Gene 25435 (Tetrahymena)
25435
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 25435.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 25435.AA | Ciliate-E1 | 26-205 | 16 | 9e-32 | 100.8 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 26-205 Range on HMM: 1-202/202 Sequence Identity: 16% (33 aa) LGKGDYSVVVQAYSNEDQ-IEVAVKIFNDEDQ-D-------IEKEIQIFEKLQGENQIVQIISTII-DPDLNMYAIVTELYDCKLPTSF----------- .|.|..|.|..|...... ..||.||.| ... . |.....|.. ...| .|.||| .|. | .....|.... .. . . . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC --TILYLQFTSLIHKQFENDSVIEQTFLLANIGSDRIITKSVTYLSSKRRNKLTFALCDFGKSHSLKDPLLDHTNSSLQGNLIYMSPEVSNGDKP--YTI . ...|. ... .| ... . . .| .| . .. . . . .. .. |....|.|...... .. .... . |..||. . .|. ... QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQ-EHNKNQKINY KADVF | |.. KSDIY |
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| Kinase | 25435.AA | Ciliate-A8 | 20-98 | 44 | 1.8e-28 | 95.64 | In-house | 1-86 (151) | Show / Hide |
Range on Protein: 20-98 Range on HMM: 1-86/151 Sequence Identity: 44% (38 aa) YQFQRFLGKGDYSVVVQAYSNEDQIEVAVKIFND-------EDQDIEKEIQIFEKLQGENQIVQIISTIIDPDLNMYAIVTELYDC | .|..|.||| | |||||| ..| ||.||... .|. .||.||...|...|. | ||| .| |..... |||||..|| YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDC |
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| Kinase | 25435.AA | Pkinase | 20-98 | 26 | 5.5e-14 | 50.54 | Pfam | 1-84 (293) | Show / Hide |
Range on Protein: 20-98 Range on HMM: 1-84/293 Sequence Identity: 26% (23 aa) YQFQRFLGKGDYSVVVQAYSNEDQIEVAVKIFNDEDQDIEK--------EIQIFEKLQGENQIVQIISTIIDPDLNMYAIVTELYDC |.. | .|.| ...| ... ....|||||.. .... .| |||| .|. .| ||... . | . ..| .|.|. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFED-KDHIY-MVMEYCEG |
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| Kinase | 25435.AA | CMGC | 20-98 | 15 | 2.1e-13 | 39.47 | In-house | 1-139 (513) | Show / Hide |
Range on Protein: 20-98 Range on HMM: 1-139/513 Sequence Identity: 15% (22 aa) YQFQRFLGKGDYSVVVQAYS--------------NEDQIEVAVKIFNDEDQDIE----------------KEIQIFEKLQ----------------GENQ |. . .|.| |.||.... .|.. .||.|.. . . | ||.| ..|. .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN IVQIISTIIDPD---------------LNMYAIVTELYDC ||... . ... .| .|.|. |. IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH |
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| Kinase | 25435.AA | S_TKc | 20-278 | 18 | 5.9e-13 | 13.1 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 20-278 Range on HMM: 1-231/231 Sequence Identity: 18% (53 aa) YQFQRFLGKGDYSVVVQAYSNEDQIEVAVKIFNDEDQDIEKEIQIFEKLQGENQIVQIISTIIDPDLNMYAIVTELYDCKLPTSFTILYLQF-------T |.. | .||| ...| ... .... .||.|| . ..|..|||| .| . ||... .. | . . .|.|. | | . |... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SLIHKQFENDSVIEQTFL-LANIGSDRII-----------TKSVTYLSSKRRNKLTFALCDFGKSHSLKDPLLDHTNSSLQGNLIYMSPEVSNGDKPYTI . | .| .. |... |. . | .|| .. . .|||| . | ... | . ||.||| .|. PE-HARF----YMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGK -KADVFSIGVVILQCMLGEQLKPEQIIFLKTSLLVDVIPSIQSHPNYDFIEKIVSYMVNFNKQERLEPLRLIQ-----KLKSFQ |.|. |.|... .. |. . | |. . .. .... ... . ... ..|. . | |. . CKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 25435.AA | TKL | 150-274 | 14 | 8e-11 | 35.21 | In-house | 186-364 (364) | Show / Hide |
Range on Protein: 150-274 Range on HMM: 186-364/364 Sequence Identity: 14% (26 aa) KRRNKLTFALCDFG----KSHSLKDPLLDHT-------------NSSLQGNLIYMSPEVSNGD---------------KPYTIKADVFSIGVVILQCMLG .. . . .|||| .|.| .. .| ... |.. .|.||| .|. ..|. |.||.| |.|. .. . NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTR EQLKPEQI-----------IFLKTSLLVDVIPSIQSHPNY--------DF---IEKIVSYMVNFNKQERLEPLRLIQKL .. .. .... . | | ..... |. . |. . . ..|. ......| CRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| Kinase | 25435.AA | CAMK | 25-95 | 14 | 5.5e-10 | 27.63 | In-house | 1-141 (425) | Show / Hide |
Range on Protein: 25-95 Range on HMM: 1-141/425 Sequence Identity: 14% (21 aa) FLGKGDYSVVVQAYSNEDQ------------IEVAVKIFN-------------------------------DEDQD-IEKEIQIFEKLQG------ENQI ||.| ...| .. ... .||.|| . ..|.. ...||.| |||| | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQIISTIIDPD-----------------LNMYAIVT---EL .... .. ||. ... .|. |. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEY |
