Gene 24612 (Tetrahymena)
24612
Group:
Other
Family:
Ciliate-E1
Sequence
Protein domains of 24612.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 24612.AA | Ciliate-E1 | 626-799 | 24 | 1e-16 | 51.29 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 626-799 Range on HMM: 1-202/202 Sequence Identity: 24% (50 aa) INSGGEADIFV----NLD-EQVAFRVLKVDDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKINEQT-YFIHLMQICSMSLYKQYV---------- | .|.....| | .||| . .. .. ... |... ..... .. .| ... .. .| .| ... |..||... IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK--FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQ ---TVDEFSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILIIN-GQYKFTDFGASQK-ISIYNPFNKPKMWTNGYVPQNIIN-------KNKPF--Y . .|...|...|.| .. || |.|. |.|.|||| |||| | |.|...||| |.. .. | . | |. | |.. .| ||.. CQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKINYK HDIY ||| SDIY |
|||||||||
| Kinase | 24612.AA | Ciliate-B2 | 620-763 | 27 | 1.3e-14 | 30.65 | In-house | 1-151 (197) | Show / Hide |
Range on Protein: 620-763
Range on HMM: 1-151/197
Sequence Identity: 27% (43 aa)
FKLGYYINSGGEADIFVNL-------DEQVAFRVLKV---DDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKINEQTYFIHLMQICSMSLYKQYV
. |. |||.||. |. . .||... . |.. . . |.. .|.|. . .. . | |. .|||. . |..| || .
YYLCKYINKGGCGFICEGYKKHSIREYQDLAFKIYFNKQDCDKEEIQH---EIKIMKMFEYNINVVKY-IDHI---QINETID-VLIMEKCECSLKQELQ
----TVDEFSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILII-NGQYKFTDFGAS
.. .| . .....| . || .| . | | |||| |||. ||.|...||| |
KIQKQQKCFNNQKLYQMIFQLIDGLIQFRMYNILHLDIKPQNILFMQNGNYVYCDFGIS
|
|||||||||
| Kinase | 24612.AA | Ciliate-C6 | 738-768 | 45 | 2.2e-10 | 33.01 | In-house | 157-189 (306) | Show / Hide |
Range on Protein: 738-768 Range on HMM: 157-189/306 Sequence Identity: 45% (15 aa) IYHSDIKPGNILIING--QYKFTDFGASQKISI | | |||| ||||... |. .|||..|.... IAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQ |
|||||||||
| Kinase | 24612.AA | Ciliate-A1 | 642-764 | 22 | 6.3e-10 | 29.91 | In-house | 28-149 (301) | Show / Hide |
Range on Protein: 642-764 Range on HMM: 28-149/301 Sequence Identity: 22% (28 aa) VAFRVLKVDDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKIN--EQTYFIHLMQICSMSLYKQYVTVDE-FSIEQILNIVFTSLHFLISLRQKYI .. .... . .|. . |.. .|. | | .|... | | ..| | | . .|. . . |.| | .... . | LCCKIIICTNFEQYKNNIQEYRKCKQINHNNVIKNYQ---QLYYNTNNKECMFII--MEYCQYGNLFNYCYQNDYMKKEEIYEICYQIIEGYADIHDHNI YHSDIKPGNILII-NGQYKFTDFGASQ |.|.||.|||| ..|. |.| |. LHRDLKPQNILIHFDDKWKICDLGMSK |
|||||||||
| Kinase | 24612.AA | Ciliate-E2c | 733-770 | 48 | 4.1e-08 | 24.62 | In-house | 130-168 (310) | Show / Hide |
Range on Protein: 733-770 Range on HMM: 130-168/310 Sequence Identity: 48% (19 aa) LRQK-YIYHSDIKPGNILIINGQYKFTDFGASQKISIYN | .. |.| |||| |||| ||. | ||| |... . | LHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDN |
|||||||||
| Kinase | 24612.AA | S_TKc | 620-847 | 13 | 1.1e-07 | -64.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 620-847
Range on HMM: 1-231/231
Sequence Identity: 13% (36 aa)
FKLGYYINSGGEADIFVNLD----EQVAFRVLKVDDQNYFKSQLLELQNVKLFQDENHILDLNISHLLEDKINEQTYFIHLMQICSM---SLYKQYVTVD
.... | .|. . . . ..|| ..| .. . |.| | . .| | . ... | |. .|.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG
E------FSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILIINGQYKFTDFGASQKISIYNPFNKPKMWTNGYVPQNIINKNKPFYH---DIYSV--
|. .. .. . | . .. | | |.|| |||. . . | .||| . .. . | |.. .. .. . |..|.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGC
------------AKTIEIILNKLKTHPTIKDTLKKLVNQLMKDDEN--SVNIDCFQ-------LPQV
... ...|.. . .| ....... | . ...| | .
ILYEMLCGYPPFP-QMQMMFKKIG-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 24612.AA | Ciliate-E2b | 733-763 | 37 | 4.3e-07 | 17.77 | In-house | 118-149 (272) | Show / Hide |
Range on Protein: 733-763 Range on HMM: 118-149/272 Sequence Identity: 37% (12 aa) LRQKYIYHSDIKPGNILIIN-GQYKFTDFGAS | ...| . |||| ||.. . |. | |.|.. LHNQNIIYRDIKPENIMVDHKGYMKLIDMGTA |
|||||||||
| Kinase | 24612.AA | Ciliate-E3 | 663-763 | 27 | 3e-06 | 16.05 | In-house | 51-153 (202) | Show / Hide |
Range on Protein: 663-763 Range on HMM: 51-153/202 Sequence Identity: 27% (29 aa) QNVKLFQDENHILDLNISHLLEDKINEQTYFIHLMQICSMSLYKQYVTVDEFSIEQILNIVFTSLHFLISLRQKYIYHSDIKPGNILIINGQ----YKFT | ...|. |. . . . |. |. .|| .. || . |. . . . |. |. . .| . .| | |||||| |||. . . |. QEFQNCQQINSQNVVKCHDQYYDQQNK-MIFI-VQEYCSNGDLYHYIKQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKIC DFGAS |||.| DFGES |
|||||||||
| Kinase | 24612.AA | ULK | 730-770 | 35 | 5e-06 | 17.33 | In-house | 139-192 (324) | Show / Hide |
Range on Protein: 730-770 Range on HMM: 139-192/324 Sequence Identity: 35% (19 aa) LISLRQKYIYHSDIKPGNILIINGQ-------------YKFTDFGASQKISIYN . |... | | |||| |||| ||| .| .||| .... .| FKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN |
|||||||||
| Kinase | 24612.AA | ULK | 730-767 | 35 | 6e-06 | 16.96 | In-house | 143-193 (329) | Show / Hide |
Range on Protein: 730-767 Range on HMM: 143-193/329 Sequence Identity: 35% (18 aa) LISLRQKYIYHSDIKPGNILIINGQ-------------YKFTDFGASQKIS . |... | | |||| |||| ||| .| .||| ..... FKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD |
|||||||||
| Kinase | 24612.AA | IKK | 713-762 | 36 | 1.7e-05 | 14.98 | In-house | 111-164 (297) | Show / Hide |
Range on Protein: 713-762 Range on HMM: 111-164/297 Sequence Identity: 36% (21 aa) E-FSIEQILNIVFTSLHFLISLR-QKYIYHSDIKPGNILII---NGQ--YKFTDFGA | . ..|... . .|. |. |. | | ||||||| . |. || ||||. EGHEFLQVCRDCCAGMHH---LHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGY |
|||||||||