 | 94.84 | In-house | 75-282 (513) | Show / Hide |
Range on Protein: 1-108
Range on HMM: 75-282/513
Sequence Identity: 18% (38 aa)
MRNLR----------------DHPNVIKLYEVFEGEH-----------------TFYFVMEIVEGTSLYEEIKKHA-------QNPYKDEE---------
...|. .|.|..|||..| .. .|.|.| .. ..||. ||.. ..| .. .
LKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMD-HDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP
---VRDIM------SMLIDGIA--YCASKN--IMHRDIKPENLLFGKVGNQ-----------------KILKIVDFGLGTYADEN---------------
.. .| ... |.. || |.. |.|||.||||.|. . . .||| |||| .. ...
PHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNV
--------PY
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NKDDKPNRPY
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| Kinase | 1090.AA | CMGC | 182-214 | 50 | 1.2e-14 | 43.68 | In-house | 474-513 (513) | Show / Hide |
Range on Protein: 182-214 Range on HMM: 474-513/513 Sequence Identity: 50% (20 aa) N-------LSDPAKDLLRRMLEKDPQKRITAAEALQHHYF | ... | ||| .||. ||.|||||..|||| || NHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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| Kinase | 1090.AA | CAMK1 | 1-32 | 50 | 1.2e-10 | 27.13 | In-house | 59-92 (276) | Show / Hide |
Range on Protein: 1-32 Range on HMM: 59-92/276 Sequence Identity: 50% (17 aa) MRNL--RDHPNVIKLYEVFEGEHTFYFVMEIVEG |... ||||.||.||..| . ||.||| | | MKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTG |
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| Kinase | 1090.AA | TyrKc | 1-214 | 18 | 3.4e-07 | -106.36 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-214 Range on HMM: 1-280/280 Sequence Identity: 18% (55 aa) MRNLR--------------------------------------------DHPNVIKLYEVFEGE-------HTFYFVMEIVEGTSLYEEIKKHAQNPYKD . .. .|||...|| | . . . ||| ... .| . ..|| . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---- EEVRDIMSMLID---GIAYCASKNIMHRDIKPENLLFGKVGNQKILKIVDFGLGTYADEN-------PYIFPKC--GTPGFV-----APEIANLVDKAQP ..| |. .. | .| .|||. |||. | | ||.... || |||| . .. |. .| |. . . ||| . LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL---VGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYGK YSTVCDMFSVGVIFHILLTGEAVFPG------KKFNEVLKKNKLCEIDLEKKEY--ENL-----SDPAKDLLRRMLEKDPQKRITAAEALQHHYF ..| | .| || ..| . . .. ||... | . ... .. . . .| .. .. . || .| | .| |..| FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR-MPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 1090.AA | CMGC | 130-159 | 36 | 0.000451 | 8.25 | In-house | 309-346 (513) | Show / Hide |
Range on Protein: 130-159 Range on HMM: 309-346/513 Sequence Identity: 36% (14 aa) AQPYSTVCDMFSVGVIFHILLTG--------EAVFPGK .. |.| .|| ||| || ..|| . |||. SMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGH |
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