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| Kinase | 25435.AA | MLK | 160-211 | 35 | 5.5e-10 | 30.95 | In-house | 175-226 (291) | Show / Hide |
Range on Protein: 160-211 Range on HMM: 175-226/291 Sequence Identity: 35% (19 aa) CDFGKSHSLKDPLLDHTNSSLQGNLIYMSPEV-SN-GDKPYTIKADVFSIGVVI |||| |..... . | .|....|.||| . .|..|.||.|.|||. CDFGTSRDWHQMC--TNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVL |
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| Kinase | 25435.AA | STE | 20-97 | 17 | 9e-10 | 30.8 | In-house | 1-120 (359) | Show / Hide |
Range on Protein: 20-97
Range on HMM: 1-120/359
Sequence Identity: 17% (21 aa)
YQFQRFLGKGDYSVVVQAYSNE---------------DQIEVAVKIFN---------------------DEDQDIEKEIQIFEKLQG-ENQIVQIISTII
.......||| . .|..|. .. . .|.|. | .| |.|.|||.| |.. ||. . . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
-----DPDLNMYAIVTELYD
. . . |. |. |
KEGHNHKNDDELWICMEYMD
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| Kinase | 25435.AA | C8 | 159-211 | 28 | 1.5e-09 | 29.39 | In-house | 168-226 (226) | Show / Hide |
Range on Protein: 159-211 Range on HMM: 168-226/226 Sequence Identity: 28% (17 aa) LCDFGKSHSLKDPL-LDHTNSSLQ-GNLIYMSPEVSNG----DKPYTIKADVFSIGVVI ||||| . ... ... . . |.. |. ||. .. | |.|. |.||.|.| LCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL |
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| Kinase | 25435.AA | Ciliate-E2 | 159-218 | 20 | 2.8e-09 | 28.0 | In-house | 197-293 (365) | Show / Hide |
Range on Protein: 159-218 Range on HMM: 197-293/365 Sequence Identity: 20% (20 aa) LCDFGKSHSLKDP-----------------------------LLDHTNSSLQGNLIYMSPEVSNG--------DKPYTIKADVFSIGVVILQCMLGE ..||| | ..|. . ... .. |.. ||.||. || |.|. |.|..|.||.. ... |. IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK |
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| Kinase | 25435.AA | STE | 159-212 | 28 | 5.6e-08 | 24.38 | In-house | 188-259 (359) | Show / Hide |
Range on Protein: 159-212 Range on HMM: 188-259/359 Sequence Identity: 28% (21 aa) LCDFGKSHSLKDPLLDH----------TNS----SLQGNLIYMSPEVSNG-----DKPYTIKADVFSIGVVIL ||||| . .| | . . |.. .. | .|.||| .. ||.|..|.|. |.| .|. LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII |
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| Kinase | 25435.AA | ULK | 159-244 | 19 | 6.8e-08 | 23.73 | In-house | 183-286 (329) | Show / Hide |
Range on Protein: 159-244 Range on HMM: 183-286/329 Sequence Identity: 19% (20 aa) LCDFGKSHSLKDP-LLDHTNSSLQ------GNLIYMSPEVSN---GDKPYT-IKADVFSIGVVILQCMLGE-----QLKPEQIIFLKTSLLVDVIPS--- ..||| . .. .. . . . . | .||.|.. . . |||. |.|..|.|... .. |. . . .|.. ...|. . |. IADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQ IQSHP |...| IKKQP |
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| Kinase | 25435.AA | ULK | 20-78 | 21 | 1.1e-07 | 23.05 | In-house | 1-84 (329) | Show / Hide |
Range on Protein: 20-78 Range on HMM: 1-84/329 Sequence Identity: 21% (18 aa) YQFQRFLGKGDYSVVVQAYSNED----QIEVAVKI-----FNDEDQD---------IEKEIQIFEKL----QGEN---QIVQII |. . |||| . .| ... ... .. ||.|. .| . .. ...||.| || ...| ||. . YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLY |
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| Kinase | 25435.AA | Pkinase | 159-224 | 27 | 1.3e-07 | 27.95 | Pfam | 153-215 (293) | Show / Hide |
Range on Protein: 159-224 Range on HMM: 153-215/293 Sequence Identity: 27% (18 aa) LCDFGKSHSLKDPLLDHTNSSLQGNLIYMSPEVSNGDKPYTIKADVFSIGVVILQCMLGEQLKPEQ .|||| . .. .. .... | . ||.||| .|...|. |.|..|.|... . ..|. . |.. ICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGH |
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| Kinase | 25435.AA | TyrKc | 20-274 | 16 | 8.9e-07 | -113.11 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 20-274
Range on HMM: 1-280/280
Sequence Identity: 16% (54 aa)
YQFQRFLGKGDYSVVVQAYSNEDQIEVAVKIFNDED-QDIEKEIQIFEKL--QGENQIVQIISTIIDP-----DLNMYAIVTELY----------DCKLP
.. . || | . .|... . |.|||| ... .|. .|..| || . .| ||... .... . ||.|. ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPN-IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK
TSFTILYLQFTSLIHKQFENDSVIEQTFLLANIGSDRIITKSVTYLSSKR-------------RNKLTFALCDFGKSHSLKDPLLDH--------TNSSL
.. | .. . | . ||.||. ...| .||| | . |. . ..
