Gene 28065 (Tetrahymena)
28065
Sequence
Protein domains of 28065.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 28065.AA | C2 | 45-179 | 33 | 1.3e-46 | 157.31 | In-house | 1-117 (245) | Show / Hide |
Range on Protein: 45-179 Range on HMM: 1-117/245 Sequence Identity: 33% (46 aa) GSFALVIKAFNKTSQKHVALKIVLCNQNEPNDAESVLKEYNLLLKIKNCPYLVDVYNQFYVYEEKILIDDSDDEEQIGEKPK--KQNEILKSFLVLELEF |.|.||.|||||....||||||. |..|..| ..|.|||... ...|.||...||| ||....|. ..|.|..|.. |... ||.. .|.|.|.|.|| GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF CNSKDYQNILLLNFSKKVDKNADIYEQYHSVQTYDQI | .. ..||..... ... CQGN--------------------LKQYFNRCRKQNS |
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| Kinase | 28065.AA | Ciliate-C8 | 45-152 | 32 | 1.9e-26 | 91.9 | In-house | 1-106 (238) | Show / Hide |
Range on Protein: 45-152 Range on HMM: 1-106/238 Sequence Identity: 32% (36 aa) GSFALVIKAFNKTSQKHVALKIVLC-NQNEPNDAESVLKEYNLLLKIKNCPYLVDVYNQFYVYEEKILIDDSDDEEQIGEKPK-KQNEILKSFLVLELEF |.|..|.|| || ... ||||.. | |... | |.. ||| .. . ..|..|.||. ||. ||. ||....... .. | |. || |.|.|. GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK-----SFFVMEMEK CNSK-DYQNIL | .. .... . CQQNCNLKQYF |
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| Kinase | 28065.AA | C8 | 36-146 | 25 | 4.2e-15 | 48.97 | In-house | 1-105 (226) | Show / Hide |
Range on Protein: 36-146 Range on HMM: 1-105/226 Sequence Identity: 25% (29 aa) YNDFEYLGNGSFALVIKAFNKTSQKHVALKIVLCNQN-EPNDAESVLKEYNLLLKIKNCPYLVDVYNQFYVYEEKILIDDSDDEEQIGEKPKKQNEILKS |.|.|| .|....|.|| | ......||. | .. . . ||. ||| ...... .| .|. || .|.. .. . | . . || FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTE-------EKS FLVLELEFCNSK . | |.| |... CFVMEMELCEQN |
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| Kinase | 28065.AA | Ciliate-E1 | 42-112 | 31 | 2.4e-14 | 43.46 | In-house | 1-73 (202) | Show / Hide |
Range on Protein: 42-112 Range on HMM: 1-73/202 Sequence Identity: 31% (23 aa) LGNGSFALVIKAFNKTSQ-KHVALKIVLCNQN-EPNDAESVLKEYNLLLKIKNCPYLVDVYNQFYVYEEKILI .|||||..|.||... .. ..||.||..|..| . |. ....|||....|.|. |.......... . .| | IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICI |
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| Kinase | 28065.AA | CMGC | 36-104 | 14 | 3.2e-14 | 42.21 | In-house | 1-108 (513) | Show / Hide |
Range on Protein: 36-104 Range on HMM: 1-108/513 Sequence Identity: 14% (16 aa) YNDFEYLGNGSFALVIKAFN--------------KTSQKHVALKIVLCNQNEPNDAE----------SVLKEYNLLLKIK----------------NCPY | ...| |... | |... . ....||.|.. .. ....| . | | .| ... . .. YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LVDVYNQFY .| |. || IVKLYDIFY |
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| Kinase | 28065.AA | Ciliate-E5 | 38-112 | 28 | 1.9e-09 | 26.67 | In-house | 3-74 (271) | Show / Hide |
Range on Protein: 38-112 Range on HMM: 3-74/271 Sequence Identity: 28% (22 aa) DFEYLGNGSFALVIKAFNKTSQKHVALKIVLCNQNEPNDAESVLKEYNLLLKIKNCPYLVDVYNQFYVYE-EKILI . || | ...|.|.. . .| .| ||..|. .. . |. ..|.|.| .. | |. . || |.| |. |.. . ENQILGKGGSGMVMKGCSEWNDKPIAIKIMKCKNQK--QCEDNQREFNILKQF-NSPHIIKVY-QIYQYQYENMNY |
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| Kinase | 28065.AA | STE | 36-100 | 18 | 2.8e-09 | 29.02 | In-house | 1-96 (359) | Show / Hide |
Range on Protein: 36-100 Range on HMM: 1-96/359 Sequence Identity: 18% (18 aa) YNDFEYLGNGSFALVIKAFNK-TSQKH--------------VALKIVLCNQNEP---------------NDAESVLKEYNLLLKIKN-CPYLVDVY . . | .|.|.| | || |. ... | .| |.. ..... .. ...||| ... | .. .|. | | WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYY |
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| Kinase | 28065.AA | STE20 | 36-97 | 26 | 3.6e-09 | 29.97 | In-house | 1-67 (288) | Show / Hide |
Range on Protein: 36-97 Range on HMM: 1-67/288 Sequence Identity: 26% (18 aa) YNDFEYLGNGSFALVIKAFN-KTSQKH---VALKIVLCNQNEP--NDAESVLKEYNLLLKIKNCPYLV |...| .|.||. | || . .| .. || |.. .. .. .. |...||.. . . | .|. | YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIV |
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| Kinase | 28065.AA | CAMK | 41-112 | 14 | 7.7e-09 | 23.87 | In-house | 1-134 (425) | Show / Hide |
Range on Protein: 41-112 Range on HMM: 1-134/425 Sequence Identity: 14% (19 aa) YLGNGSFALVIKAFNKTSQ------------KHVALKIVLCNQNE--------------------------PNDAESVLKEYNLLLKIK------NCPYL || |||. | ....| .. ..|| ||. .. |.| ..|..|.... |.. . | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VDVYNQFY----------------VYEE---KILI . | . |. . .. . IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYM |
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| Kinase | 28065.AA | ULK | 36-100 | 27 | 1.2e-08 | 26.9 | In-house | 1-81 (324) | Show / Hide |
Range on Protein: 36-100 Range on HMM: 1-81/324 Sequence Identity: 27% (22 aa) YNDFEYLGNGSFA-LVIKAFNKTS---QKHVALKIVL-CNQNE-PNDAE------SVLKEYNLLLKIK--NCPY--LVDVY |. . || |||. | |..|| . ...|| |.. ...|. .|..| . .| ... |.| ..|. | | YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY |
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| Kinase | 28065.AA | Pkinase | 36-97 | 26 | 4e-06 | 22.85 | Pfam | 1-63 (293) | Show / Hide |
Range on Protein: 36-97 Range on HMM: 1-63/293 Sequence Identity: 26% (17 aa) YNDFEYLGNGSFALVIKAFNKTSQKHVALKIVLCNQNEPNDAESVLK--EYNLLLKIKNCPYLV | . .| |||. | |. .| ..| ||.||. .... .. .. | ..... |.|. | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIV |
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