------------------------LCMKDLLSFCWQ--IACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKK
---QGN--LIY--MSPEVSNGDKPYTIKADVFSIGVVI--LQCMLGEQLKPE---QIIFLKTSLLVDVIPSI--QSHPNYD-------FIEKIVSYMVNF
.|. | . |.||. | | .|.| ||.| ||.. . . .|.| |. | ... . .. . . | .| ... . |
EHKGGKTMLPIRWMAPECINYGK-FTTKSDVWSFGVCMWEI-FTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQC
NKQ---ERLEPLRLIQKL
. .| .....
WHEDPEDRPTFSEIHECF
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| Kinase | 25435.AA | MLK | 20-94 | 25 | 1e-06 | 18.94 | In-house | 1-90 (291) | Show / Hide |
Range on Protein: 20-94 Range on HMM: 1-90/291 Sequence Identity: 25% (23 aa) YQFQRFLGKGDYSVVVQA-YSNED--QIEVAVKIFN-------DE---DQDIEKEIQIFEKLQGEN---QIVQIISTIIDPDLNMYAIVTE ||....|.| . .| . . |.| . .||||... |. ..|.|.|. .. .|. .| |.|. ....| . ..||.| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP-CHFCIVME |
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| Kinase | 25435.AA | CAMK | 159-210 | 20 | 7e-06 | 14.11 | In-house | 237-323 (425) | Show / Hide |
Range on Protein: 159-210 Range on HMM: 237-323/425 Sequence Identity: 20% (18 aa) LCDFGKSHSLKDPLLDHTNSS---------------------LQGNLIYMS-PEVSNG-------------DKPYTIKADVFSIGVV ..||| . ... ....|. | . ||. ||| || ..|. |.|. |.||. IIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI |
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| Kinase | 25435.AA | TKL | 26-98 | 16 | 1.6e-05 | 15.84 | In-house | 1-122 (364) | Show / Hide |
Range on Protein: 26-98 Range on HMM: 1-122/364 Sequence Identity: 16% (20 aa) LGKGDYSVVVQA-YSNED-------QIEVAVKIFNDED-------------------------------QDIEKEIQIFEKLQGENQIVQIISTIIDPDL .|.| ...| .. . ... .||||.|. .. . .|.|| . .|. .| |||.. ..|. IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPN-IVQFMGYCCCPPC NM-----------YAIVTELYDC .. ..||.|.... GCVCMHPVGPWGQLCIVMEYCPG |
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| Kinase | 25435.AA | C8 | 18-76 | 26 | 0.00122 | 8.64 | In-house | 2-57 (226) | Show / Hide |
Range on Protein: 18-76 Range on HMM: 2-57/226 Sequence Identity: 26% (16 aa) NNYQFQRFLGKGDYSVVVQAYSNEDQIEVAVKIFNDEDQ-DIEKEIQIFEKLQGENQIVQ ||.| .| .| |..|..|. .|. |.. |. ... ||.....| ... . |..| NNFQ---YLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYE-MPQVFQ |
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| Kinase | 25435.AA | Ciliate-E2 | 20-97 | 14 | 0.002208 | 7.45 | In-house | 1-117 (365) | Show / Hide |
Range on Protein: 20-97 Range on HMM: 1-117/365 Sequence Identity: 14% (17 aa) YQFQRFLGKGDYSVVVQA--YSN---------------------EDQIEVAVKIFN-DEDQDIEKEIQIFEKLQGEN----Q------------IVQIIS | |.. .|.| ...| .. ... .. ..|.||.. .. . |..||.|. ... . |.... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE TIIDPDLNMYAIVTELYD . .. | | . .|.|... CFQEKDDNNIYLVMEYCQ |
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